| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dongpei Zhuang, Nan Yu, Shuo Han, Xinyao Zhang, Chuanxia J. The Kv7 channel opener Retigabine reduces neuropathology and alleviates behavioral deficits in APP/PS1 transgenic mice. Behavioural brain research. vol 471. 2024-07-09. PMID:38971432. |
moreover, western blot analysis revealed a reduction in the expression of the p-tau protein in both the hippocampus and cortex upon kv7 channel opening. |
2024-07-09 |
2024-07-12 |
mouse |
| Sin Ho Kweon, Hye Guk Ryu, Seung-Hwan Kwon, Hyeonwoo Park, Saebom Lee, Nam-Shik Kim, Shi-Xun Ma, Hee-Jung Jee, Sangjune Kim, Han Seok K. Gba1 E326K renders motor and non-motor symptoms with pathologic α-syn, tau and glial activation. Brain : a journal of neurology. 2024-07-08. PMID:38976650. |
at 9 and 24 months, we assessed gba1 protein and activity, α-synuclein pathology, neurodegeneration, motor deficits, and gliosis in the ventral midbrain and hippocampus using immunohistochemistry (ihc), western blot (wb), and gcase assays. |
2024-07-08 |
2024-07-12 |
mouse |
| Sha Sha, Ni Jin, Xinyi Xie, Ruiyu Zhou, Yanghao Ruan, Ying Ouyan. Ethyl pyruvate alleviates NLRP3/Caspase-1/GSDMD-mediated neuronal pyroptosis in neonatal rats with hypoxic-ischemic brain damage. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2024-06-28. PMID:38940222. |
we used he staining, immunofluorescence double staining, transmission electron microscopy, and western blot to demonstrate that ep effectively inhibited hippocampal neuronal pyroptosis and attenuated the activation of the nlrp3/caspase-1/gsdmd signaling pathway in hibd rats, which resulted in a reduction of neuroinflammation and facilitated neural recovery. |
2024-06-28 |
2024-06-30 |
rat |
| Kwan Joong Kim, Zukhra Akhmedova, Ho Jin Heo, Dae-Ok Ki. Red Pine Bark Extract Alleviates Akt/GSK-3β Signaling Disruption in the Hippocampus of Streptozotocin-Induced Diabetic Sprague-Dawley Rats. Journal of microbiology and biotechnology. vol 34. issue 6. 2024-06-17. PMID:38881175. |
after 20 days of oral administration of pbe, the rat hippocampus was collected, and the production of akt, p-akt, gsk-3β, p-gsk-3β, tau, ptau, bax, and bcl-2 proteins were determined by western blot analysis. |
2024-06-17 |
2024-06-19 |
rat |
| Caíque Olegário Diniz E Magalhães, Ricardo Augusto Leoni De Sousa, Bruno Ferreira Mendes, Isabela Rocha Dias, Ramona Ramalho Souza Pereira, Gabriela Cruz Pereira, Kil Sun Lee, Marco Fabricio Dias Peixoto, Ricardo Cardoso Cassilha. Accumulated HIIT inhibits anxiety and depression, improves cognitive function, and memory-related proteins in the hippocampus of aged rats. Experimental brain research. 2024-06-12. PMID:38864869. |
rats were euthanized, and the hippocampus was harvested for western blot analyses (camkii and bdnf). |
2024-06-12 |
2024-06-14 |
rat |
| Qian Huang, Guo-Liang Dai, Xin-Yi Yang, Yang Cao, Wen-Zheng J. [Mechanism of Jiaotai Pills in treatment of depression by UHPLC-TOF-MS combined with network pharmacology and experimental validation]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 7. 2024-05-30. PMID:38812202. |
the expression of inflammatory factors in serum and the neurotransmitters in the brain were detected by elisa, and the expression of key targets in the hippocampus was detected by western blot. |
2024-05-30 |
2024-06-17 |
rat |
| Pei-Xun Yang, Xiao-Xue Fan, Min-Xuan Liu, Jing Liu, Liang Cao, Zhen-Zhong Wang, Xin Wang, Xin-Zhuang Zhang, Wei Xia. [Effects of epimedium total flavone capsules on post-stroke cognitive impairment in rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 8. 2024-05-30. PMID:38812240. |
moreover, western blot was utilized to test the expression of nuclear factor-kappab(nf-κb), p-nf-κb, alpha inhibitor of nf-κb(iκbα) protein, and p-iκbα protein in the hippocampus. |
2024-05-30 |
2024-06-17 |
rat |
| Jiangxia Cheng, Zhuo Wang, Hui Yu, Ye Chen, Zhengchao Wang, Liangcheng Zhang, Xiaohong Pen. The duration-dependent and sex-specific effects of neonatal sevoflurane exposure on cognitive function in rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 57. 2024-05-29. PMID:38808889. |
blood gas analysis and western blot detection in the hippocampus were conducted after exposure. |
2024-05-29 |
2024-06-02 |
rat |
| Xiaofang Zhang, Jiyuan Guo, Ce Zhang, Wenhua Wang, Shuailin Du, Xusheng Tia. Suanzaoren decoction exerts its antidepressant effect via the CaMK signaling pathway. Translational neuroscience. vol 15. issue 1. 2024-05-13. PMID:38736723. |
protein and mrna relative expression levels of cam, camk i, and camk iv in the hippocampus were measured by western blot, quantitative polymerase chain reaction, and immunohistochemistry in the hippocampus. |
2024-05-13 |
2024-05-27 |
rat |
| Zhengdong Yang, You Wu, Jun Tang, Renhuai Liu, Zongping Fang, Binxiao S. [Cannabinoid receptor 1 agonist arachidonyl-2'-chloroethylamide (ACEA) improves sepsis-associated encephalopathy by inhibiting inflammatory factors]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 40. issue 4. 2024-05-06. PMID:38710516. |
western blot analysis was used to assess the protein levels of il-6 and tnf-α in the hippocampus. |
2024-05-06 |
2024-05-27 |
mouse |
| Luis A Rojas-Colón, John B Redell, Pramod K Dash, Pedro E Vegas, Wanda Vélez-Torre. 4R-cembranoid suppresses glial cells inflammatory phenotypes and prevents hippocampal neuronal loss in LPS-treated mice. Journal of neuroscience research. vol 102. issue 4. 2024-04-24. PMID:38656664. |
hippocampal lysates were used to measure the expression levels of neuronal nuclear protein (neun), inducible nitrous oxide synthase (inos), arginase-1, thrombospondin-1 (thbs1), glial cell-derived neurotrophic factor (gdnf), and orosomucoid-2 (orm2) by western blot. |
2024-04-24 |
2024-04-28 |
mouse |
| You Yang, Dongyu Zhou, Su Min, Di Liu, Mou Zou, Chang Yu, Lihao Chen, Jia Huang, Ruiyang Hon. Ciprofol ameliorates ECS-induced learning and memory impairment by modulating aerobic glycolysis in the hippocampus of depressive-like rats. Pharmacology, biochemistry, and behavior. 2024-04-24. PMID:38657873. |
changes in aerobic glycolysis and synaptic plasticity in the hippocampal region of depressive-like rats post-ecs were documented using immunofluorescence analysis, western blot, lactate assay kit and transmission electron microscopy. |
2024-04-24 |
2024-04-28 |
rat |
| Jingjing Wu, Jian Chen, Ying Ge, Nanqu Huang, Yong Lu. Neuroprotective effect of tanshinone IIA-modified mesenchymal stem cells in a lipopolysaccharide-induced neuroinflammation model. Heliyon. vol 10. issue 8. 2024-04-19. PMID:38638958. |
the cognitive performance of the mice was assessed using the y-maze and morris water maze tests, while immunofluorescence and western blot analyses were employed to evaluate the hippocampal expression of pertinent markers and inflammatory factors, respectively. |
2024-04-19 |
2024-04-21 |
mouse |
| Ya-Jie Zhang, Wen-Jing Li, Jie Li, Tian Zhu, Jian-You Gu. [Essential oil of Cinnamomum camphora mitigates depression-like behavior in mice by regulating Nrf2/HO-1 pathway and inhibiting inflammatory cytokines]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 3. 2024-04-15. PMID:38621882. |
western blot and qrt-pcr were employed to determine the expression of proteins and genes in the nrf2/ho-1 pathway in the hippocampus. |
2024-04-15 |
2024-04-18 |
mouse |
| Jiuseng Zeng, Li Chen, Xi Peng, Fei Luan, Jingwen Hu, Zhiqiang Xie, Hongxiao Xie, Rong Liu, Haizhen Lv, Nan Zen. The anti-depression effect and potential mechanism of the petroleum ether fraction of CDB: Integrated network pharmacology and metabolomics. Heliyon. vol 10. issue 7. 2024-04-08. PMID:38586416. |
furthermore, western blot analysis confirmed that pefc significantly influenced the main protein levels of the pi3k/akt/mtor signaling pathways in the hippocampus of mice subjected to cums. |
2024-04-08 |
2024-04-10 |
mouse |
| Jun Chang, Huimin Yang, Xiaoqian Shan, Lan Zhao, Yujiao Li, Zhao Zhang, Joseph Kofi Abankwah, Mingxing Zhang, Yuhong Bian, Yi Gu. Bergamot essential oil improves CUMS-induced depression-like behaviour in rats by protecting the plasticity of hippocampal neurons. Journal of cellular and molecular medicine. vol 28. issue 8. 2024-03-30. PMID:38553964. |
immunohistochemistry and western blot were used to detect the postsynaptic density protein-95 (psd-95) and synaptophysin (syp) in the hipp of rats. |
2024-03-30 |
2024-04-01 |
rat |
| Sharif Ahmed, Ning Ma, Jun Kawanokuchi, Keiya Matsuoka, Shinji Oikawa, Hatasu Kobayashi, Yusuke Hiraku, Mariko Murat. Taurine reduces microglia activation in the brain of aged senescence-accelerated mice by increasing the level of TREM2. Scientific reports. vol 14. issue 1. 2024-03-29. PMID:38548872. |
immunohistochemical and western blot analyses revealed that taurine significantly reduced the number of activated microglia, levels of phospho-tau and aβ deposit in the hippocampus and cortex. |
2024-03-29 |
2024-03-31 |
mouse |
| Yunlin Feng, Jia Qin, Yanfei Lu, Mengdie Wang, Shengqiang Wang, Foquan Lu. Suberoylanilide hydroxamic acid attenuates cognitive impairment in offspring caused by maternal surgery during mid-pregnancy. PloS one. vol 19. issue 3. 2024-03-29. PMID:38551911. |
the protein levels of histone deacetylase 2 (hdac2), phosphorylated camp response-element binding (p-creb), brain-derived neurotrophic factor (bdnf), and phosphorylated tyrosine kinase b (p-trkb) in the hippocampus of the offspring rats were evaluated by immunofluorescence staining and western blot. |
2024-03-29 |
2024-04-01 |
rat |
| Sami Alzarea, Amna Khan, Patrick J Ronan, Kabirullah Lutfy, Shafiqur Rahma. The α-7 Nicotinic Receptor Positive Allosteric Modulator Alleviates Lipopolysaccharide Induced Depressive-like Behavior by Regulating Microglial Function, Trophic Factor, and Chloride Transporters in Mice. Brain sciences. vol 14. issue 3. 2024-03-28. PMID:38539677. |
therefore, we examined the effects of pnu120596, an α7 nachr positive allosteric modulator, on the expression of bdnf, kcc2, and nkcc1 in the hippocampus and prefrontal cortex using western blot analysis, immunofluorescence assay, and real-time polymerase chain reaction. |
2024-03-28 |
2024-03-30 |
mouse |
| Kaili Du, Qianwen Shi, Xiuya Zhou, Lifei Zhang, Hongliang Su, Chao Zhang, Zhiwen Wei, Ting Liu, Li Wang, Xiaohui Wang, Bin Cong, Keming Yu. Melatonin attenuates fentanyl - induced behavioral sensitization and circadian rhythm disorders in mice. Physiology & behavior. 2024-03-16. PMID:38492912. |
the accompanying changes in the expression of brain and muscle arnt-like (bmal1), tyrosine hydroxylase (th), and monoamine oxidase a (mao-a) in relevant brain regions including the suprachiasmatic nucleus (scn), nucleus accumbens (nac), prefrontal cortex (pfc), and hippocampus (hip) were investigated by western blot assays to dissect the mechanism by which melatonin modulates fentanyl - induced behavioral sensitization and circadian rhythm disorders. |
2024-03-16 |
2024-03-19 |
mouse |