| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hannah Benedictine Maier, Alexandra Neyazi, Gabriel L Bundies, Fiona Meyer-Bockenkamp, Stefan Bleich, Hansi Pathak, Yvonne Ziert, Barbara Neuhaus, Franz-Josef Müller, Iris Pollmann, Thomas Illig, Stefanie Mücke, Meike Müller, Brinja Kira Möller, Steffen Oeltze-Jafra, Tim Kacprowski, Jan Voges, Fabian Müntefering, Josef Scheiber, Andreas Reif, Mareike Aichholzer, Christine Reif-Leonhard, Maren Schmidt-Kassow, Ulrich Hegerl, Hanna Reich, Stefan Unterecker, Heike Weber, Jürgen Deckert, Nicole Bössel-Debbert, Hans J Grabe, Michael Lucht, Helge Frielin. Validation of the predictive value of BDNF -87 methylation for antidepressant treatment success in severely depressed patients-a randomized rater-blinded trial. Trials. vol 25. issue 1. 2024-04-09. PMID:38594753. |
our repeated studies suggest that dna methylation of a specific cpg site in the promoter region of exon iv of the bdnf gene (cpg -87) might be predictive of the efficacy of monoaminergic antidepressants such as selective serotonin reuptake inhibitors (ssris), serotonin-norepinephrine reuptake inhibitors (snris), and others. |
2024-04-09 |
2024-04-12 |
Not clear |
| Nastaran Talaee, Shataw Azadvar, Sanaz Khodadadi, Nahal Abbasi, Zahra Najafi Asli-Pashaki, Yasaman Mirabzadeh, Gita Kholghi, Shahin Akhondzadeh, Salar Vasegh. Comparing the effect of fluoxetine, escitalopram, and sertraline, on the level of BDNF and depression in preclinical and clinical studies: a systematic review. European journal of clinical pharmacology. 2024-04-01. PMID:38558317. |
it seems that selective serotonin reuptake inhibitors (ssris) improve depression via affecting bdnf level. |
2024-04-01 |
2024-04-04 |
human |
| Svetlana Adonina, Ekaterina Bazhenova, Darya Bazovkin. Effect of Short Photoperiod on Behavior and Brain Plasticity in Mice Differing in Predisposition to Catalepsy: The Role of BDNF and Serotonin System. International journal of molecular sciences. vol 25. issue 5. 2024-03-13. PMID:38473717. |
both the neurotransmitter serotonin (5-ht) and brain-derived neurotrophic factor (bdnf) are involved in the pathophysiological mechanisms underlying catalepsy and depressive disorders. |
2024-03-13 |
2024-03-15 |
mouse |
| Flóra Gölöncsér, Mária Baranyi, Pál Tod, Fruzsina Maácz, Beáta Sperlág. P2X7 receptor inhibition alleviates mania-like behavior independently of interleukin-1β. iScience. vol 27. issue 3. 2024-03-06. PMID:38444608. |
amph increased il-10, tnf-α, and tbars levels, but did not influence bdnf levels, serotonin, dopamine, and noradrenaline content in brain tissues in either genotypes. |
2024-03-06 |
2024-03-08 |
mouse |
| Yuhua Jin, Lamei Yu, Yan L. Paroxetine Effect on Nerve Growth Factor, Human Neurotrophin-4, Brain-Derived Neurotrophic Factor Levels in Post-stroke Depression. Molecular neurobiology. 2024-03-05. PMID:38443730. |
the levels of ngf, nt-4, bdnf, 5-hydroxytryptamine (5-ht), homocysteine (hcy), noradrenaline (ne), hamilton depression scale (hamd) changes of national institute of health stroke scale (nihss). |
2024-03-05 |
2024-03-08 |
human |
| Yuhua Jin, Lamei Yu, Yan L. Paroxetine Effect on Nerve Growth Factor, Human Neurotrophin-4, Brain-Derived Neurotrophic Factor Levels in Post-stroke Depression. Molecular neurobiology. 2024-03-05. PMID:38443730. |
for post-stroke depression, paroxetine treatment can effectively improve ngf, nt-4, bdnf, 5-ht, hcy, and ne levels and effectively reduce the degree of neurological damage and depression, which has high clinical application value. |
2024-03-05 |
2024-03-08 |
human |
| Ping Yang, Sheng Huang, Zhihong Luo, Shaoming Zhou, Changjuan Zhang, Yong Zhu, Jingjing Yang, Liang L. Radix Bupleuri aqueous extract attenuates MK801-induced schizophrenia-like symptoms in mice: Participation of intestinal flora. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 172. 2024-02-16. PMID:38364739. |
radix bupleuri aqueous extract significantly improved the aberrant behaviors and neuronal damage in scz mice, upregulated syp and psd-95 expression and bdnf levels in hippocampal homogenates, down-regulated da and 5-ht levels, and suppressed microglial activation in scz mice. |
2024-02-16 |
2024-02-19 |
mouse |
| Ping Yang, Sheng Huang, Zhihong Luo, Shaoming Zhou, Changjuan Zhang, Yong Zhu, Jingjing Yang, Liang L. Radix Bupleuri aqueous extract attenuates MK801-induced schizophrenia-like symptoms in mice: Participation of intestinal flora. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 172. 2024-02-16. PMID:38364739. |
lactobacillus abundance was decreased in scz mice and reversed by radix bupleuri aqueous extract administration which exhibited a significant negative correlation with il-6, il-1β, da, and 5-ht, and a significant positive correlation with bdnf levels in hippocampal tissues. |
2024-02-16 |
2024-02-19 |
mouse |
| Ping Yang, Sheng Huang, Zhihong Luo, Shaoming Zhou, Changjuan Zhang, Yong Zhu, Jingjing Yang, Liang L. Radix Bupleuri aqueous extract attenuates MK801-induced schizophrenia-like symptoms in mice: Participation of intestinal flora. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 172. 2024-02-16. PMID:38364739. |
it was reversed by radix bupleuri aqueous extract administration, which exhibited a positive correlation with il-6, il-1β, and 5-ht and a negative correlation with bdnf. |
2024-02-16 |
2024-02-19 |
mouse |
| Kavitha Ukkirapandian, Kayalvizhi Elumalai, Karthika Priyadharshini Udaykumar, Sundaravadivel Vp, Muthulakshmi Rangasm. Behavioral and Biochemical Assays for Autism Models of Wistar Rats. Cureus. vol 16. issue 1. 2024-02-13. PMID:38344592. |
the estimation of antioxidant profile (malondialdehyde {mda}, glutathione {gsh}, catalase (cat), and superoxide dismutase {sod}), proinflammatory markers (tumor necrosis factor {tnf} alpha, transforming growth factor {tgf} beta, interleukin {il} 6, and il-1 beta), neurotransmitters (gamma-aminobutyric acid {gaba} and serotonin), and brain-derived neurotrophic factor (bdnf) in the hippocampal region was done. |
2024-02-13 |
2024-02-15 |
rat |
| Mina Sadighi, Lingling Mai, Yifan Xu, Morgane Boillot, Giorgia Targa, Francesca Mottarlini, Paolo Brambilla, Peter Gass, Lucia Caffino, Fabio Fumagalli, Judith R Homber. Chronic exposure to imipramine induces a switch from depression-like to mania-like behavior in female serotonin transporter knockout rats: Role of BDNF signaling in the infralimbic cortex. Journal of affective disorders. 2024-01-27. PMID:38280571. |
chronic exposure to imipramine induces a switch from depression-like to mania-like behavior in female serotonin transporter knockout rats: role of bdnf signaling in the infralimbic cortex. |
2024-01-27 |
2024-01-30 |
rat |
| Xiaoyang Ma, Jeong-Woo Shin, Jae-Hyun Cho, Seung-Won Han, Dong-Hyun Ki. IL-6 expression-suppressing Lactobacillus reuteri strains alleviate gut microbiota-induced anxiety and depression in mice. Letters in applied microbiology. 2023-12-21. PMID:38126116. |
here, we investigated the effects of six lactobacillus reuteri strains on bdnf, serotonin, and il-6 expression in neuronal or macrophage cells and pdi fecal microbiota-cultured microbiota (pcm)-induced depression in mice. |
2023-12-21 |
2023-12-23 |
mouse |
| Xiaoyang Ma, Jeong-Woo Shin, Jae-Hyun Cho, Seung-Won Han, Dong-Hyun Ki. IL-6 expression-suppressing Lactobacillus reuteri strains alleviate gut microbiota-induced anxiety and depression in mice. Letters in applied microbiology. 2023-12-21. PMID:38126116. |
of these strains, l6 most potently increased bdnf and serotonin levels in corticosterone-stimulated sh-sy5ycells and pc12 cells, followed by l3. |
2023-12-21 |
2023-12-23 |
mouse |
| Xiaoyang Ma, Jeong-Woo Shin, Jae-Hyun Cho, Seung-Won Han, Dong-Hyun Ki. IL-6 expression-suppressing Lactobacillus reuteri strains alleviate gut microbiota-induced anxiety and depression in mice. Letters in applied microbiology. 2023-12-21. PMID:38126116. |
when l1 (weakest in vitro), l3, and l6 were orally administered in mice with pcm-induced depression, l6 most potently suppressed depression-like behaviors and hippocampal tnf-α and il-6 expression and increased hippocampal serotonin, bdnf, 5ht7, gabaarα1, and gababr1b expression, followed by l3 and l1. |
2023-12-21 |
2023-12-23 |
mouse |
| Xiaoyang Ma, Jeong-Woo Shin, Jae-Hyun Cho, Seung-Won Han, Dong-Hyun Ki. IL-6 expression-suppressing Lactobacillus reuteri strains alleviate gut microbiota-induced anxiety and depression in mice. Letters in applied microbiology. 2023-12-21. PMID:38126116. |
bdnf or serotonin levels in corticosterone-stimulated neuronal cells were negatively correlated with depression-related biomarkers in pcm-transplanted mice, while il-6 levels in lps-stimulated macrophage were positively correlated. |
2023-12-21 |
2023-12-23 |
mouse |
| Handan Deng, Yongjun Yu, Qi Sha, Weiyi Sun, Lundan Liang, Feier Ren, Hua Ji, Xiangdi Shen, Xingli Fa. Construction of antibiotic-induced depression mice model and the function of intestinal microbiota. Frontiers in microbiology. vol 14. 2023-12-13. PMID:38088959. |
by using these antibiotics, the concentrations of norepinephrine (ne), 5-hydroxytryptamine (5-ht), and brain-derived neurotrophic factor (bdnf) in mice hippocampus and prefrontal cortex tissues were significantly decreased. |
2023-12-13 |
2023-12-17 |
mouse |
| Naif H Ali, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Ali K Albuhadily, Rabab S Hamad, Athanasios Alexiou, Marios Papadakis, Hebatallah M Saad, Gaber El-Saber Batih. Role of brain renin-angiotensin system in depression: A new perspective. CNS neuroscience & therapeutics. 2023-11-13. PMID:37953501. |
dysregulation of brain ras triggers the development and progression of depression through the reduction of brain 5ht and expression of brain-derived neurotrophic factor (bdnf) and the induction of mitochondrial dysfunction, oxidative stress, and neuroinflammation. |
2023-11-13 |
2023-11-20 |
Not clear |
| Naif H Ali, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Ali K Albuhadily, Rabab S Hamad, Athanasios Alexiou, Marios Papadakis, Hebatallah M Saad, Gaber El-Saber Batih. Role of brain renin-angiotensin system in depression: A new perspective. CNS neuroscience & therapeutics. 2023-11-13. PMID:37953501. |
therefore, inhibition of central classical ras by arbs and aceis and activation of non-classical ras prevent the development of depression by regulating 5ht, bdnf, mitochondrial dysfunction, oxidative stress, and neuroinflammation. |
2023-11-13 |
2023-11-20 |
Not clear |
| Doaa S Ibrahim, Eman M S Shahe. Effect of royal jelly on acrylamide-induced neurotoxicity in rats. Journal of chemical neuroanatomy. 2023-11-04. PMID:37925036. |
the administration of aa increased the level of malondialdehyde (mda), decreases levels of haematological parameters, superoxide dismutase (sod), reduced glutathione (gsh), brain-derived neurotrophic factor (bdnf), neurotransmitters (serotonin, dopamine, and acetylcholine), and cleaved caspase-3, as well as increase the damage to the brain tissues. |
2023-11-04 |
2023-11-08 |
rat |
| Nuo Chen, Ming Zhao, Yaxin Guo, Nan Wu, Baihui Cao, Bing Zhan, Tian Zhou, Yubin Li, Faliang Zhu, WanJun Chen, Yan Li, Lining Zhan. D-mannose is a rapid inducer of ACSS2 to trigger rapid and long-lasting antidepressant responses through augmenting BDNF and TPH2 levels. Translational psychiatry. vol 13. issue 1. 2023-11-02. PMID:37914710. |
the potentiation of synaptic plasticity and serotonin generation by brain-derived neurotrophic factor (bdnf) and tryptophan hydroxylase 2 (tph2) is well characterized to facilitate rapid and long-lasting antidepressant actions. |
2023-11-02 |
2023-11-08 |
mouse |