| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hong-Kun Wang, Jin-Ming He, Yue-Heng Yan, Zi-Hao Wang, Ruo-Xuan Li, Yan-Yan Wan. [Effect of Suanzaoren Decoction on expression of ionotropic glutamate receptors and synaptic plasticity in hippocampus of anxiety rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 20. 2023-12-19. PMID:38114151. |
real-time fluorescence quantitative pcr(qrt-pcr) and western blot were employed to assess the gene and protein expression of ionotropic glutamate receptors in the hippocampal region. |
2023-12-19 |
2023-12-23 |
mouse |
| Ping Li, Yang Liu, Man-Shu Zou, Ting-Ting Wang, Hai-Peng Guo, Ting-Ting Ren, Ying He, Hua Wang, Yu-Hong Wan. [Neuroprotective effect and mechanism of Zuogui Jiangtang Jieyu Formula on diabetes mellitus complicated with depression model rats based on CX3CL1-CX3CR1 axis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 21. 2023-12-19. PMID:38114178. |
western blot was used to measure the expression levels of cx3cl1, cx3cr1, a2a adenosine receptor(a2ar), glutamate receptor 2a(nr2a), glutamate receptor 2b(nr2b), and brain-derived neurotrophic factor(bdnf) in the hippocampus. |
2023-12-19 |
2023-12-23 |
rat |
| Yu Xiang Han, Rui Liang, Xian Ping Yi, Xue Xia Zhang, Shao Peng Zho. Sevoflurane anesthesia reduces the expression of inflammatory response genes and β-site amyloid precursor protein-cleaving enzyme in hippocampi of diabetic mice. Neuroreport. 2023-12-18. PMID:38109363. |
the expression level of neurotoxicity and neuroprotection-related proteins in dm mice hippocampus were estimated using western blot assay. |
2023-12-18 |
2023-12-21 |
mouse |
| Richard L Spinieli, Rafael Cazuza, Amanda J Sales, Ruither Carolino, Janete A Franci, Maral Tajerian, Christie R A Leite-Paniss. Acute restraint stress regulates brain DNMT3a and promotes defensive behaviors in male rats. Neuroscience letters. 2023-12-15. PMID:38101612. |
we employed biochemical (radioimmunoassay for corticosterone; global dna methylation by enzyme immunoassay and western blot for dnmt3a expression in the amygdala, ventral hippocampus, and prefrontal cortex) and behavioral (elevated plus maze and dark-light box for anxiety and hot plate test for nociception) tests in adult male wistar rats exposed to ars or handling (control). |
2023-12-15 |
2023-12-18 |
rat |
| Dan Shi, Zikang Hao, Wenxiao Qi, Fengyi Jiang, Kerui Liu, Xiao Sh. Aerobic exercise combined with chlorogenic acid exerts neuroprotective effects and reverses cognitive decline in Alzheimer's disease model mice (APP/PS1) via the SIRT1/ /PGC-1α/PPARγ signaling pathway. Frontiers in aging neuroscience. vol 15. 2023-12-04. PMID:38046466. |
the study used western blot to detect the expression of signaling pathway-related proteins, enzyme-linked immunosorbent assay to detect the expression of inflammatory factors, hematoxylin-eosin staining to detect hippocampal neuronal morphology, immunohistochemistry to detect changes in aβ deposition in the hippocampus, an oxidative stress marker kit to detect oxidative stress status and the morris water maze to detect changes in cognitive performance. |
2023-12-04 |
2023-12-10 |
mouse |
| Yongri Hong, Caichuan Wei, Miaoying Fu, Xinyang Li, Haiju Zhang, Baozhen Ya. MCC950 alleviates seizure severity and angiogenesis by inhibiting NLRP3/ IL-1β signaling pathway-mediated pyroptosis in mouse model of epilepsy. International immunopharmacology. vol 126. 2023-12-01. PMID:38039716. |
in addition, immunofluorescence staining, rt-qpcr, and western blot demonstrated that mcc950 inhibited the expression of the nlrp3 inflammasome and its related proteins in microglia, whereas microangiogenesis was found to be increased in the cerebral cortex and hippocampus of epileptic mice, and these effects could be reversed by mcc950. |
2023-12-01 |
2023-12-10 |
mouse |
| Haotian Chen, Xiaokun Yang, Yushan Gao, Huili Jiang, Mengwei Guo, Yingyi Zhou, Chenlu Li, Yunxiang Tan, Yang Zhang, Weiguo Xu. Electroacupuncture ameliorates cognitive impairment in APP/PS1 mouse by modulating TFEB levels to relieve ALP dysfunction. Brain research. 2023-11-22. PMID:37992796. |
western blot analysis was performed to evaluate the changes of lc3, p62, ctsd, lamp1, tfeb and n-tfeb (nuclear tfeb) in the hippocampus. |
2023-11-22 |
2023-11-29 |
mouse |
| Huifang Zhang, Yudan Zhang, Kaixuan Xu, Lawen Wang, Xin Zhou, Mingge Yang, Jiangli Xie, Hui L. Inhibition of FLT1 Attenuates Neurodevelopmental Abnormalities and Cognitive Impairment in Offspring Caused by Maternal Prenatal Stress. Applied biochemistry and biotechnology. 2023-11-18. PMID:37979086. |
the apoptosis level of hippocampal neurons and the expression of nmdars were detected by mtt assay, tunel assay, and western blot. |
2023-11-18 |
2023-11-20 |
rat |
| Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun W. Sex differences in a corticosterone-induced depression model in mice: Behavioral, neurochemical, and molecular insights. Brain research. 2023-11-18. PMID:37979605. |
behavioral tests, nissl staining, uplc-ms/ms, and western blot analysis were performed to assess behavioral changes, as well as neuronal alterations, neurotransmitter levels, and protein expressions in the hippocampus. |
2023-11-18 |
2023-11-20 |
mouse |
| Aiai Dong, Zhen Gao, Haijun Wang, Ronglin Wu, Weifeng Wang, Xiaofei Jin, Yufang Ji, Faming Yang, Tao Zhu, Ziwen Jiang, Yongrong Xu, Jilong Guo, Laixi J. Acupuncture Alleviates Chronic Ischemic White Matter Injury in SHR Rats via JNK-NMDAR Circuit. Molecular neurobiology. 2023-11-17. PMID:37976026. |
myelin density was detected by luxol fast blue (lfb) staining, also axon arrangement, myelin integrity, and thickness of neurons were detected by electron microscopy; neuronal morphology and the number of nissl bodies in the hippocampus were detected by nissl staining, dendritic spine density changes were detected by golgi staining, and jnk, nmdar1, and n-methyl-d-receptor 2b (nmdar2b) in dg, ca3 region of hippocampus were detected by immunohistochemistry, protein expression of p-jnk/jnk, p-nmdar1/nmdar1, nmdar2b, gsk3β protein expression in the fimbria of hippocampus was detected by western blot. |
2023-11-17 |
2023-11-20 |
rat |
| Yanmei Chen, Xiaotao Zhou, Boling Chu, Qunqun Xie, Zhenkun Liu, Di Luo, Jichuan Zhan. Restraint Stress, Foot Shock and Corticosterone Differentially Alter Autophagy in the Rat Hippocampus, Basolateral Amygdala and Prefrontal Cortex. Neurochemical research. 2023-11-13. PMID:37955816. |
in this study, we assessed autophagy flux in the rat hippocampus (hpc), medial prefrontal cortex (mpfc), and basal lateral amygdala (bla) by quantifying protein levels of p-ulk1, lc3-i, lc3-ii, and p62 via western blot analysis at 15 min, 30 min, and 60 min following various stress paradigms: restraint stress, foot shock, single corticosterone injection, and chronic corticosterone treatment. |
2023-11-13 |
2023-11-20 |
rat |
| Ahmad H Alhowail, Matthew Eggert, Jenna Bloemer, Priyanka D Pinky, Lauren Woodie, Subhrajit Bhattacharya, Dwipayan Bhattacharya, Manal A Buabeid, Bruce Smith, Muralikrishnan Dhanasekaran, Gary Piazza, Miranda N Reed, Martha Escobar, Robert D Arnold, Vishnu Suppiramania. Phenyl-2-aminoethyl selenide ameliorates hippocampal long-term potentiation and cognitive deficits following doxorubicin treatment. PloS one. vol 18. issue 11. 2023-11-10. PMID:37948406. |
western blot analyses were performed to assess hippocampal protein and phosphorylation levels. |
2023-11-10 |
2023-11-20 |
mouse |
| Liming Yu, Yujun Wen, Juan Yang, Guowei Wang, Na Zhang, Xinlei Gao, Jiayu Guo, Zhenhai Wan. Autoimmune receptor encephalitis in ApoE Molecular medicine reports. vol 28. issue 6. 2023-11-03. PMID:37921064. |
western blot analysis of nmda1 and psd‑95 protein expression levels in the hippocampus was also performed. |
2023-11-03 |
2023-11-08 |
mouse |
| Huili Jiang, Xianqi Long, Yu Wang, Xuhui Zhang, Lu Chen, Xinjing Yang, Bingcong Zhao, Ye Zhang, Yemao Chai, Tuya Ba. Acupuncture Ameliorates Depression-Like Behaviors Through Modulating the Neuroinflammation Mediated by TLR4 Signaling Pathway in Rats Exposed to Chronic Restraint Stress. Molecular neurobiology. 2023-11-02. PMID:37917302. |
the expression of key proteins on tlr4 signaling pathway of tlr4, myd88, traf6, nf-κb p65, tnf-α, and mrna of tlr4 in the hippocampus was detected by western blot and real-time quantitative polymerase chain reaction to investigate the effect of acupuncture on stress-induced activation of neuroinflammation. |
2023-11-02 |
2023-11-08 |
rat |
| Jazmine David, Marike Mousset, Kirby Trombetti, Beverly Sayasouk, Calvin Neilsen, Parker Suorsa, Melissa Ruben, Elias Ruben, Jacob Thiessen, Taylor Pychewicz, Ping Chu, Thu N Huyn. Chronic mild stress leads to anxiety-like behavior and decreased p70 S6K1 activity in the hippocampus of male mice. Physiology & behavior. 2023-10-20. PMID:37863347. |
after behavior analysis, samples of the hippocampus were harvested for quantification of s6k1, s6 ribosomal protein, gsk3β and beta tubulin via western blot. |
2023-10-20 |
2023-11-08 |
mouse |
| Tong Li, DaJing Su, HuaWen Lu, YunQing Gao, YongGang Liu, ShaoHua Wang, YuTing Hou, KeMin Qin, XianTing Que, XiaoPing Chen, BaiLing Qin, ZiJun Wang, Yan Den. Recombinant human brain natriuretic peptide attenuates ischemic brain injury in mice by inhibiting oxidative stress and cell apoptosis via activation of PI3K/AKT/Nrf2/HO-1 pathway. Experimental brain research. 2023-10-17. PMID:37847304. |
protein levels of antioxidant enzymes (ho-1 and nqo1) in cerebral cortex, apoptotic markers (bax, bcl-2, and cleaved caspase), and pi3k/akt pathway-associated factors in hippocampus were tested by western blot analysis. |
2023-10-17 |
2023-11-08 |
mouse |
| Gehua Wen, Xiaoni Zhan, Xiaoming Xu, Xi Xia, Shukun Jiang, Xinghua Ren, Weishu Ren, Haoyang Lou, Lei Lu, Anca Hermenean, Jun Yao, Lina Gao, Baoman Li, Yan Lu, Xu W. Ketamine Improves the Glymphatic Pathway by Reducing the Pyroptosis of Hippocampal Astrocytes in the Chronic Unpredictable Mild Stress Model. Molecular neurobiology. 2023-10-15. PMID:37840071. |
meanwhile, ketamine reduced the level of hippocampus nlrp3 and the expression of its downstream molecules in chronic unpredictable mild stress (cums) mice model by western blot and reduced the colocalization of gfap and gsdmd by nearly 25% via immunofluorescent staining. |
2023-10-15 |
2023-11-08 |
mouse |
| Timna Hitrec, Fabio Squarcio, Emiliana Piscitiello, Matteo Cerri, Davide Martelli, Alessandra Occhinegro, Ludovico Taddei, Domenico Tupone, Roberto Amici, Marco Lupp. Sleep deprivation soon after recovery from synthetic torpor enhances tau protein dephosphorylation in the rat brain. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. 2023-10-09. PMID:37812305. |
the effects of sd were studied by assessing: (i) deep brain temperature (tb); (ii) immunofluorescent staining for at8 (phosphorylated tau) and tau-1 (non-phosphorylated tau), assessed in 19 brain structures; (iii) different phosphorylated forms of tau and the main cellular factors involved in tau phospho-regulation, including pro- and anti-apoptotic markers, assessed through western blot in the parietal cortex and hippocampus; (iv) systemic factors which are involved in natural torpor; (v) microglia activation state, by considering morphometric variations. |
2023-10-09 |
2023-10-15 |
rat |
| Helia Aghamiri, Majid Jafari-Sabet, Mahmood Hoorman. Ameliorative Effect of Cannabidiol on Topiramate-Induced Memory Loss: The Role of Hippocampal and Prefrontal Cortical NMDA Receptors and CREB/BDNF Signaling Pathways in Rats. Neurochemical research. 2023-10-09. PMID:37814133. |
western blot analysis was used to evaluate variations in brain-derived neurotrophic factor (bdnf) and phosphorylated cyclic amp response element-binding protein (pcreb)/creb ratio in the prefrontal cortex (pfc) and hippocampus (hpc). |
2023-10-09 |
2023-10-15 |
rat |
| Zan Zhou, Wen-Jun Jiang, Li Li, Jun-Qiang S. Noise exposure increase apoptosis in the hippocampus of AD mice through the upregulation of CTSS. Biochemical and biophysical research communications. vol 681. 2023-10-06. PMID:37801777. |
utilizing experimental techniques such as western blot, immunofluorescence, and rt-qpcr, we confirmed the expression of ctss in the hippocampus of app/ps1 mice after noise exposure. |
2023-10-06 |
2023-10-15 |
mouse |