| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J A Siuciak, C Boylan, M Fritsche, C A Altar, R M Lindsa. BDNF increases monoaminergic activity in rat brain following intracerebroventricular or intraparenchymal administration. Brain research. vol 710. issue 1-2. 1996-12-05. PMID:8963648. |
these results suggest that bdnf increased synthesis and/or turnover of serotonin, and to a lesser extent dopamine, in the mature rat forebrain. |
1996-12-05 |
2023-08-12 |
rat |
| J S Rudge, M J Eaton, P Mather, R M Lindsay, S R Whittemor. CNTF induces raphe neuronal precursors to switch from a serotonergic to a cholinergic phenotype in vitro. Molecular and cellular neurosciences. vol 7. issue 3. 1996-11-05. PMID:8726104. |
in the rn46a serotonergic cell line which is induced to become serotonergic by brain-derived neurotrophic factor (bdnf), the addition of cntf suppressed tryptophan hydroxylase and 5ht synthesis and increased choline acetyl transferase (chat) expression by 6-fold and chat activity by 20- to 30-fold over 12 days. |
1996-11-05 |
2023-08-12 |
mouse |
| J S Rudge, M J Eaton, P Mather, R M Lindsay, S R Whittemor. CNTF induces raphe neuronal precursors to switch from a serotonergic to a cholinergic phenotype in vitro. Molecular and cellular neurosciences. vol 7. issue 3. 1996-11-05. PMID:8726104. |
as with the primary neurons, removal and replacement of cntf with bdnf after 4 days resulted in a partial restitution of 5ht expression. |
1996-11-05 |
2023-08-12 |
mouse |
| P Celada, J A Siuciak, T M Tran, C A Altar, J M Teppe. Local infusion of brain-derived neurotrophic factor modifies the firing pattern of dorsal raphé serotonergic neurons. Brain research. vol 712. issue 2. 1996-10-04. PMID:8814905. |
previous studies have reported a neuromodulatory effect of brain-derived neurotrophic factor (bdnf) on serotonin neurons in the central nervous system. |
1996-10-04 |
2023-08-12 |
rat |
| M J Eaton, S R Whittemor. Autocrine BDNF secretion enhances the survival and serotonergic differentiation of raphe neuronal precursor cells grafted into the adult rat CNS. Experimental neurology. vol 140. issue 2. 1996-08-27. PMID:8690054. |
brain-derived neurotrophic factor (bdnf) regulates the in vitro survival and serotonergic phenotype of rn46a cells, and we hypothesized that expression of bdnf in rn46a cells would potentiate their survival and serotonin (5ht) expression in vivo. |
1996-08-27 |
2023-08-12 |
rat |
| M J Eaton, S R Whittemor. Autocrine BDNF secretion enhances the survival and serotonergic differentiation of raphe neuronal precursor cells grafted into the adult rat CNS. Experimental neurology. vol 140. issue 2. 1996-08-27. PMID:8690054. |
the gene encoding rat bdnf was transfected into rn46a cells and the clonal 46a-b14 cell line isolated, 46a-b14 cells synthesize and secrete biologically active bdnf in vitro and synthesize 5ht following partial membrane depolarization. |
1996-08-27 |
2023-08-12 |
rat |
| M J Eaton, S R Whittemor. Autocrine BDNF secretion enhances the survival and serotonergic differentiation of raphe neuronal precursor cells grafted into the adult rat CNS. Experimental neurology. vol 140. issue 2. 1996-08-27. PMID:8690054. |
the grafted 46a-b14 cells immunohistochemically stain for bdnf and 5ht, while rn46a cells transfected with vector only are negative for both bdnf and 5ht. |
1996-08-27 |
2023-08-12 |
rat |
| M J Eaton, S R Whittemor. Autocrine BDNF secretion enhances the survival and serotonergic differentiation of raphe neuronal precursor cells grafted into the adult rat CNS. Experimental neurology. vol 140. issue 2. 1996-08-27. PMID:8690054. |
autocrine secretion of bdnf by rn46a cells thus potentiates survival and can be used to deliver both bdnf and 5ht in vivo. |
1996-08-27 |
2023-08-12 |
rat |
| L A Mamounas, M E Blue, J A Siuciak, C A Alta. Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 12. 1996-06-06. PMID:8613731. |
the present study examined whether chronic pain parenchymal administration of the neurotrophins brain-derived neurotrophic factor (bdnf), neurotrophin-3 (nt-3) or ngf could prevent the severe degenerative loss of serotonergic axons normally caused by the selective 5-ht neurotoxin p-chloroamphetamine (pca). |
1996-06-06 |
2023-08-12 |
rat |
| L A Mamounas, M E Blue, J A Siuciak, C A Alta. Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 12. 1996-06-06. PMID:8613731. |
as revealed with 5-ht immunocytochemistry, bdnf infusions into the neocortex of intact (non-pca-lesioned) rats caused a substantial increase in 5-ht axon density in a 3 mm diameter region surrounding the cannula tip. |
1996-06-06 |
2023-08-12 |
rat |
| L A Mamounas, M E Blue, J A Siuciak, C A Alta. Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 12. 1996-06-06. PMID:8613731. |
in pca-lesioned rats, intracortical infusions of bdnf completely prevented the severe neurotoxin-induced loss of 5-ht axons near the infusion cannula. |
1996-06-06 |
2023-08-12 |
rat |
| L A Mamounas, M E Blue, J A Siuciak, C A Alta. Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 12. 1996-06-06. PMID:8613731. |
the immunocytochemical data were supported by neurochemical evaluations which showed that bdnf attenuated the pca-induced loss of 5-ht and 5-hiaa contents and 3h-5-ht uptake near the infusion cannula. |
1996-06-06 |
2023-08-12 |
rat |
| L A Mamounas, M E Blue, J A Siuciak, C A Alta. Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 12. 1996-06-06. PMID:8613731. |
thus, bdnf can promote the sprouting of mature, uninjured serotonergic axons and dramatically enhance the survival or sprouting of 5-ht axons normally damaged by the serotonergic neurotoxin pca. |
1996-06-06 |
2023-08-12 |
rat |
| M J Eaton, J K Staley, M Y Globus, S R Whittemor. Developmental regulation of early serotonergic neuronal differentiation: the role of brain-derived neurotrophic factor and membrane depolarization. Developmental biology. vol 170. issue 1. 1995-08-07. PMID:7601307. |
trkb, p75ntr, and tph, but not 5ht, expressions increase with differentiation and treatment with brain-derived neurotrophic factor (bdnf). |
1995-08-07 |
2023-08-12 |
rat |
| M J Eaton, J K Staley, M Y Globus, S R Whittemor. Developmental regulation of early serotonergic neuronal differentiation: the role of brain-derived neurotrophic factor and membrane depolarization. Developmental biology. vol 170. issue 1. 1995-08-07. PMID:7601307. |
5ht synthesis in rn46a cells requires initial treatment with bdnf, followed by growth under partial membrane depolarizing conditions. |
1995-08-07 |
2023-08-12 |
rat |
| M J Eaton, J K Staley, M Y Globus, S R Whittemor. Developmental regulation of early serotonergic neuronal differentiation: the role of brain-derived neurotrophic factor and membrane depolarization. Developmental biology. vol 170. issue 1. 1995-08-07. PMID:7601307. |
embryonic raphe cultures treated similarly with bdnf and partial depolarizing conditions also demonstrate increased 5ht synthesis. |
1995-08-07 |
2023-08-12 |
rat |
| M J Eaton, J K Staley, M Y Globus, S R Whittemor. Developmental regulation of early serotonergic neuronal differentiation: the role of brain-derived neurotrophic factor and membrane depolarization. Developmental biology. vol 170. issue 1. 1995-08-07. PMID:7601307. |
the sodium-dependent transporter for 5ht reuptake is present in undifferentiated rn46a cells, and the apparent km and bmax are unchanged by differentiation or bdnf treatment and membrane depolarization. |
1995-08-07 |
2023-08-12 |
rat |
| C A Altar, C B Boylan, M Fritsche, C Jackson, C Hyman, R M Lindsa. The neurotrophins NT-4/5 and BDNF augment serotonin, dopamine, and GABAergic systems during behaviorally effective infusions to the substantia nigra. Experimental neurology. vol 130. issue 1. 1995-02-14. PMID:7821394. |
the neurotrophins nt-4/5 and bdnf augment serotonin, dopamine, and gabaergic systems during behaviorally effective infusions to the substantia nigra. |
1995-02-14 |
2023-08-12 |
rat |
| L A White, M J Eaton, M C Castro, K J Klose, M Y Globus, G Shaw, S R Whittemor. Distinct regulatory pathways control neurofilament expression and neurotransmitter synthesis in immortalized serotonergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 11 Pt 1. 1994-12-06. PMID:7965075. |
low levels of serotonin immunoreactivity are detected in differentiated rn46a cells, and this was potentiated by differentiating rn46a cells with bdnf for 8 d and 40 mm kcl for days 4-8. |
1994-12-06 |
2023-08-12 |
rat |
| C A Altar, C B Boylan, M Fritsche, B E Jones, C Jackson, S J Wiegand, R M Lindsay, C Hyma. Efficacy of brain-derived neurotrophic factor and neurotrophin-3 on neurochemical and behavioral deficits associated with partial nigrostriatal dopamine lesions. Journal of neurochemistry. vol 63. issue 3. 1994-09-08. PMID:7519657. |
thus, bdnf and to a lesser extent nt-3 reverse rotational behavioral deficits and augment striatal da and 5-ht metabolism in a partial da lesion model. |
1994-09-08 |
2023-08-12 |
rat |