| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ke-Zhuo Chen, Shi Chen, Jie-Yi Ren, Shi Lin, Ming-Jun Xiao, Li Cheng, Xiao-Chuan Y. [Antidepressant effect of acidic polysaccharides from Poria and their regulation of neurotransmitters and NLRP3 pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 19. 2021-11-08. PMID:34738405. |
the levels of brain-derived neurotrophic factor(bdnf), 5-hydroxytryptamine(5-ht), 5-hydroxyindoleacetic acid(5-hiaa), dopamine(da), norepinephrine(ne), glutamic acid(glu), interleukin-1β(il-1β), interleukin-18(il-18), and tumor necrosis factor-α(tnf-α) were detected by enzyme-linked immunosorbent assay(elisa). |
2021-11-08 |
2023-08-13 |
rat |
| Ke-Zhuo Chen, Shi Chen, Jie-Yi Ren, Shi Lin, Ming-Jun Xiao, Li Cheng, Xiao-Chuan Y. [Antidepressant effect of acidic polysaccharides from Poria and their regulation of neurotransmitters and NLRP3 pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 19. 2021-11-08. PMID:34738405. |
the results showed that compared with the model group, acidic polysaccharides from poria at the low-, medium-, and high-doses(0.1, 0.3 and 0.5 g·kg~(-1)·d~(-1)) all improved the depression-like behavior of rats, increased the number of neurons and the levels of bdnf, 5-ht, 5-hiaa, da, and ne in the hippocampus, and reduced glu and serum il-1β, il-18, and tnf-α levels. |
2021-11-08 |
2023-08-13 |
rat |
| Andrey Sequeira-Cordero, Juan C Brene. Time-dependent changes in striatal monoamine levels and gene expression following single and repeated amphetamine administration in rats. European journal of pharmacology. vol 904. 2021-11-05. PMID:33961872. |
prone subjects characterized by having reduced striatal 5-ht metabolism, higher accumbal bdnf and trkb expression, and lower levels of creb in the dorsal striatum and p250gap in both regions. |
2021-11-05 |
2023-08-13 |
human |
| Feng Tai, Che Wang, Xin Deng, Ruojin Li, Zimeng Guo, Haiying Quan, Song L. Treadmill exercise ameliorates chronic REM sleep deprivation-induced anxiety-like behavior and cognitive impairment in C57BL/6J mice. Brain research bulletin. vol 164. 2021-10-29. PMID:32877716. |
in addition, 2m-sd exposure increased ne and da, decreased 5-ht and gaba, and reduced igf-1 and bdnf levels in mouse hippocampus. |
2021-10-29 |
2023-08-13 |
mouse |
| Mahmoud S Abdallah, Esraa M Mosalam, Abdel-Aziz A Zidan, Khaled S Elattar, Shimaa A Zaki, Ahmed N Ramadan, Abla M Ebei. The Antidiabetic Metformin as an Adjunct to Antidepressants in Patients with Major Depressive Disorder: A Proof-of-Concept, Randomized, Double-Blind, Placebo-Controlled Trial. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 17. issue 4. 2021-10-28. PMID:32500486. |
the serum levels of tnf-α, il-1β, il-6, igf-1, mda, crp, bdnf, and serotonin were measured before and after therapy. |
2021-10-28 |
2023-08-13 |
Not clear |
| Markus Petermann, Golo Kronenberg, Valentina Mosienko, Michael Bader, Natalia Alenina, Rainer Hellweg, Friederike Klempi. Alterations in BDNF Protein Concentrations in the Hippocampus do not Explain the Pro-Neurogenic Effect of Citalopram on Adult Neurogenesis. Pharmacopsychiatry. vol 54. issue 3. 2021-10-28. PMID:33197939. |
brain-derived neurotrophic factor (bdnf) has been implicated in the pro-neurogenic effect of selective serotonin reuptake inhibitors. |
2021-10-28 |
2023-08-13 |
Not clear |
| Shirley Y Hill, Shuhui Wang, Howard Carter, Michael D McDermott, Nicholas Zezza, Scott Stiffle. Amygdala Volume in Offspring from Multiplex for Alcohol Dependence Families: The Moderating Influence of Childhood Environment and 5-HTTLPR Variation. Journal of alcoholism and drug dependence. vol Suppl 1. 2021-10-21. PMID:25285331. |
early childhood environment, genetic variation in the serotonin transporter-linked polymorphic region (5-httlpr) of the slca4 gene and allelic variation in the brain derived neurotrophic factor (bdnf) gene have each been reported to be related to volumetric differences in the temporal lobe especially the amygdala. |
2021-10-21 |
2023-08-13 |
Not clear |
| Asia Afzal, Zehra Batool, Sadia Sadir, Laraib Liaquat, Sidrah Shahzad, Saiqa Tabassum, Saara Ahmad, Noor Kamil, Tahira Perveen, Saida Haide. Therapeutic Potential of Curcumin in Reversing the Depression and Associated Pseudodementia via Modulating Stress Hormone, Hippocampal Neurotransmitters, and BDNF Levels in Rats. Neurochemical research. vol 46. issue 12. 2021-10-21. PMID:34409523. |
in addition to this, high corticosterone levels and decreased hippocampal bdnf, 5-ht, dopamine (da), and acetylcholine (ach) levels were also observed in depressed animals. |
2021-10-21 |
2023-08-13 |
rat |
| Lorena Henn, Natália C Zanta, Carlos Eduardo N Girardi, Deborah Sucheck. Chronic Escitalopram Treatment Does Not Alter the Effects of Neonatal Stress on Hippocampal BDNF Levels, 5-HT Molecular neurobiology. vol 58. issue 3. 2021-10-13. PMID:33063280. |
chronic escitalopram treatment does not alter the effects of neonatal stress on hippocampal bdnf levels, 5-ht early life stress is considered a risk factor for the development of long-term psychiatric disorders. |
2021-10-13 |
2023-08-13 |
Not clear |
| Lorena Henn, Natália C Zanta, Carlos Eduardo N Girardi, Deborah Sucheck. Chronic Escitalopram Treatment Does Not Alter the Effects of Neonatal Stress on Hippocampal BDNF Levels, 5-HT Molecular neurobiology. vol 58. issue 3. 2021-10-13. PMID:33063280. |
the goal of the present study was to examine the effects of a chronic treatment with escitalopram (esc) on the hippocampal levels of bdnf and neuropeptide y (npy), expression of serotonin type 1a receptor (5-ht |
2021-10-13 |
2023-08-13 |
Not clear |
| Phatcharee Chukaew, Alex Leow, Witchuda Saengsawang, Mark M Rasenic. Potential depression and antidepressant-response biomarkers in human lymphoblast cell lines from treatment-responsive and treatment-resistant subjects: roles of SSRIs and omega-3 polyunsaturated fatty acids. Molecular psychiatry. vol 26. issue 6. 2021-10-11. PMID:32327735. |
here we showed that n-3 pufas and escitalopram (selective serotonin reuptake inhibitors, ssris) treatment increased adenylyl cyclase (ac) and bdnf gene expression in lcls. |
2021-10-11 |
2023-08-13 |
human |
| Aneta Bednarova, Martina Cizmarikova, Viera Habalova, Dominika Jarcuskov. Evaluation of 5-HTTLPR (insertion/deletion) and BDNF (rs6265) genetic variations in the Slovakian individuals suffering from affective disorders. General physiology and biophysics. vol 40. issue 5. 2021-10-05. PMID:34602450. |
to understand risk factors of the disorders, we evaluated genetic variations of the serotonin reuptake transporter (5-httlpr, ins/del) and the brain-derived neurotrophic factor (bdnf, rs6265) in slovak patients suffering from ad. |
2021-10-05 |
2023-08-13 |
Not clear |
| Emilio Garro-Martínez, Maria Neus Fullana, Eva Florensa-Zanuy, Julia Senserrich, Verónica Paz, Esther Ruiz-Bronchal, Albert Adell, Elena Castro, Álvaro Díaz, Ángel Pazos, Analía Bortolozzi, Fuencisla Pilar-Cuélla. mTOR Knockdown in the Infralimbic Cortex Evokes A Depressive-like State in Mouse. International journal of molecular sciences. vol 22. issue 16. 2021-09-15. PMID:34445375. |
in parallel, decreased brain-derived neurotrophic factor (bdnf) expression was found bilaterally in both il and prl cortices along with a dysregulation of serotonin (5-ht) and glutamate (glu) release in the dorsal raphe nucleus (drn). |
2021-09-15 |
2023-08-13 |
mouse |
| Nina K Popova, Tatiana V Ilchibaeva, Egor V Antonov, Arina V Pershina, Darya V Bazovkina, Vladimir S Naumenk. On the interaction between BDNF and serotonin systems: The effects of long-term ethanol consumption in mice. Alcohol (Fayetteville, N.Y.). vol 87. 2021-09-14. PMID:32330588. |
on the interaction between bdnf and serotonin systems: the effects of long-term ethanol consumption in mice. |
2021-09-14 |
2023-08-13 |
mouse |
| Nina K Popova, Tatiana V Ilchibaeva, Egor V Antonov, Arina V Pershina, Darya V Bazovkina, Vladimir S Naumenk. On the interaction between BDNF and serotonin systems: The effects of long-term ethanol consumption in mice. Alcohol (Fayetteville, N.Y.). vol 87. 2021-09-14. PMID:32330588. |
we investigated the effect of chronic (6 weeks) consumption of 10% alcohol on the principal elements of bdnf (bdnf, probdnf, p75, and trkb receptors) and 5-ht (5-ht, 5-hiaa, tryptophan hydroxylase-2 [tph-2], 5-ht transporter [5-htt], 5-ht |
2021-09-14 |
2023-08-13 |
mouse |
| Yuanyuan Huang, Dangwei Peng, Hao Geng, Yutian Dai, Hui Jiang, Xiansheng Zhan. Endogenous Deficiency of Brain-Derived Neurotrophic Factor Induces the Downregulation of Tryptophan Hydroxylase-2 Expression in Raphe Nuclei of Rapid Ejaculator Rats. The journal of sexual medicine. vol 18. issue 9. 2021-09-13. PMID:34384732. |
recent studies have suggested a close relationship between the serotonin (5-hydroxytryptamine [5-ht]) system and brain-derived neurotrophic factor (bdnf), raising the question of whether bdnf plays a role in ejaculation regulation. |
2021-09-13 |
2023-08-13 |
rat |
| Yuanyuan Huang, Dangwei Peng, Hao Geng, Yutian Dai, Hui Jiang, Xiansheng Zhan. Endogenous Deficiency of Brain-Derived Neurotrophic Factor Induces the Downregulation of Tryptophan Hydroxylase-2 Expression in Raphe Nuclei of Rapid Ejaculator Rats. The journal of sexual medicine. vol 18. issue 9. 2021-09-13. PMID:34384732. |
at the same time, the interaction of central bdnf and 5-ht systems has not been undertaken in ejaculation regulation field. |
2021-09-13 |
2023-08-13 |
rat |
| Paul G Nestor, Victoria Choate Hasler, Keira O'Donovan, Hannah E Lapp, Sara B Boodai, Richard Hunte. In search of positive mental health: Personality profiles and genetic polymorphisms. Stress and health : journal of the International Society for the Investigation of Stress. vol 37. issue 2. 2021-08-20. PMID:33049110. |
participants also provided saliva samples, genotyped for both the serotonin transporter (5-httlpr) and the brain-derived neurotrophic factor (bdnf), each assayed for naturally occurring polymorphisms, 5-httlpr (short/long) and bdnf (valine/methionine). |
2021-08-20 |
2023-08-13 |
human |
| Fenghua Chen, Jibrin Danladi, Maryam Ardalan, Jens R Nyengaard, Connie Sanchez, Gregers Wegene. The rat hippocampal gliovascular system following one week vortioxetine and fluoxetine. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 42. 2021-08-20. PMID:33199100. |
we have previously reported that vortioxetine, unlike the selective serotonin reuptake inhibitor fluoxetine, produces a rapid increase of dendritic spine number and brain derived neurotrophic factor (bdnf)-associated formation of synapses with mitochondrial support in the rat hippocampal ca1 and dentate gyrus. |
2021-08-20 |
2023-08-13 |
rat |
| Safa Sefidgari-Abrasi, Leila Roshangar, Pouran Karimi, Mohammad Morshedi, Marziyeh Rahimiyan-Heravan, Maryam Saghafi-As. From the gut to the heart: L. plantarum and inulin administration as a novel approach to control cardiac apoptosis via 5-HT2B and TrkB receptors in diabetes. Clinical nutrition (Edinburgh, Scotland). vol 40. issue 1. 2021-08-17. PMID:32446786. |
brain-derived neurotrophic factor (bdnf) and serotonin are two neurotransmitters that can control cardiomyocyte apoptosis and myocardial fibrosis through their cardiac receptors. |
2021-08-17 |
2023-08-13 |
Not clear |