| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Prakasham Rumajogee, Alexandra Madeira, Daniel Vergé, Michel Hamon, Marie-Christine Mique. Up-regulation of the neuronal serotoninergic phenotype in vitro: BDNF and cAMP share Trk B-dependent mechanisms. Journal of neurochemistry. vol 83. issue 6. 2003-01-16. PMID:12472905. |
these changes were associated with marked increases in the levels of mrnas encoding the serotonin transporter, the 5-ht1a and 5-ht1b receptors and the bdnf receptor tyrosine kinase b (trkb). |
2003-01-16 |
2023-08-12 |
rat |
| Prakasham Rumajogee, Alexandra Madeira, Daniel Vergé, Michel Hamon, Marie-Christine Mique. Up-regulation of the neuronal serotoninergic phenotype in vitro: BDNF and cAMP share Trk B-dependent mechanisms. Journal of neurochemistry. vol 83. issue 6. 2003-01-16. PMID:12472905. |
concomitant blockade of tyrosine kinases by genistein suppressed all the up-regulating effects of bdnf and camp on 5-hydroxytryptamine (5-ht) neurones. |
2003-01-16 |
2023-08-12 |
rat |
| Hironobu Fujimura, C Anthony Altar, Ruoyan Chen, Takashi Nakamura, Takeshi Nakahashi, Jun-ichi Kambayashi, Bing Sun, Narendra N Tando. Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation. Thrombosis and haemostasis. vol 87. issue 4. 2003-01-02. PMID:12008958. |
up to only half of platelet bdnf was secreted upon agonist stimulation, suggesting that platelets may have a non-releasable pool of bdnf, or that the released bdnf binds to a recognition site on the platelet surface and is internalized, as occurs with serotonin. |
2003-01-02 |
2023-08-12 |
human |
| M Bourin, D J P David, P Jolliet, A Gardie. [Mechanism of action of antidepressants and therapeutic perspectives]. Therapie. vol 57. issue 4. 2002-12-10. PMID:12422559. |
indirect activation of neurotransmitter receptors by antidepressants may also lead, via increases in endogenous levels of serotonin in synapses in specific brain regions, to activation of various g proteins coupled to a receptor, signal of transduction, transcription factors and neurotrophic factors such as brain-derived neurotrophic factor (bdnf). |
2002-12-10 |
2023-08-12 |
Not clear |
| Julian Goggi, Ian A Pullar, Stephen L Carney, Henry F Bradfor. Modulation of neurotransmitter release induced by brain-derived neurotrophic factor in rat brain striatal slices in vitro. Brain research. vol 941. issue 1-2. 2002-08-14. PMID:12031545. |
this study examined the influence of brain-derived neurotrophic factor (bdnf) on the basal and depolarisation-induced release of the neurotransmitters gaba, dopamine and serotonin from rat striatal brain slices in vitro. |
2002-08-14 |
2023-08-12 |
rat |
| Julian Goggi, Ian A Pullar, Stephen L Carney, Henry F Bradfor. Modulation of neurotransmitter release induced by brain-derived neurotrophic factor in rat brain striatal slices in vitro. Brain research. vol 941. issue 1-2. 2002-08-14. PMID:12031545. |
bdnf potentiated the potassium or veratrine-stimulated release of gaba, dopamine and serotonin. |
2002-08-14 |
2023-08-12 |
rat |
| J Benninghoff, A Schmitt, R Mössner, K-P Lesc. When cells become depressed: focus on neural stem cells in novel treatment strategies against depression. Journal of neural transmission (Vienna, Austria : 1996). vol 109. issue 5-6. 2002-08-06. PMID:12111481. |
not surprisingly, antidepressant drugs interfering with neurotransmitters such as serotonin (5-ht) influence neurotrophins like bdnf, since 5-ht homeostasis is essential for brain development, neurogenesis, and neuroplasticity as well as complex behavior. |
2002-08-06 |
2023-08-12 |
Not clear |
| Tania Vitalis, Olivier Cases, Katy Gillies, Naima Hanoun, Michel Hamon, Isabelle Seif, Patricia Gaspar, Peter Kind, David J Pric. Interactions between TrkB signaling and serotonin excess in the developing murine somatosensory cortex: a role in tangential and radial organization of thalamocortical axons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 12. 2002-07-15. PMID:12077195. |
this study reveals the following: (1) expression of trkb, bdnf, and nt-4 are not modulated by an excess of serotonin during barrel formation, (2) trkb signaling limits branching of tcas in inappropriate supragranular cortical layers, and (3) serotonin and trkb signaling act together to cluster thalamocortical axons in layer iv. |
2002-07-15 |
2023-08-12 |
mouse |
| E C Azmiti. Neuronal instability: implications for Rett's syndrome. Brain & development. vol 23 Suppl 1. 2002-03-13. PMID:11738834. |
serotonin neurons contain trk-b receptors and are sensitive to availability of the trophic factor, bdnf. |
2002-03-13 |
2023-08-12 |
Not clear |
| B C Hains, S D Fullwood, M J Eaton, C E Hulsebosc. Subdural engraftment of serotonergic neurons following spinal hemisection restores spinal serotonin, downregulates serotonin transporter, and increases BDNF tissue content in rat. Brain research. vol 913. issue 1. 2001-12-12. PMID:11532245. |
subdural engraftment of serotonergic neurons following spinal hemisection restores spinal serotonin, downregulates serotonin transporter, and increases bdnf tissue content in rat. |
2001-12-12 |
2023-08-12 |
rat |
| B C Hains, S D Fullwood, M J Eaton, C E Hulsebosc. Subdural engraftment of serotonergic neurons following spinal hemisection restores spinal serotonin, downregulates serotonin transporter, and increases BDNF tissue content in rat. Brain research. vol 913. issue 1. 2001-12-12. PMID:11532245. |
we hypothesize that lumbar transplantation of non-mitotic cells that tonically secrete 5-ht and brain-derived neurotrophic factor (bdnf) will restore alterations in 5-ht and 5-ht(t) systems within the spinal dorsal horn. |
2001-12-12 |
2023-08-12 |
rat |
| B C Hains, S D Fullwood, M J Eaton, C E Hulsebosc. Subdural engraftment of serotonergic neurons following spinal hemisection restores spinal serotonin, downregulates serotonin transporter, and increases BDNF tissue content in rat. Brain research. vol 913. issue 1. 2001-12-12. PMID:11532245. |
we used an immortalized rat neuronal cell line derived from e13 raphe (rn46a-b14) which is shown to secrete 5-ht and bdnf in vitro and in vivo. |
2001-12-12 |
2023-08-12 |
rat |
| B C Hains, S D Fullwood, M J Eaton, C E Hulsebosc. Subdural engraftment of serotonergic neurons following spinal hemisection restores spinal serotonin, downregulates serotonin transporter, and increases BDNF tissue content in rat. Brain research. vol 913. issue 1. 2001-12-12. PMID:11532245. |
twenty-eight days following transplantation, animals were perfused and tissue examined for changes in 5-ht, 5-ht(t), and bdnf at the site of transplantation or at lumbar enlargements (l5). |
2001-12-12 |
2023-08-12 |
rat |
| B C Hains, K M Johnson, D J McAdoo, M J Eaton, C E Hulsebosc. Engraftment of serotonergic precursors enhances locomotor function and attenuates chronic central pain behavior following spinal hemisection injury in the rat. Experimental neurology. vol 171. issue 2. 2001-12-05. PMID:11573989. |
we used rn46a-b14 cells, a conditionally immortalized (sv40tstag) rat neuronal cell line derived from e13 raphe bioengineered to secrete both 5-ht and bdnf in vitro at both permissive (33 degrees c) and nonpermissive (39 degrees c) temperatures. |
2001-12-05 |
2023-08-12 |
rat |
| V Butterweck, H Winterhoff, M Herkenha. St John's wort, hypericin, and imipramine: a comparative analysis of mRNA levels in brain areas involved in HPA axis control following short-term and long-term administration in normal and stressed rats. Molecular psychiatry. vol 6. issue 5. 2001-10-18. PMID:11526469. |
it decreased mrna levels of 5-ht(1a) and brain-derived neurotrophic factor (bdnf) in the hippocampus. |
2001-10-18 |
2023-08-12 |
rat |
| V Butterweck, H Winterhoff, M Herkenha. St John's wort, hypericin, and imipramine: a comparative analysis of mRNA levels in brain areas involved in HPA axis control following short-term and long-term administration in normal and stressed rats. Molecular psychiatry. vol 6. issue 5. 2001-10-18. PMID:11526469. |
the stress-induced decreases in bdnf and 5-ht(1a)mrna levels were not prevented by either drug. |
2001-10-18 |
2023-08-12 |
rat |
| C Virgos, L Martorell, J Valero, L Figuera, F Civeira, J Joven, A Labad, E Vilell. Association study of schizophrenia with polymorphisms at six candidate genes. Schizophrenia research. vol 49. issue 1-2. 2001-08-09. PMID:11343865. |
in this study, we assessed the associations between schizophrenia and polymorphisms in the d2 and d3 dopamine receptor (drd2, drd3), the serotonin 2a receptor (5htr2a), the brain-derived neurotrophic factor (bdnf), the ciliary neurotrophic factor (cntf) and the neurotrophin-3 (nt-3) genes. |
2001-08-09 |
2023-08-12 |
Not clear |
| V A Vaidya, M E Castro, Q Pei, M E Sprakes, D G Grahame-Smit. Influence of thyroid hormone on 5-HT(1A) and 5-HT(2A) receptor-mediated regulation of hippocampal BDNF mRNA expression. Neuropharmacology. vol 40. issue 1. 2001-01-09. PMID:11077070. |
influence of thyroid hormone on 5-ht(1a) and 5-ht(2a) receptor-mediated regulation of hippocampal bdnf mrna expression. |
2001-01-09 |
2023-08-12 |
rat |
| V A Vaidya, M E Castro, Q Pei, M E Sprakes, D G Grahame-Smit. Influence of thyroid hormone on 5-HT(1A) and 5-HT(2A) receptor-mediated regulation of hippocampal BDNF mRNA expression. Neuropharmacology. vol 40. issue 1. 2001-01-09. PMID:11077070. |
chronic t3 administration prior to treatment with the 5-ht(1a) agonist, 8-oh-dpat, significantly decreased bdnf mrna in the dentate gyrus region of the hippocampus. |
2001-01-09 |
2023-08-12 |
rat |
| V A Vaidya, M E Castro, Q Pei, M E Sprakes, D G Grahame-Smit. Influence of thyroid hormone on 5-HT(1A) and 5-HT(2A) receptor-mediated regulation of hippocampal BDNF mRNA expression. Neuropharmacology. vol 40. issue 1. 2001-01-09. PMID:11077070. |
pretreatment with the 5-ht(1a) antagonist, way 100635, completely blocked the 8-oh-dpat-induced down-regulation of bdnf mrna in chronic t3-treated rats. |
2001-01-09 |
2023-08-12 |
rat |