| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sen Yang, Qiang Zheng, Guoan Yi. A 24-h restraint with food and water deprivation: a potential method to establish a model of depression in pigs. Frontiers in veterinary science. vol 10. 2023-10-26. PMID:37876629. |
the levels of cor and acth in the serum and the levels of 5-ht, ne, and bdnf in the hippocampus and medial prefrontal cortex were detected using elisa to identify the physiological state. |
2023-10-26 |
2023-11-08 |
Not clear |
| Xiaoyan Peng, Sujuan Feng, Poxuan Zhang, Shengmei Sang, Yi Zhan. Analysis of influencing factors of anxiety and depression in maintenance hemodialysis patients and its correlation with BDNF, NT-3 and 5-HT levels. PeerJ. vol 11. 2023-09-26. PMID:37750080. |
analysis of influencing factors of anxiety and depression in maintenance hemodialysis patients and its correlation with bdnf, nt-3 and 5-ht levels. |
2023-09-26 |
2023-10-07 |
Not clear |
| Xiaoyan Peng, Sujuan Feng, Poxuan Zhang, Shengmei Sang, Yi Zhan. Analysis of influencing factors of anxiety and depression in maintenance hemodialysis patients and its correlation with BDNF, NT-3 and 5-HT levels. PeerJ. vol 11. 2023-09-26. PMID:37750080. |
the aim of this study is to examine the factors that contribute to anxiety and depression in individuals undergoing maintenance hemodialysis (mhd), as well as their association with serum levels of brain-derived neurotrophic factor (bdnf), neurotrophin-3 (nt-3), and serotonin (5-ht). |
2023-09-26 |
2023-10-07 |
Not clear |
| Chaonan Zhang, Xiaojun Lin, Dawu Lin, Taojie Liang, Lu Huang, Li Zheng, Yanbin X. Study on toxicity responses and their mechanisms in Xenopus tropicalis long-term exposure to Shigella flexneri and ciprofloxacin. The Science of the total environment. 2023-09-14. PMID:37709083. |
significant changes in the expression of intestinal neurotransmitters (5-ht, cgrp) and brain peptides (bdnf, ncam, npy) (p < 0.05) also indicated that the brain-gut axis interaction was disrupted. |
2023-09-14 |
2023-10-07 |
cat |
| Qi Ma, Li Wang, Xiang-Xin Liu, Zhi-Guo An, Xiao Luo, Li-Li Zhang, Ping Yan, Lu Jin, Ren Cai, Qi-Zhong Y. GLP-1 plays a protective role in hippocampal neuronal cells by activating cAMP-CREB-BDNF signaling pathway against CORT+HG-induced toxicity. Heliyon. vol 9. issue 8. 2023-08-14. PMID:37576283. |
however, the bdnf, 5-hydroxytryptamine (5-ht), dopamine (da), norepinephrine (ne), pka, |
2023-08-14 |
2023-08-16 |
mouse |
| Hu Lou, Xue Liu, Ping Li. Mechanism and implications of pro-nature physical activity in antagonizing psychological stress: the key role of microbial-gut-brain axis. Frontiers in psychology. vol 14. 2023-08-10. PMID:37560094. |
pro-nature physical activity can improve the number of firmicutes, short-chain fatty acids, akkermansia bacteria, and the gut-brain barrier and further affect the hpa axis, bdnf, and serotonin pathways of gut-brain two-way communication, thereby maintaining the body's homeostasis and reducing antagonistic psychological stress. |
2023-08-10 |
2023-08-16 |
human |
| Xiaoke Di, Meiyu Wan, Ya-Nan Bai, Fengjuan Lu, Minghui Zhao, Zhifei Zhang, Yang L. Exploring the mechanism of Icariin in the treatment of depression through BDNF-TrkB pathway based on network pharmacology. Naunyn-Schmiedeberg's archives of pharmacology. 2023-07-20. PMID:37470804. |
in a cums-induced depression model, we found that icariin could effectively improve depression-like behavior of mice, increase the expression of monoamine neurotransmitters 5-hydroxytryptamine, dopamine, and norepinephrine, decrease the secretion of inflammatory factors tumor necrosis factor-α, interleukin-6, and interleukin-1β, and upregulate the relative expression levels of bdnf, p-trkb/trkb, p-akt/akt, p-creb/creb, mapk3, mapk1, bcl-2, egfr, and mtor. |
2023-07-20 |
2023-08-14 |
mouse |
| Anjali Suman, Archisman Mahapatra, Priya Gupta, Shubhendu Shekhar Ray, Rahul Kumar Sing. Polystyrene microplastics modulated bdnf expression triggering neurotoxicity via apoptotic pathway in zebrafish embryos. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2023-07-16. PMID:37454885. |
on the last day of exposure, behaviour, accumulation, embryotoxicity, acridine orange staining, antioxidant enzyme assay, acetylcholinesterase assay, nitric oxide (no) estimation, along with neurotransmitter (serotonin, dopamine) quantification and gene expression using qrt-pcr (bdnf, p53, bcl-2, caspase-3, caspase-9) were performed. |
2023-07-16 |
2023-08-14 |
human |
| Anjali Suman, Archisman Mahapatra, Priya Gupta, Shubhendu Shekhar Ray, Rahul Kumar Sing. Polystyrene microplastics modulated bdnf expression triggering neurotoxicity via apoptotic pathway in zebrafish embryos. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2023-07-16. PMID:37454885. |
moreover, polystyrene microplastics exposure resulted in reduced acetylcholinesterase activity leading to elevated no concentration along with altered serotonin and dopamine levels and subsequently leading to down-regulated bdnf gene expression and modulated downstream apoptotic signalling, confirming the neurotoxicity potential of microplastics causing neuronal dysfunction. |
2023-07-16 |
2023-08-14 |
human |
| Denis Zosen, Elena Kondratskaya, Oykum Kaplan-Arabaci, Fred Haugen, Ragnhild Elisabeth Paulse. Antidepressants escitalopram and venlafaxine up-regulate BDNF promoter IV but down-regulate neurite outgrowth in differentiating SH-SY5Y neurons. Neurochemistry international. 2023-07-14. PMID:37451345. |
the pharmacological actions of these drugs generally determine the uptake and metabolism of a series of neurotransmitters, such as serotonin, norepinephrine, or dopamine, along with an increase in bdnf expression. |
2023-07-14 |
2023-08-14 |
human |
| Huiwen Kang, Wei Zhang, Jiaru Jing, Danyang Huang, Lei Zhang, Jingyu Wang, Lin Han, Ziyan Liu, Ziyan Wang, Ai Ga. The gut-brain axis involved in polystyrene nanoplastics-induced neurotoxicity via reprogramming the circadian rhythm-related pathways. Journal of hazardous materials. vol 458. 2023-07-01. PMID:37392641. |
we found that 80 nm ps-nps could reach and cause neuronal damage in the hippocampus, and alter the expression of neuroplasticity-related molecules (5-ht, ache, gaba, bdnf and creb), and even affect the learning and memory ability of mice. |
2023-07-01 |
2023-08-14 |
mouse |
| Pei-Pei Li, Shuo Wang, Tao Chen, Ruo-Lan Long, Dan Feng, Yang-Fei Wei, Zhi-Bo Song, Yu-Lin Li, Jing Su. [Comparison of mouse models of depression induced by different modeling methods]. Sheng li xue bao : [Acta physiologica Sinica]. vol 75. issue 3. 2023-06-21. PMID:37340647. |
after modeling, forced swimming test (fst), tail suspension test (tst) and sucrose preference test (spt) were used to detect the behavioral changes of mice, and the serum levels of brain-derived neurotrophic factor (bdnf), 5-hydroxytryptamine (5-ht) and cort were detected with elisa kits. |
2023-06-21 |
2023-08-14 |
mouse |
| Pei-Pei Li, Shuo Wang, Tao Chen, Ruo-Lan Long, Dan Feng, Yang-Fei Wei, Zhi-Bo Song, Yu-Lin Li, Jing Su. [Comparison of mouse models of depression induced by different modeling methods]. Sheng li xue bao : [Acta physiologica Sinica]. vol 75. issue 3. 2023-06-21. PMID:37340647. |
the serum 5-ht levels of model mice from the cort and cc groups were significantly reduced, while the serum bdnf and cort levels of model mice from the cums, cort, and cc groups showed no significant changes. |
2023-06-21 |
2023-08-14 |
mouse |
| Yan Xu, Dong-Guang Liu, Ting-Bo Ning, Jian-Guo Zhu, Ru Yao, Xue Meng, Jing-Chun Yao, Wen-Xue Zha. [Antidepressant mechanism of Shenling Kaixin Granules based on BDNF/TrkB/CREB pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 8. 2023-06-07. PMID:37282906. |
the contents of interleukin 1 beta(il-1β), tumor necrosis factor α(tnf-α), brain-derived neurotrophic factor(bdnf) and 5-hydroxytryptamine(5-ht) in serum were determined by enzyme linked immunosorbent assay(elisa), and the activities of superoxide dismutase(sod) and catalase(cat) in hippocampal ca1 region were also detected. |
2023-06-07 |
2023-08-14 |
rat |
| Yan Xu, Dong-Guang Liu, Ting-Bo Ning, Jian-Guo Zhu, Ru Yao, Xue Meng, Jing-Chun Yao, Wen-Xue Zha. [Antidepressant mechanism of Shenling Kaixin Granules based on BDNF/TrkB/CREB pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 8. 2023-06-07. PMID:37282906. |
additionally, the serum contents of il-1β and tnf-α and the expression of caspase-3 were higher, while the contents of bdnf and 5-ht, the activities of sod and cat in hippocampal ca1 region, the expressions of ngf, bdnf, p-trkb/trkb, p-creb/creb, ho-1 and bcl-2/bax, and the nrf2 nuclear translocation were lower in model group than in control group. |
2023-06-07 |
2023-08-14 |
rat |
| Yan Xu, Dong-Guang Liu, Ting-Bo Ning, Jian-Guo Zhu, Ru Yao, Xue Meng, Jing-Chun Yao, Wen-Xue Zha. [Antidepressant mechanism of Shenling Kaixin Granules based on BDNF/TrkB/CREB pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 8. 2023-06-07. PMID:37282906. |
compared with the conditions in model group, the sugar preference, the number of entries and time spent in the center of open, total distance of movement, and the number of entries and proportion of time spent in open arm in treatment groups were increased while the number and time of immobility in forced swimming experiment were decreased; the serum contents of il-1β and tnf-α and the expression of caspase-3 were down regulated, while the contents of bdnf and 5-ht, the activities of sod and cat in hippocampal ca1 region, the expressions of ngf, bdnf, p-trkb/trkb, p-creb/creb, ho-1, bcl-2/bax, and nrf2 nuclear translocation were enhanced. |
2023-06-07 |
2023-08-14 |
rat |
| Rafael Moliner, Mykhailo Girych, Cecilia A Brunello, Vera Kovaleva, Caroline Biojone, Giray Enkavi, Lina Antenucci, Erik F Kot, Sergey A Goncharuk, Katja Kaurinkoski, Mirjami Kuutti, Senem M Fred, Lauri V Elsilä, Sven Sakson, Cecilia Cannarozzo, Cassiano R A F Diniz, Nina Seiffert, Anna Rubiolo, Hele Haapaniemi, Elsa Meshi, Elina Nagaeva, Tiina Öhman, Tomasz Róg, Esko Kankuri, Marçal Vilar, Markku Varjosalo, Esa R Korpi, Perttu Permi, Konstantin S Mineev, Mart Saarma, Ilpo Vattulainen, Plinio C Casarotto, Eero Castré. Psychedelics promote plasticity by directly binding to BDNF receptor TrkB. Nature neuroscience. vol 26. issue 6. 2023-06-06. PMID:37280397. |
the effects of psychedelics on neurotrophic signaling, plasticity and antidepressant-like behavior in mice depend on trkb binding and promotion of endogenous bdnf signaling but are independent of serotonin 2a receptor (5-ht |
2023-06-06 |
2023-08-14 |
mouse |
| Ivan R Romash, Iryna B Romash, Kateryna V Dzivak, Ihor S Tymkiv, Vasyl Ye Neyko, Viktor I Vus, Mykhaylo M Pustovoy. TRAUMATIC EVENTS AND MENTAL DISEASES: THE ROLE OF CERTAIN NEUROTRANSMITTERS, METALLOENZYMES AND HORMONES. SYSTEMATIC LITERATURE REVIEW. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. vol 51. issue 2. 2023-05-31. PMID:37254764. |
aim: to study the role of certain neurotransmitters (brain-derived neurotrophic factor (bdnf), 5-hydroxytryptamine (5-ht)), metalloenzymes (matrix met-alloproteinase-9) (mmp-9) and hormones (ghrelin) in the pathogenesis of mental disorders associated with stress under the impact of traumatic events. |
2023-05-31 |
2023-08-14 |
Not clear |
| Xiao Qiu, Pengcheng Lu, Xinyu Zeng, Shengjie Jin, Xianghe Che. Study on the Mechanism for SIRT1 during the Process of Exercise Improving Depression. Brain sciences. vol 13. issue 5. 2023-05-27. PMID:37239191. |
by induction and analysis, sirt1 can be activated by exercise and then improve the function of the hypothalamic-pituitary-adrenal (hpa) axis by upregulating brain-derived neurotrophic factors (bdnf), inhibit the inflammatory response (suppression of the nf-κb and tnf-α/indoleamine 2,3-dioxygenase (ido)/5-hydroxytryptamine (5-ht) pathways), and promote neurogenesis (activation of the insulin-like growth factor1 (igf-1) and growth-associated protein-43 (gap-43) pathways, etc. |
2023-05-27 |
2023-08-14 |
Not clear |
| Saira Jahangir, Manoj Allala, Armughan S Khan, Veronica E Muyolema Arce, Anandkumar Patel, Karsh Soni, Alireza Sharafsha. A Review of Biomarkers in Delirium Superimposed on Dementia (DSD) and Their Clinical Application to Personalized Treatment and Management. Cureus. vol 15. issue 5. 2023-05-09. PMID:37159618. |
we identify 17 genes commonly associated with both dementia and delirium including apolipoprotein e (apoe), brain-derived neurotrophic factor (bdnf), catechol-o-methyltransferase (comt), butyrylcholinesterase (bche), acetylcholinesterase (ache), dna methyltransferase 1 (dnmt1), prion protein (prp), tumor necrosis factor (tnf), serine palmitoyltransferase long chain base subunit 1 (sptlc1), microtubule-associated protein tau (mapt), alpha-synuclein (αs), superoxide dismutase 1 (sod1), amyloid beta precursor protein (app), neurofilament light (nfl), neurofilament heavy, 5-hydroxytryptamine receptor 2a (htr2a), and serpin family a member 3 (erap3). |
2023-05-09 |
2023-08-14 |
Not clear |