| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chun Li, Weining Ma, Yajuan Zhao, Hua Wan. Changes in the expression of endothelial monocyte‑activating polypeptide II in the rat hippocampus following status epilepticus. International journal of molecular medicine. vol 47. issue 2. 2021-07-12. PMID:33416103. |
the protein expression levels of emap ii, cd31, zonula occludens 1 (zo‑1) and occludin in the hippocampus were determined by immunofluorescence and western blot analyses. |
2021-07-12 |
2023-08-13 |
rat |
| Dae Young Yoo, Hyo Young Jung, Woosuk Kim, Kyu Ri Hahn, Hyun Jung Kwon, Sung Min Nam, Jin Young Chung, Yeo Sung Yoon, Dae Won Kim, In Koo Hwan. Entacapone Treatment Modulates Hippocampal Proteins Related to Synaptic Vehicle Trafficking. Cells. vol 9. issue 12. 2021-07-09. PMID:33352833. |
immunohistochemical staining showed the localization of the proteins, and western blot confirmed the significant increases in dynamin i (203.5% of control) in the hippocampus as well as synapsin i (254.0% of control) and munc18-1 (167.1% of control) in the synaptic vesicle fraction of hippocampus after entacapone treatment. |
2021-07-09 |
2023-08-13 |
mouse |
| Xinfei Ma, Zhenhua Zhu, Sheng Guo, Jinao Dua. The effect of deoxyschizandrin on chronic unpredictable mild stress-induced depression. Biotechnology and applied biochemistry. vol 68. issue 1. 2021-07-06. PMID:31985079. |
additionally, the expressions of tlr4, myd88, traf6, p-nf-κbp65, nlrp3, cleaved caspase-1, cleaved il-1β, glur, and psd95 in hippocampus were detected by western blot. |
2021-07-06 |
2023-08-13 |
mouse |
| Jijun Xiong, Jie Quan, Chaosheng Qin, Xiaogang Wang, Qinghua Dong, Bingdong Zhan. Dexmedetomidine Exerts Brain-Protective Effects Under Cardiopulmonary Bypass Through Inhibiting the Janus Kinase 2/Signal Transducers and Activators of Transcription 3 Pathway. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 40. issue 2. 2021-07-01. PMID:31834821. |
western blot and quantitative real-time polymerase chain reaction were performed to detect related proteins and mrna expressions in the hippocampus tissues. |
2021-07-01 |
2023-08-13 |
rat |
| Minzhen Deng, Liping Huang, Xiaoqin Zhong, Manting Huan. Dynamic Changes of Beclin-1 in the Hippocampus of Male Mice with Vascular Dementia at Different Time Points. Journal of molecular neuroscience : MN. vol 70. issue 10. 2021-06-29. PMID:32468217. |
the expression of beclin-1, lc3b, p62, bcl-2, bax, bace1, gfap, mbp and et-1 mrna were determined by rt-pcr; the expression of beclin-1 was detected by western blot and immunofluorescence; the pathological characteristics of the hippocampus were observed by haematoxylin-eosin (he) staining; and the correlation of beclin-1 with other vd-related proteins was analysed by pearson's correlation. |
2021-06-29 |
2023-08-13 |
mouse |
| Adila Aji, Rena Aihemaiti, Shaohong Zou, Alimujiang Maisiyiti, Cheng Zhang, Ruonan Liu, Xiaokaiti Sulida. BHLHE40 modulates post-traumatic stress disorder behaviors with the involvement of the PI3K/AKT signaling pathway. Anais da Academia Brasileira de Ciencias. vol 93. issue 3. 2021-06-28. PMID:34161515. |
western blot was performed to identify proteins and reveal their levels in hippocampal tissues. |
2021-06-28 |
2023-08-13 |
mouse |
| Qiongqiong Zhan, Yanfeng Wu, Lin Li. Effects of notoginsenoside R1 on attenuating depressive behavior induced by chronic stress in rats through induction of PI3K/AKT/NF-κB pathway. Drug development research. 2021-06-26. PMID:34173680. |
subsequently, the morphology of hippocampal neurons and protein expression of brain-derived neurotrophic factor in each group were examined by hematoxylin and eosin staining and western blot to show the neuroprotective effects of ngr1. |
2021-06-26 |
2023-08-13 |
rat |
| Kaili Du, Zhuoyi Wang, Huimin Zhang, Yaofang Zhang, Hongliang Su, Zhiwen Wei, Chao Zhang, Keming Yun, Bin Con. Levo-tetrahydropalmatine attenuates the acquisition of fentanyl-induced conditioned place preference and the changes in ERK and CREB phosphorylation expression in mice. Neuroscience letters. vol 756. 2021-06-22. PMID:34029649. |
western blot assays were used to dissect the accompanying changes in the phosphorylation of extracellular signal-regulated kinase (erk) and camp response element binding protein (creb) in related brain regions, including the hippocampus (hip), caudate putamen (cpu), prefrontal cortex (pfc), and nucleus accumbens (nac), which may mediate the effects of l-thp on fentanyl-induced cpp. |
2021-06-22 |
2023-08-13 |
mouse |
| Shengyi Yang, Huanhuan Zhou, Guiping Wang, Xiao-Hong Zhong, Qi-Liang Shen, Xue-Jing Zhang, Ru-Yi Li, Li-Hua Chen, Ya-Han Zhang, Zhongxiao Wa. Quercetin is protective against short-term dietary advanced glycation end products intake induced cognitive dysfunction in aged ICR mice. Journal of food biochemistry. vol 44. issue 4. 2021-06-21. PMID:32065675. |
key markers involved in aβ, tau, and neuroinflammation from hippocampus and cortex were measured via western blot. |
2021-06-21 |
2023-08-13 |
mouse |
| Athira K V, Rajaram Mohanrao Madhana, Akhilesh Kumar Bais, Vijay Bahadur Singh, Arpit Malik, Swapnil Sinha, Mangala Lahkar, Pramod Kumar, Pavan Kumar Samudral. Cognitive Improvement by Vorinostat through Modulation of Endoplasmic Reticulum Stress in a Corticosterone-Induced Chronic Stress Model in Mice. ACS chemical neuroscience. vol 11. issue 17. 2021-06-18. PMID:32673474. |
after behavior tests, mice were sacrificed, and hippocampus was separated from brain tissue for reverse transcriptase polymerase chain reaction (rt-pcr), western blot, and immunohistochemistry studies. |
2021-06-18 |
2023-08-13 |
mouse |
| Aiping Li, Jing Tian, Jianwen Yang, Xiang Ren, Zhiwen Zhou, Wensheng Zho. Expression of fibroblast growth factor 9 and its receptors in the dentate gyrus of hippocampus in poststroke depression rats. Neuroreport. vol 32. issue 4. 2021-06-18. PMID:33470768. |
weight measurement, sucrose preference test, open-field test and forced swim test were performed to evaluate the behavioral changes, and then western blot and real-time quantitative pcr were used to detect the expression level of fgf9, fibroblast growth factor receptor 1 (fgfr1) and receptor 3 (fgfr3) in the dentate gyrus of rat hippocampus. |
2021-06-18 |
2023-08-13 |
rat |
| An-Rong Wang, Lian-Fang Mi, Zhi-Lei Zhang, Ming-Zhe Hu, Ze-Yu Zhao, Bin Liu, Yan-Bin Li, Shu Zhen. Saikosaponin A improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia through p-CREB/BDNF pathway. Behavioural brain research. vol 403. 2021-06-18. PMID:33493495. |
western blot and immunohistochemistry were adopted to evaluate expression of phosphorylated camp response element binding protein(p-creb), brain derived neurotrophic factor(bdnf) and apoptosis-related molecules in the dentate gyrus region of rat hippocampus. |
2021-06-18 |
2023-08-13 |
rat |
| Xue Bai, Liu-Lin Xiong, Chang-Le Fang, Hao-Li Zhou, Lu-Lu Xue, Yue Hu, Qing-Jie Xia, Jia Liu, Jun-Yan Zhang, Ting-Hua Wang, Si-Jin Yan. Interleukin 10 Plays an Important Role in Neonatal Rats with Hypoxic-Ischemia Associated with B-Cell Lymphoma 2 and Endoplasmic Reticulum Protein 29. Analytical cellular pathology (Amsterdam). vol 2021. 2021-06-15. PMID:34123712. |
the expression of il-10 in the cortex, hippocampus, and lung tissues was measured with immunohistochemistry, real-time quantitative polymerase chain reaction (rt-qpcr), and western blot (wb). |
2021-06-15 |
2023-08-13 |
human |
| Nashwa Amin, Shiyi Xie, Xiaoning Tan, Yili Chen, Qiannan Ren, Benson O A Botchway, Shaohua Hu, Yongchun Ma, Zhiying Hu, Marong Fan. Optimized integration of fluoxetine and 7, 8-dihydroxyflavone as an efficient therapy for reversing depressive-like behavior in mice during the perimenopausal period. Progress in neuro-psychopharmacology & biological psychiatry. vol 101. 2021-06-04. PMID:32243998. |
inflammatory, autophagic and apoptotic changes of hippocampus and cortex are examined by using western blot, immunofluorescence, and real-time quantitative reverse transcription-polymerase chain reaction (rt-qpcr) techniques. |
2021-06-04 |
2023-08-13 |
mouse |
| Nashwa Amin, Shiyi Xie, Xiaoning Tan, Yili Chen, Qiannan Ren, Benson O A Botchway, Shaohua Hu, Yongchun Ma, Zhiying Hu, Marong Fan. Optimized integration of fluoxetine and 7, 8-dihydroxyflavone as an efficient therapy for reversing depressive-like behavior in mice during the perimenopausal period. Progress in neuro-psychopharmacology & biological psychiatry. vol 101. 2021-06-04. PMID:32243998. |
the protein levels of phosphatidylinositol 3 kinase (pi3k)/ protein kinase b (akt)/mechanistic target of rapamycin (mtor)/phosphorylated extracellular signal-regulated kinase1/2 (p-erk 1/2)/brain-derived neurotrophic factor (bdnf)/tropomyosin-related kinase b (trkb) of hippocampus and cortex are assessed by western blot. |
2021-06-04 |
2023-08-13 |
mouse |
| Li- Tian Yin, Xiao-Yan Xie, Lin-Yuan Xue, Xiao- Rong Yang, Juan Jia, Yu Zhang, Ce Zhan. Matrix Metalloproteinase-9 Overexpression Regulates Hippocampal Synaptic Plasticity and Decreases Alcohol Consumption and Preference in Mice. Neurochemical research. vol 45. issue 8. 2021-06-03. PMID:32415404. |
western blot analysis indicated that glun1 expression in the hippocampus of alcohol drinking group was lower than that in the control group, while the expression of glun1 was increased in mmp-9 overexpressing mice. |
2021-06-03 |
2023-08-13 |
mouse |
| Fan Hu, Liang Shao, Ji Zhang, Hong Zhang, An Wen, Ping Zhan. Knockdown of ZFAS1 Inhibits Hippocampal Neurons Apoptosis and Autophagy by Activating the PI3K/AKT Pathway via Up-regulating miR-421 in Epilepsy. Neurochemical research. vol 45. issue 10. 2021-06-01. PMID:32725369. |
hippocampal neurons viability, apoptosis and autophagy were analyzed via cell counting kit-8, flow cytometry and western blot. |
2021-06-01 |
2023-08-13 |
mouse |
| Wen-Yuan Zhang, Yu-Jin Guo, Ke-Yi Wang, Lin-Mu Chen, Pei Jian. Neuroprotective effects of vitamin D and 17ß-estradiol against ovariectomy-induced neuroinflammation and depressive-like state: Role of the AMPK/NF-κB pathway. International immunopharmacology. vol 86. 2021-05-27. PMID:32604067. |
using the method of immunofluorescent staining and western blot, vitamin d and 17β-estradiol were demonstrated to upregulate each other's receptors, including vdr, erα, and erβ in the hippocampus of ovx rats. |
2021-05-27 |
2023-08-13 |
rat |
| Jinfeng Xie, Bingtian Bi, Yunyun Qin, Wenli Dong, Jiahong Zhong, Mengfan Li, Yufang Cheng, Jiangping Xu, Haitao Wan. Inhibition of phosphodiesterase-4 suppresses HMGB1/RAGE signaling pathway and NLRP3 inflammasome activation in mice exposed to chronic unpredictable mild stress. Brain, behavior, and immunity. vol 92. 2021-05-27. PMID:33221489. |
western blot analysis showed that pde4 inhibition suppressed the high-mobility group box 1 protein (hmgb1)/rage signaling pathway, as the levels of hmgb1, rage, toll-like receptor 4, phosphorylated p38 mitogen-activated protein kinase, and nuclear factor κ-b were decreased in both hippocampus and cortex in mice after treatment with rof. |
2021-05-27 |
2023-08-13 |
mouse |
| Cuiting Wang, Feng Niu, Ningna Ren, Xiaokun Wang, Hequan Zhong, Jie Zhu, Bing L. Hyperbaric Oxygen Improves Cerebral Ischemia/Reperfusion Injury in Rats Probably via Inhibition of Autophagy Triggered by the Downregulation of Hypoxia-Inducing Factor-1 Alpha. BioMed research international. vol 2021. 2021-05-26. PMID:33816617. |
as shown by western blot analysis, hbo significantly reduced autophagy by regulating autophagy-related proteins (mtor, p-mtor, atg13, lc3b ii and lc3b ii) in the hippocampus 72 hours after i/r, which was accompanied by inhibiting the expression of hypoxia inducible factor-1 |
2021-05-26 |
2023-08-13 |
rat |