| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L A Mamounas, C A Altar, M E Blue, D R Kaplan, L Tessarollo, W E Lyon. BDNF promotes the regenerative sprouting, but not survival, of injured serotonergic axons in the adult rat brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 2. 2000-02-09. PMID:10632606. |
the dose-response profiles for bdnf to stimulate 5-ht sprouting and trk signaling were remarkably similar, suggesting a physiological link between the two events; both responses were maximal at intermediate doses of bdnf but declined at higher doses ("inverted-u-shaped" dose-response curves). |
2000-02-09 |
2023-08-12 |
rat |
| W E Lyons, L A Mamounas, G A Ricaurte, V Coppola, S W Reid, S H Bora, C Wihler, V E Koliatsos, L Tessaroll. Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 26. 2000-01-27. PMID:10611369. |
brain-derived neurotrophic factor (bdnf) has trophic effects on serotonergic (5-ht) neurons in the central nervous system. |
2000-01-27 |
2023-08-12 |
mouse |
| W E Lyons, L A Mamounas, G A Ricaurte, V Coppola, S W Reid, S H Bora, C Wihler, V E Koliatsos, L Tessaroll. Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 26. 2000-01-27. PMID:10611369. |
in the present study, we use heterozygous bdnf(+/-) mice that have a normal life span and show that these animals develop enhanced intermale aggressiveness and hyperphagia accompanied by significant weight gain in early adulthood; these behavioral abnormalities are known to correlate with 5-ht dysfunction. |
2000-01-27 |
2023-08-12 |
mouse |
| W E Lyons, L A Mamounas, G A Ricaurte, V Coppola, S W Reid, S H Bora, C Wihler, V E Koliatsos, L Tessaroll. Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 26. 2000-01-27. PMID:10611369. |
forebrain 5-ht levels and fiber density in bdnf(+/-) mice are normal at an early age but undergo premature age-associated decrements. |
2000-01-27 |
2023-08-12 |
mouse |
| W E Lyons, L A Mamounas, G A Ricaurte, V Coppola, S W Reid, S H Bora, C Wihler, V E Koliatsos, L Tessaroll. Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 26. 2000-01-27. PMID:10611369. |
however, young adult bdnf(+/-) mice show a blunted c-fos induction by the specific serotonin releaser-uptake inhibitor dexfenfluramine and alterations in the expression of several 5-ht receptors in the cortex, hippocampus, and hypothalamus. |
2000-01-27 |
2023-08-12 |
mouse |
| W E Lyons, L A Mamounas, G A Ricaurte, V Coppola, S W Reid, S H Bora, C Wihler, V E Koliatsos, L Tessaroll. Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 26. 2000-01-27. PMID:10611369. |
our results indicate that endogenous bdnf is critical for the normal development and function of central 5-ht neurons and for the elaboration of behaviors that depend on these nerve cells. |
2000-01-27 |
2023-08-12 |
mouse |
| T S Zetterström, Q Pei, T R Madhav, A L Coppell, L Lewis, D G Grahame-Smit. Manipulations of brain 5-HT levels affect gene expression for BDNF in rat brain. Neuropharmacology. vol 38. issue 7. 1999-09-03. PMID:10428425. |
manipulations of brain 5-ht levels affect gene expression for bdnf in rat brain. |
1999-09-03 |
2023-08-12 |
rat |
| T S Zetterström, Q Pei, T R Madhav, A L Coppell, L Lewis, D G Grahame-Smit. Manipulations of brain 5-HT levels affect gene expression for BDNF in rat brain. Neuropharmacology. vol 38. issue 7. 1999-09-03. PMID:10428425. |
the aim of the present study was to investigate whether changes in brain 5-ht concentrations affect the expression of bdnf mrna in rat brain. |
1999-09-03 |
2023-08-12 |
rat |
| T S Zetterström, Q Pei, T R Madhav, A L Coppell, L Lewis, D G Grahame-Smit. Manipulations of brain 5-HT levels affect gene expression for BDNF in rat brain. Neuropharmacology. vol 38. issue 7. 1999-09-03. PMID:10428425. |
multiple pca injections also increased bdnf mrna expression in parietal cortex, while pcpa induced 5-ht depletion was ineffective. |
1999-09-03 |
2023-08-12 |
rat |
| T S Zetterström, Q Pei, T R Madhav, A L Coppell, L Lewis, D G Grahame-Smit. Manipulations of brain 5-HT levels affect gene expression for BDNF in rat brain. Neuropharmacology. vol 38. issue 7. 1999-09-03. PMID:10428425. |
these results suggests that 5-ht modulates bdnf mrna levels in rat brain. |
1999-09-03 |
2023-08-12 |
rat |
| V A Vaidya, R M Terwilliger, R S Duma. Role of 5-HT2A receptors in the stress-induced down-regulation of brain-derived neurotrophic factor expression in rat hippocampus. Neuroscience letters. vol 262. issue 1. 1999-05-06. PMID:10076858. |
this study examines the influence of selective 5-ht, as well as norepinephrine, receptor antagonists on the stress-induced down-regulation of bdnf mrna. |
1999-05-06 |
2023-08-12 |
rat |
| M J Eaton, J A Plunkett, S Karmally, M A Martinez, K Montane. Changes in GAD- and GABA- immunoreactivity in the spinal dorsal horn after peripheral nerve injury and promotion of recovery by lumbar transplant of immortalized serotonergic precursors. Journal of chemical neuroanatomy. vol 16. issue 1. 1999-04-13. PMID:9924973. |
rn46a cells require brain-derived neurotrophic factor (bdnf) for increased survival and serotonin (5ht) synthesis in vitro and in vivo. |
1999-04-13 |
2023-08-12 |
rat |
| M J Eaton, J A Plunkett, S Karmally, M A Martinez, K Montane. Changes in GAD- and GABA- immunoreactivity in the spinal dorsal horn after peripheral nerve injury and promotion of recovery by lumbar transplant of immortalized serotonergic precursors. Journal of chemical neuroanatomy. vol 16. issue 1. 1999-04-13. PMID:9924973. |
these cells survive longer than 7 weeks after transplantation into the subarachnoid space of the lumbar spinal cord and synthesize 5ht and bdnf. |
1999-04-13 |
2023-08-12 |
rat |
| M J Eaton, J A Plunkett, S Karmally, M A Martinez, K Montane. Changes in GAD- and GABA- immunoreactivity in the spinal dorsal horn after peripheral nerve injury and promotion of recovery by lumbar transplant of immortalized serotonergic precursors. Journal of chemical neuroanatomy. vol 16. issue 1. 1999-04-13. PMID:9924973. |
transplants of 46a-b14 cells placed 1 week after cci alleviated chronic neuropathic pain, while transplants of 46a-v1 control cells, negative for 5ht and without the bdnf gene, had no effect on the induction of thermal and tactile nociception. |
1999-04-13 |
2023-08-12 |
rat |
| M J Eaton, J A Plunkett, S Karmally, M A Martinez, K Montane. Changes in GAD- and GABA- immunoreactivity in the spinal dorsal horn after peripheral nerve injury and promotion of recovery by lumbar transplant of immortalized serotonergic precursors. Journal of chemical neuroanatomy. vol 16. issue 1. 1999-04-13. PMID:9924973. |
collectively, these data suggest that altered 5ht levels, and perhaps bdnf secretion, related to the transplants ameliorate chronic pain and reverse the induction and maintenance of an endogenous pain mechanism in the dorsal horn. |
1999-04-13 |
2023-08-12 |
rat |
| J A Siuciak, M S Clark, H B Rind, S R Whittemore, A F Russ. BDNF induction of tryptophan hydroxylase mRNA levels in the rat brain. Journal of neuroscience research. vol 52. issue 2. 1998-07-28. PMID:9579405. |
these results suggest that bdnf augments 5-ht synthesis in vivo by directly enhancing steady-state tph mrna levels, and subsequently leading to marked behavioral alterations. |
1998-07-28 |
2023-08-12 |
rat |
| S Mansour-Robaey, N Mechawar, F Radja, C Beaulieu, L Descarrie. Quantified distribution of serotonin transporter and receptors during the postnatal development of the rat barrel field cortex. Brain research. Developmental brain research. vol 107. issue 1. 1998-07-27. PMID:9602106. |
these data suggest that 5-ht exerts a dual role in the developing somatosensory cortex: a local regulation of the peripherally-induced activity of thalamocortical axons via 5-ht1b receptors, and a trophic-like influence mediated by 5-ht2a receptors and possibly involving bdnf. |
1998-07-27 |
2023-08-12 |
rat |
| M A Pelleymounter, M J Cullen, M B Baker, M Gollub, C Wellma. The effects of intrahippocampal BDNF and NGF on spatial learning in aged Long Evans rats. Molecular and chemical neuropathology. vol 29. issue 2-3. 1997-04-02. PMID:8971697. |
although bdnf did not improve spatial learning, it did induce a partial, long-term normalization of the elevated hypothalamic 5-ht levels observed in our aged rats. |
1997-04-02 |
2023-08-12 |
rat |
| M T Martin-Iverson, C A Alta. Spontaneous behaviours of rats are differentially affected by substantia nigra infusions of brain-derived neurotrophic factor and neurotrophin-3. The European journal of neuroscience. vol 8. issue 8. 1997-02-06. PMID:8921260. |
in addition, bdnf increased backwards walking, a behaviour that requires the activation of both dopamine and serotonin systems. |
1997-02-06 |
2023-08-12 |
rat |
| M T Martin-Iverson, C A Alta. Spontaneous behaviours of rats are differentially affected by substantia nigra infusions of brain-derived neurotrophic factor and neurotrophin-3. The European journal of neuroscience. vol 8. issue 8. 1997-02-06. PMID:8921260. |
most of the behavioural effects of the neurotrophins are consistent with the view that bdnf increases activity of both dopaminergic and serotonergic systems within the nigrostriatal system, and that nt-3 increases serotonin activity. |
1997-02-06 |
2023-08-12 |
rat |