| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhongying Shao, Yanjun Lu, Aihong Xing, Xiying He, Hongyan Xie, Ming H. Effect of outer membrane vesicles of Lactobacillus pentosus on Tau phosphorylation and CDK5-Calpain pathway in mice. Experimental gerontology. 2024-03-14. PMID:38484904. |
immunohistochemistry and western blot assessments unveiled elevated levels of hyperphosphorylated tau in the cortex and hippocampus of mice treated with ad-omvs. |
2024-03-14 |
2024-03-17 |
mouse |
| Wen-Hao Zhang, Yi-Ning Yan, John P Williams, Jian Guo, Bao-Feng Ma, Jian-Xiong A. Dexmedetomidine prevents spatial learning and memory impairment induced by chronic REM sleep deprivation in rats. Sleep and biological rhythms. vol 21. issue 3. 2024-03-13. PMID:38476312. |
the gene expression in hippocampus of each group was detected by rna-seq and verified by rt-pcr and western blot. |
2024-03-13 |
2024-03-15 |
rat |
| Zhao Wang, Jing Zhang, Qian Tang, Yujie Ta. Epigenetic mechanism of SETD1B-mediated histone methylation in cognitive impairment induced by sevoflurane anesthesia in neonatal mice. Neuroscience. 2024-03-06. PMID:38447691. |
setd1b, c-x-c motif chemokine receptor 4 (cxcr4), nlr family pyrin domain containing 1 (nlrp1), cleaved caspase1, and gsdmd-n expressions in hippocampal tissues or cells were determined by quantitative real-time polymerase chain reaction and western blot. |
2024-03-06 |
2024-03-09 |
mouse |
| Irena Majkutewicz, Ewelina Kurowska-Rucińska, Jan Ruciński, Dorota Myślińska, Beata Grembecka, Jagoda Mantej, Katarzyna P Dzi. Diverse Efficacy of Dimethyl Fumarate in Alleviating the Late Streptozotocin-Induced Cognitive Impairment and Neuropathological Features in Rat. Molecular neurobiology. 2024-03-02. PMID:38430351. |
spatial memory was assessed with morris water maze (mwm), general brain level of amyloid β (aβ) and p-tau was measured by western blot, immunofluorescent labelling of active microglia (iba1), aβ and p-tau and histological assay of neurodegeneration (fluoro-jade c) were performed in hippocampus and cortex. |
2024-03-02 |
2024-03-04 |
human |
| Li Lin, Xiao-Na Li, Zhen-Yan Xie, Yong-Zhen Hu, Qing-Shan Long, Yi-Qi Wen, Xiao-Bing Wei, Li-Yang Zhang, Xue-Song L. Pivotal Role of GSTO2 in Ferroptotic Neuronal Injury After Intracerebral Hemorrhage. Journal of molecular neuroscience : MN. vol 74. issue 1. 2024-02-22. PMID:38386166. |
further, we determined the expression of gsto2 in hemin-treated hippocampal neurons and in a mouse model of hippocampus-intracerebral hemorrhage (h-ich) by using western blot. |
2024-02-22 |
2024-02-24 |
mouse |
| Qing Liu, Xiaoyan Ding, Ying Wang, Hairong Chu, Yan Guan, Meng Li, Kuisheng Su. Artemisinin reduces PTSD-like symptoms, improves synaptic plasticity, and inhibits apoptosis in rats subjected to single prolonged stress. Frontiers in pharmacology. vol 15. 2024-02-21. PMID:38379899. |
the expression of hippocampal synaptic plasticity-related proteins was detected using western blot and immunofluorescence. |
2024-02-21 |
2024-02-23 |
rat |
| Qing Liu, Xiaoyan Ding, Ying Wang, Hairong Chu, Yan Guan, Meng Li, Kuisheng Su. Artemisinin reduces PTSD-like symptoms, improves synaptic plasticity, and inhibits apoptosis in rats subjected to single prolonged stress. Frontiers in pharmacology. vol 15. 2024-02-21. PMID:38379899. |
the apoptosis of hippocampal neurons was examined with western blot, tunel staining, and he staining. |
2024-02-21 |
2024-02-23 |
rat |
| b' David Olivares-Berjaga, Albert Mart\\xc3\\xadnez-Pinte\\xc3\\xb1o, Natalia Rodr\\xc3\\xadguez, Santiago Madero, Lluc\\xc3\\xada Prohens, Irene Mart\\xc3\\xadnez-Serrano, Sergi Mas, Constanza Mor\\xc3\\xa9n, Eduard Parellada, Patricia Gass\\xc3\\xb. Effects of the PAM of mGluR2, JNJ-46356479, on brain apoptotic protein levels in a mouse model of schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 131. 2024-02-10. PMID:38296154.' |
we analysed the levels of proapoptotic (caspase-3 and bax) and antiapoptotic (bcl-2) proteins by western blot in the prefrontal cortex and hippocampus of jnj-treated mice. |
2024-02-10 |
2024-02-14 |
mouse |
| Guang-Jun Hu, Xiao-Yang Jiang, Si-Yu Du, Kun Zhang, Zhuo Che. miR-107-5p ameliorates neurological damage, oxidative stress, and immune responses in mice with Alzheimer's disease by suppressing the Toll-like receptor 4 (TLR4)/nuclear factor-kappaB(NF-κB) pathway. The Kaohsiung journal of medical sciences. vol 40. issue 2. 2024-02-02. PMID:38305705. |
mir-107-5p expression, along with tlr4, apoe, and trem2 in hippocampal tissue homogenate, and nf-κb p65 protein expression in the nucleus and cytoplasm were assessed via rt-qpcr and western blot. |
2024-02-02 |
2024-02-04 |
mouse |
| Takashi Iwai, Rei Mishima, Shigeto Hirayama, Honoka Nakajima, Misa Oyama, Shun Watanabe, Hideaki Fujii, Mitsuo Tanab. SYK-623, a δ Opioid Receptor Inverse Agonist, Mitigates Chronic Stress-Induced Behavioral Abnormalities and Disrupted Neurogenesis. Journal of clinical medicine. vol 13. issue 2. 2024-01-26. PMID:38276114. |
in addition, the number of parvalbumin-positive gaba neurons, which play a crucial role in neurogenesis, was reduced in the hippocampus, and western blot analysis showed decreased glutamic acid decarboxylase protein levels. |
2024-01-26 |
2024-01-28 |
mouse |
| Lulu Ren, Huazheng Liang, Li Zhu, Xiao Yang, Hong Zhang, Nianyi Sun, Dunbing Huang, Jing Feng, Yufeng Wu, Lize Xiong, Xiaohua Ke, Min Li, Anren Zhan. Dietary restriction improves perioperative neurocognitive disorders by inhibiting neuroinflammation and gut microbial dysbiosis. Neuroscience. 2024-01-25. PMID:38272300. |
the western blot technique was utilized to assess expression levels of hippocampal psd 95, synaptophysin, tlr4, myd88, and nf-kb p65. |
2024-01-25 |
2024-01-28 |
mouse |
| Chunli Zou, Tingting Yang, Jiuhong Zhang, Xiao Chen, Jing Zhao, Desheng Wu, Chen Yang, Peiyi Liu, Xinfeng Huang, Jianjun Liu, Benhong X. A quantitative proteomic study reveals oxidative stress and synapse-related proteins contributed to TDCIPP exposure induced neurotoxicity. Ecotoxicology and environmental safety. vol 271. 2024-01-23. PMID:38262093. |
proteomic and bioinformatic analyses revealed dysregulation of numerous hippocampal proteins, particularly those associated with synapses (pkn1) or oxidative stress (gstm4, nqo1, and bmal1), which was further confirmed by western blot analysis. |
2024-01-23 |
2024-01-26 |
rat |
| Katarzyna Stachowicz, Patrycja Pańczyszyn-Trzewik, Paulina Misztak, Szymon Rzeźniczek, Magdalena Sowa-Kućm. Cyclooxygenase-2 inhibition affects the ratio of GluN2A/GluN2B receptor subunits through interaction with mGluR5 in the mouse brain. Neuropeptides. vol 104. 2024-01-20. PMID:38244260. |
the prefrontal cortex (pfc) and hippocampus (hc) were selected for pcr and western blot analyses. |
2024-01-20 |
2024-01-23 |
mouse |
| Álvaro G Bris, Karina S MacDowell, Cristina Ulecia-Morón, David Martín-Hernández, Beatriz Moreno, José L M Madrigal, Borja García-Bueno, Javier R Caso, Juan C Lez. Differential regulation of innate immune system in frontal cortex and hippocampus in a "double-hit" neurodevelopmental model in rats. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 21. issue 1. 2024-01-19. PMID:38241165. |
inflammasome, mapks, and tlrs inflammatory elements expression in the frontal cortex (fc) and hippocampus (hp) was analysed through western blot and qrt-pcr. |
2024-01-19 |
2024-01-22 |
rat |
| Ronyson Kharkongor, Pradeepkumar Nambi, Rameshkumar Radhakrishna. Fucoidan protects CA1 pyramidal neurons of the hippocampus and preserves the cognitive profile of rats subjected to transient forebrain ischemia. Brain research. 2024-01-18. PMID:38237671. |
the rats were assessed for cognitive behaviour performance through novel object task, t-maze and morris water maze, and finally, the hippocampus from the brain was harvested to quantify the profile of ca1 pyramidal neurons through cfv staining and the expression of inflammatory markers and angiogenic markers were quantified through western blot assessment on day7 and 30 of the study period. |
2024-01-18 |
2024-01-21 |
rat |
| Li-Qin Che, Zhen-Zhen Qu, Tao Xie, Yan-Ge Zhang, Dong-Juan Yuan, Qing Li, Li-Jing Jia, Wei-Ping Wan. Effect of low‑frequency repetitive transcranial magnetic stimulation on cognitive function in rats with medial temporal lobe epilepsy. Acta neurobiologiae experimentalis. vol 83. issue 4. 2024-01-15. PMID:38224282. |
further assessments included patch clamp and western blot techniques to estimate the synaptic function in the hippocampus. |
2024-01-15 |
2024-01-17 |
rat |
| Kara Snyder, C Edward Dixon, Jeremy Henchir, Kiersten Gorse, Vincent A Vagni, Keri Janesko-Feldman, Patrick M Kochanek, Travis C Jackso. Gene knockout of RNA binding motif 5 in the brain alters RIMS2 protein homeostasis in the cerebellum and Hippocampus and exacerbates behavioral deficits after a TBI in mice. Experimental neurology. 2024-01-13. PMID:38218585. |
immunoprecipitation and western blot confirmed protein expression of a novel ~170 kda rims2 variant in the cerebellum, and in the hippocampus, it was significantly increased in ko vs wt (p < 0.0001), and in a sex-dependent manner (p = 0.0390). |
2024-01-13 |
2024-01-16 |
mouse |
| Guo-Liang Dai, Bing-Ting Sun, Ze-Yu Chen, Pei-Yao Chen, Zhi-Tao Jiang, Wen-Zheng J. [Mechanism of Jiaotai Pills in treatment of depression based on quantitative proteomics]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 23. 2024-01-11. PMID:38212007. |
the western blot results of ppp2r2b, cers1, and ndufv3 in the hippocampus were consistent with the results of proteomics. |
2024-01-11 |
2024-01-14 |
rat |
| Gonçalo M Melo, Adriana M Capucho, Joana F Sacramento, José Ponce-de-Leão, Marcos V Fernandes, Inês F Almeida, Fátima O Martins, Silvia V Cond. Overnutrition during Pregnancy and Lactation Induces Gender-Dependent Dysmetabolism in the Offspring Accompanied by Heightened Stress and Anxiety. Nutrients. vol 16. issue 1. 2024-01-11. PMID:38201896. |
the offspring were analyzed at postnatal days 21 and 28 and at 2 months old (pd21, pd28, and pd60) for their metabolic profiles (weight, fasting glycemia insulin sensitivity, and glucose tolerance) and euthanized for brain collection to evaluate metabolism and inflammation in the hypothalamus, hippocampus, and prefrontal cortex using western blot markers of synaptic dynamics. |
2024-01-11 |
2024-01-13 |
rat |
| Khadijeh Esmaeilpour, Elham Jafari, Fahimeh Rostamabadi, Mina Khaleghi, Faezeh Akhgarandouz, Maryam Hosseini, Hamid Najafipour, Mahdi Khodadoust, Vahid Sheibani, Mohammad Amin Rajizade. Myrtenol Inhalation Mitigates Asthma-Induced Cognitive Impairments: an Electrophysiological, Behavioral, Histological, and Molecular Study. Molecular neurobiology. 2023-12-26. PMID:38148370. |
myrtenol (8 mg/kg) or budesonide (160 μg/kg) was administered through inhalation once a day for 1 week, and at the end of the inhalation period, behavioral tests (mwm and open field), field potential recording, hippocampal brain-derived neurotrophic factor (bdnf), il1β (elisa), and nfκb measurement (western blot) were performed to evaluate cognitive performance. |
2023-12-26 |
2023-12-29 |
rat |