| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jie Wu, Jing-Qiu Qu, Yan-Jun Zhou, Yong-Jian Zhou, Yuan-Yuan Li, Nan-Qu Huang, Cheng-Min Deng, Yong Lu. Icariin improves cognitive deficits by reducing the deposition of β-amyloid peptide and inhibition of neurons apoptosis in SAMP8 mice. Neuroreport. vol 31. issue 9. 2021-08-18. PMID:32427716. |
western blot of hippocampal specimens revealed that ica down-regulated the expression of bace1 to reduce the expression of cytotoxic aβ1-42. |
2021-08-18 |
2023-08-13 |
mouse |
| He Yu, Zhong-Mei He, Kun Shi, Yan Zhao, Ying Zong, Jian-Ming Li, Wei-Jia Chen, Rui D. [Study on antidepressant effect of total alkaloids of Fibraurea recisa]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 14. 2021-08-18. PMID:34402292. |
this study aimed to investigate the antidepressant effects of total alkaloids of fibraurea recisa in ht22 cells damaged by corticosterone (cort) in vitro and in a mouse model of chronic unpredictable mild stress (cums) as well as the underlying mechanisms.in cellular experiments,the viability of cort-damaged ht22 cells was detected using cell counting kit-8 (cck-8),and the cell apoptosis was detected by hoechst 33258 staining.in animal experiments,c57bl/6n mice were randomly divided into the control group,model group,low (100 mg·kg~(-1)),medium (200 mg·kg~(-1)) and high (400 mg·kg~(-1))-dose of total alkaloids of f.recisa groups,and positive control group.after 21 days of cums exposure,their depressive behaviors were observed in behavioral and morris water maze tests.the serum levels of 5-hydroxytryptamine (5-ht),dopamine (da),and norepinephrine (ne) were assessed by elisa.the expression levels of apoptosis-related proteins bcl-2,bax and cleaved caspase-3 in ht22 cells and mouse hippocampus were detected by western blot.the results suggested that total alkaloids of f.recisa alleviated the damage of ht22 cells induced by cort in a dose-dependent manner.the hoechst 33258 staining uncovered that total alkaloids of f.recisa better reduced the blue spots and inhibited cell apoptosis.the results of animal experiments showed that total alkaloids of f.recisa significantly improved the depression-like behaviors of mice and increased the serum levels of 5-ht,da and ne as compared with those in the model group.the western blot assays revealed a significant up-regulation of bcl-2 protein expression,but an obvious reduction in bax and cleaved caspase-3protein expression in the total alkaloids of f.recisa group.in conclusion,total alkaloids of f.recisa inhibited depression possibly by regulating the apoptosis-related protein expression or elevating the monoamine neurotransmitter levels in the brain. |
2021-08-18 |
2023-08-13 |
mouse |
| Ting-Ting Chen, Xue Zhou, Yi-Ni Xu, Yue Li, Xiao-Ying Wu, Quan Xiang, Ling-Yun Fu, Xiao-Xia Hu, Ling Tao, Xiang-Chun She. Gastrodin ameliorates learning and memory impairment in rats with vascular dementia by promoting autophagy flux via inhibition of the Ca Aging. vol 13. issue 7. 2021-08-16. PMID:33714957. |
immunohistochemical and western blot analyses revealed that gas attenuated hippocampal levels of lc3 (microtubule-associated protein 1 light chain 3), p62, and phosphorylated camkii (ca |
2021-08-16 |
2023-08-13 |
human |
| Ming Wang, Vijay Sankar Ramasamy, Hee Kyung Kang, Jihoon J. Oleuropein promotes hippocampal LTP via intracellular calcium mobilization and Ca Neuropharmacology. vol 176. 2021-08-13. PMID:32598912. |
as assessed by surface biotinylation and western blot analysis, ole caused a significant increase in protein kinase a (pka)-mediated phosphorylation and the surface expression of glua1 containing calcium permeable- amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (cp-ampars) in the hippocampus. |
2021-08-13 |
2023-08-13 |
mouse |
| Jiefu Lin, Fuyi Shen, Jing Lu, Feng Liang, Yiying Zhang, Zhongcong Xie, Yuanlin Don. WS635 Attenuates the Anesthesia/Surgery-Induced Cognitive Impairment in Mice. Frontiers in aging neuroscience. vol 13. 2021-08-10. PMID:34366827. |
we measured the amounts of postsynaptic density (psd)-95, synaptophysin, and atp in the hippocampus and cortex of the mice using western blot and atp colorimetric/fluorometric assay, respectively. |
2021-08-10 |
2023-08-13 |
mouse |
| Agata Ciechanowska, Katarzyna Popiolek-Barczyk, Katarzyna Pawlik, Katarzyna Ciapała, Marco Oggioni, Domenico Mercurio, Maria-Grazia De Simoni, Joanna Mik. Changes in macrophage inflammatory protein-1 (MIP-1) family members expression induced by traumatic brain injury in mice. Immunobiology. vol 225. issue 3. 2021-08-06. PMID:32059938. |
we investigated changes in mrna (rt-qpcr) and/or protein (elisa and western blot) expression in brain structures (the cortex, hippocampus, thalamus, and striatum) at different time points (24 h, 4 days, 7 days, 2 weeks, and/or 5 weeks) after trauma. |
2021-08-06 |
2023-08-13 |
mouse |
| Widuri Kho, Clarissa von Haefen, Nadine Paeschke, Fatme Nasser, Stefanie Endesfelder, Marco Sifringer, Adrián González-López, Nadine Lanzke, Claudia D Spie. Dexmedetomidine Restores Autophagic Flux, Modulates Associated microRNAs and the Cholinergic Anti-inflammatory Pathway upon LPS-Treatment in Rats. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2021-08-06. PMID:34357471. |
we used western blot and activity assays to study how dex modulated autophagy- and apoptosis-associated proteins as well as molecules of the cholinergic anti-inflammatory pathway, and qpcr to analyse the expression of autophagy and inflammation-associated micrornas (mirna) in the spleen, cortex and hippocampus at different time points (6 h, 24 h, 7 d). |
2021-08-06 |
2023-08-13 |
rat |
| Yunxuan Xu, Lingyun Lian. Vitamin D3/vitamin D receptor signaling mitigates symptoms of post-stroke depression in mice by upregulating hippocampal BDNF expression. Neuroscience research. vol 170. 2021-08-04. PMID:32882254. |
for the mice in each group, longa and berderson behavioral tests were performed to evaluate motor function, sucrose preference and forced swimming tests were conducted to assess the cardinal depression-like behaviors anhedonia and helplessness, and western blot and immunohistochemistry were conducted to measure the levels of vitamin d receptor (vdr) and bdnf expression levels in mouse hippocampus. |
2021-08-04 |
2023-08-13 |
mouse |
| S W Carlson, H Q Yan, Y Li, J Henchir, X Ma, M S Young, M D Ikonomovic, C E Dixo. Differential Regional Responses in Soluble Monomeric Alpha Synuclein Abundance Following Traumatic Brain Injury. Molecular neurobiology. vol 58. issue 1. 2021-08-04. PMID:32948930. |
western blot analysis demonstrated decreased levels of monomer α-synuclein protein in the ipsilateral hippocampus at 6 h, 1 day, 1, 2, and 8 weeks, as well as in the ipsilateral cortex at 1 and 2 weeks and in the ipsilateral striatum at 6 h after cci compared with sham animals. |
2021-08-04 |
2023-08-13 |
rat |
| Wei Sun, Hong Cheng, Yang Yang, Dongxin Tang, Xiaolian Li, Lei A. Requirements of Postnatal proBDNF in the Hippocampus for Spatial Memory Consolidation and Neural Function. Frontiers in cell and developmental biology. vol 9. 2021-08-03. PMID:34336832. |
the expression of hippocampal probdnf was blocked in postnatal weeks, and multiple behavioral tests, western blot and morphological techniques, and neural recordings were employed to investigate how probdnf played a role in spatial cognition in adults. |
2021-08-03 |
2023-08-13 |
Not clear |
| Wei-Ting Xuan, Han Wang, Peng Zhou, Ting Ye, Hua-Wu Gao, Shu Ye, Jing-Hui Wang, Meng-Lian Chen, Hang Song, Yan Wang, Biao Ca. Berberine ameliorates rats model of combined Alzheimer's disease and type 2 diabetes mellitus via the suppression of endoplasmic reticulum stress. 3 Biotech. vol 10. issue 8. 2021-08-02. PMID:32832321. |
the morris water maze, biochemical analysis, hematoxylin-eosin staining, immunohistochemical study, immunofluorescent staining, tunel assay, rt-qpcr and western blot were used to reveal the effect of bbr on blood glucose, lipid changes, hippocampal injuries and cognitive impairment. |
2021-08-02 |
2023-08-13 |
rat |
| Beibei Liu, Jingjing Li, Xiaojing Lin, Jingyun Hu, Shujie Lo. The metabolic changes in the hippocampus of an atherosclerotic rat model and the regulation of aerobic training. Metabolic brain disease. vol 35. issue 6. 2021-07-29. PMID:32240489. |
metabolomics based on gc-ms was applied to detect small molecules metabolites and western blot was used to detect the concentration of enzymes involved in metabolic changes in rat hippocampus. |
2021-07-29 |
2023-08-13 |
rat |
| Manana G Dashniani, Maia A Burjanadze, Nino C Chkhikvishvili, Revaz O Solomonia, Manana Kandashvili, Temur L Naneishvili, Gela V Beselia, Lali B Kruashvili, Mariam R Chighladz. Modulation of spatial memory and expression of hippocampal neurotransmitter receptors by selective lesion of medial septal cholinergic and GABAergic neurons. Experimental brain research. vol 238. issue 10. 2021-07-28. PMID:32770352. |
western blot analyses revealed the ms cholinergic lesions have significant effect on the expression level of the m1 mach receptors, while ms gabaergic lesions induce dramatic modulations of hippocampal glutamatergic, cholinergic and gabaergic receptors expression. |
2021-07-28 |
2023-08-13 |
rat |
| Zhao Jin, Zongze Zhang, Jianjuan Ke, Yanlin Wang, Huisheng W. Exercise-Linked Irisin Prevents Mortality and Enhances Cognition in a Mice Model of Cerebral Ischemia by Regulating Klotho Expression. Oxidative medicine and cellular longevity. vol 2021. 2021-07-27. PMID:34306305. |
the expressions of klotho, mnsod, and foxo3a in the hippocampus of mice were detected by western blot. |
2021-07-27 |
2023-08-13 |
mouse |
| Michael Zhang, Haley F Spencer, Rina Y Berman, Kennett D Radford, Kwang H Cho. Effects of subanesthetic intravenous ketamine infusion on neuroplasticity-related proteins in male and female Sprague-Dawley rats. IBRO neuroscience reports. vol 11. 2021-07-22. PMID:34286313. |
two hours after the infusion, brain tissue was dissected to obtain the medial prefrontal cortex (mpfc), hippocampus including the ca1, ca3, and dentate gyrus, and amygdala followed by western blot analyses of a transcription factor (c-fos), brain-derived neurotrophic factor (bdnf), and phosphorylated extracellular signal-regulated kinase (perk). |
2021-07-22 |
2023-08-13 |
rat |
| Halime Dana, Keziban Korkmaz Bayramov, Nesrin Delibaşı, Reyhan Tahtasakal, Ruslan Bayramov, Zuhal Hamurcu, Elif Funda Sene. Disregulation of Autophagy in the Transgenerational Cc2d1a Mouse Model of Autism. Neuromolecular medicine. vol 22. issue 2. 2021-07-19. PMID:31721010. |
western blot confirmed the changes of the proteins in the hippocampus. |
2021-07-19 |
2023-08-13 |
mouse |
| Rong He, Wei Han, Xiaojie Song, Li Cheng, Hengsheng Chen, Li Jian. Knockdown of Lingo-1 by short hairpin RNA promotes cognitive function recovery in a status convulsion model. 3 Biotech. vol 11. issue 7. 2021-07-17. PMID:34221810. |
the hippocampal changes of the ngr1 pathway during epileptogenesis were determined by western blot analysis of multiple proteins, including neurite outgrowth inhibitor protein a (nogoa), myelin-associated glycoprotein (mag), oligodendrocyte-myelin glycoprotein (omgp), lingo-1, ras homolog family member a (rhoa) and phosphorylated rhoa (p-rhoa). |
2021-07-17 |
2023-08-13 |
rat |
| Sofie D Shirenova, Nadezhda N Khlebnikova, Nataliya A Krupin. Long-Term Social Isolation Reduces Expression of the BDNF Precursor and Prolyl Endopeptidase in the Rat Brain. Biochemistry. Biokhimiia. vol 86. issue 6. 2021-07-15. PMID:34225593. |
the present study aimed to assess synaptophysin (syp), brain-derived neurotrophic factor precursor (probdnf), and prep expression using western blot in the brain structures - the hippocampus, frontal cortex, and striatum of the rats subjected to prolonged social isolation compared with group-housed animals. |
2021-07-15 |
2023-08-13 |
rat |
| Zhiguo Chen, Jiangang Liu, Qingmei Chen, Min Su, Haifeng Lu, Yi Yang, Guoqing Zhou, Xianxian Zhang, Yuan Liu, Wanli Dong, Qi Fan. Down-regulation of UBA6 exacerbates brain injury by inhibiting the activation of Notch signaling pathway to promote cerebral cell apoptosis in rat acute cerebral infarction model. Molecular and cellular probes. vol 53. 2021-07-13. PMID:32497710. |
the results of flow cytometry and western blot assays further demonstrated that uba6 inhibition induced the apoptosis of hippocampal neurons and increased cleaved-caspase-3/9 protein levels. |
2021-07-13 |
2023-08-13 |
rat |
| Hongxin Wang, Guangyan Yao, Lei Li, Zhaoyin Ma, Jing Chen, Wen Che. LncRNA-UCA1 inhibits the astrocyte activation in the temporal lobe epilepsy via regulating the JAK/STAT signaling pathway. Journal of cellular biochemistry. vol 121. issue 10. 2021-07-12. PMID:31909503. |
furthermore, the immunofluorescence and western blot analysis revealed that the overexpression of uca1 inhibited ka-induced abnormal elevation of glast, astrocyte activation of the jak/stat signaling pathway, as well as hippocampus of epilepsy rats. |
2021-07-12 |
2023-08-13 |
rat |