| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao-Min Luo, Bo-Yu Zhang, Yi Ding, Cun-Ping Wang, Qiu-Lin Luo, Rui Tan, Jian Gu, Pu-Yang Gon. [Ershiwuwei Shanhu Pills regulate Akt/mTOR/GSK-3β signaling pathway to alleviate Alzheimer's disease mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 8. 2022-05-09. PMID:35531723. |
western blot was adopted to detect the protein levels of p-mtor, p-akt, and gsk-3β in the hippocampus. |
2022-05-09 |
2023-08-13 |
mouse |
| Bo-Yu Zhang, Xiao-Min Luo, Yi Ding, Bin Yang, Han-Yun Que, Rui Tan, Pu-Yang Gong, Jian G. [Mechanism of Tibetan medicine Ershiwuwei Shanhu Pills on scopolamine-induced learning and memory impairment in mice based on Keap1/Nrf2/HO-1 signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 8. 2022-05-09. PMID:35531724. |
the content of kelch-like ech-associated protein 1(keap1), nuclear factor erythroid 2-related factor 2(nrf2), and heme oxygenase 1(ho-1) in hippocampus was determined by western blot. |
2022-05-09 |
2023-08-13 |
mouse |
| Jia-Hui Liu, Chao Yang, Qiu-Xiang Gu, Hai-Ying Liang, Dong Liu, Jun Liu, Tao Liu, Cheng-Yun Ca. [Effect of high-intensity interval exercise on depression-related behavior in mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 74. issue 2. 2022-05-03. PMID:35503064. |
western blot and elisa results showed that in the hippocampus, medial prefrontal cortex (mpfc) and amygdala of the cums model mice, glucocorticoid receptor (gr) protein expression was down-regulated, and the content of tumor necrosis factor α (tnf-α) was increased, compared with those in the control group, whereas hiit exercise could effectively reverse these changes in cums model mice. |
2022-05-03 |
2023-08-13 |
mouse |
| Ge Ou, Qian Li, Lin Zhu, Yuanyuan Zhang, Yijing Liu, Xin Li, Lina Du, Yiguang Ji. Intranasal hydrogel of armodafinil hydroxypropyl-β-cyclodextrin inclusion complex for the treatment of post-traumatic stress disorder. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society. vol 30. issue 3. 2022-05-02. PMID:35498223. |
besides, the western blot (wb) of hippocampal brain-derived neurotrophic factor (bdnf) and amygdala dopamine transporter (dat) immunohistochemistry sections indicated that aic hydrogel had a protective effect on the brain tissue of ptsd mice. |
2022-05-02 |
2023-08-13 |
mouse |
| Dan Yao, Yingjun Mu, Yong Lu, Li Li, Shuya Shao, Jiahao Zhou, Jing Li, Shengquan Chen, Dan Zhang, Yifan Zhang, Zhongliang Zhu, Hui L. Hippocampal AMPA receptors mediate the impairment of spatial learning and memory in prenatally stressed offspring rats. Journal of psychiatric research. vol 151. 2022-04-15. PMID:35427874. |
the mrna and protein expression of ampa receptors in the hippocampus were measured by qrt-pcr and western blot, respectively. |
2022-04-15 |
2023-08-13 |
rat |
| Ayşenur Sümer Coşkun, Hatice Aslı Bedel, Mustafa Munzuroğlu, Narin Derin, Coşkun Ust. Does Resveratrol Prevent Sevoflurane Toxicity in Newborn Rats? Journal of medicinal food. 2022-04-14. PMID:35420459. |
after performing the open field test on the postnatal 41st day, the animals were dissected, and the hippocampal bdnf levels were determined by western blot method. |
2022-04-14 |
2023-08-13 |
rat |
| Juan Turati, Julieta Rudi, Juan Beauquis, Lila Carniglia, Federico López Couselo, Julieta Saba, Carla Caruso, Flavia Saravia, Mercedes Lasaga, Daniela Duran. A metabotropic glutamate receptor 3 (mGlu3R) isoform playing neurodegenerative roles in astrocytes is prematurely up-regulated in an Alzheimer's model. Journal of neurochemistry. 2022-04-12. PMID:35411603. |
as assessed by western blot, hippocampal mglu3r levels progressively decreased with age in pdapp-j20 mice. |
2022-04-12 |
2023-08-13 |
mouse |
| Xiaomi Ding, Jing Zhou, Li Zhao, Mingyue Chen, Shenglin Wang, Ming Zhang, Xiaodong Zhang, Guohui Jian. Intestinal Flora Composition Determines Microglia Activation and Improves Epileptic Episode Progress. Frontiers in cellular and infection microbiology. vol 12. 2022-03-31. PMID:35356535. |
the seizure grade, duration, latency, hippocampal potential, and energy density were used to evaluate seizures, and the changes in the polarization of microglia were detected by western blot. |
2022-03-31 |
2023-08-13 |
mouse |
| Maia A Burjanadze, Manana G Dashniani, Revaz O Solomonia, Gela V Beselia, Lia Tsverava, Vincenzo Lagani, Nino C Chkhikvishvili, Temur L Naneishvili, Lali B Kruashvili, Mariam R Chighladz. Age-related changes in medial septal cholinergic and GABAergic projection neurons and hippocampal neurotransmitter receptors: relationship with memory impairment. Experimental brain research. 2022-03-31. PMID:35357523. |
western blot analysis moreover showed a decrease in the level of expression of cholinergic, gabaergic and glutamatergic receptors in the hippocampus of middle-aged-impaired and aged rats in contrast to middle-aged-unimpaired and young rats. |
2022-03-31 |
2023-08-13 |
rat |
| Ellis Nelissen, Nina Possemis, Nick P Van Goethem, Melissa Schepers, Danielle A J Mulder-Jongen, Lisa Dietz, Wiebke Janssen, Michael Gerisch, Jörg Hüser, Peter Sandner, Tim Vanmierlo, Jos Prickaert. The sGC stimulator BAY-747 and activator runcaciguat can enhance memory in vivo via differential hippocampal plasticity mechanisms. Scientific reports. vol 12. issue 1. 2022-03-05. PMID:35246566. |
in vivo only runcaciguat acted on the glutamatergic ampar system in hippocampal memory acquisition processes, while for bay-747 the effects on the neurotrophic system were more pronounced as measured in male mice using western blot. |
2022-03-05 |
2023-08-13 |
mouse |
| Ping Xu, Liang Xu, Shuyun Huang, Danfeng Li, Yanping Liu, Hongmin Guo, Niuniu Dai, Zongyuan Hong, Shuzhi Zhon. Analysis of the Molecular Mechanism of Punicalagin in the Treatment of Alzheimer's Disease by Computer-Aided Drug Research Technology. ACS omega. vol 7. issue 7. 2022-02-28. PMID:35224375. |
the amyloid β protein (aβ) in the hippocampus was examined by immunohistochemistry, and the phosphorylation of serine at position 404 of the tau protein (tau-ps404) was examined by western blot in the mouse brain. |
2022-02-28 |
2023-08-13 |
mouse |
| Changjing Zhang, Leilei Zhu, Shuaifei Lu, Mengyuan Li, Ming Bai, Yucheng Li, Erping X. The antidepressant-like effect of formononetin on chronic corticosterone-treated mice. Brain research. 2022-02-26. PMID:35218705. |
the serum corticosterone levels and hippocampal protein expression were detected by elisa and western blot. |
2022-02-26 |
2023-08-13 |
mouse |
| Naoki Yoshida, Yugo Kato, Hirokatsu Takatsu, Koji Fuku. Relationship between Cognitive Dysfunction and Age-Related Variability in Oxidative Markers in Isolated Mitochondria of Alzheimer's Disease Transgenic Mouse Brains. Biomedicines. vol 10. issue 2. 2022-02-25. PMID:35203488. |
in a western blot analysis using isolated mitochondria from three brain regions (cerebral cortex, cerebellum, and hippocampus), nmnat-3 expression in the hippocampi of aged ad mice was significantly lower than that of young ad mice. |
2022-02-25 |
2023-08-13 |
mouse |
| Michaela D Filiou, Larysa Teplytska, Markus Nussbaumer, David-M Otte, Andreas Zimmer, Christoph W Turc. Multi-Omics Analysis Reveals Myelin, Presynaptic and Nicotinate Alterations in the Hippocampus of G72/G30 Transgenic Mice. Journal of personalized medicine. vol 12. issue 2. 2022-02-25. PMID:35207732. |
decreased hippocampal protein expression for selected proteins, namely myelin oligodentrocyte glycoprotein (mog), cldn11 and myelin proteolipid protein (plp), was confirmed with western blot in a larger population of g72tg and wt mice. |
2022-02-25 |
2023-08-13 |
mouse |
| Soojin Park, Jing Zhu, Kyoung Hoon Jeong, Won-Joo Ki. Adjudin prevents neuronal damage and neuroinflammation via inhibiting mTOR activation against pilocarpine-induced status epilepticus. Brain research bulletin. 2022-02-19. PMID:35182690. |
immunofluorescence staining, terminal deoxynucleotidyl transferase dutp nick end labeling staining, and western blot analysis were used to evaluate the effects of adjudin treatment in the hippocampus after se. |
2022-02-19 |
2023-08-13 |
mouse |
| Xiao-Bo Yang, Heng-Bing Zu, Yong-Fei Zhao, Kai Ya. Agomelatine Prevents Amyloid Plaque Deposition, Tau Phosphorylation, and Neuroinflammation in APP/PS1 Mice. Frontiers in aging neuroscience. vol 13. 2022-02-14. PMID:35153715. |
then, all mice were sacrificed, and the hippocampus tissues were collected for elisa, western blot, and immunofluorescence analysis. |
2022-02-14 |
2023-08-13 |
mouse |
| Nadia Di Franco, Guillaume Drutel, Valérie Roullot-Lacarrière, Francisca Julio-Kalajzic, Valérie Lalanne, Agnès Grel, Thierry Leste-Lasserre, Isabelle Matias, Astrid Cannich, Delphine Gonzales, Vincent Simon, Daniela Cota, Giovanni Marsicano, Pier Vincenzo Piazza, Monique Vallée, Jean-Michel Reves. Differential expression of the neuronal CB1 cannabinoid receptor in the hippocampus of male Ts65Dn Down syndrome mouse model. Molecular and cellular neurosciences. 2022-02-14. PMID:35158060. |
combining various protein and gene expression targeted approaches using western blot, qrt-pcr and fish techniques, we investigated the expression pattern of ecs components in the hippocampus (hpc) of male ts65dn mice. |
2022-02-14 |
2023-08-13 |
mouse |
| Ali Mooshekhian, Thaisa Sandini, Zelan Wei, Rebekah Van Bruggen, Haibo Li, Xin-Min Li, Yanbo Zhan. Low-field magnetic stimulation improved cuprizone-induced depression-like symptoms and demyelination in female mice. Experimental and therapeutic medicine. vol 23. issue 3. 2022-02-07. PMID:35126713. |
the prefrontal cortex and hippocampus were then collected to perform immunohistochemistry and western blot analysis to verify myelination status. |
2022-02-07 |
2023-08-13 |
mouse |
| Kaifang Wang, Meiyan Sun, Zhaodong Juan, Jianxin Zhang, Yingui Sun, Guizhi Wang, Chunling Wang, Yanjing Li, Wenwen Kong, Lulu Fan, Yue Zhang, Hongxiang Zhao, Xiaoyong Zha. The Improvement of Sepsis-Associated Encephalopathy by P2X7R Inhibitor through Inhibiting the Omi/HtrA2 Apoptotic Signaling Pathway. Behavioural neurology. vol 2022. 2022-02-07. PMID:35126784. |
we established a sepsis model using lipopolysaccharide (lps) stimulation, followed by an assessment of cognitive function using morris water maze, and then western blot was used to analyze the expression of tight junction proteins zo-1 and occludin in the hippocampus of mice. |
2022-02-07 |
2023-08-13 |
mouse |
| Xianlin Zhu, Fan Zhang, Yufeng You, Hongbai Wang, Su Yuan, Banglin Wu, Rongyu Zhu, Dawei Liu, Fuxia Yan, Zaiping Wan. S-Ketamine Exerts Antidepressant Effects by Regulating Rac1 GTPase Mediated Synaptic Plasticity in the Hippocampus of Stressed Rats. Cellular and molecular neurobiology. 2022-01-27. PMID:35083636. |
the protein expression of rac1, glua1, synapsin1, and psd95 in the hippocampus was detected by western blot. |
2022-01-27 |
2023-08-13 |
rat |