| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ning Kang, Yuanyuan Shi, Jiaxi Song, Fei Gao, Mingyue Fan, Wei Jin, Yaran Gao, Peiyuan L. Resveratrol reduces inflammatory response and detrimental effects in chronic cerebral hypoperfusion by down-regulating stimulator of interferon genes/TANK-binding kinase 1/interferon regulatory factor 3 signaling. Frontiers in aging neuroscience. vol 14. 2022-08-08. PMID:35936778. |
the neuroinflammatory responses in white matter and hippocampus of the rat brain were assessed by western blot, immunofluorescence staining, and qrt-pcr analyses. |
2022-08-08 |
2023-08-14 |
rat |
| Z Junde, L Tingting, Z Lu, C Shan, Y Da. Lithium chloride promotes neural functional recovery after local cerebral ischemia injury in rats through Wnt signaling pathway activation. Folia morphologica. 2022-08-02. PMID:35916382. |
apoptosis of the hippocampal neurons was tested by western blot. |
2022-08-02 |
2023-08-14 |
human |
| Kornrawee Suwannakot, Nataya Sritawan, Salinee Naewla, Anusara Aranarochana, Apiwat Sirichoat, Wanassanun Pannangrong, Peter Wigmore, Jariya Umka Welba. Melatonin Attenuates Methotrexate-Induced Reduction of Antioxidant Activity Related to Decreases of Neurogenesis in Adult Rat Hippocampus and Prefrontal Cortex. Oxidative medicine and cellular longevity. vol 2022. 2022-07-25. PMID:35873801. |
the hippocampus and pfc were harvested for western blot analysis and biochemical assessments of malondialdehyde (mda), catalase (cat), glutathione peroxidase (gpx), and superoxide dismutase (sod). |
2022-07-25 |
2023-08-14 |
rat |
| Sarah E Svirsky, Nicholas S Ranellone, Madison Parry, Erik Holets, Jeremy Henchir, Youming Li, Shaun W Carlson, C Edward Dixo. All-trans retinoic acid has limited therapeutic effects on cognition and hippocampal protein expression after controlled cortical impact. Neuroscience. 2022-07-25. PMID:35878718. |
hippocampal expression of synaptic plasticity proteins neurogranin (ng), and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) receptor glua1 sub-unit, as well as ra signaling proteins stra6, adlh1a1, cyp26a1 and cyp26b1 were evaluated by western blot at 2-weeks post-injury. |
2022-07-25 |
2023-08-14 |
rat |
| Sang-Seo Park, Seong-Hyun Kim, Chang-Ju Kim, Mal-Soon Shin, Yun-Jin Park, Tae-Woon Ki. Effects of exercise and microbiota transplant on the memory of obesity-induced mice. Journal of exercise rehabilitation. vol 18. issue 3. 2022-07-18. PMID:35846232. |
the short-term memory and spatial learning memory were determined by step-down avoidance test and morris water maze task, immunohistochemistry for glial fibrillary acidic protein, western blot analysis for brain-derived neurotrophic factor and tropomyosin receptor kinase b were performed in the hippocampus. |
2022-07-18 |
2023-08-14 |
mouse |
| Sang-Seo Park, Tae-Woon Kim, Bo-Kyun Kim, Seong-Hyun Kim, Jong-Suk Park, Mal-Soon Shi. The effects of exercise and diet on mental status, insulin signaling pathway, and microbiome in obese mice. Journal of exercise rehabilitation. vol 18. issue 3. 2022-07-18. PMID:35846233. |
immunohistochemistry for tryptophan hydroxylase (tph) in the dorsal raphe, western blot analysis for phosphorylated protein kinase b (p-atk), total akt (t-akt), phosphorylated phosphoinositide 3-kinase (p-pi3k), and total pi3k (t-pi3k) in the hippocampus were performed. |
2022-07-18 |
2023-08-14 |
mouse |
| Nazanin Mozafari, Jalal Hassanshahi, Hamid Ostadebrahimi, Ali Shamsizadeh, Fatemeh Ayoobi, Elham Hakimizadeh, Mohammad Pak-Hashemi, Ayat Kaeid. Neuroprotective effect of Achillea millefolium aqueous extract against oxidative stress and apoptosis induced by chronic morphine in rat hippocampal CA1 neurons. Acta neurobiologiae experimentalis. vol 82. issue 2. 2022-07-14. PMID:35833817. |
caspase‑3, bax, and bcl‑2 proteins expression in the ca1 region of hippocampal tissue was analyzed using the western blot method. |
2022-07-14 |
2023-08-14 |
human |
| Anika Pupak, Ankita Singh, Anna Sancho-Balsells, Rafael Alcalá-Vida, Marc Espina, Albert Giralt, Eulàlia Martí, Ulf Andersson Vang Ørom, Silvia Ginés, Verónica Brit. Altered m6A RNA methylation contributes to hippocampal memory deficits in Huntington's disease mice. Cellular and molecular life sciences : CMLS. vol 79. issue 8. 2022-07-12. PMID:35819730. |
m6a modifications were evaluated in hd mice subjected to a hippocampal cognitive training task through m6a immunoprecipitation sequencing (merip-seq) and the relative levels of m6a-modifying proteins (fto and mettl14) by subcellular fractionation and western blot analysis. |
2022-07-12 |
2023-08-14 |
mouse |
| Xing-Yuan Zhao, Dong Yu, Xingjie Shi, Shiqiang Hou, Da Ten. Resveratrol reduces p38 mitogen-activated protein kinase phosphorylation by activating Sirtuin 1 to alleviate cognitive dysfunction after traumatic brain injury in mice. Neuroreport. vol 33. issue 11. 2022-07-01. PMID:35775323. |
two days after tbi, the hippocampus of mice was extracted, and western blot analysis was performed for sirtuin 1 (sirt1), synaptophysin (syp), p38 mitogen-activated protein kinase (mapk), and p-p38 mapk. |
2022-07-01 |
2023-08-14 |
mouse |
| Xing-Yuan Zhao, Dong Yu, Xingjie Shi, Shiqiang Hou, Da Ten. Resveratrol reduces p38 mitogen-activated protein kinase phosphorylation by activating Sirtuin 1 to alleviate cognitive dysfunction after traumatic brain injury in mice. Neuroreport. vol 33. issue 11. 2022-07-01. PMID:35776938. |
two days after tbi, the hippocampus of mice was extracted, and western blot analysis was performed for sirtuin 1 (sirt1), synaptophysin (syp), p38 mitogen-activated protein kinase (mapk), and p-p38 mapk. |
2022-07-01 |
2023-08-14 |
mouse |
| Lu Chen, Huili Jiang, Tuya Bao, Yu Wang, Hong Meng, Yang Sun, Pengfei Liu, Songxiao Quan, Wenshan Li, Simin Qi, Xiujun Re. Acupuncture Ameliorates Depressive Behaviors by Modulating the Expression of Hippocampal Iba-1 and HMGB1 in Rats Exposed to Chronic Restraint Stress. Frontiers in psychiatry. vol 13. 2022-06-23. PMID:35733802. |
the expression of hippocampal interleukin-10 (il-10) was detected by western blot. |
2022-06-23 |
2023-08-14 |
rat |
| Hai Duc Nguyen, Won Hee Jo, Ngoc Hong Minh Hoang, Byung Pal Yu, Hae Young Chung, Min-Sun Ki. 1,2-Diacetylbenzene impaired hippocampal memory by activating proinflammatory cytokines and upregulating the prolactin pathway: An in vivo and in vitro study. International immunopharmacology. vol 108. 2022-06-22. PMID:35729834. |
qpcr, western blot, morris water maze, and rnaseq analysis were used to identify the association between inflammation and hyperphosphorylated tau in male dab-treated mice (1 or 5 mg/kg/day), rats (3 mg/kg/day), in vitro bv2 microglial cells (1 or 5 µm), and the hippocampal transcriptome of male dab-treated rats. |
2022-06-22 |
2023-08-14 |
mouse |
| Li-Ping Huang, Xiao-Qin Zhong, Xin-Yu Zhou, Min-Qi Deng, Man-Jing Wu, Min-Zhen Den. [Galangin alleviates learning and memory impairments in APP/PS1 double- transgenic mice by regulating Akt/MEF2D/Beclin-1 signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 10. 2022-06-19. PMID:35718493. |
the pathological changes in hippocampus were observed after he staining, and the expression of akt, mef2 d, and beclin-1 in hippocampus were assayed by western blot. |
2022-06-19 |
2023-08-14 |
mouse |
| Fabrizio Sanna, Maria Pina Serra, Marianna Boi, Jessica Bratzu, Laura Poddighe, Francesco Sanna, Antonella Carta, Maria Giuseppa Corda, Osvaldo Giorgi, Maria Rosaria Melis, Antonio Argiolas, Marina Quart. Neuroplastic changes in c-Fos, ΔFosB, BDNF, trkB, and Arc expression in the hippocampus of male Roman rats: differential effects of sexual activity. Hippocampus. 2022-06-18. PMID:35716117. |
sexual activity causes differential changes in the expression of markers of neural activation (c-fos and Δfosb) and neural plasticity (arc and bdnf/trkb), as determined either by western blot (bdnf, trkb, arc, and Δfosb) or immunohistochemistry (bdnf, trkb, arc, and c-fos), in the hippocampus of male roman high (rha) and low avoidance (rla) rats, two psychogenetically selected rat lines that display marked differences in sexual behavior (rha rats exhibit higher sexual motivation and better copulatory performance than rla rats). |
2022-06-18 |
2023-08-14 |
rat |
| Stephanie V Koebele, Mallori L Poisson, Justin M Palmer, Claire Berns-Leone, Steven N Northup-Smith, Veronica L Peña, Isabel M Strouse, Haidyn L Bulen, Shruti Patel, Corissa Croft, Heather A Bimonte-Nelso. Evaluating the Cognitive Impacts of Drospirenone, a Spironolactone-Derived Progestin, Independently and in Combination With Ethinyl Estradiol in Ovariectomized Adult Rats. Frontiers in neuroscience. vol 16. 2022-06-13. PMID:35692432. |
the hippocampus, entorhinal cortex, and perirhinal cortex were then probed for proteins known to elicit estrogen- and progestin- mediated effects on learning and memory, including glutamate decarboxylase (gad)65, gad67, and insulin-like growth factor receptor protein expression, using western blot. |
2022-06-13 |
2023-08-14 |
rat |
| Qin Zhang, Yao Jiang, Yang Zhang, Jingling Zhang, Ying H. GLP-1 Analog Alleviated Cognitive Dysfunction in Aged Rats Anaesthetized with Sevoflurane. BioMed research international. vol 2022. 2022-05-26. PMID:35615010. |
morris water maze task was applied for the detection of spatial learning and memory in rats; he and tunel for staining; and western blot for quantifying bax, bcl-2 expression, and examining caspase-3 activity in hippocampal tissues as well as for revealing the antiapoptotic mechanism. |
2022-05-26 |
2023-08-13 |
rat |
| Li Cai, Zeng-Yu Yao, Lu Yang, Xiu-Hong Xu, Meng Luo, Miao-Miao Dong, Guo-Ping Zho. Mechanism of Electroacupuncture Against Cerebral Ischemia-Reperfusion Injury: Reducing Inflammatory Response and Cell Pyroptosis by Inhibiting NLRP3 and Caspase-1. Frontiers in molecular neuroscience. vol 15. 2022-05-23. PMID:35600074. |
ea was conducted at acupoints chize (lu5), hegu (li4), sanyinjiao (sp6), and zusanli (st36) for 1.5 h after cerebral ischemia-reperfusion injury for 20 min, and observation was carried out after 24 h. neurological deficit scores evaluated the neurological function, cerebral infarction volume was observed by triphenyl tetrazolium chloride (ttc) staining, hematoxylin and eosin (h&e) staining, tunel and caspase-1 double-labeled fluorescence staining, and nlrp3 and caspase-1 double-labeled immunofluorescence staining that were used to observe the morphology of neurons in hippocampus, and the protein expression of nlrp3, pro-caspase-1, cleaved caspase-1 p20, pro-interleukin-1β (il-1β), cleaved il-1β, and gsdmd was detected by western blot assay. |
2022-05-23 |
2023-08-13 |
mouse |
| Shafiqur Rahman, Ghallab Alotaib. Glutamate transporter activator LDN-212320 attenuates CFA-induced cognitive deficits and anxiety-like behavior in mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555963. |
we have also evaluated the effects of ldn-212320 on camp response element-binding protein (pcreb) expression in the hippocampus and acc during cfa-induced cognitive deficits and anxiety-like behaviors using western blot analysis and immunofluorescence assay. |
2022-05-13 |
2023-08-13 |
mouse |
| Erin R Saito, Cali E Warren, Rachel J Campbell, Gavin Miller, Johannes D du Randt, Mio E Cannon, Jeremy Y Saito, Cameron M Hanegan, Colin M Kemberling, Jeffrey G Edwards, Benjamin T Bikma. A Low-carbohydrate, Ketogenic Diet Enhances Hippocampal Mitochondrial Bioenergetics and Efficiency. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556976. |
hippocampal mitochondrial physiology was assessed using high-resolution respirometry to measure changes in oxygen flux, biochemical assays to quantify atp production, and western blot to measure changes in drp1 expression. |
2022-05-13 |
2023-08-13 |
mouse |
| Deunsol Hwang, Sunghwan Kyun, Inkwon Jang, Hun-Young Park, Jisu Kim, Kiwon Li. The Effects of Exercise Training with Oral Intake of Lactate on Hippocampal Neurogenesis and Neurotrophic Factors in Mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35560403. |
after the experiment ended, hippocampal neurogenesis (ki67, neural stem cell proliferation marker; dcx, marker of differentiation to immature neurons) and neurotrophic factors (pgc1α, fndc5, vegfa, and bdnf) were evaluated respectively by immunohistochemistry (ihc) and by western blot (wb) on hippocampus. |
2022-05-13 |
2023-08-13 |
mouse |