| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guo-Liang Dai, Xin-Yi Yang, Shan-Shan Chen, Yi-Qing Wang, Mei-Chen Liu, Yang Cao, Fei-Ran Li, Cheng-Yao Ma, Wen-Zheng J. [Effects of Jiaotai Pills on CUMS-induced depression model in mice based on changes of SIRT1 expression in hippocampus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 24. 2022-01-07. PMID:34994144. |
the treatment with high-dose jiaotai pills increased the sucrose preference rate, movement distance, and the number of crossing centers(p<0.05), reduced tail suspension time and swimming immobility time(p<0.01), elevated hippocampal sirt1 expression level(p<0.01), decreased hippocampal and serum il-1β, il-6, tnf-α, and mda levels(p<0.01), potentiated sod activity, and up-regulated gsh, da, 5-ht, ne, and bdnf levels in the hippocampus and serum(p<0.05, p<0.01) in model mice. |
2022-01-07 |
2023-08-13 |
mouse |
| Tayebeh Noori, Antoni Sureda, Eduardo Sobarzo-Sánchez, Samira Shirooi. The Role of Natural Products in Treatment of Depressive Disorder. Current neuropharmacology. 2022-01-04. PMID:34979889. |
numerous factors are involved in depression, including inflammation, brain-derived neurotrophic factor (bdnf), gabaergic system, hypothalamic-pituitary-adrenal (hpa) axis, monoamine neurotransmitters (serotonin (5-ht), noradrenaline, and dopamine). |
2022-01-04 |
2023-08-13 |
Not clear |
| Evan M Hess, Lace M Riggs, Michael Michaelides, Todd D Goul. Mechanisms of Ketamine and its Metabolites as Antidepressants. Biochemical pharmacology. 2021-12-30. PMID:34968492. |
specifically, we explore effects on glutamate neurotransmission through n-methyl d-aspartate receptors (nmdars) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (ampars), synaptic structural changes via brain derived neurotrophic factor (bdnf) signaling, interactions with opioid receptors, and the enhancement of serotonin, norepinephrine, and dopamine signaling. |
2021-12-30 |
2023-08-13 |
Not clear |
| Valentina S Evsiukova, Daria Bazovkina, Ekaterina Bazhenova, Elizabeth A Kulikova, Alexander V Kuliko. Tryptophan Hydroxylase 2 Deficiency Modifies the Effects of Fluoxetine and Pargyline on the Behavior, 5-HT- and BDNF-Systems in the Brain of Zebrafish ( International journal of molecular sciences. vol 22. issue 23. 2021-12-10. PMID:34884655. |
serotonin (5-ht) and brain-derived neurotrophic factor (bdnf) play a key role in the therapeutic effect of many antidepressants. |
2021-12-10 |
2023-08-13 |
zebrafish |
| Yanlan Chen, Nan Xiao, Yuxin Chen, Xinye Chen, Chunfei Zhong, Yuying Cheng, Bing Du, Pan L. Semen Sojae Praeparatum alters depression-like behaviors in chronic unpredictable mild stress rats via intestinal microbiota. Food research international (Ottawa, Ont.). vol 150. issue Pt B. 2021-12-05. PMID:34863499. |
in addition, semen sojae praeparatum significantly promoted the contents of norepinephrine (ne), 5-hydroxytryptamine (5-ht), brain-derived neurotrophic factor (bdnf), and gamma-aminobutyric acid (gaba) in the hippocampus and the content of bdnf in the serum (p < 0.05). |
2021-12-05 |
2023-08-13 |
rat |
| Yanlan Chen, Nan Xiao, Yuxin Chen, Xinye Chen, Chunfei Zhong, Yuying Cheng, Bing Du, Pan L. Semen Sojae Praeparatum alters depression-like behaviors in chronic unpredictable mild stress rats via intestinal microbiota. Food research international (Ottawa, Ont.). vol 150. issue Pt B. 2021-12-05. PMID:34863499. |
genus ruminococcaceae_ucg-008 was positively correlated with gaba and bdnf levels in the hippocampus; genus lactobacillus had a positive correlation with 5-ht; and genus bacteroides had negative correlations with 5-ht, bdnf, and ne. |
2021-12-05 |
2023-08-13 |
rat |
| Yuan-Shuo Chan, Jia-Tzer Jang, Chin-Shan H. Effects of physical exercise in children with attention deficit/hyperactivity disorder. Biomedical journal. 2021-12-02. PMID:34856393. |
serotonin, dopamine, bdnf and brain blood flow. |
2021-12-02 |
2023-08-13 |
Not clear |
| Mengshi Zhou, QuanQiu Wang, Chunlei Zheng, A John Rush, Nora D Volkow, Rong X. Drug repurposing for opioid use disorders: integration of computational prediction, clinical corroboration, and mechanism of action analyses. Molecular psychiatry. vol 26. issue 9. 2021-11-25. PMID:33432189. |
genetic and functional analyses showed these five candidate drugs directly target multiple oud-associated genes including bdnf, cyp2d6, oprd1, oprk1, oprm1, htr1b, pomc, slc6a4 and oud-associated pathways, including opioid signaling, g-protein activation, serotonin receptors, and gpcr signaling. |
2021-11-25 |
2023-08-13 |
Not clear |
| Varsha Ramesh, Vettriselvi Venkatesan, Darling Chellathai, Santhi Silamba. Association of Serum Biomarker Levels and BDNF Gene Polymorphism with Response to Selective Serotonin Reuptake Inhibitors in Indian Patients with Major Depressive Disorder. Neuropsychobiology. vol 80. issue 3. 2021-11-22. PMID:32731218. |
association of serum biomarker levels and bdnf gene polymorphism with response to selective serotonin reuptake inhibitors in indian patients with major depressive disorder. |
2021-11-22 |
2023-08-13 |
Not clear |
| Hakimeh Saadati, Farshid Sadegzadeh, Nona Sakhaie, Hamdollah Panahpour, Mohsen Sagh. Serotonin depletion during the postnatal developmental period causes behavioral and cognitive alterations and decreases BDNF level in the brain of rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 81. issue 2. 2021-11-18. PMID:33404066. |
serotonin depletion during the postnatal developmental period causes behavioral and cognitive alterations and decreases bdnf level in the brain of rats. |
2021-11-18 |
2023-08-13 |
rat |
| Hakimeh Saadati, Farshid Sadegzadeh, Nona Sakhaie, Hamdollah Panahpour, Mohsen Sagh. Serotonin depletion during the postnatal developmental period causes behavioral and cognitive alterations and decreases BDNF level in the brain of rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 81. issue 2. 2021-11-18. PMID:33404066. |
therefore, in the present study, we examined the effects of postnatal days (pnd 10-20) administration of para-chlorophenylalanine (pcpa, 100 mg/kg, s.c) a 5-ht synthesis inhibitor, on anxiety-related behaviors, pain sensitivity, short-term recognition memory, and hippocampal and prefrontal cortex (pfc) brain-derived neurotrophic factor (bdnf) mrna expression in adult male and female rats. |
2021-11-18 |
2023-08-13 |
rat |
| Hakimeh Saadati, Farshid Sadegzadeh, Nona Sakhaie, Hamdollah Panahpour, Mohsen Sagh. Serotonin depletion during the postnatal developmental period causes behavioral and cognitive alterations and decreases BDNF level in the brain of rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 81. issue 2. 2021-11-18. PMID:33404066. |
in addition, postnatal days serotonin depletion decreased bdnf level in the hippocampus and pfc of both male and female rats. |
2021-11-18 |
2023-08-13 |
rat |
| Darya Bazovkina, Vladimir Naumenko, Ekaterina Bazhenova, Elena Kondaurov. Effect of Central Administration of Brain-Derived Neurotrophic Factor (BDNF) on Behavior and Brain Monoamine Metabolism in New Recombinant Mouse Lines Differing by 5-HT International journal of molecular sciences. vol 22. issue 21. 2021-11-18. PMID:34769417. |
effect of central administration of brain-derived neurotrophic factor (bdnf) on behavior and brain monoamine metabolism in new recombinant mouse lines differing by 5-ht experiments were carried out on recombinant b6.cba-d13mit76c (b6-m76c) and b6.cba-d13mit76b (b6-m76b) mouse lines created by transferring a 102.73-118.83 mbp fragment of chromosome 13, containing the 5-ht |
2021-11-18 |
2023-08-13 |
mouse |
| Shaghayegh Rezaei, Nour Mohammad Bakhshani, Hamed Fanaei, Irina Trofimov. Opium Effect in Pregnancy on the Dynamics of Maternal Behavior: Testing a Neurochemical Model. Neuropsychobiology. vol 80. issue 2. 2021-11-17. PMID:33611320. |
to test the predictions of this model, we compared the impact of massive mor dysregulation on 3 behavioral aspects of behavior and on serotonin, bdnf, and corticosterone levels. |
2021-11-17 |
2023-08-13 |
Not clear |
| Jinghong Chen, Qingjie Li, Genevieve Saliuk, Sonia Bazhanov, John H Winsto. Estrogen and serotonin enhance stress-induced visceral hypersensitivity in female rats by up-regulating brain-derived neurotrophic factor in spinal cord. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 33. issue 10. 2021-11-09. PMID:33705592. |
the aims of this study were to examine the roles of estrogen receptor alpha (erα) and an increase in spinal serotonin signaling in promoting this enhanced vhs in female rats and up-regulation of spinal cord bdnf transcription. |
2021-11-09 |
2023-08-13 |
rat |
| Francisco J Flores-Ramirez, Anapaula Themann, Jorge A Sierra-Fonseca, Israel Garcia-Carachure, Samuel A Castillo, Minerva Rodriguez, Omar Lira, Joshua Preciado-Piña, Brandon L Warren, Alfred J Robison, Sergio D Iñigue. Adolescent fluoxetine treatment mediates a persistent anxiety-like outcome in female C57BL/6 mice that is ameliorated by fluoxetine re-exposure in adulthood. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:33833356. |
an additional goal was to assess the impact of adolescent flx pretreatment, and its re-exposure in adulthood, on serotonin transporters (5-htt) and brain-derived-neurotrophic-factor (bdnf)-related signaling markers (trkb-erk1/2-creb-probdnf-mbdnf) within the hippocampus and prefrontal cortex. |
2021-11-08 |
2023-08-13 |
mouse |
| Shanshan Liu, Qing Liu, Yanjie Ju, Lei Li. Downregulation of miR-383 reduces depression-like behavior through targeting Wnt family member 2 (Wnt2) in rats. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:33927285. |
the expression levels of mirnas were detected by qrt-pcr, and the expression levels of wnt2, depression-impacted proteins (gfap, bdnf, creb), brain neurotransmitters (5-ht, ne, da) and apoptosis-related proteins (bax and bcl-2) were evaluated by qrt-pcr and western blot. |
2021-11-08 |
2023-08-13 |
rat |
| Ke-Zhuo Chen, Shi Chen, Jie-Yi Ren, Shi Lin, Ming-Jun Xiao, Li Cheng, Xiao-Chuan Y. [Antidepressant effect of acidic polysaccharides from Poria and their regulation of neurotransmitters and NLRP3 pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 19. 2021-11-08. PMID:34738405. |
the levels of brain-derived neurotrophic factor(bdnf), 5-hydroxytryptamine(5-ht), 5-hydroxyindoleacetic acid(5-hiaa), dopamine(da), norepinephrine(ne), glutamic acid(glu), interleukin-1β(il-1β), interleukin-18(il-18), and tumor necrosis factor-α(tnf-α) were detected by enzyme-linked immunosorbent assay(elisa). |
2021-11-08 |
2023-08-13 |
rat |
| Ke-Zhuo Chen, Shi Chen, Jie-Yi Ren, Shi Lin, Ming-Jun Xiao, Li Cheng, Xiao-Chuan Y. [Antidepressant effect of acidic polysaccharides from Poria and their regulation of neurotransmitters and NLRP3 pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 19. 2021-11-08. PMID:34738405. |
the results showed that compared with the model group, acidic polysaccharides from poria at the low-, medium-, and high-doses(0.1, 0.3 and 0.5 g·kg~(-1)·d~(-1)) all improved the depression-like behavior of rats, increased the number of neurons and the levels of bdnf, 5-ht, 5-hiaa, da, and ne in the hippocampus, and reduced glu and serum il-1β, il-18, and tnf-α levels. |
2021-11-08 |
2023-08-13 |
rat |
| Andrey Sequeira-Cordero, Juan C Brene. Time-dependent changes in striatal monoamine levels and gene expression following single and repeated amphetamine administration in rats. European journal of pharmacology. vol 904. 2021-11-05. PMID:33961872. |
prone subjects characterized by having reduced striatal 5-ht metabolism, higher accumbal bdnf and trkb expression, and lower levels of creb in the dorsal striatum and p250gap in both regions. |
2021-11-05 |
2023-08-13 |
human |