| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Meng Zhang, Li-Yuan Liu, Yong Xu, Wen-Zhi Wang, Nian-Zhuang Qiu, Fang-Fang Zhang, Feng Zhang, Xiao-Dan Wang, Wei Chen, Xiao-Yan Xu, Yong-Feng Gao, Mei-Hua Chen, Yu-Qin Li, Han-Ting Zhang, Hao Wan. Imbalance of multiple neurotransmitter pathways leading to depression-like behavior and cognitive dysfunction in the triple transgenic mouse model of Alzheimer disease. Metabolic brain disease. 2023-05-31. PMID:37256468. |
most neurotransmitters exert their effects by binding to the corresponding receptor, so the expression of relative receptors in the hippocampus of mice was detected using western blot. |
2023-05-31 |
2023-08-14 |
mouse |
| Franziska T Wunsch, Nils Metzler-Nolte, Carsten Theiss, Veronika Matschk. Defects in Glutathione System in an Animal Model of Amyotrophic Lateral Sclerosis. Antioxidants (Basel, Switzerland). vol 12. issue 5. 2023-05-27. PMID:37237880. |
we analyzed changes in glutathione metabolism in the spinal cord, hippocampus, cerebellum, liver, and blood samples of the als model, wobbler mouse, using qpcr, western blot, hplc, and fluorometric assays. |
2023-05-27 |
2023-08-14 |
mouse |
| Ghallab Alotaibi, Amna Khan, Patrick J Ronan, Kabirullah Lutfy, Shafiqur Rahma. Glial Glutamate Transporter Modulation Prevents Development of Complete Freund's Adjuvant-Induced Hyperalgesia and Allodynia in Mice. Brain sciences. vol 13. issue 5. 2023-05-27. PMID:37239279. |
furthermore, the effects of ldn-212320 on the protein expression of glial markers, such as ionized calcium-binding adaptor molecule 1 (iba1), cluster of differentiation molecule 11b (cd11b), mitogen-activated protein kinases (p38), astroglial glt-1, and connexin 43 (cx43), were measured in the hippocampus and acc following cfa injection using the western blot analysis and immunofluorescence assay. |
2023-05-27 |
2023-08-14 |
mouse |
| Masahiro Sano, Hikaru Iwashita, Chihiro Suzuki, Mari Kawaguchi, Atsuhiko Chib. Effects of melatonin on phosphorylation of memory-related proteins in the hippocampus and the perirhinal cortex in male mice. Neuroreport. vol 34. issue 9. 2023-05-10. PMID:37161988. |
next, the effects of the same doses of these drugs on relative phosphorylation levels of the extracellular signal-regulated kinase (erk) and calcium/calmodulin-dependent kinases (camks) in the hippocampus and the perirhinal cortex (prc) were examined by western blot analysis. |
2023-05-10 |
2023-08-14 |
mouse |
| Mikel L Olson, Bretton Badenoch, Megan Blatti, Christine Buching, Nic Gleww. Muscarinic Cholinergic Receptor Antagonism Impairs Spatial Memory Retrieval and Minimizes Retrieval-Induced Alterations in Matrix Metalloproteinase-9. Behavioural brain research. 2023-04-29. PMID:37119978. |
western blot analysis of hippocampal tissue shows elevated levels of a truncated form of mmp-9 associated with spatial memory retrieval. |
2023-04-29 |
2023-08-14 |
rat |
| Jiaxin Zheng, Hong Zhu, Zhenyu Zhao, Miaoyu Du, Zhitian Wang, Liuyi Lan, Junjian Zhan. Vesicular acetylcholine transporter in the basal forebrain improves cognitive impairment in chronic cerebral hypoperfusion rats by modulating theta oscillations in the hippocampus. Neuroscience letters. 2023-04-29. PMID:37120008. |
we employed enzyme-linked immunosorbent assay (elisa), western blot (wb), and immunohistochemistry (ihc) to assess hippocampal cholinergic levels. |
2023-04-29 |
2023-08-14 |
rat |
| Hao Zhang, Zhan Gao, Ya Sun, Tian Lu, Zhenzhen Wang, Dongmei Gao, Jieqiong Wang, Mingqi Qiao, Mingzhou Ga. Profiling GABA(A) Receptor Subunit Expression in the Hippocampus of PMDD Rat Models Based on TCM Theories. Molecular neurobiology. 2023-04-27. PMID:37103685. |
western blot analysis was used to investigate protein levels of gabaar α1, α2, α4, α5, β2, β3, and δ subunits, whereas ultra-high performance liquid chromatography-tandem mass spectrometry (uhplc-ms/ms) analysis was performed to determine gamma-aminobutyric acid (gaba) and glutamate (glu) levels in the hippocampus across each group. |
2023-04-27 |
2023-08-14 |
rat |
| Chengcheng Guo, Yang Yao, Chunchao Ma, Zhiyun Wan. High-intensity interval training improves cognitive impairment of vascular dementia rats by up-regulating expression of brain-derived neurotrophic factor in the hippocampus. Neuroreport. vol 34. issue 8. 2023-04-27. PMID:37104097. |
moreover, brain-derived neurotrophic factor (bdnf) expression level in the cerebral cortex and hippocampus tissue detected by western blot were significantly up-regulated in hiit group compared to sed group and mict group. |
2023-04-27 |
2023-08-14 |
rat |
| Kylie A Huckleberry, Roberto Calitri, Anna J Li, Mackenna Mejdell, Ashna Singh, Vasvi Bhutani, Mikaela A Laine, Andrei S Nastase, Maria Morena, Matthew N Hill, Rebecca M Shansk. CB1R blockade unmasks TRPV1-mediated contextual fear generalization in female, but not male rats. bioRxiv : the preprint server for biology. 2023-04-24. PMID:37090594. |
to identify a potential synaptic mechanism for these sex differences, we next used liquid chromatography/tandem mass spectrometry, western blot, and confocal-assisted immunofluorescence techniques to quantify anandamide (aea), trpv1r, and perisomatic cb1r expression, respectively, focusing on the ventral hippocampus (vhip). |
2023-04-24 |
2023-08-14 |
rat |
| Lei Zhang, Xunrui Zhang, Ruijie Ji, Yaya Ji, Yuhang Wu, Xiuyu Ding, Zhiying Shang, Xueyuan Liu, Wen Li, Jingjing Guo, Jue Wang, Xiang Cheng, Jianbing Qin, Meiling Tian, Guohua Jin, Xinhua Zhan. Lama2 And Samsn1 Mediate the Effects of Brn4 on Hippocampal Neural Stem Cell Proliferation and Differentiation. Stem cells international. vol 2023. 2023-04-24. PMID:37091532. |
immunofluorescence staining, rt-qpcr, and western blot suggested that lama2 and samsn1 mediated the promoting effect of brn4 on the differentiation of hippocampal nscs into neurons. |
2023-04-24 |
2023-08-14 |
Not clear |
| Jian Lu, Xiaoyan Tao, Hongyu Dai, Sunan Gao, Hongmei Zho. Peripheral and cerebral inflammation induced by repeated anesthesia and surgery do not cause impairment of learning and memory in middle‑aged mice. Acta neurobiologiae experimentalis. vol 83. issue 1. 2023-04-20. PMID:37078813. |
the expressions of chat, ache, and aβ in the hippocampus were measured by western blot. |
2023-04-20 |
2023-08-14 |
mouse |
| Lu Ji, Rong-Jie Jin, Lin L. Platelet-rich Plasma Improves Radiotherapy-induced Emotional Disorder and Cognitive Dysfunction, Neuroinflammation in Aged Rats by Inhibiting the Activation of NLRP3 Inflammasomes. Neurochemical research. 2023-04-12. PMID:37043084. |
besides, immunohistochemistry was used to detect the expression of microglial marker protein iba-1 in rat hippocampus; enzyme linked immunosorbent assay (elisa) to examine the levels of pro-inflammatory cytokines tumor necrosis factor-alpha (tnf-α), interleukin (il)-1 beta (il-1β), il-18, and monocyte chemoattractant protein 1 (mcp-1) in rat hippocampus; real-time quantitative reverse transcription pcr (qrt-pcr) and western blot to measure the levels of neurotrophic factors brain-derived neurotrophic factor (bdnf), tropomyosin-related kinase b receptor (trkb), and nerve growth factor (ngf) in rat hippocampus; and western blot also to observe the protein expression levels of nod-like receptor protein 3 (nlrp3), caspase-1, apoptosis-associated speck-like protein containing a card (asc), and il-1β in rat hippocampus. |
2023-04-12 |
2023-08-14 |
rat |
| Brandon Emanuel León, Lee Peyton, Hesham Essa, Tia Wieden, Nicole Marion, Wayne E Childers, Magid Abou-Gharbia, Doo-Sup Cho. A novel monobactam lacking antimicrobial activity, MC-100093, reduces sex-specific ethanol preference and depressive-like behaviors in mice. Neuropharmacology. 2023-03-31. PMID:37001726. |
western blot analysis of the medial prefrontal cortex and hippocampus revealed no changes in male or female glt1 protein abundance relative to gapdh. |
2023-03-31 |
2023-08-14 |
mouse |
| Lan Wei, Qiang Tao, Minmin Yao, Zhimeng Zhao, Shengjin G. Caloric Restriction Can Ameliorate Postoperative Cognitive Dysfunction by Upregulating the Expression of Sirt1, MeCP2 and BDNF in the Hippocampal CA1 Region of Aged C57BL/6 Mice. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979272. |
by using western blot and immunofluorescence, the expression of sirt1, mecp2, and bdnf in the hippocampus and hippocampal ca1 region was quantified. |
2023-03-29 |
2023-08-14 |
mouse |
| Ana Knezovic, Marija Piknjac, Jelena Osmanovic Barilar, Ana Babic Perhoc, Davor Virag, Jan Homolak, Melita Salkovic-Petrisi. Association of Cognitive Deficit with Glutamate and Insulin Signaling in a Rat Model of Parkinson's Disease. Biomedicines. vol 11. issue 3. 2023-03-29. PMID:36979662. |
the expression of tyrosine hydroxylase (th) and proteins involved in insulin (insulin receptor - ir, phosphoinositide 3 kinase - pi3k, extracellular signal-regulated kinases-erk) and glutamate receptor (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptos-ampar, n-methyl-d-aspartate receptor - nmdar) signaling was assessed in the hippocampus (hpc), hypothalamus (hpt) and striatum (s) by immunofluorescence, western blot and enzyme-linked immunosorbent assay (elisa). |
2023-03-29 |
2023-08-14 |
rat |
| Helin Chen, Qibin Kan, Ling Zhao, Gang Ye, Xiaoli He, Huaqiao Tang, Fei Shi, Yuanfeng Zou, Xiaoxia Liang, Xu Song, Rui Liu, Jie Luo, Yinglun L. Prophylactic effect of Tongxieyaofang polysaccharide on depressive behavior in adolescent male mice with chronic unpredictable stress through the microbiome-gut-brain axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 161. 2023-03-15. PMID:36921537. |
rt-qpcr, western blot, and elisa detected tryptophan metabolism in the colon, serum, and hippocampus. |
2023-03-15 |
2023-08-14 |
mouse |
| Jin Zhang, Jian-Jian Dong, Qing-Jun Zhu, Yan-Min Zheng, Hai-Yang Tong, Yun Wu, Lu-Lu Wang, Hong-Yi Yang, Jian-You Gu. [Effect of Ganmai Dazao Decoction on ethology of rats with PTSD and its mechanism]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 3. 2023-03-05. PMID:36872240. |
three rats in each group were selected to detect the expression of neuropeptide receptor y1(npy1r) protein in the hippocampus by western blot. |
2023-03-05 |
2023-08-14 |
rat |
| Jin Zhang, Jian-Jian Dong, Qing-Jun Zhu, Yan-Min Zheng, Hai-Yang Tong, Yun Wu, Lu-Lu Wang, Hong-Yi Yang, Jian-You Gu. [Effect of Ganmai Dazao Decoction on ethology of rats with PTSD and its mechanism]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 3. 2023-03-05. PMID:36872240. |
the results of western blot showed that ganmai dazao decoction significantly reduced the expression of nyp1r protein in the hippocampus of rats with ptsd. |
2023-03-05 |
2023-08-14 |
rat |
| Tian-Tian Qin, Hong-Xiao Xie, Jing-Wen Hu, Jiu-Seng Zeng, Rong Liu, Nan Zen. [Mechanism of essential oil from Schizonepeta tenuifolia in treatment of depression based on network pharmacology and experimental verification]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 4. 2023-03-05. PMID:36872277. |
the content of interleukin(il)-1β was determined by enzyme-linked immunosorbent assay(elisa), and the protein expression levels of il-1β and pro il-1β in the hippocampus were determined by western blot. |
2023-03-05 |
2023-08-14 |
mouse |
| Keisuke Suzuki, Junko Shibato, Randeep Rakwal, Masahiko Takaura, Ryotaro Hotta, Yoshinori Masu. Biomarkers in the Rat Hippocampus and Peripheral Blood for an Early Stage of Mental Disorders Induced by Water Immersion Stress. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834565. |
reverse-transcription pcr and western blot analyses revealed significant alterations in the expressions of hippocampal genes and proteins by the stress for no longer than 24 h, such as |
2023-02-25 |
2023-08-14 |
rat |