| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hidehito Saito-Takatsuji, Yasuo Yoshitomi, Ryo Yamamoto, Takafumi Furuyama, Yasuhito Ishigaki, Nobuo Kato, Hideto Yonekura, Takayuki Iked. Transthyretin Is Commonly Upregulated in the Hippocampus of Two Stress-Induced Depression Mouse Models. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36835151. |
transthyretin (ttr) was commonly upregulated in the hippocampus of both mouse models, as determined by microarray, rt-qpcr, and western blot analyses. |
2023-02-25 |
2023-08-14 |
mouse |
| Xiuli Zhang, Shivakumar Subbanna, Colin R O Williams, Stefanie Canals-Baker, John F Smiley, Donald A Wilson, Bhaskar C Das, Mariko Sait. Anti-inflammatory Action of BT75, a Novel RARα Agonist, in Cultured Microglia and in an Experimental Mouse Model of Alzheimer's Disease. Neurochemical research. 2023-02-13. PMID:36781685. |
western blot results showed that bt75 decreased levels of neuronal nitric oxide synthase (nnos), gfap, and phosphorylated tau, and increased levels of synaptophysin in the hippocampus of icv-stz mice. |
2023-02-13 |
2023-08-14 |
mouse |
| Nevien Hendawy, Tala H Salaheldin, Sally A Abuelez. PCSK9 Inhibition Reduces Depressive like Behavior in CUMS-Exposed Rats: Highlights on HMGB1/RAGE/TLR4 Pathway, NLRP3 Inflammasome Complex and IDO-1. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023-02-13. PMID:36781714. |
western blot and pcr analysis showed that alirocumab favorably modulated the hmgb1/rage/tlr4 axis, nuclear-factor-kappa-beta, nlrp3 inflammasome complex and ido-1 in the hippocampus of cums rats. |
2023-02-13 |
2023-08-14 |
rat |
| Panos Zanos, Kyle A Brown, Polymnia Georgiou, Peixiong Yuan, Carlos A Zarate, Scott M Thompson, Todd D Goul. NMDA Receptor Activation-Dependent Antidepressant-Relevant Behavioral and Synaptic Actions of Ketamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 43. issue 6. 2023-02-10. PMID:36596696. |
we tested the hypothesis that induction of rapid antidepressant effects requires nmdar activation, by using behavioral pharmacology, western blot quantification of hippocampal synaptoneurosomal protein levels, and |
2023-02-10 |
2023-08-16 |
Not clear |
| Li-Tian Yin, Rui-Rui Feng, Xiao-Yan Xie, Xiao-Rong Yang, Zhuan-Fang Yang, Jia-Jia Hu, Shu-Fen Wu, Ce Zhan. Matrix metalloproteinase-9 overexpression in the hippocampus reduces alcohol-induced conditioned-place preference by regulating synaptic plasticity in mice. Behavioural brain research. 2023-02-06. PMID:36746309. |
western blot analysis demonstrated that protein expression of nmda receptors (glun1, glun2a and glun2b) in the hippocampus of alcohol-exposed mice were higher than that of the saline group. |
2023-02-06 |
2023-08-14 |
mouse |
| Yangjie Li, Zhengdong Wang, Jing Li, Yang Yu, Yuan Wang, Xiaoxia Jin, Yun Dong, Qingsong Liu, Xiaoxu Duan, Nan Ya. Sodium Butyrate Ameliorates Fluorosis-Induced Neurotoxicity by Regulating Hippocampal Glycolysis In Vivo. Biological trace element research. 2023-01-29. PMID:36710293. |
western blot results showed that the abundance of malate dehydrogenase 2 (mdh2) and pyruvate dehydrogenase (pdh) in the hippocampus of fluorosis mice was increased, the abundance of pyruvate kinase m (pkm), lactate dehydrogenase (ldh), hexokinase (hk), phosphatidylinositol 3-kinase (pi3k), phosphorylated akt (p-akt), and hypoxia-inducible factor 1α (hif-1α) was inhibited, and the content of lactate and atp was decreased. |
2023-01-29 |
2023-08-14 |
mouse |
| Pan Meng, Xi Zhang, Dandan Li, Hui Yang, Xiaoyuan Lin, Hongqing Zhao, Ping Li, Yuhong Wang, Xiaoye Wang, Jinwen G. Leonurine Regulates Hippocampal Nerve Regeneration in Rats with Chronic and Unpredictable Mild Stress by Activating SHH/GLI Signaling Pathway and Restoring Gut Microbiota and Microbial Metabolic Homeostasis. Neural plasticity. vol 2023. 2023-01-17. PMID:36647544. |
western blot was utilized to measure the expression of bdnf and 5-ht in the hippocampus. |
2023-01-17 |
2023-08-14 |
rat |
| Madiha Rasheed, Han Wang, Chaolei Wang, Jingyan Sun, Zixuan Chen, Yulin Den. Opposing manner of miR-455-3p against NR2B-PSD-95-nNOS complex in the cortex and hippocampus of depressive rats under simulated complex space environment. Journal of neurochemistry. 2023-01-17. PMID:36648213. |
using a simulated space environment complex model (scse) for 21 days, we induced depressive behavior in rats to analyze mir-455-3p expression and nr2b-psd-95-nnos complex in the cortex and hippocampus of the scse depressed rats through qrt-pcr and western blot analysis. |
2023-01-17 |
2023-08-14 |
rat |
| Zhongxuan Ma, Dingding Feng, Wenjuan Rui, Zhiqing Wan. Baicalin attenuates chronic unpredictable mild stress-induced hippocampal neuronal apoptosis through regulating SIRT1/PARP1 signaling pathway. Behavioural brain research. 2023-01-15. PMID:36642102. |
intriguingly, western blot and immunohistochemistry (ihc) results showed that the protein level of parp1 was significantly increased in hippocampal tissue after cums, which was reversed by ba treatment. |
2023-01-15 |
2023-08-14 |
mouse |
| Tatyana Y Postnikova, Dmitry V Amakhin, Alina M Trofimova, Natalia L Tumanova, Nadezhda M Dubrovskaya, Daria S Kalinina, Anna A Kovalenko, Anastasiia D Shcherbitskaia, Dmitry S Vasilev, Aleksey V Zaitse. Maternal Hyperhomocysteinemia Produces Memory Deficits Associated with Impairment of Long-Term Synaptic Plasticity in Young Rats. Cells. vol 12. issue 1. 2023-01-08. PMID:36611852. |
no significant alterations of glutamate receptor subunit expression except glun1 were detected in the hippocampus of hcy rats using the quantitative real-time pcr and western blot methods. |
2023-01-08 |
2023-08-14 |
rat |
| Lixia DU, Zhongmin Fan, Yi Li, Zongping Fang, Xijing Zhan. [Rapamycin alleviates cognitive impairment in mice with sepses-associated encephalopathy by promoting autophagy]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 12. 2022-12-30. PMID:36585229. |
the expression levels of microtubule-associated protein 1 light chain 3 (lc3) and p62 in the hippocampus of the sae mice were detected by western blot analysis. |
2022-12-30 |
2023-08-14 |
mouse |
| Velia Cassano, Martina Tallarico, Giuseppe Armentaro, Caterina De Sarro, Michelangelo Iannone, Antonio Leo, Rita Citraro, Emilio Russo, Giovambattista De Sarro, Marta Letizia Hribal, Angela Sciacqu. Ranolazine Attenuates Brain Inflammation in a Rat Model of Type 2 Diabetes. International journal of molecular sciences. vol 23. issue 24. 2022-12-23. PMID:36555798. |
the presence of neurodegeneration was evaluated in the hippocampal cornus ammonis 1 (ca1) region by cresyl violet staining histological methods, while astrocyte activation was assessed by western blot analysis. |
2022-12-23 |
2023-08-14 |
rat |
| Guo-Jie Han, Xiang-Zhen Min, Shuang-Shuang Ma, Chuan Ding, Xiu-Qin Wan. Xuesaitong Combined with Dexmedetomidine Improves Cerebral Ischemia-Reperfusion Injury in Rats by Activating Keap1/Nrf2 Signaling and Mitophagy in Hippocampal Tissue. Oxidative medicine and cellular longevity. vol 2022. 2022-12-19. PMID:36531207. |
the atp, mitochondrial membrane potential levels, and qrt-pcr of genes related to mitochondrial function were determined to assess mitochondrial functions in the hippocampus and western blot to determine keap1/nrf2 signaling pathway and mitophagy-related protein expression. |
2022-12-19 |
2023-08-14 |
rat |
| Mariana Uczay, Pricila Pflüger, Jaqueline Nascimento Picada, João Denis Medeiros de Oliveira, Iraci Lucena da SilvaTorres, Helouise Richardt Medeiros, Maria Helena Vendruscolo, Gilsane von Poser, Patrícia Pereir. Geniposide and asperuloside alter the COX-2 and GluN2B receptor expression after pilocarpine-induced seizures in mice. Naunyn-Schmiedeberg's archives of pharmacology. 2022-12-19. PMID:36536207. |
afterward, the hippocampus and blood samples were collected for western blot analyses, elisa and comet assay, and bone marrow to the micronucleus test. |
2022-12-19 |
2023-08-14 |
mouse |
| Zhihao Zhang, Huiqing Liu, Sansan Jia, Jianshuai Zhao, Jiajia Wang, Yang Liu, Fang Zhou, Qi Li, Zhaofei Li, Hailong Dong, Yi Zeng, Rui Zhang, Haixing Zhon. Spatial and temporal alterations of developing oligodendrocytes induced by repeated sevoflurane exposure in neonatal mice. Biochemical and biophysical research communications. vol 640. 2022-12-10. PMID:36495605. |
to investigate the spatial and temporal alterations in oligodendrocytes in the corpus callosum (cc) and hippocampus following repeated sevoflurane exposures (3%, for 2 h) from postnatal day 6 (p6) to p8, we used immunofluorescence, western blot, and a battery of behavioral tests. |
2022-12-10 |
2023-08-14 |
mouse |
| Zhi-Yuan Lu, Chen-Yi Zhao, Guang Yang, Yu-Ting Tong, Zong-Tao Ba, Ahelijiang Reaila, Jian-Mei Yang, Ying X. [Modified Kaixin San improves memory and synaptic damage of mice with Alzheimer's disease by modulating αCaMKⅡ-PSD95 protein binding through inhibition of neuroinflammation:a study of mechanism]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 22. 2022-12-06. PMID:36471948. |
novel object reco-gnition task was employed to detect the recognition memory of mice, and western blot to detect the protein levels of synapse-associated proteins in the hippocampus(hpc) of mice, such as nr1, nr2 a, nr2 b, p-αcamkⅡ, tau, and p-tau. |
2022-12-06 |
2023-08-14 |
mouse |
| Mengyu Cai, Yicui Qu, Zifu Ren, Xin Xu, Chuyang Ye, Hongtao Lu, Yinyin Zhang, Wenlan Pan, Hui Shen, Hongxia L. Nutritional supplements formulated to prevent cognitive impairment in animals. Current research in food science. vol 5. 2022-11-28. PMID:36439642. |
likewise, western blot results showed that the formula could activate the camp pathway and increase the expression of phosphorylated pka and bdnf in hippocampal cells. |
2022-11-28 |
2023-08-14 |
Not clear |
| Yao Lin, Man Ding, Qiaoyu Gong, Zheman Xia. Downregulation of GABAARα1 Aggravates Comorbidity of Epilepsy and Migraine via the TLR4 Signaling Pathway. Brain sciences. vol 12. issue 11. 2022-11-11. PMID:36358363. |
western blot and immunofluorescence staining were used to detect the protein expression levels of tlr4 and gabaarα1 in the temporal cortex, hippocampus, trigeminal ganglion, and medullary dorsal horn. |
2022-11-11 |
2023-08-14 |
rat |
| Yao Lin, Man Ding, Qiaoyu Gong, Zheman Xia. Downregulation of GABAARα1 Aggravates Comorbidity of Epilepsy and Migraine via the TLR4 Signaling Pathway. Brain sciences. vol 12. issue 11. 2022-11-11. PMID:36358363. |
western blot was used to detect the protein expression levels of tlr4 and gabaarα1 in the temporal cortex, hippocampus, trigeminal ganglion, and medullary dorsal horn. |
2022-11-11 |
2023-08-14 |
rat |
| Jameel N Hamdan, Jorge A Sierra-Fonseca, Rodolfo J Flores, Sigifredo Saucedo, Manuel Miranda-Arango, Laura E O'Dell, Kristin L Gosselin. Early-life adversity increases anxiety-like behavior and modifies synaptic protein expression in a region-specific manner. Frontiers in behavioral neuroscience. vol 16. 2022-11-07. PMID:36338879. |
the hippocampus (hipp), medial prefrontal cortex (mpfc), nucleus accumbens (nac), and caudate putamen (cpu) were isolated from one subgroup of animals and subjected to western blot and protein quantitation for tyrosine hydroxylase (th), α-synuclein (alpha), nmda receptor (nmdar), dopamine receptor-1 (d1) and -2 (d2), dopamine transporter (dat), and postsynaptic density 95 (psd95). |
2022-11-07 |
2023-08-14 |
rat |