| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ming-Cheng Li, Jun Zhou, Yun-Yun Hu, Zhi-Peng Meng, Yu-Jie Lyu, Hu-Ping Wan. [Heixiaoyao Powder interferes with microglia polarization in AD model mice by regulating NOX2/ROS/NF-κB signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 15. 2023-10-06. PMID:37802770. |
western blot was used to detect the protein expression of β-amyloid protein(aβ), iba-1, cd16/32, cd206, nox2, nf-κb, p-nf-κb, nf-κb inhibitor alpha(iκbα), and p-ikbα in the hippocampus. |
2023-10-06 |
2023-10-15 |
mouse |
| En-Long Zhao, Yong-Chang Diwu, Hu Zhang, Li-Qi Duan, Xin-Yue Han, Ya-Li Wang, Yuan Zho. [Xixin Decoction improves learning and memory ability of SAMP8 by enhancing neuroprotective effect and inhibiting neuroinflammation]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 18. 2023-10-06. PMID:37802845. |
western blot was employed to test the protein expression levels of silencing information regulator 2 related enzyme 1(sirt1), ager, tlr1, and tlr2 in the hippocampus of mice. |
2023-10-06 |
2023-10-15 |
mouse |
| Qi-Qin Dan, Zheng Ma, Ya-Xin Tan, Belegu Visar, Li Che. AQP4 knockout promotes neurite outgrowth via upregulating GAP43 expression in infant rats with hypoxic-ischemic brain injury. Ibrain. vol 8. issue 3. 2023-10-03. PMID:37786741. |
neonatal sprague-dawley rats were used to establish neonatal hypoxic-ischemic (hi) models, and the expression of aqp4 in the cortex, hippocampus, and lung tissues was detected by real-time quantitative polymerase chain reaction as well as western blot. |
2023-10-03 |
2023-10-07 |
rat |
| Fernanda Nunes, Bruna Lotufo, Yury Velho Martins Lages, Sílvia Maisonnette, Thomas Krahe, Antonio Pedro Mello Cruz, J Landeira-Fernande. Increased hippocampal CREB phosphorylation after retrieval of remote contextual fear memories in Carioca High-conditioned Freezing rats. Neurobiology of learning and memory. 2023-09-20. PMID:37730100. |
western blot results indicated that pcreb levels were significantly increased in the hippocampus of chf rats for both context and control conditions when compared to the other experimental groups. |
2023-09-20 |
2023-10-07 |
rat |
| Dandan Xu, Yayun Xu, Xinran Gao, Mengyu Yan, Chen Zhang, Xian Wu, Qingrong Xia, Jinfang G. Potential value of Interleukin-6 as a diagnostic biomarker in human MDD and the antidepressant effect of its receptor antagonist tocilizumab in lipopolysaccharide-challenged rats. International immunopharmacology. vol 124. issue Pt B. 2023-09-17. PMID:37717319. |
the activity of the hypothalamic-pituitary-adrenal (hpa) axis was observed, and the protein expression levels in the hippocampus were detected via western blot. |
2023-09-17 |
2023-10-07 |
human |
| Xiao Wu, Xiaona Zhang, Lulu Sun, Xiaoming Lu, Cunsi She. Icariin prevents depression-like behaviors in chronic unpredictable mild stress-induced rats through Bax/cytoplasm C/caspase-3 axis to alleviate neuronal apoptosis. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 7. 2023-09-16. PMID:37715385. |
subsequently, expression of the glucocorticoid receptor (gr), bcl-2, cytochrome c, caspase-3 and bax in the hippocampus was tested by western blot. |
2023-09-16 |
2023-10-07 |
rat |
| Federico Ravanelli, Laura Musazzi, Silvia Stella Barbieri, Gianenrico Rovati, Maurizio Popoli, Alessandro Barbon, Alessandro Ierac. Differential Epigenetic Changes in the Dorsal Hippocampus of Male and Female SAMP8 Mice: A Preliminary Study. International journal of molecular sciences. vol 24. issue 17. 2023-09-09. PMID:37685895. |
here we used western blot and qpcr analyses to investigate whether epigenetic markers are differentially altered in the dorsal hippocampus, a region important for the regulation of learning and memory, of 9-month-old male and female samp8 mice. |
2023-09-09 |
2023-10-07 |
mouse |
| Manickam Rajkumar, Soundarapandian Kannan, Ramasundaram Thangara. Voglibose attenuates cognitive impairment, Aβ aggregation, oxidative stress, and neuroinflammation in streptozotocin-induced Alzheimer's disease rat model. Inflammopharmacology. 2023-09-04. PMID:37665449. |
at the end of the study, all experimental rats were sacrificed, and their brain parts, the cortex and hippocampus, were subjected to biochemical, western blot, and histopathological analysis. |
2023-09-04 |
2023-09-07 |
rat |
| Chong Wang, Linding Xie, Yien Xing, Min Liu, Jun Yang, Nannan Gao, Yihong Ca. Iron-overload-induced ferroptosis in mouse cerebral toxoplasmosis promotes brain injury and could be inhibited by Deferiprone. PLoS neglected tropical diseases. vol 17. issue 8. 2023-08-31. PMID:37651502. |
we used inductively coupled plasma mass spectrometry, an iron ion assay kit, western blot analysis, glutathione and glutathione disulfide assay kits, a malonaldehyde assay kit, and immunofluorescence to detect the ferroptosis-related indexes in the mouse hippocampus and ht-22 cells. |
2023-08-31 |
2023-09-07 |
mouse |
| Chong Wang, Linding Xie, Yien Xing, Min Liu, Jun Yang, Nannan Gao, Yihong Ca. Iron-overload-induced ferroptosis in mouse cerebral toxoplasmosis promotes brain injury and could be inhibited by Deferiprone. PLoS neglected tropical diseases. vol 17. issue 8. 2023-08-31. PMID:37651502. |
the inflammatory factors interferon-γ, tumor necrosis factor-α, transforming growth factor-β, and arginase 1 in the hippocampus and cells were detected using the western blot assay. |
2023-08-31 |
2023-09-07 |
mouse |
| Zhi-Hao Mu, Zhi-Min Zhao, Su-Su Yang, Lei Zhou, Yi-Dan Liu, Zhong-Yi Qian, Xin-Jie Liu, Peng-Chao Zhao, Ren-Bo Tang, Jia-Yin Li, Jing-Yao Zeng, Zhi-Hong Yang, Yong-Hua Ruan, Ying Zhang, Yue-Qin Zeng, Ying-Ying Zo. Gastrodin ameliorates cognitive dysfunction in diabetes by inhibiting PAK2 phosphorylation. Aging. vol 15. 2023-08-23. PMID:37610708. |
transcriptomics analysis identified differential expression genes critical for diabetes-induced hippocampal damage and gastrodin treatment, which were further confirmed by qpcr and western blot. |
2023-08-23 |
2023-09-07 |
rat |
| Lu-Lu Lin, Gui-Jun Song, Hui Zhang, Yan Yin, Shi-Meng Xin, Li Ding, Yu L. GPR34 knockdown relieves cognitive deficits and suppresses neuroinflammation in Alzheimer's disease via the ERK/NF-κB signal. Neuroscience. 2023-08-09. PMID:37557947. |
the level of gpr34 in hippocampus and bv-2 cells as well as the activation of erk/nf-κb signal was determined by quantitative real-time pcr, western blot or immunofluorescence. |
2023-08-09 |
2023-08-16 |
mouse |
| Marjan Shariatpanahi, Zahra Sojoudi, Fariba Khodagholi, Hiva Rahmati, Seyed Behnamedin Jameie, Mina Eftekharzadeh, Maryam Soleimani Karizmeh, Mostafa Shabani, Ehsan Zaman. Effect of sex differences and time of oxytocin administration on treatment of rat model of autism spectrum disorder: Focused on necroptosis markers. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2023-07-28. PMID:37503701. |
western blot was performed on the hippocampus and amygdala tissues to investigate the expression of rip3 and mlkl markers. |
2023-07-28 |
2023-08-14 |
rat |
| Ricarina Rabinovitz, Mirit Eyna. CNS-oxygen toxicity and blood glucose levels in MnSOD enzyme knockdown mice. Respiratory physiology & neurobiology. 2023-07-22. PMID:37481014. |
we used rt-pcr and western blot to measure levels of glucose transporter 1 (glut1) and hypoxia inducible factor (hif)1a in the cortex and hippocampus. |
2023-07-22 |
2023-08-14 |
mouse |
| Manolia R Ghouli, Carrie R Jonak, Rajan Sah, Todd A Fiacco, Devin K Binde. Regulation of the Volume-Regulated Anion Channel Pore-Forming Subunit LRRC8A in the Intrahippocampal Kainic Acid Model of Mesial Temporal Lobe Epilepsy. ASN neuro. vol 15. 2023-07-06. PMID:37410995. |
western blot analysis revealed the upregulation of total dorsal hippocampal lrrc8a 14-days post-ihka in both the ipsilateral and contralateral hippocampus. |
2023-07-06 |
2023-08-14 |
Not clear |
| Christina Kjær, Oana Palasca, Guido Barzaghi, Lasse K Bak, Rúna K J Durhuus, Emil Jakobsen, Louise Pedersen, Emil D Bartels, David P D Woldbye, Lars H Pinborg, Lars Juhl Jense. Differential Expression of the β3 Subunit of Voltage-Gated Ca Molecular neurobiology. 2023-06-21. PMID:37341859. |
next, we attempted to validate lead targets using qpcr, immunohistochemistry, and western blot on hippocampal and temporal lobe neocortical tissue from mtle patients and non-epilepsy controls, respectively. |
2023-06-21 |
2023-08-14 |
Not clear |
| E Abdelkareem, E M Tayee, A M Taha, M S Abdelellati. Effect of Sevoflurane and Isoflurane on Post-Anaesthesia Cognitive Dysfunction in Normal and Type II Diabetic Rats. Archives of Razi Institute. vol 78. issue 1. 2023-06-14. PMID:37312692. |
1 week later, animals were undergone cognitive tests in (a morris water maze, t maze and open field arena), the animals were sacrificed, and hippocampus homogenates were studied for caspase 3 activity by western blot assay. |
2023-06-14 |
2023-08-14 |
human |
| Jingyuan Ma, Feng Xiong, Zhouru Li, Guokai Dong, Xiaoming Sun, Wenjiang Yin, Hongxing Ca. The effect of chronic alcohol exposure on spatial memory and BDNF-TrkB- PLCγ1 signaling in the hippocampus of male and female mice. Heliyon. vol 9. issue 6. 2023-06-12. PMID:37303582. |
after 4 weeks of intermittent access to 20% alcohol, memory impairment in both male and female mice was evaluated using the morris water maze and the expression of bdnf, trkb, phosphorylation of plcγ1 (p-plcγ1) and plcγ1 in the hippocampus was examined using western blot. |
2023-06-12 |
2023-08-14 |
mouse |
| Xiuqin Li, Shaopeng Chen, Guiming Zheng, Yanyan Yang, Nan Yin, Xiaoli Niu, Lixia Yao, Peiyuan L. Atorvastatin calcium ameliorates cognitive deficits through the AMPK/mTOR pathway in rats with vascular dementia. Combinatorial chemistry & high throughput screening. 2023-06-07. PMID:37282650. |
western blot and qrt-pcr indicated that ac in vd rats inhibited bax and promoted lc3-ii, beclin-1, and bcl-2 in the hippocampus region. |
2023-06-07 |
2023-08-14 |
mouse |
| Yuanming Lu, Wanshi Wang, Yanping Ma, Zilian Fan, Lan Xiong, Junhao Zhao, Yongwen He, Chao Li, Anjie Wang, Nanping Xiao, Tianxun Wan. miR-10a induces inflammatory responses in epileptic hippocampal neurons of rats via PI3K/Akt/mTOR signaling pathway. Neuroreport. vol 34. issue 10. 2023-06-04. PMID:37270844. |
the hippocampal neurons were transfected with mir-10a mimics, and transcript levels of mir-10a, pi3k, akt and mtor were detected by quantitative reverse transcription-pcr, and pi3k, mtor, akt, tnf-α, il-1β, il-6 protein expression levels were detected by western blot. |
2023-06-04 |
2023-08-14 |
rat |