| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fengjiao Liu, Yaxin Jia, Liwei Zhao, Li-Na Xiao, Xizhen Cheng, Yingying Xiao, Ying Zhang, Yuling Zhang, Huimin Yu, Qiao-En Deng, Yuanyuan Zhang, Yimeng Feng, Junfang Wang, Yonggang Gao, Xuan Zhang, Yunyun Gen. Escin ameliorates CUMS-induced depressive-like behavior via BDNF/TrkB/CREB and TLR4/MyD88/NF-κB signaling pathways in rats. European journal of pharmacology. 2024-10-19. PMID:39426465. |
it also decreased serum adrenal cortical hormone (acth) and corticosterone (cort) levels while increasing 5-ht and brain-derived neurotrophic factor (bdnf) levels in the cums rats, as measured by the enzyme-linked immunosorbent assay (elisa). |
2024-10-19 |
2024-10-22 |
rat |
| b' Dominika Jar\\xc4\\x8du\\xc5\\xa1kov\\xc3\\xa1, Ivan Tk\\xc3\\xa1\\xc4\\x8d, Nata\\xc5\\xa1a Hlav\\xc3\\xa1\\xc4\\x8dov\\xc3\\xa1, Alena Stan\\xc4\\x8d\\xc3\\xa1kov\\xc3\\xa1 Yaluri, Miriam Koz\\xc3\\xa1rov\\xc3\\xa1, Viera Habalov\\xc3\\xa1, Lucia Klim\\xc4\\x8d\\xc3\\xa1kov\\xc3\\xa1, Jozef \\xc5\\xbdidzik, Martin Javorsk\\xc3\\xbd, Aneta Bedn\\xc3\\xa1\\xc5\\x99ov\\xc3\\xa. Serotonin transporter 5-HTTLPR polymorphism and escitalopram treatment response in patients with major depressive disorder. BMC psychiatry. vol 24. issue 1. 2024-10-16. PMID:39407134.' |
this study investigated the association between genetic variants involved in serotonin signaling and brain-derived neurotrophic factor (bdnf) with the response to escitalopram treatment in patients with mdd. |
2024-10-16 |
2024-10-18 |
Not clear |
| Nevine Fathy, Merna A Labib, Reham M Essam, Noha A El-Boghdad. The Interplay between MiR-134/BDNF and LKB1/AMPK/SIRT1 Accentuates the Antidepressant Efficacy of Empagliflozin in Ovariectomized Rats. ACS chemical neuroscience. 2024-10-01. PMID:39350330. |
moreover, empa curtailed ovx-induced alterations of serum estradiol, hippocampal serotonin, mir-134 expression, as well as bdnf. |
2024-10-01 |
2024-10-03 |
rat |
| Yangbo Zhang, Yong Lin, Yifan Xiong, Jianan Huang, Zhonghua Li. An Analysis of the Intestinal Microbiome Combined with Metabolomics to Explore the Mechanism of How Jasmine Tea Improves Depression in CUMS-Treated Rats. Foods (Basel, Switzerland). vol 13. issue 16. 2024-08-29. PMID:39200564. |
the results found that jasmine tea significantly ameliorated the depressive behavior induced by cums, significantly improved the neurotransmitter concentration (bdnf and 5-ht), and decreased the pro-inflammation levels (tnf-α and nf-κb). |
2024-08-29 |
2024-09-01 |
rat |
| Qinyu Jiang, Yu Qi, Meiyan Zhou, Yaqi Dong, Wenting Zheng, Lijiao Zhu, Yanyu Li, Hai Zhou, Liwei Wan. Effect of esketamine on serum neurotransmitters in patients with postpartum depression: a randomized controlled trial. BMC anesthesiology. vol 24. issue 1. 2024-08-19. PMID:39160473. |
the development of postpartum depression has been linked to fluctuations in the levels of neurotransmitters in the human body, such as 5-hydroxytryptamine (5-ht), dopamine (da), noradrenaline (norepinephrine, ne), and brain derived neurotrophic factor (bdnf). |
2024-08-19 |
2024-08-22 |
human |
| Hussam A Althagaf. Neuroprotective role of chlorogenic acid against hippocampal neuroinflammation, oxidative stress, and apoptosis following acute seizures induced by pentylenetetrazole. Metabolic brain disease. 2024-08-12. PMID:39133453. |
further, cga pre-treatment caused significant increases in acetylcholinesterase (ache) activity and brain-derived neurotrophic factor (bdnf) levels, along with marked increases in dopamine, norepinephrine, and serotonin levels. |
2024-08-12 |
2024-08-14 |
mouse |
| Dongge Wang, Tingjuan Wu, Jinghui Jin, Yanpo Si, Yushi Wang, Xiaojia Ding, Tao Guo, Wenjun We. Periostracum Cicadae Extract and N-Acetyldopamine Regulate the Sleep-Related Neurotransmitters in PCPA-Induced Insomnia Rats. Molecules (Basel, Switzerland). vol 29. issue 15. 2024-08-10. PMID:39125043. |
the results indicated that pc extract and nada could effectively ameliorate hypothalamic pathology of insomnia rats, increase the levels of 5-ht, gaba, and bdnf, and decrease the levels of da, dopac, and hva. |
2024-08-10 |
2024-08-13 |
rat |
| Shi Bai, Zhong-Ming Ying, Jia-Kang Ying, Qin-Ying Zhang, Yu-Hang Lv, Zhong-Min W. Inhibition of 5-HT alleviates PTSD-like behaviors and promotes hippocampal neuroplasticity by modulating hippocampal autophagy in rats. Journal of neurophysiology. 2024-08-07. PMID:39110517. |
rats exposed to single prolonged stress (sps) exhibited typical ptsd-like phenotypes, with decreased levels of 5-ht in the hippocampus and significant reductions in its downstream targets, brain-derived neurotrophic factor (bdnf) and trkb. |
2024-08-07 |
2024-08-10 |
rat |
| Kazim Sahin, Emre Sahin, Cemal Orhan, Besir Er, Bayram Akoglan, Ibrahim Hanifi Ozercan, Nurhan Sahin, James R Komorowsk. The impact of magnesium biotinate and arginine silicate complexes on metabolic dysfunctions, antioxidant activity, inflammation, and neuromodulation in high-fat diet-fed rats. Clinical and experimental medicine. vol 24. issue 1. 2024-08-06. PMID:39105860. |
moreover, this combination increased the activities of antioxidant enzymes (p < 0.05) and boosted the brain-derived neurotrophic factor (bdnf), serotonin, dopamine (p < 0.001), as well as liver insulin receptor substrate 1 (irs-1) and peroxisome proliferator-activated receptor gamma (ppar-γ) (p < 0.001). |
2024-08-06 |
2024-08-08 |
rat |
| Estíbaliz Ampuero, Alejandro Luarte, Francisca Sofia Flores, Antonia Ignacia Soto, Catalina Pino, Viviana Silva, Macarena Erlandsen, Teresita Concha, Ursula Wyneke. The multifaceted effects of fluoxetine treatment on cognitive functions. Frontiers in pharmacology. vol 15. 2024-07-31. PMID:39081952. |
in this review, we first examine the well-substantiated biological mechanisms underlying fluoxetine's antidepressant effects, which include serotonin reuptake inhibition and activation of trkb receptors-key to brain-derived neurotrophic factor (bdnf) signaling. |
2024-07-31 |
2024-08-02 |
Not clear |
| Xiangjuan Guo, Lili Su, Meiling Shi, Li Sun, Weijia Chen, Jianan Geng, Jianming Li, Ying Zong, Zhongmei He, Rui D. Network Pharmacology and Transcriptomics to Explore the Pharmacological Mechanisms of 20(S)-Protopanaxatriol in the Treatment of Depression. International journal of molecular sciences. vol 25. issue 14. 2024-07-27. PMID:39062817. |
in this study, we demonstrated that ppt improved depression-like behavior and brain histopathological changes in cums mice, downregulated nitric oxide (no) and interleukin-6 (il-6) levels, and elevated serum levels of 5-hydroxytryptamine (5-ht) and brain-derived neurotrophic factor (bdnf) after ppt treatment compared to the cums group. |
2024-07-27 |
2024-07-29 |
mouse |
| Heba S Mehran, Soad Nady, Rami B Kassab, Omar A Ahmed-Farid, Rehab E El-Hennam. Recombinant Interleukin - 2 2 Immunotherapy Ameliorates Inflammation and Promotes the Release of Monoamine Neurotransmitters in the Gut-Brain Axis of Schistosoma mansoni-Infected Mice. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 19. issue 1. 2024-07-25. PMID:39052165. |
brain-derived neurotrophic factor (bdnf) and neurotransmitter release (serotonin, 5ht, norepinephrine, ne, dopamine, da, glutamate, glu, and -amino butyric acid, gaba) were improved by ril-22. |
2024-07-25 |
2024-07-28 |
mouse |
| Е М Кондаурова, A A Komarova, T V Ilchibaeva, A Ya Rodnyy, E A Zalivina, V S Naumenk. Effect of amisulpride on the expression of serotonin receptors, neurotrophic factor BDNF and its receptors in mice with overexpression of the aggregation-prone [R406W] mutant tau protein. Vavilovskii zhurnal genetiki i selektsii. vol 28. issue 4. 2024-07-19. PMID:39027123. |
effect of amisulpride on the expression of serotonin receptors, neurotrophic factor bdnf and its receptors in mice with overexpression of the aggregation-prone [r406w] mutant tau protein. |
2024-07-19 |
2024-07-21 |
mouse |
| Efthalia Angelopoulou, Anastasia Bougea, Alexandros Hatzimanolis, Nikolaos Scarmeas, Sokratis G Papageorgio. Unraveling the Potential Underlying Mechanisms of Mild Behavioral Impairment: Focusing on Amyloid and Tau Pathology. Cells. vol 13. issue 13. 2024-07-12. PMID:38995015. |
dysregulation of the hypothalamic-pituitary-adrenal (hpa) axis, disruption of neurotrophic factors, such as the brain-derived neurotrophic factor (bdnf), abnormal neuroinflammatory responses including the kynurenine pathway, dysregulation of transforming growth factor beta (tgf-β1), epigenetic alterations including micro-rna (mir)-451a and mir-455-3p, synaptic dysfunction, imbalance in neurotransmitters including acetylcholine, dopamine, serotonin, gamma-aminobutyric acid (gaba) and norepinephrine, as well as altered locus coeruleus (lc) integrity are some of the potential mechanisms connecting mbi with amyloid and tau pathology. |
2024-07-12 |
2024-07-14 |
Not clear |
| Zahra Mashahadi, Hakimeh Saadati, Safa Ghaheri Far. Early-life manipulation of the serotonergic system exacerbates the harmful effects of sleep deprivation on cognitive functions. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2024-07-10. PMID:38984677. |
our findings showed that postnatal serotonin depletion and sleep deprivation impaired the novel object recognition and passive avoidance memories and changed the bdnf levels. |
2024-07-10 |
2024-07-12 |
Not clear |
| Zahra Mashahadi, Hakimeh Saadati, Safa Ghaheri Far. Early-life manipulation of the serotonergic system exacerbates the harmful effects of sleep deprivation on cognitive functions. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2024-07-10. PMID:38984677. |
in the same way, the serotonin depletion in early life before sleep deprivation exacerbated the harmful effects of sleep deprivation on cognitive function and bdnf levels. |
2024-07-10 |
2024-07-12 |
Not clear |
| b' Talise E M\xfcller, Matheus M Dos Santos, Sabrina A Ferreira, Mariana T Claro, Gabriel T de Macedo, Barbara D Fontana, Nilda V Barbos. Negative impacts of social isolation on behavior and neuronal functions are recovered after short-term social reintroduction in zebrafish. Progress in neuro-psychopharmacology & biological psychiatry. vol 134. 2024-05-30. PMID:38810717.' |
b'behavioral analyses to evaluate locomotion, anxiety-like and social-related behaviors were performed after si protocol, and 3 and 6\xa0days after sr. cortisol and transcript levels from genes involved in neuronal homeostasis (c-fos, egr, bdnf), and serotonergic (5-ht) and dopaminergic (da) neurotransmission (thp, th) were also measured.' |
2024-05-30 |
2024-06-02 |
zebrafish |
| Yihan Liu, Chen Chen, Hanbin Du, Mengzhou Xue, Ning Zh. Impact of Baduanjin exercise combined with rational emotive behavior therapy on sleep and mood in patients with poststroke depression: A randomized controlled trial. Medicine. vol 103. issue 19. 2024-05-10. PMID:38728460. |
in this study, the method of combining chinese traditional exercise baduanjin with psychotherapy was used to intervene in patients with psd and to explore the improvement of sleep, mood, and serum levels of brain-derived neurotrophic factor (bdnf), 5-hydroxytryptamine (5-ht), and interleukin-6 (il-6) levels in patients with psd by combined treatment. |
2024-05-10 |
2024-05-27 |
Not clear |
| Xiayun Zhou, Guoao Shi, Ruiming Chen, Lingsan Hu, Zhongxian Li, Yifu Zhou, Pan Zhang, Xiang Ji, Min Peng, Kengyu Chen, Luda Yan, Peng Zho. Acupuncture for generalized anxiety disorder: a study protocol for a randomized controlled trial. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 57. 2024-05-08. PMID:38716983. |
secondary results will include blood analysis of γ-aminobutyric acid (gaba), glutamate (glu), glutamine (gln), serotonin (5-ht), and brain-derived nerve growth factor (bdnf). |
2024-05-08 |
2024-05-27 |
human |
| Laila A Damiati, Marwa El Sour. Bone-nerve crosstalk: a new state for neuralizing bone tissue engineering-A mini review. Frontiers in medicine. vol 11. 2024-05-01. PMID:38690172. |
receptors of important central nervous system peptides such as serotonin, leptin, semaphorins, and bdnf are expressed in bone tissue playing a role in bone homeostasis, metabolism and regeneration. |
2024-05-01 |
2024-05-03 |
human |