| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li-Ling He, Yun-Cui Wang, Ya-Ting Ai, Ling Wang, Si-Meng Gu, Ping Wang, Qing-Hua Long, Hui H. Qiangji Decoction Alleviates Neurodegenerative Changes and Hippocampal Neuron Apoptosis Induced by D-Galactose Frontiers in pharmacology. vol 12. 2021-10-12. PMID:34630111. |
besides, the protein expression levels of bcl-2, bax, caspase-3, cleaved caspase-3, ampkα, p-ampkα-thr172, sirt1, iκbα, nf-κb p65, p-iκbα-ser32, and p-nf-κb p65-ser536 in the hippocampus of different groups were detected by western blot (wb). |
2021-10-12 |
2023-08-13 |
mouse |
| Shuang Zhao, Wen-Jie Cheng, Xin Liu, Zhao Li, Hui-Zhou Li, Na Shi, Xiu-Li Wan. Effects of Dexmedetomidine and Oxycodone on Neurocognitive and Inflammatory Response After Tourniquet-Induced Ischemia-Reperfusion Injury. Neurochemical research. 2021-10-09. PMID:34625874. |
the expression of nf-κb, tlr4, nr2b, m1 (cd68 and tnf-α) and m2 (cd206 and il-10) polarization markers in mice hippocampus were detected by western blot or immunofluorescent staining. |
2021-10-09 |
2023-08-13 |
mouse |
| Rafael A Cazuza, Ana Luisa F Arantes, Olga Pol, Christie R A Leite-Paniss. HO-CO pathway activation may be associated with hippocampal μ and δ opioid receptors in inhibiting inflammatory pain aversiveness and nociception in WT but not NOS2-KO mice. Brain research bulletin. vol 169. 2021-10-07. PMID:33422660. |
the ho-1, neuronal nitric oxide synthase, nos2, mor, and dor expression in the dorsal hippocampus were evaluated by western blot. |
2021-10-07 |
2023-08-13 |
mouse |
| Carolina Aparecida Faria Almeida, Antonio Alves Pereira-Junior, Jéssica Gonçalves Rangel, Bruna Pinheiro Pereira, Karla Cristinne Mancini Costa, Vitor Bruno, Gabriela Oliveira Silveira, Carla Speroni Ceron, Mauricio Yonamine, Rosana Camarini, Raphael Caio Tamborelli Garcia, Tania Marcourakis, Larissa Helena Torre. Ayahuasca, a psychedelic beverage, modulates neuroplasticity induced by ethanol in mice. Behavioural brain research. vol 416. 2021-10-05. PMID:34437939. |
dopamine receptors, serotonin receptors, dynorphin, and prodynorphin levels were quantified in the striatum and hippocampus by blot analysis. |
2021-10-05 |
2023-08-13 |
mouse |
| Donya Nazarinia, Mojtaba Dolatshahi, Masoumeh Faezi, Solmaz Nasseri Maleki, Nahid Aboutale. TLR4 /NF-ĸB and JAK2/STAT3 signaling pathways: Cellular signaling pathways targeted by cell-conditioned medium therapy in protection against ischemic stroke. Journal of chemical neuroanatomy. vol 113. 2021-10-01. PMID:33636320. |
immunohistochemistry of hippocampus and western blot assay were performed to evaluate the expression of tlr4 /nf-ĸb and jak2/stat3, respectively. |
2021-10-01 |
2023-08-13 |
human |
| Jiefeng Geng, Haibiao Zhao, Xing Liu, Junjie Geng, Yuyuan Gao, Bingzheng H. MiR-101a-3p Attenuated Pilocarpine-Induced Epilepsy by Downregulating c-FOS. Neurochemical research. vol 46. issue 5. 2021-09-27. PMID:33559830. |
expression of mir-101a-3p and c-fos in hippocampus tissues of rat models were detected by qrt-pcr and western blot. |
2021-09-27 |
2023-08-13 |
rat |
| Cihao Jiang, Yi Zhang, Xiaolu Tang, Chenchen Jing, Shasha Qiu, Baolin Li, Yanning L. IL-6 and IL-1β upregulation and tau protein phosphorylation in response to chronic alcohol exposure in the mouse hippocampus. Neuroreport. vol 32. issue 10. 2021-09-20. PMID:34029285. |
immunohistochemical and western blot assays were used to assess the expression levels of il-1β and il-6, as well as tau protein and its phosphorylation status in the hippocampus. |
2021-09-20 |
2023-08-13 |
mouse |
| Qing Shang, Min Liang, Jing Xiao, Baoyao Gao, Hongyan Qian, Jing Wang, Gang Chen, Jie Fang, Tao Li, Xinshe Li. LB100 attenuates methamphetamine-induced behavioral sensitization by inhibiting the Raf1-ERK 1/2 cascade in the caudate putamen. Neuroreport. vol 32. issue 12. 2021-09-20. PMID:34102646. |
in addition, western blot was used to examine the levels of p-raf1 (ser 259) and p-erk 1/2 (thr 202/tyr 204) in the cpu, hippocampus (hip) and nucleus accumbens (nac). |
2021-09-20 |
2023-08-13 |
mouse |
| Lian Liu, Ming Liu, Wei Zhao, Yuan-Ling Zhao, Yun Wan. Tetrahydropalmatine Regulates BDNF through TrkB/CAM Interaction to Alleviate the Neurotoxicity Induced by Methamphetamine. ACS chemical neuroscience. vol 12. issue 18. 2021-09-20. PMID:34448569. |
extracted hippocampus and mesencephalon tissue were detected by western blot, he staining, and immunohistochemistry. |
2021-09-20 |
2023-08-13 |
rat |
| Xiaoying Li, Ciqing Yang, Yaping Shi, Lihong Guan, Han Li, Shuanqing Li, Yunxiao Li, Yong Zhang, Juntang Li. Abnormal neuronal damage and inflammation in the hippocampus of kainic acid-induced epilepsy mice. Cell biochemistry and function. vol 39. issue 6. 2021-09-16. PMID:34057222. |
the hippocampal tissue was also collected and frozen to detect protein expression by western blot. |
2021-09-16 |
2023-08-13 |
mouse |
| Robert Theodor Mallmann, Norbert Klugbaue. Genetic Inactivation of Two-Pore Channel 1 Impairs Spatial Learning and Memory. Behavior genetics. vol 50. issue 6. 2021-09-15. PMID:32889694. |
western blot analysis indicated a broad expression of tpc1 in the neocortex, cerebellum and hippocampus. |
2021-09-15 |
2023-08-13 |
Not clear |
| Wenxiang Fan, Ying Zhang, Xiaomin Li, Chi X. S-oxiracetam Facilitates Cognitive Restoration after Ischemic Stroke by Activating α7nAChR and the PI3K-Mediated Pathway. Neurochemical research. vol 46. issue 4. 2021-09-14. PMID:33481205. |
by using y-maze test, morris water maze, triphenyl tetrazolium chloride (ttc) staining, terminal deoxynucleotidyl transferase-mediated 2'-deoxyuridine 5'-triphosphate (dutp) nick end labeling (tunel) assay, hematoxylin and eosin, immunohistochemical staining and western blot to evaluate the protective effect of s-orc on cognitive recovery, we were able to confirm that s-orc ameliorated spatial learning impairment, tissue loss, and hippocampal neuronal apoptosis and injury induced by mcao/r in rats. |
2021-09-14 |
2023-08-13 |
rat |
| Anastasia Noël, Bénédicte Foveau, Andréa C LeBlan. Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits. Cell death & disease. vol 12. issue 3. 2021-09-14. PMID:33649324. |
region-specific hippocampal and cortical hcasp6 and htau expression were confirmed with western blot and immunohistochemistry in 2-25-month-old brains. |
2021-09-14 |
2023-08-13 |
mouse |
| Paulina Wigner, Ewelina Synowiec, Piotr Czarny, Michal Bijak, Paweł Jóźwiak, Janusz Szemraj, Piotr Gruca, Mariusz Papp, Tomasz Śliwińsk. Effects of venlafaxine on the expression level and methylation status of genes involved in oxidative stress in rats exposed to a chronic mild stress. Journal of cellular and molecular medicine. vol 24. issue 10. 2021-09-07. PMID:32281745. |
after completion of both stress conditions and drug administration, the mrna and protein expression of selected genes and the methylation status of their promoters were measured in peripheral mononuclear blood cells (pbmcs) and in brain structures (hippocampus, amygdala, hypothalamus, midbrain, cortex, basal ganglia) with the use of taqman gene expression assay, western blot and methylation-sensitive high-resolution melting techniques. |
2021-09-07 |
2023-08-13 |
human |
| Jian-Ping Zhu, Hua-Ying Wu, Yuan Zi, Xin-Bin Xia, Meng-Zhou Xie, Zhi-Ying Yua. Baihe Jizihuang Tang Ameliorates Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior: Integrating Network Pharmacology and Brain-Gut Axis Evaluation. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-09-04. PMID:34475963. |
network pharmacological analysis; chronic unpredictable mild stress (cums) rat model assessment; behavioral tests; analysis of hippocampal neurotransmitter levels, hippocampal pathological structure, and hypothalamic-pituitary-adrenal (hpa) axis; western blot analysis; 16s rna sequencing; ultraperformance liquid chromatography (uplc)/mass spectrometry (ms); and high-performance liquid chromatography (hplc)/ultraviolet (uv) analysis were used. |
2021-09-04 |
2023-08-13 |
rat |
| Shaunik Sharma, Steven Carlson, Adriana Gregory-Flores, Andy Hinojo-Perez, Ashley Olson, Thimmasettappa Thippeswam. Mechanisms of disease-modifying effect of saracatinib (AZD0530), a Src/Fyn tyrosine kinase inhibitor, in the rat kainate model of temporal lobe epilepsy. Neurobiology of disease. vol 156. 2021-09-03. PMID:34087381. |
immunohistochemistry of brain sections and western blot analyses of hippocampal lysates at 8-day (8d) and 4-month post-se revealed a significant reduction of se-induced astrogliosis, microgliosis, neurodegeneration, phosphorylated fyn/src-419 and pkcδ-tyr311, in sar-treated group when compared with the vehicle control. |
2021-09-03 |
2023-08-13 |
rat |
| Yuangui Zhang, Qingqing Sun, Aixia Fan, Guimin Don. Isoflurane triggers the acute cognitive impairment of aged rats by damaging hippocampal neurons via the NR2B/CaMKII/CREB pathway. Behavioural brain research. vol 405. 2021-09-02. PMID:33636236. |
isoflurane also decreased the viabilities and strengthened the apoptotic potential of hippocampal neurons by damaging the mitochondria in a time-dependent manner compared with the control group which was reported by mtt, immunofluorescent assay, flow cytometry and western blot assay in vitro. |
2021-09-02 |
2023-08-13 |
rat |
| Hui Yang, Lin Tang, Zhan Qu, Shi-Hui Lei, Wei Li, Yu-Hong Wan. Hippocampal insulin resistance and the Sirtuin 1 signaling pathway in diabetes-induced cognitive dysfunction. Neural regeneration research. vol 16. issue 12. 2021-08-26. PMID:33907035. |
at 8 weeks after streptozotocin injection, the morris water maze test and western blot assays confirmed that the diabetic model rats had learning and memory deficits, insulin resistance, and sirtuin 1 expression could be detected in the hippocampus. |
2021-08-26 |
2023-08-13 |
rat |
| Narmin Farazi, Javad Mahmoudi, Saeed Sadigh-Eteghad, Fereshteh Farajdokht, Seyed Hossein Rast. Synergistic effects of combined therapy with transcranial photobiomodulation and enriched environment on depressive- and anxiety-like behaviors in a mice model of noise stress. Lasers in medical science. 2021-08-25. PMID:34432186. |
bdnf, tyrosine receptor kinase b (trkb), and camp response element-binding (creb) protein levels in the hippocampus were determined by the western blot method, and also serum corticosterone levels were assessed using an elisa kit. |
2021-08-25 |
2023-08-13 |
mouse |
| Sarah Svirsky, Jeremy Henchir, Youming Li, Xiecheng Ma, Shaun Carlson, C Edward Dixo. Neurogranin Protein Expression Is Reduced after Controlled Cortical Impact in Rats. Journal of neurotrauma. vol 37. issue 7. 2021-08-19. PMID:31691647. |
expression of neurogranin and post-synaptic density 95 (psd-95) were evaluated by western blot in the cortex and hippocampus at 24 h and 1, 2, and 4 weeks post-injury. |
2021-08-19 |
2023-08-13 |
rat |