| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Zhou, L Iacovitt. Mechanisms governing the differentiation of a serotonergic phenotype in culture. Brain research. vol 877. issue 1. 2000-11-28. PMID:10980241. |
this effect was mimicked by co-treatment with a growth factor (afgf, bfgf or bdnf; but not gdnf, igf-1, egf or tgf) and the neurotransmitter 5-ht (but not gaba, dopamine, glutamate) and/or a protein kinase activator (ibmx, forskolin, tpa). |
2000-11-28 |
2023-08-12 |
Not clear |
| S Y Chow, J Moul, C A Tobias, B T Himes, Y Liu, M Obrocka, L Hodge, A Tessler, I Fische. Characterization and intraspinal grafting of EGF/bFGF-dependent neurospheres derived from embryonic rat spinal cord. Brain research. vol 874. issue 2. 2000-11-06. PMID:10960593. |
these spinal cord cell grafts are permissive for growth by several populations of host axons, especially when combined with exogenous bdnf administration, as demonstrated by penetration into the graft of axons immunopositive for 5-ht and cgrp. |
2000-11-06 |
2023-08-12 |
rat |
| M Nishi, M Kawata, E C Azmiti. Trophic interactions between brain-derived neurotrophic factor and s100beta on cultured serotonergic neurons. Brain research. vol 868. issue 1. 2000-08-04. PMID:10841894. |
combined treatment with bdnf and s100beta for 3 days increased the soma area of 5-ht neurons, but not the neurite length. |
2000-08-04 |
2023-08-12 |
rat |
| D Galter, K Unsicke. Sequential activation of the 5-HT1(A) serotonin receptor and TrkB induces the serotonergic neuronal phenotype. Molecular and cellular neurosciences. vol 15. issue 5. 2000-07-27. PMID:10833301. |
we show now that 5-ht, the 5-ht1(a) receptor, brain-derived neurotrophic factor (bdnf), and its receptor, trkb, form an auto/paracrine loop for the regulation of the serotonergic phenotype. |
2000-07-27 |
2023-08-12 |
rat |
| D Galter, K Unsicke. Sequential activation of the 5-HT1(A) serotonin receptor and TrkB induces the serotonergic neuronal phenotype. Molecular and cellular neurosciences. vol 15. issue 5. 2000-07-27. PMID:10833301. |
serotonin also increased bdnf mrna and protein in embryonic raphe cultures. |
2000-07-27 |
2023-08-12 |
rat |
| D Galter, K Unsicke. Sequential activation of the 5-HT1(A) serotonin receptor and TrkB induces the serotonergic neuronal phenotype. Molecular and cellular neurosciences. vol 15. issue 5. 2000-07-27. PMID:10833301. |
taken together, our data indicate that serotonin acts on 5-ht1(a) autoreceptors, causing up-regulation of bdnf, which activates trkb to promote serotonergic phenotype-specific markers. |
2000-07-27 |
2023-08-12 |
rat |
| D Frechilla, R Insausti, P Ruiz-Golvano, A García-Osta, M P Rubio, J M Almendral, J Del Rí. Implanted BDNF-producing fibroblasts prevent neurotoxin-induced serotonergic denervation in the rat striatum. Brain research. Molecular brain research. vol 76. issue 2. 2000-06-05. PMID:10762706. |
grafting of fibroblasts carrying the bdnf or the lac-z gene did not modify striatal 5-ht or da content in sham-operated animals. |
2000-06-05 |
2023-08-12 |
human |
| R Mössner, S Daniel, D Albert, A Heils, O Okladnova, A Schmitt, K P Lesc. Serotonin transporter function is modulated by brain-derived neurotrophic factor (BDNF) but not nerve growth factor (NGF). Neurochemistry international. vol 36. issue 3. 2000-03-02. PMID:10676853. |
serotonin transporter function is modulated by brain-derived neurotrophic factor (bdnf) but not nerve growth factor (ngf). |
2000-03-02 |
2023-08-12 |
Not clear |
| R Mössner, S Daniel, D Albert, A Heils, O Okladnova, A Schmitt, K P Lesc. Serotonin transporter function is modulated by brain-derived neurotrophic factor (BDNF) but not nerve growth factor (NGF). Neurochemistry international. vol 36. issue 3. 2000-03-02. PMID:10676853. |
after treatment with bdnf or ngf, 5-ht uptake and proliferation of the cell lines were assessed. |
2000-03-02 |
2023-08-12 |
Not clear |
| R Mössner, S Daniel, D Albert, A Heils, O Okladnova, A Schmitt, K P Lesc. Serotonin transporter function is modulated by brain-derived neurotrophic factor (BDNF) but not nerve growth factor (NGF). Neurochemistry international. vol 36. issue 3. 2000-03-02. PMID:10676853. |
two of the b cell lines showed a dose-dependent reduction of 5-ht uptake after exposure to bdnf. |
2000-03-02 |
2023-08-12 |
Not clear |
| R Mössner, S Daniel, D Albert, A Heils, O Okladnova, A Schmitt, K P Lesc. Serotonin transporter function is modulated by brain-derived neurotrophic factor (BDNF) but not nerve growth factor (NGF). Neurochemistry international. vol 36. issue 3. 2000-03-02. PMID:10676853. |
thus, bdnf but not ngf may influence 5-ht uptake in some b lymphocytes. |
2000-03-02 |
2023-08-12 |
Not clear |
| L A Mamounas, C A Altar, M E Blue, D R Kaplan, L Tessarollo, W E Lyon. BDNF promotes the regenerative sprouting, but not survival, of injured serotonergic axons in the adult rat brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 2. 2000-02-09. PMID:10632606. |
brain-derived neurotrophic factor (bdnf) has trophic effects on serotonergic (5-ht) neurons in the adult brain and can prevent the severe loss of cortical 5-ht axons caused by the neurotoxin p-chloroamphetamine (pca). |
2000-02-09 |
2023-08-12 |
rat |
| L A Mamounas, C A Altar, M E Blue, D R Kaplan, L Tessarollo, W E Lyon. BDNF promotes the regenerative sprouting, but not survival, of injured serotonergic axons in the adult rat brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 2. 2000-02-09. PMID:10632606. |
however, it has not been determined whether bdnf promotes the survival of 5-ht axons during pca-insult or facilitates their regenerative sprouting after injury. |
2000-02-09 |
2023-08-12 |
rat |
| L A Mamounas, C A Altar, M E Blue, D R Kaplan, L Tessarollo, W E Lyon. BDNF promotes the regenerative sprouting, but not survival, of injured serotonergic axons in the adult rat brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 2. 2000-02-09. PMID:10632606. |
we show here that bdnf fails to protect most 5-ht axons from pca-induced degeneration. |
2000-02-09 |
2023-08-12 |
rat |
| L A Mamounas, C A Altar, M E Blue, D R Kaplan, L Tessarollo, W E Lyon. BDNF promotes the regenerative sprouting, but not survival, of injured serotonergic axons in the adult rat brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 2. 2000-02-09. PMID:10632606. |
instead, chronic bdnf infusions markedly stimulate the sprouting of both intact and pca-lesioned 5-ht axons, leading to a hyperinnervation at the neocortical infusion site. |
2000-02-09 |
2023-08-12 |
rat |
| L A Mamounas, C A Altar, M E Blue, D R Kaplan, L Tessarollo, W E Lyon. BDNF promotes the regenerative sprouting, but not survival, of injured serotonergic axons in the adult rat brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 2. 2000-02-09. PMID:10632606. |
bdnf treatment promoted the regrowth of 5-ht axons when initiated up to a month after pca administration. |
2000-02-09 |
2023-08-12 |
rat |
| L A Mamounas, C A Altar, M E Blue, D R Kaplan, L Tessarollo, W E Lyon. BDNF promotes the regenerative sprouting, but not survival, of injured serotonergic axons in the adult rat brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 2. 2000-02-09. PMID:10632606. |
bdnf also encouraged the regrowth of the 5-ht plexus in the hippocampus, but only in those lamina where 5-ht axons normally ramify. |
2000-02-09 |
2023-08-12 |
rat |
| L A Mamounas, C A Altar, M E Blue, D R Kaplan, L Tessarollo, W E Lyon. BDNF promotes the regenerative sprouting, but not survival, of injured serotonergic axons in the adult rat brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 2. 2000-02-09. PMID:10632606. |
the dose-response profiles for bdnf to stimulate 5-ht sprouting and trk signaling were remarkably similar, suggesting a physiological link between the two events; both responses were maximal at intermediate doses of bdnf but declined at higher doses ("inverted-u-shaped" dose-response curves). |
2000-02-09 |
2023-08-12 |
rat |
| W E Lyons, L A Mamounas, G A Ricaurte, V Coppola, S W Reid, S H Bora, C Wihler, V E Koliatsos, L Tessaroll. Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 26. 2000-01-27. PMID:10611369. |
brain-derived neurotrophic factor (bdnf) has trophic effects on serotonergic (5-ht) neurons in the central nervous system. |
2000-01-27 |
2023-08-12 |
mouse |
| W E Lyons, L A Mamounas, G A Ricaurte, V Coppola, S W Reid, S H Bora, C Wihler, V E Koliatsos, L Tessaroll. Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 26. 2000-01-27. PMID:10611369. |
in the present study, we use heterozygous bdnf(+/-) mice that have a normal life span and show that these animals develop enhanced intermale aggressiveness and hyperphagia accompanied by significant weight gain in early adulthood; these behavioral abnormalities are known to correlate with 5-ht dysfunction. |
2000-01-27 |
2023-08-12 |
mouse |