| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rebeca Martínez-Turrillas, Sonia Moyano, Joaquín Del Río, Diana Frechill. Differential effects of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") on BDNF mRNA expression in rat frontal cortex and hippocampus. Neuroscience letters. vol 402. issue 1-2. 2007-01-16. PMID:16644117. |
the differential regulation of bdnf mrna expression in the two brain regions examined appears to account for the enhanced tph expression and the recovery of 5-ht levels in the frontal cortex, but not in the hippocampus, after neurotoxin treatment. |
2007-01-16 |
2023-08-12 |
rat |
| Hiroki Koizumi, Kenji Hashimoto, Masaomi Iy. Dietary restriction changes behaviours in brain-derived neurotrophic factor heterozygous mice: role of serotonergic system. The European journal of neuroscience. vol 24. issue 8. 2006-12-21. PMID:17074054. |
after carrying out a behavioural evaluation, we determined the bdnf mrna levels, as well as mrna levels for subtypes (5-ht(1a), 5-ht(1b), 5-ht(2a) and 5-ht(2c)) of the 5-ht receptor and 5-ht transporter (5-htt), protein levels of bdnf and concentrations of 5-ht and 5-hiaa in the hypothalamus, hippocampus and frontal cortex. |
2006-12-21 |
2023-08-12 |
mouse |
| Hiroki Koizumi, Kenji Hashimoto, Masaomi Iy. Dietary restriction changes behaviours in brain-derived neurotrophic factor heterozygous mice: role of serotonergic system. The European journal of neuroscience. vol 24. issue 8. 2006-12-21. PMID:17074054. |
the concentrations of 5-ht and 5-hiaa in the frontal cortex, and 5-ht in the hippocampus, of bdnf(+/-) mice were significantly lower than those of wild-type mice. |
2006-12-21 |
2023-08-12 |
mouse |
| Hiroki Koizumi, Kenji Hashimoto, Masaomi Iy. Dietary restriction changes behaviours in brain-derived neurotrophic factor heterozygous mice: role of serotonergic system. The European journal of neuroscience. vol 24. issue 8. 2006-12-21. PMID:17074054. |
interestingly, dr significantly increased the levels of 5-ht and 5-hiaa in the frontal cortex of bdnf(+/-) mice. |
2006-12-21 |
2023-08-12 |
mouse |
| J P Chan, T J Unger, J Byrnes, M Rio. Examination of behavioral deficits triggered by targeting Bdnf in fetal or postnatal brains of mice. Neuroscience. vol 142. issue 1. 2006-12-20. PMID:16844311. |
interestingly, depletion of bdnf from the fetal brain had more pronounced effects on aggressive and depressive-like behaviors and led to deficits in 5-ht(2a) receptor content in the medial frontal cortex, highlighting the importance of this neurotrophin during development. |
2006-12-20 |
2023-08-12 |
mouse |
| Damijana Mojca Juric, Spela Miklic, Marija Carman-Krza. Monoaminergic neuronal activity up-regulates BDNF synthesis in cultured neonatal rat astrocytes. Brain research. vol 1108. issue 1. 2006-12-06. PMID:16828062. |
because brain-derived neurotrophic factor (bdnf) is produced by astrocytes, in addition to neurons, we focused our present study on the regulatory effects of monoamines noradrenaline (na), serotonin (5-ht), and dopamine (da) on the synthesis of bdnf protein in rat neonatal astrocytes from specific brain regions (cortex, cerebellum). |
2006-12-06 |
2023-08-12 |
rat |
| Damijana Mojca Juric, Spela Miklic, Marija Carman-Krza. Monoaminergic neuronal activity up-regulates BDNF synthesis in cultured neonatal rat astrocytes. Brain research. vol 1108. issue 1. 2006-12-06. PMID:16828062. |
in cultured cortical astrocytes, na (1 microm; 6 h) elevates bdnf levels by a 4-fold, 5-ht (1 microm; 4 h) by a 2.3-fold, and da (150 microm; 4 h) by a 2.2-fold. |
2006-12-06 |
2023-08-12 |
rat |
| Damijana Mojca Juric, Spela Miklic, Marija Carman-Krza. Monoaminergic neuronal activity up-regulates BDNF synthesis in cultured neonatal rat astrocytes. Brain research. vol 1108. issue 1. 2006-12-06. PMID:16828062. |
in cerebellar astrocytes, na (1 microm; 4 h) increases bdnf content by a 4.7-fold, 5-ht (1 microm; 4 h) by a 1.7-fold, and da (150 microm; 4 h) by a 1.4-fold. |
2006-12-06 |
2023-08-12 |
rat |
| Damijana Mojca Juric, Spela Miklic, Marija Carman-Krza. Monoaminergic neuronal activity up-regulates BDNF synthesis in cultured neonatal rat astrocytes. Brain research. vol 1108. issue 1. 2006-12-06. PMID:16828062. |
the initial increase in the bdnf levels return to basal levels when incubation with monoamines is extended beyond 12 h (for 5-ht) or 24 h (for na and da). |
2006-12-06 |
2023-08-12 |
rat |
| Jacob P R Jacobsen, Arne Mør. Chronic corticosterone decreases brain-derived neurotrophic factor (BDNF) mRNA and protein in the hippocampus, but not in the frontal cortex, of the rat. Brain research. vol 1110. issue 1. 2006-12-06. PMID:16876769. |
because evidence suggests that bdnf is an important determinant of the function of the 5-hydroxytryptamine (5-ht) system, we also quantified tissue levels of 5-ht and its major metabolite, 5-hydroxyindoleacetic acid (5-hiaa), to investigate if changes in bdnf mrna and protein paralleled changes in the 5-ht system. |
2006-12-06 |
2023-08-12 |
rat |
| Jacob P R Jacobsen, Arne Mør. Chronic corticosterone decreases brain-derived neurotrophic factor (BDNF) mRNA and protein in the hippocampus, but not in the frontal cortex, of the rat. Brain research. vol 1110. issue 1. 2006-12-06. PMID:16876769. |
combined, these data suggests that the effects of corticosterone on the bdnf system are not linked to the effects on the 5-ht systems. |
2006-12-06 |
2023-08-12 |
rat |
| Leandro Michelon, Ivanor Meira-Lima, Quirino Cordeiro, Karen Miguita, Gerome Breen, David Collier, Homero Vallad. Association study of the INPP1, 5HTT, BDNF, AP-2beta and GSK-3beta GENE variants and restrospectively scored response to lithium prophylaxis in bipolar disorder. Neuroscience letters. vol 403. issue 3. 2006-09-01. PMID:16787706. |
association study of the inpp1, 5htt, bdnf, ap-2beta and gsk-3beta gene variants and restrospectively scored response to lithium prophylaxis in bipolar disorder. |
2006-09-01 |
2023-08-12 |
Not clear |
| Prakasham Rumajogee, Daniel Vergé, Michel Hamon, Marie-Christine Mique. Somato-dendritic distribution of 5-HT(1A) and 5-HT(1B) autoreceptors in the BDNF- and cAMP-differentiated RN46A serotoninergic raphe cell line. Brain research. vol 1085. issue 1. 2006-08-10. PMID:16579976. |
in conclusion, both bdnf and camp-differentiated rn46a cells towards a neuronal serotoninergic-like phenotype without the typical differential targeting of the 5-ht(1) autoreceptors, an interesting model to study the molecular mechanisms ensuing the targeting of 5-ht(1) autoreceptors to somas and dendrites. |
2006-08-10 |
2023-08-12 |
rat |
| Marek Lommatzsch, Katharina Hornych, Christiana Zingler, Peter Schuff-Werner, Jacqueline Höppner, J Christian Vircho. Maternal serum concentrations of BDNF and depression in the perinatal period. Psychoneuroendocrinology. vol 31. issue 3. 2006-06-08. PMID:16289360. |
bdnf correlated with decreased serotonin (5-ht) levels in serum (r>0.6 and p<0.001 at all time points). |
2006-06-08 |
2023-08-12 |
human |
| Marek Lommatzsch, Katharina Hornych, Christiana Zingler, Peter Schuff-Werner, Jacqueline Höppner, J Christian Vircho. Maternal serum concentrations of BDNF and depression in the perinatal period. Psychoneuroendocrinology. vol 31. issue 3. 2006-06-08. PMID:16289360. |
there was a trend to a decrease of bdnf and 5-ht levels in cases of maternal depression (as compared to cases without depression), but this was not significant. |
2006-06-08 |
2023-08-12 |
human |
| Beth A Luellen, Matthew E Szapacs, Christopher K Materese, Anne M Andrew. The neurotoxin 2'-NH2-MPTP degenerates serotonin axons and evokes increases in hippocampal BDNF. Neuropharmacology. vol 50. issue 3. 2006-05-24. PMID:16288930. |
the neurotoxin 2'-nh2-mptp degenerates serotonin axons and evokes increases in hippocampal bdnf. |
2006-05-24 |
2023-08-12 |
mouse |
| Maribel Rios, Evelyn K Lambe, Rongjian Liu, Sarah Teillon, JinHong Liu, Schahram Akbarian, Suzanne Roffler-Tarlov, Rudolf Jaenisch, George K Aghajania. Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant mice. Journal of neurobiology. vol 66. issue 4. 2006-04-28. PMID:16408297. |
bdnf is thought to provide critical trophic support for serotonin neurons. |
2006-04-28 |
2023-08-12 |
mouse |
| Eija Koponen, Tomi Rantamäki, Vootele Voikar, Tommi Saarelainen, Ewen MacDonald, Eero Castré. Enhanced BDNF signaling is associated with an antidepressant-like behavioral response and changes in brain monoamines. Cellular and molecular neurobiology. vol 25. issue 6. 2006-03-27. PMID:16392030. |
brain-derived neurotrophic factor (bdnf) influences the growth and plasticity of serotonergic (5-ht) neurons via the activation of trkb receptor. |
2006-03-27 |
2023-08-12 |
mouse |
| Franck Chenu, Michel Bouri. Potentiation of antidepressant-like activity with lithium: mechanism involved. Current drug targets. vol 7. issue 2. 2006-03-10. PMID:16475957. |
however, the underlaying mechanism of action involved in the potentiatory effect of lithium is still unclear and many hypotheses have been suggested such as activity on bdnf, acth, thyroid hormones and serotonin neurotransmission. |
2006-03-10 |
2023-08-12 |
Not clear |
| Joke Beuten, Jennie Z Ma, Thomas J Payne, Randolph T Dupont, Paulina Quezada, Weihua Huang, Karen M Crews, Ming D L. Significant association of BDNF haplotypes in European-American male smokers but not in European-American female or African-American smokers. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 139B. issue 1. 2006-01-27. PMID:16152573. |
brain-derived neurotrophic factor (bdnf) influences dopamine and serotonin neurotransmission in the brain, both of which are involved in the reward system of addiction. |
2006-01-27 |
2023-08-12 |
Not clear |