| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Saara Ahmad, Arfa Azhar, Prashant Tikmani, Hamna Rafique, Asra Khan, Hanif Mesiya, Humera Saee. A randomized clinical trial to test efficacy of chamomile and saffron for neuroprotective and anti-inflammatory responses in depressive patients. Heliyon. vol 8. issue 10. 2022-10-11. PMID:36217471. |
long-term reduction of 5-ht may disseminate to high sensitivity of mdd and alters the level of bdnf. |
2022-10-11 |
2023-08-14 |
human |
| Tejesvi Mishra, Kandasamy Nagarajan, Praveen Kumar Dixit, Vinay Kuma. Neuroprotective potential of ferulic acid against cyclophosphamide-induced neuroinflammation and behavioral changes. Journal of food biochemistry. 2022-09-27. PMID:36166506. |
cyclophosphamide administration also reduced the activity of antioxidant enzymes, reduced the level of neurotransmitters (i.e., dopamine, 5-ht, and bdnf), anti-inflammatory cytokines (il-10), and increased lipid peroxidation and proinflammatory cytokines (il-1β, il-6, and tnf-α). |
2022-09-27 |
2023-08-14 |
mouse |
| Peng-Ning Wu, Shuai Xiong, Peng Zhong, Wan-Qing Yang, Min Chen, Tai-Chun Tan. Global trends in research on irritable bowel syndrome and the brain-gut axis: Bibliometrics and visualization analysis. Frontiers in pharmacology. vol 13. 2022-09-26. PMID:36160395. |
furthermore, the physiological and pathological mechanisms of the brain-gut axis influencing ibs (related to gastrointestinal dysfunction, vagus nerve, visceral pain, intestinal flora, serotonin, tryptophan metabolism, stress, brain-derived neurotrophic factor (bdnf), and malonyldialdehyde) are the future research trends, especially the mechanisms related to intestinal flora. |
2022-09-26 |
2023-08-14 |
Not clear |
| León Jesús German-Ponciano, Gilberto Uriel Rosas-Sánchez, Jonathan Cueto-Escobedo, Rafael Fernández-Demeneghi, Gabriel Guillén-Ruiz, César Soria-Fregozo, Emma Virginia Herrera-Huerta, Juan Francisco Rodríguez-Land. Participation of the Serotonergic System and Brain-Derived Neurotrophic Factor in the Antidepressant-like Effect of Flavonoids. International journal of molecular sciences. vol 23. issue 18. 2022-09-23. PMID:36142808. |
in this sense, evidence shows that depressive individuals have low levels of serotonin and bdnf, while flavonoids can reverse it. |
2022-09-23 |
2023-08-14 |
Not clear |
| León Jesús German-Ponciano, Gilberto Uriel Rosas-Sánchez, Jonathan Cueto-Escobedo, Rafael Fernández-Demeneghi, Gabriel Guillén-Ruiz, César Soria-Fregozo, Emma Virginia Herrera-Huerta, Juan Francisco Rodríguez-Land. Participation of the Serotonergic System and Brain-Derived Neurotrophic Factor in the Antidepressant-like Effect of Flavonoids. International journal of molecular sciences. vol 23. issue 18. 2022-09-23. PMID:36142808. |
finally, the elucidation of the mechanism used by flavonoids to modulate serotonin and bdnf will contribute to our understanding of the neurobiological bases underlying the antidepressant-like effects produced by these natural compounds. |
2022-09-23 |
2023-08-14 |
Not clear |
| Björn Wieland, Marie-Therese Fleddermann, Karen Zentgra. Acute effects of real and imagined endurance exercise on sustained attention performance. Frontiers in psychology. vol 13. 2022-09-16. PMID:36110286. |
the neural similarities between both imagined and physically performed movements reveal that imagery induces transient hypofrontality, whereas real exercise reflects both transient hypofrontality effects and the global release of signaling factors (e.g., bdnf or serotonin) due to muscle contraction and the accompanying sensory feedback. |
2022-09-16 |
2023-08-14 |
Not clear |
| Heba M A Khalil, Dina B Mahmoud, Riham A El-Shiekh, Alaa F Bakr, Amira A Boseila, Sally Mehanna, Reham A Naggar, Hesham A Eliw. Antidepressant and Cardioprotective Effects of Self-Nanoemulsifying Self-Nanosuspension Loaded with Hypericum perforatum on Post-Myocardial Infarction Depression in Rats. AAPS PharmSciTech. vol 23. issue 7. 2022-08-26. PMID:36028598. |
furthermore, it ameliorates anxiety, depressive-like behavior, and cognitive dysfunction by decreasing brain tnf-α, elevating neurotransmitters (norepinephrine and serotonin), and brain-derived neurotrophic factor (bdnf). |
2022-08-26 |
2023-08-14 |
rat |
| Wenjing Yan, Hulin Zhu, Pengbo Zhang, Ting Sun, Shuai Gong, Guoxiu Sun, Zeqiang Re. Heterotopic 4T1 breast cancer transplantation induces hippocampal inflammation and depressive-like behaviors in mice. Metabolic brain disease. 2022-08-10. PMID:35947291. |
immunohistochemistry studies revealed reduced levels of serotonin, norepinephrine, and bdnf in the hippocampus and serum. |
2022-08-10 |
2023-08-14 |
mouse |
| Roberto Laureano-Melo, Raoni Conceição Dos-Santos, Rodrigo Rodrigues da Conceição, Janaina Sena de Souza, Claudio da Silva Almeida, Luís Carlos Reis, Bruno Guimarães Marinho, Gisele Giannocco, Ahmed Rg, Wellington da Silva Côrte. Neonatal D-fenfluramine Treatment Promotes Long-Term Behavioral Changes in Adult Mice. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2022-06-19. PMID:35718760. |
the programmed animals had a decrease in 5ht1a, serotonin transporter (sert), and brain-derived neurotrophic factor (bdnf) expression in the mesencephalic raphe region. |
2022-06-19 |
2023-08-14 |
mouse |
| Olamide Wilson Fasakin, Ganiyu Oboh, Ayokunle Olubode Ademosun, Akeem O Lawa. The modulatory effects of alkaloid extracts of Cannabis sativa, Datura stramonium, Nicotiana tabacum and male Carica papaya on neurotransmitter, neurotrophic and neuroinflammatory systems linked to anxiety and depression. Inflammopharmacology. 2022-06-06. PMID:35665872. |
same doses of csae, ntae and cmae also depleted the gene expressions of gsk3β, jnk, nf-ĸb, and nesfatin-1 while increasing expressions of creb, bdnf, serotonin and nrf2. |
2022-06-06 |
2023-08-14 |
rat |
| Aiqin Zhu, Xing Zhong, Yi Zhu, Peng Li, Junxia Zhang, Yonglan Hou, Lele Son. Ratanasampil is more effective than Flunarizine in relieving migraine. The International journal of neuroscience. 2022-05-18. PMID:35583486. |
serum levels of 5-hydroxytryptamine(5-ht), brain-derived neurotrophic factor(bdnf), calcitonin gene related peptide(cgrp), nerve growth factor(ngf) and β-endorphin(β-ep) before and after therapy were measured. |
2022-05-18 |
2023-08-13 |
Not clear |
| Marcin Andrzejewski, Marek Konefał, Tomasz Podgórski, Beata Pluta, Paweł Chmura, Jan Chmura, Jakub Marynowicz, Kamil Melka, Marius Brazaitis, Jakub Kryścia. How training loads in the preparation and competitive period affect the biochemical indicators of training stress in youth soccer players? PeerJ. vol 10. 2022-05-11. PMID:35539014. |
this study aimed to investigate the effect of a 6-month training program on the training-related stress indicators (creatine kinase - ck; cortisol - cor; serotonin - ser; brain-derived neurotrophic factor - bdnf) in youth soccer players. |
2022-05-11 |
2023-08-13 |
Not clear |
| Emilio Merlo Pich, Laura Cavalleri, Caterina Toma, Ginetta Coll. Involvement of DA D3 Receptors in Structural Neuroplasticity of Selected Limbic Brain Circuits: Possible Role in Treatment-Resistant Depression. Current topics in behavioral neurosciences. 2022-05-10. PMID:35538302. |
converging studies point to evidence of structural plasticity in circuits operated by glutamate, gaba, dopamine, and serotonin neurotransmitters, in concert with neurotrophic factors such as brain derived neurotrophic factor (bdnf) or insulin growth factor 1 (igf1) and a series of modulators that include circulating hormones. |
2022-05-10 |
2023-08-13 |
human |
| F Bavato, S Stamatakos, C M Yde Ohki, E Seifritz, P Romualdi, E Grünblatt, B B Quedno. Brain-derived neurotrophic factor protects serotonergic neurons against 3,4-methylenedioxymethamphetamine ("Ecstasy") induced cytoskeletal damage. Journal of neural transmission (Vienna, Austria : 1996). 2022-04-14. PMID:35420371. |
the brain-derived neurotrophic factor (bdnf) promotes the growth and sprouting of 5-ht neurons and its differential response to mdma administration was suggested to mediate dose- and region-dependent 5-ht damage by mdma. |
2022-04-14 |
2023-08-13 |
human |
| F Bavato, S Stamatakos, C M Yde Ohki, E Seifritz, P Romualdi, E Grünblatt, B B Quedno. Brain-derived neurotrophic factor protects serotonergic neurons against 3,4-methylenedioxymethamphetamine ("Ecstasy") induced cytoskeletal damage. Journal of neural transmission (Vienna, Austria : 1996). 2022-04-14. PMID:35420371. |
therefore, a differentiated 5-ht neuronal cell line obtained from rat raphe nucleus (rn46a) was treated in vitro with either mdma, bdnf, mdma + bdnf, or vehicle. |
2022-04-14 |
2023-08-13 |
human |
| F Bavato, S Stamatakos, C M Yde Ohki, E Seifritz, P Romualdi, E Grünblatt, B B Quedno. Brain-derived neurotrophic factor protects serotonergic neurons against 3,4-methylenedioxymethamphetamine ("Ecstasy") induced cytoskeletal damage. Journal of neural transmission (Vienna, Austria : 1996). 2022-04-14. PMID:35420371. |
our findings confirmed that bdnf levels can influence mdma-induced 5-ht damage, and support bdnf to be a crucial target for neuroprotective interventions of the 5-ht system. |
2022-04-14 |
2023-08-13 |
human |
| Rebeca Vindas-Smith, Dayana Quesada, Mónica I Hernández-Solano, Maripaz Castro, Andrey Sequeira-Cordero, Jaime Fornaguera, Georgina Gómez, Juan C Brene. Fat intake and obesity-related parameters predict striatal BDNF gene expression and dopamine metabolite levels in cafeteria diet-fed rats. Neuroscience. 2022-04-10. PMID:35398176. |
the cafeteria diet increased bdnf expression in the dorsal striatum (ds), and norepinephrine, 5-ht, trkb, creb, and dnmt3a levels in the hippocampus. |
2022-04-10 |
2023-08-13 |
rat |
| Princewill Ikechukwu Ugwu, Benneth Ben-Azu, Sandra Ugonne Ugwu, Christian I Uruaka, Chinecherem Choice Nworgu, Pamela Onyinye Okorie, Kizito Oluchukwu Okafor, Kenneth Kelechi Anachuna, Melford Uche Elendu, Amogechukwu Onyinye Ugwu, Ugochukwu Bond Anyaehie, Azubuike A Nwankwo, Eme Effiom Osi. Putative mechanisms involved in the psychopathologies of mice passively coping with psychosocial defeat stress by quercetin. Brain research bulletin. 2022-03-12. PMID:35278662. |
the decreased serotonin in the prefrontal-cortex and dopamine in the striatum, elevated levels of noradrenaline and acetylcholinesterase in the prefrontal-cortex and hippocampus with corresponding decrease in bdnf were reversed by quercetin. |
2022-03-12 |
2023-08-13 |
mouse |
| Ning Wang, Rui Li, Bainian Feng, Yuliang Cheng, Yahui Guo, He Qia. Chicoric Acid Prevents Neuroinflammation and Neurodegeneration in a Mouse Parkinson's Disease Model: Immune Response and Transcriptome Profile of the Spleen and Colon. International journal of molecular sciences. vol 23. issue 4. 2022-02-26. PMID:35216146. |
in this study, we observe that ca prevented dopaminergic neuronal lesions, motor deficits and glial activation in pd mice, along with the increment in striatal brain-derived neurotrophic factor (bdnf), dopamine (da) and 5-hydroxyindoleacetic acid (5-ht). |
2022-02-26 |
2023-08-13 |
mouse |
| Lluis Miquel-Rio, Diana Alarcón-Arís, María Torres-López, Valentín Cóppola-Segovia, Rubén Pavia-Collado, Verónica Paz, Esther Ruiz-Bronchal, Leticia Campa, Carme Casal, Andrés Montefeltro, Miquel Vila, Francesc Artigas, Raquel Revilla, Analia Bortolozz. Human α-synuclein overexpression in mouse serotonin neurons triggers a depressive-like phenotype. Rescue by oligonucleotide therapy. Translational psychiatry. vol 12. issue 1. 2022-02-25. PMID:35210396. |
specifically, aav5-injected mice displayed axonal impairment in the output brain regions of raphe neurons, and deficits in brain-derived neurotrophic factor (bdnf) expression and 5-ht neurotransmission, resulting in a depressive-like phenotype. |
2022-02-25 |
2023-08-13 |
mouse |