| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paulina Misztak, Magdalena Sowa-Kućma, Patrycja Pańczyszyn-Trzewik, Bernadeta Szewczyk, Gabriel Nowa. Antidepressant-like Effects of Combined Fluoxetine and Zinc Treatment in Mice Exposed to Chronic Restraint Stress Are Related to Modulation of Histone Deacetylase. Molecules (Basel, Switzerland). vol 27. issue 1. 2022-01-11. PMID:35011254. |
furthermore, the effects of crs, flu and zn given alone and combined treatment with flu + zn on the expression of proteins involved in the apoptotic, inflammatory, and epigenetic processes were evaluated in selected brain structures (prefrontal cortex, pfc; and hippocampus, hp) using western blot analysis or enzyme-linked immunosorbent assays (elisa). |
2022-01-11 |
2023-08-13 |
mouse |
| Guo-Liang Dai, Xin-Yi Yang, Shan-Shan Chen, Yi-Qing Wang, Mei-Chen Liu, Yang Cao, Fei-Ran Li, Cheng-Yao Ma, Wen-Zheng J. [Effects of Jiaotai Pills on CUMS-induced depression model in mice based on changes of SIRT1 expression in hippocampus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 24. 2022-01-07. PMID:34994144. |
western blot was used to detect the protein expression levels of sirt1, p-nf-κb p65, nf-κb p65, and foxo1 in the hippocampus of mice. |
2022-01-07 |
2023-08-13 |
mouse |
| Kumari Vandana Singh, Rakesh Arya, Jay Prakash Nirala, Debasis Sahu, Ranjan Kumar Nanda, Paulraj Rajaman. Effects of mobile phone electromagnetic radiation on rat hippocampus proteome. Environmental toxicology. 2022-01-05. PMID:34984797. |
in this study, we attempted a global proteome profiling study of rat hippocampus exposed to mobile phone radiation for 20 weeks (for 3 h/day for 5 days/week) to identify deregulated proteins and western blot analysis for validation. |
2022-01-05 |
2023-08-13 |
rat |
| Zhuoyu Ren, Mingling Wang, Mokhtar Aldhabi, Rui Zhang, Yongxin Liu, Shaoyan Liu, Rundong Tang, Zuolei Che. Low-dose S-ketamine exerts antidepressant-like effects via enhanced hippocampal synaptic plasticity in postpartum depression rats. Neurobiology of stress. vol 16. 2022-01-03. PMID:34977283. |
synaptic plasticity of the hippocampus can be demonstrated by western blot, golgi staining, transmission electron microscopy, and electrophysiological recording. |
2022-01-03 |
2023-08-13 |
rat |
| Naoki Ito, Akiko Maruko, Kenshiro Oshima, Masaaki Yoshida, Kengo Honma, Chika Sugiyama, Takayuki Nagai, Yoshinori Kobayashi, Hiroshi Odaguchi, Norihiro Okad. Kampo formulas alleviate aging-related emotional disturbances and neuroinflammation in male senescence-accelerated mouse prone 8 mice. Aging. vol 14. issue undefined. 2022-01-03. PMID:34979499. |
western blot analysis revealed that hippocampal neuroinflammation was significantly abrogated by kampo formulas. |
2022-01-03 |
2023-08-13 |
mouse |
| Ayse Ozkan, Mutay Aydin Aslan, Osman Sinen, Mustafa Munzuroglu, Narin Derin, Hande Parlak, Mehmet Bulbul, Aysel Aga. Effects of adropin on learning and memory in rats tested in the Morris water maze. Hippocampus. 2021-12-31. PMID:34971006. |
the expression of akt, phospho-akt, creb, phospho-creb, erk1/2, phospho-erk1/2, glycogen synthase kinase 3 β (gsk3β), phospho-gsk3β, brain-derived neurotrophic factor (bdnf), and n-methyl-d-aspartate receptor nr2b subunit were determined in the hippocampal tissues by using western blot. |
2021-12-31 |
2023-08-13 |
rat |
| Ayse Ozkan, Mutay Aydin Aslan, Osman Sinen, Mustafa Munzuroglu, Narin Derin, Hande Parlak, Mehmet Bulbul, Aysel Aga. Effects of adropin on learning and memory in rats tested in the Morris water maze. Hippocampus. 2021-12-31. PMID:34971006. |
meanwhile, the western blot analyses revealed that the phosphorylated form of the akt and creb were enhanced with adropin administration in the hippocampus. |
2021-12-31 |
2023-08-13 |
rat |
| Ting Chen, Lan Shou, Xiaowen Guo, Mingyang Wei, Hui Zheng, Tao Ta. Magnolol attenuates the locomotor impairment, cognitive deficit, and neuroinflammation in Alzheimer's disease mice with brain insulin resistance via up-regulating miR-200c. Bioengineered. vol 13. issue 1. 2021-12-30. PMID:34968163. |
the levels of malondialdehyde (mda), glutathione (gsh), superoxide dismutase (sod), tumor necrosis factor-α (tnf-α), interleukin-6 (il-6), c-reactive protein (crp), and mir-200c in the mice hippocampus were evaluated by enzyme-linked immunosorbent assay, western blot, or quantitative real-time polymerase chain reaction. |
2021-12-30 |
2023-08-13 |
mouse |
| Menglin Li, Xiaolin Zhong, Zhibo Zhao, Zhaolin Zeng, Qing Yuan, Xinhua Xiao, Xuyu Zu, Jinghua Li. The expression of m6A enzymes in the hippocampus of diabetic cognitive impairment mice and the possible improvement of YTHDF1. Brain research. 2021-12-26. PMID:34953798. |
western blot analysis showed that compared with the control group, the protein levels of ythdc2 and alkbh5 were significantly upregulated in the hippocampus in the stz group, while the expression of ythdf1, ythdf3 and wtap was significantly downregulated. |
2021-12-26 |
2023-08-13 |
mouse |
| Vahid Reza Ostovan, Zeynab Amiri, Leila Moezi, Fatema Pirsalami, Zahra Esmaili, Maryam Moosav. The effects of subchronic agmatine on passive avoidance memory, anxiety-like behavior and hippocampal Akt/GSK-3β in mice. Behavioural pharmacology. 2021-12-26. PMID:34954711. |
furthermore, considering the roles of akt/gsk-3β signaling pathway in memory and alzheimer's disease, the hippocampal contents of phosphorylated and total forms of akt and gsk-3β proteins were determined using the western blot technique. |
2021-12-26 |
2023-08-13 |
mouse |
| Mawj Mandwie, Jocelyn Karunia, Aram Niaz, Kevin A Keay, Giuseppe Musumeci, Claire Rennie, Kristine McGrath, Ghaith Al-Badri, Alessandro Castorin. Metformin Treatment Attenuates Brain Inflammation and Rescues PACAP/VIP Neuropeptide Alterations in Mice Fed a High-Fat Diet. International journal of molecular sciences. vol 22. issue 24. 2021-12-24. PMID:34948457. |
after 16 weeks, the proinflammatory profile, glial activation markers, and changes within the pi3k/akt intracellular pathway and the pacap/vip system were evaluated by real-time qpcr and/or western blot in the hypothalamus, hippocampus, prefrontal cortex, and amygdala. |
2021-12-24 |
2023-08-13 |
mouse |
| De-Ping Zhao, Da-Long Li, Yan-Hang Zhang, Yue Cui, Hong-Dan Xu, Bo Yang, Xia Lei, Ning Zhan. [Total flavonoids of Drynariae Rhizoma regulates ER-p38 MAPK signaling pathway to improve scopolamine-induced learning and memory impairments in model mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 22. 2021-12-24. PMID:34951183. |
following the measurement of mouse learning and memory abilities in morris water maze test, the hippocampal erβ expression was detected by immunohistochemistry, and the expression levels of erβ and phosphorylated p38(p-p38) in the hippocampus and b-cell lymphoma 2(bcl-2), bcl-2-associated death promoter(bad), and cysteinyl aspartate-specific protease-3(caspase-3) in the apoptotic system were assayed by western blot. |
2021-12-24 |
2023-08-13 |
mouse |
| Nader Asadian, Houman Parsaie, Abbas Ali Vafaei, Masoumeh Dadkhah, Samira Omoumi, Katayoun Sedagha. Chronic light deprivation induces different effects on spatial and fear memory and hippocampal BDNF/TRKB expression during light and dark phases of rat diurnal rhythm. Behavioural brain research. vol 418. 2021-12-11. PMID:34695541. |
bdnf and trkb protein levels in the hippocampus of rats from the four sub-groups were measured by western blot, at the completion of the 3 week constant darkness exposure and after the behavioral experiments. |
2021-12-11 |
2023-08-13 |
human |
| Yujiao Yang, Junke Song, NanNan Liu, Guangyi Wei, Shan Liu, Sen Zhang, Nan Jiang, Haiguang Yang, Guanhua D. Salvianolic acid A relieves cognitive disorder after chronic cerebral ischemia: Involvement of Drd2/Cryab/NF-κB pathway. Pharmacological research. vol 175. 2021-12-11. PMID:34800628. |
tunel staining, enzyme-linked immunosorbent assay, and western blot analysis were used to detect the inflammatory and apoptosis in the cortex and hippocampus. |
2021-12-11 |
2023-08-13 |
rat |
| Jing Zhu, Si Tang, Dong Zhao, Zhaofu Zeng, Huaheng Mo, Ke H. Orexin A improves the cognitive impairment induced by chronic intermittent hypoxia in mice. Brain research bulletin. vol 173. 2021-12-09. PMID:34051297. |
apoptotic cell death and oxidative stress in hippocampus were evaluated using multiple methods including tunel, western blot and biochemical analysis. |
2021-12-09 |
2023-08-13 |
mouse |
| Cailian Ruan, Hongtao Guo, Jiaqi Gao, Yiwei Wang, Zhiyong Liu, Jinyi Yan, Xiaoji Li, Haixia L. Neuroprotective effects of metformin on cerebral ischemia-reperfusion injury by regulating PI3K/Akt pathway. Brain and behavior. vol 11. issue 10. 2021-12-09. PMID:34473417. |
western blot method was used to detect the expression of pi3k, p-pi3k, akt, and p-akt in hippocampus. |
2021-12-09 |
2023-08-13 |
rat |
| Yuechen Guan, Junming Wang, Xiaohui Wu, Lingling Song, Yanmei Wang, Mingzhu Gong, Bingyin L. Quercetin reverses chronic unpredictable mild stress-induced depression-like behavior in vivo by involving nuclear factor-E2-related factor 2. Brain research. vol 1772. 2021-12-09. PMID:34529966. |
further western blot analysis showed that cums caused the phosphorylation or expression levels of phosphoinositide 3-kinase (pi3k), protein kinase b (akt), nrf2 and heme oxygenase-1 (ho-1) proteins in the hippocampus of mice to significantly down-regulate by 60.0%, 72.1%, 90.0% and 50.1% (all p < 0.01), while after chronic oral administration of high dose quercetin at 40 mg/kg, the abnormalities of these proteins were significantly up-regulated by 85.8%, 182.0%, 325.1% and 60.3% (all p < 0.01). |
2021-12-09 |
2023-08-13 |
mouse |
| Zhang Bao, Yin Jin. Brominated flame retardant TBPH induced oxidative damage and reduced the expression of memory-related proteins in mice, with no discernable impairment of learning and memory. Human & experimental toxicology. vol 40. issue 12_suppl. 2021-12-08. PMID:34784780. |
western blot was used to detect the expression of glucose-regulated protein 78-kda (grp78), pkr-like er kinase (perk), and c/ebp homologous protein (chop) in the hippocampus. |
2021-12-08 |
2023-08-13 |
mouse |
| Choong Hyun Lee, Ji Hyeon Ahn, Bai Hui Chen, Dae Won Kim, Hyejin Sim, Tae-Kyeong Lee, Joon Ha Park, Moo-Ho Won, Soo Young Cho. Differences in TNF‑α and TNF‑R1 expression in damaged neurons and activated astrocytes of the hippocampal CA1 region between young and adult gerbils following transient forebrain ischemia. Molecular medicine reports. vol 24. issue 3. 2021-11-30. PMID:34212986. |
the present study compared the time‑dependent changes of tnf‑α and tnf‑r1 protein expression levels in the hippocampal subfield cornu ammonis 1 (ca1) between adult and young gerbils following transient forebrain ischemia (tfi), via western blot and immunohistochemistry analyses. |
2021-11-30 |
2023-08-13 |
Not clear |
| Yi Li, Lixia DU, Xiaofeng Guo, Xijing Zhan. [Cognitive impairments relate to the expression of α7 nicotinic acetylcholinergic receptor (α7nAChR) and the proportion of M1/M2 microglia in the hippocampus of male mice with sepsis-associated encephalopathy]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 37. issue 11. 2021-11-24. PMID:34809734. |
the expression and distribution of α7 nicotinic acetylcholinergic receptor (α7nachr) and the proportion of m2 microglia in hippocampus of sae mice were detected by immunofluorescence staining, and the level of α7nachr protein was detected by western blot. |
2021-11-24 |
2023-08-13 |
mouse |