| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A S Ivy, F G Rodriguez, C Garcia, M J Chen, A A Russo-Neustad. Noradrenergic and serotonergic blockade inhibits BDNF mRNA activation following exercise and antidepressant. Pharmacology, biochemistry, and behavior. vol 75. issue 1. 2004-01-07. PMID:12759116. |
in contrast, 5-ht(2a/c) blockade only minimally altered exercise-induced bdnf mrna levels, but inhibited up-regulation of bdnf transcription via tranylcypromine. |
2004-01-07 |
2023-08-12 |
Not clear |
| A S Ivy, F G Rodriguez, C Garcia, M J Chen, A A Russo-Neustad. Noradrenergic and serotonergic blockade inhibits BDNF mRNA activation following exercise and antidepressant. Pharmacology, biochemistry, and behavior. vol 75. issue 1. 2004-01-07. PMID:12759116. |
finally, 5-ht(1a) blockade did not inhibit exercise-induced bdnf mrna elevations, but significantly enhanced levels above those achieved with exercise alone in the ca4. |
2004-01-07 |
2023-08-12 |
Not clear |
| A S Ivy, F G Rodriguez, C Garcia, M J Chen, A A Russo-Neustad. Noradrenergic and serotonergic blockade inhibits BDNF mRNA activation following exercise and antidepressant. Pharmacology, biochemistry, and behavior. vol 75. issue 1. 2004-01-07. PMID:12759116. |
5-ht(1a) and 5-ht(2a/c) activation, on the other hand, appear to be most important for antidepressant-induced bdnf regulation, but may also participate significantly in exercise-induced regulation in the ca4. |
2004-01-07 |
2023-08-12 |
Not clear |
| Cynthia L Bethea, Nicholas Z Lu, Arubala Reddy, Terry Shlaes, John M Streicher, Scott R Whittemor. Characterization of reproductive steroid receptors and response to estrogen in a rat serotonergic cell line. Journal of neuroscience methods. vol 127. issue 1. 2003-09-30. PMID:12865146. |
immunohistochemistry with a panel of antibodies, rt-pcr and a serotonin elisa were utilized to characterize the rn46a-v1 cells (herein called rn46a), and the subclone rn46a-b14 (herein called b14) that is stably transfected with brain derived neurotrophic factor (bdnf). |
2003-09-30 |
2023-08-12 |
rat |
| Cynthia L Bethea, Nicholas Z Lu, Arubala Reddy, Terry Shlaes, John M Streicher, Scott R Whittemor. Characterization of reproductive steroid receptors and response to estrogen in a rat serotonergic cell line. Journal of neuroscience methods. vol 127. issue 1. 2003-09-30. PMID:12865146. |
b14 cells contain more immunodetectable bdnf and serotonin than the rn46a parent line. |
2003-09-30 |
2023-08-12 |
rat |
| F Scott Hall, Jana Drgonova, Michelle Goeb, George R Uh. Reduced behavioral effects of cocaine in heterozygous brain-derived neurotrophic factor (BDNF) knockout mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 8. 2003-09-12. PMID:12784114. |
brain-derived neurotrophic factor (bdnf) affects the development of brain neurotransmitter systems, including dopamine and serotonin systems that are important for cocaine's rewarding and locomotor stimulatory properties. |
2003-09-12 |
2023-08-12 |
mouse |
| F Scott Hall, Jana Drgonova, Michelle Goeb, George R Uh. Reduced behavioral effects of cocaine in heterozygous brain-derived neurotrophic factor (BDNF) knockout mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 8. 2003-09-12. PMID:12784114. |
these data confirm important roles for bdnf in psychostimulant actions, presumably via neurotrophic effects on dopamine and serotonin systems. |
2003-09-12 |
2023-08-12 |
mouse |
| A L Coppell, Q Pei, T S C Zetterströ. Bi-phasic change in BDNF gene expression following antidepressant drug treatment. Neuropharmacology. vol 44. issue 7. 2003-08-04. PMID:12726822. |
it was found that repeated administration of either the monoamine oxidase inhibitor tranylcypromine (tcp) or 5-hydroxytryptamine (5-ht) re-uptake inhibitors (fluoxetine, paroxetine and sertraline), evoke a bi-phasic and time-dependent effect on bdnf gene expression in the rat hippocampus (especially dentate gyrus). |
2003-08-04 |
2023-08-12 |
rat |
| J G Hensler, E E Ladenheim, W E Lyon. Ethanol consumption and serotonin-1A (5-HT1A) receptor function in heterozygous BDNF (+/-) mice. Journal of neurochemistry. vol 85. issue 5. 2003-07-24. PMID:12753073. |
as disturbances of serotonin neurotransmission are implicated in alcohol abuse and aggression, we have examined in bdnf (+/-) mice alcohol drinking behavior, as well as central 5-hydroxytryptamine (5-ht)1a receptor function at the level of 5-ht1a receptor-g protein interaction. |
2003-07-24 |
2023-08-12 |
mouse |
| Julian Goggi, Ian A Pullar, Stephen L Carney, Henry F Bradfor. The control of [125I]BDNF release from striatal rat brain slices. Brain research. vol 967. issue 1-2. 2003-06-05. PMID:12650981. |
[125i]bdnf release was also modulated by 5ht(3) receptor ligands and by receptors coupled to adenylate cyclase. |
2003-06-05 |
2023-08-12 |
rat |
| Cindy L Yee, Kevin R Jones, Thomas E Finge. Brain-derived neurotrophic factor is present in adult mouse taste cells with synapses. The Journal of comparative neurology. vol 459. issue 1. 2003-05-06. PMID:12629664. |
bdnf mainly colocalizes with markers of type ii and type iii taste cells: ubiquitin carboxyl terminal hydrolase (pgp 9.5), serotonin (5-ht), neural cell adhesion molecule (n-cam), synaptic associated protein of 25 kda (snap-25), and to a lesser extent with alpha-gustducin. |
2003-05-06 |
2023-08-12 |
mouse |
| Jonathan C Gewirtz, Andrew C Chen, Rose Terwilliger, Ronald C Duman, Gerard J Mare. Modulation of DOI-induced increases in cortical BDNF expression by group II mGlu receptors. Pharmacology, biochemistry, and behavior. vol 73. issue 2. 2003-02-05. PMID:12117585. |
previous studies have shown that 5-hydroxytryptamine(2a) (5-ht(2a)) receptor activation induces changes in the pattern of brain-derived neurotrophic factor (bdnf) mrna expression in the neocortex and hippocampus, and that 5-ht(2a) receptor blockade interferes with the induction of bdnf mrna by stress. |
2003-02-05 |
2023-08-12 |
Not clear |
| Jonathan C Gewirtz, Andrew C Chen, Rose Terwilliger, Ronald C Duman, Gerard J Mare. Modulation of DOI-induced increases in cortical BDNF expression by group II mGlu receptors. Pharmacology, biochemistry, and behavior. vol 73. issue 2. 2003-02-05. PMID:12117585. |
the current study examined the effects of the highly selective mglu2/3 agonist (1s,2s,5r,6s)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate monohydrate (ly354740) and the mglu2/3 antagonist 2s-2-amino-2-(1s,2s-2-carboxycycloprop-1-yl)-3(xanthy-9-yl)propanoic acid (ly341495) on bdnf mrna expression in medial prefrontal cortex induced by the hallucinogen and 5-ht(2a/2b/2c) agonist 1-(2,5-dimethoxy-4-iodophenethyl)-2-aminopropane (doi). |
2003-02-05 |
2023-08-12 |
Not clear |
| Robert Meller, Joseph M Babity, David G Grahame-Smit. 5-HT2A receptor activation leads to increased BDNF mRNA expression in C6 glioma cells. Neuromolecular medicine. vol 1. issue 3. 2003-01-28. PMID:12095161. |
it has recently been suggested that an increase in brain-derived neurotrophic factor (bdnf) expression may mediate some of the therapeutic effect of antidepressant drugs, via their effects on the neurotransmitter 5-hydroxytryptamine (5-ht). |
2003-01-28 |
2023-08-12 |
Not clear |
| Robert Meller, Joseph M Babity, David G Grahame-Smit. 5-HT2A receptor activation leads to increased BDNF mRNA expression in C6 glioma cells. Neuromolecular medicine. vol 1. issue 3. 2003-01-28. PMID:12095161. |
however, because it is unclear whether 5-ht manipulations directly affect bdnf expression, we examined bdnf mrna levels in c6 glioma cells following incubation with 5-ht using reverse transcription polymerase chain reaction (rt-pcr) and northern blot analysis. |
2003-01-28 |
2023-08-12 |
Not clear |
| Robert Meller, Joseph M Babity, David G Grahame-Smit. 5-HT2A receptor activation leads to increased BDNF mRNA expression in C6 glioma cells. Neuromolecular medicine. vol 1. issue 3. 2003-01-28. PMID:12095161. |
incubation of c6 glioma cells with 5-ht increased the bdnf mrna expression approx twofold. |
2003-01-28 |
2023-08-12 |
Not clear |
| Robert Meller, Joseph M Babity, David G Grahame-Smit. 5-HT2A receptor activation leads to increased BDNF mRNA expression in C6 glioma cells. Neuromolecular medicine. vol 1. issue 3. 2003-01-28. PMID:12095161. |
our data show that 5-ht increases de novo bdnf mrna synthesis following direct activation of the 5-ht2a receptor, via a calcium-dependent and protein kinase-dependent pathway. |
2003-01-28 |
2023-08-12 |
Not clear |
| Prakasham Rumajogee, Alexandra Madeira, Daniel Vergé, Michel Hamon, Marie-Christine Mique. Up-regulation of the neuronal serotoninergic phenotype in vitro: BDNF and cAMP share Trk B-dependent mechanisms. Journal of neurochemistry. vol 83. issue 6. 2003-01-16. PMID:12472905. |
these changes were associated with marked increases in the levels of mrnas encoding the serotonin transporter, the 5-ht1a and 5-ht1b receptors and the bdnf receptor tyrosine kinase b (trkb). |
2003-01-16 |
2023-08-12 |
rat |
| Prakasham Rumajogee, Alexandra Madeira, Daniel Vergé, Michel Hamon, Marie-Christine Mique. Up-regulation of the neuronal serotoninergic phenotype in vitro: BDNF and cAMP share Trk B-dependent mechanisms. Journal of neurochemistry. vol 83. issue 6. 2003-01-16. PMID:12472905. |
concomitant blockade of tyrosine kinases by genistein suppressed all the up-regulating effects of bdnf and camp on 5-hydroxytryptamine (5-ht) neurones. |
2003-01-16 |
2023-08-12 |
rat |
| Hironobu Fujimura, C Anthony Altar, Ruoyan Chen, Takashi Nakamura, Takeshi Nakahashi, Jun-ichi Kambayashi, Bing Sun, Narendra N Tando. Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation. Thrombosis and haemostasis. vol 87. issue 4. 2003-01-02. PMID:12008958. |
up to only half of platelet bdnf was secreted upon agonist stimulation, suggesting that platelets may have a non-releasable pool of bdnf, or that the released bdnf binds to a recognition site on the platelet surface and is internalized, as occurs with serotonin. |
2003-01-02 |
2023-08-12 |
human |