| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Danielle M Diniz, Francesca Calabrese, Paola Brivio, Marco A Riva, Joanes Grandjean, Judith R Homber. BDNF Overexpression in the Ventral Hippocampus Promotes Antidepressant- and Anxiolytic-Like Activity in Serotonin Transporter Knockout Rats. International journal of molecular sciences. vol 22. issue 9. 2021-06-15. PMID:34068707. |
bdnf overexpression in the ventral hippocampus promotes antidepressant- and anxiolytic-like activity in serotonin transporter knockout rats. |
2021-06-15 |
2023-08-13 |
human |
| Danielle M Diniz, Francesca Calabrese, Paola Brivio, Marco A Riva, Joanes Grandjean, Judith R Homber. BDNF Overexpression in the Ventral Hippocampus Promotes Antidepressant- and Anxiolytic-Like Activity in Serotonin Transporter Knockout Rats. International journal of molecular sciences. vol 22. issue 9. 2021-06-15. PMID:34068707. |
bdnf was found to be reduced in patients carrying the human polymorphism in the serotonin transporter promoter region (5-httlpr). |
2021-06-15 |
2023-08-13 |
human |
| Xiayang Xie, Kai Shang, Xuejing L. Tuling Wendan Decoction combined with flunarizine in the treatment of migraine patients and the effect of intervention on serum cyclooxygenase-2, endothelin-1 and nitric oxide. Cellular and molecular biology (Noisy-le-Grand, France). vol 66. issue 6. 2021-06-07. PMID:33040782. |
comparing the efficacy, incidence of adverse reactions, the incidence of headache, cerebral blood flow rate [basal artery (ba), vertebral artery (va), middle cerebral artery (mca)], vascular endothelial function (serum cox-2, et-1, no levels), neurological function [5-hydroxytryptamine (5-ht), brain-derived neurotrophic factor (bdnf), calcitonin gene-related peptide (cgrp)] before treatment, 4 weeks and 8 weeks after treatment between the two groups. |
2021-06-07 |
2023-08-13 |
Not clear |
| Xiayang Xie, Kai Shang, Xuejing L. Tuling Wendan Decoction combined with flunarizine in the treatment of migraine patients and the effect of intervention on serum cyclooxygenase-2, endothelin-1 and nitric oxide. Cellular and molecular biology (Noisy-le-Grand, France). vol 66. issue 6. 2021-06-07. PMID:33040782. |
the serum bdnf and cgrp levels of the observation group were lower than those of the control group after 4 weeks and 8 weeks of treatment, and the serum 5-ht levels were higher than the control group (p<0.05). |
2021-06-07 |
2023-08-13 |
Not clear |
| Xi Li, Qingqing Liu, Jiaoyan Yu, Ruitao Zhang, Ting Sun, Wei Jiang, Na Hu, Peng Yang, Li Luo, Jing Ren, Qinhui Wang, Yan Wang, Qi Yan. Costunolide ameliorates intestinal dysfunction and depressive behaviour in mice with stress-induced irritable bowel syndrome Food & function. vol 12. issue 9. 2021-06-07. PMID:33977961. |
cos was also found to upregulate glun2a, bdnf, p-erk1/2, and p-creb expression and 5-ht levels in hippocampal cells but inhibited 5-ht metabolism. |
2021-06-07 |
2023-08-13 |
mouse |
| Li Guo, Peilun Xiao, Xiaoxia Zhang, Yang Yang, Miao Yang, Ting Wang, Haixia Lu, Hongyan Tian, Hao Wang, Juan Li. Inulin ameliorates schizophrenia Food & function. vol 12. issue 3. 2021-06-04. PMID:33432310. |
the results of 16s rrna sequencing and analysis showed that inulin increased the abundance of lactobacillus and bifidobacterium, which were negatively correlated with 5-hydroxytryptamine and inflammatory cytokines and positively correlated with brain-derived neurotrophic factor (bdnf). |
2021-06-04 |
2023-08-13 |
mouse |
| Fang Gu, Yanyan Wu, Ying Liu, Mei Dou, Yushan Jiang, Hui Lian. Lactobacillus casei improves depression-like behavior in chronic unpredictable mild stress-induced rats by the BDNF-TrkB signal pathway and the intestinal microbiota. Food & function. vol 11. issue 7. 2021-06-03. PMID:32578646. |
furthermore, l. casei intervention reversed the cums-induced protein expression changes of monoamines dopamine, noradrenaline and 5-hydroxytryptamine, brain-derived neurotrophic factor (bdnf) and its receptor tyrosine kinase receptor b (trkb), and n-methyl-d-aspartic acid receptor 1, as well as cums-induced activations of erk1/2 and p38 mapk signal pathways. |
2021-06-03 |
2023-08-13 |
rat |
| Eun-Young Kim, Jeong-Eun Choi, Mijin Kim, Jisu Hong, Yongsoon Par. N-3 PUFA Have Antidepressant-like Effects Via Improvement of the HPA-Axis and Neurotransmission in Rats Exposed to Combined Stress. Molecular neurobiology. vol 57. issue 9. 2021-06-03. PMID:32613466. |
n-3 pufa also modulated brain phospholipid fatty acid concentration, thus reducing inflammatory cytokines; improved the serotonergic pathway, thus increasing the expression of the brain-derived neurotrophic factor (bdnf), camp response element-binding protein (creb), serotonin-1a receptor, and serum levels of serotonin; but did not affect glutamatergic neurotransmission. |
2021-06-03 |
2023-08-13 |
rat |
| Subramanian Thangaleela, Durairaj Ragu Varman, Karunanithi Sivasangari, Koilmani Emmanuvel Raja. Inhibition of monoamine oxidase attenuates social defeat-induced memory impairment in goldfish, (Carassius auratus): A possible involvement of synaptic proteins and BDNF. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 239. 2021-05-19. PMID:32805442. |
in addition, we noted that the expression of monoamine oxidase-a (mao-a) was up-regulated and level of serotonin (5-hydroxytryptamine; 5-ht), expression of serotonin transporter (sert), synaptophysin (syp), synaptotagmin -1 (syt-1), n-methyl-d-asparate (nmda) receptors subunits (nr2a and nr2b), postsynaptic density-95 (psd-95) and brain-derived neurotrophic factor (bdnf) were reduced by sd, while maois pretreatment protects the effect of sd. |
2021-05-19 |
2023-08-13 |
Not clear |
| Kata Nyárády, Réka Turai, Simone Funke, Erzsébet Györgyi, Alexandra Makai, Viktória Prémusz, József Bódis, Endre Sulyo. Effects of perinatal factors on sirtuin 3, 8-hydroxy-2'- deoxyguanosine, brain-derived neurotrophic factor and serotonin in cord blood and early breast milk: an observational study. International breastfeeding journal. vol 15. issue 1. 2021-05-17. PMID:32552911. |
the profile of sirtuin 3 (sirt3), 8-hydroxy-2'-deoxyguanosine (8-ohdg), brain-derived neurotrophic factor (bdnf) and serotonin (5-ht) in cord blood and in early breast milk was studied and it was related to perinatal factors. |
2021-05-17 |
2023-08-13 |
Not clear |
| Kata Nyárády, Réka Turai, Simone Funke, Erzsébet Györgyi, Alexandra Makai, Viktória Prémusz, József Bódis, Endre Sulyo. Effects of perinatal factors on sirtuin 3, 8-hydroxy-2'- deoxyguanosine, brain-derived neurotrophic factor and serotonin in cord blood and early breast milk: an observational study. International breastfeeding journal. vol 15. issue 1. 2021-05-17. PMID:32552911. |
5-ht and bdnf signalling systems have been claimed to play a critical role in intrauterine development, postnatal adaptation and lactation. |
2021-05-17 |
2023-08-13 |
Not clear |
| József Bódis, Endre Sulyok, Tamás Kőszegi, Viktória Prémusz, Ákos Várnagy, Miklós Koppá. Serum and follicular fluid levels of serotonin, kisspeptin, and brain-derived neurotrophic factor in patients undergoing The Journal of international medical research. vol 48. issue 4. 2021-05-14. PMID:31868047. |
serum and follicular fluid levels of serotonin, kisspeptin, and brain-derived neurotrophic factor in patients undergoing this study aimed to examine the effect of interactions between serotonin (5-ht), brain-derived neurotrophic factor (bdnf), and kisspeptin on the reproductive potential in women receiving |
2021-05-14 |
2023-08-13 |
Not clear |
| Fantao Meng, Jing Liu, Juanjuan Dai, Min Wu, Wentao Wang, Cuilan Liu, Di Zhao, Hongcai Wang, Jingyan Zhang, Min Li, Chen L. Brain-derived neurotrophic factor in 5-HT neurons regulates susceptibility to depression-related behaviors induced by subchronic unpredictable stress. Journal of psychiatric research. vol 126. 2021-05-14. PMID:32416387. |
bdnf was highly expressed in 5- hydroxytryptamine (5-ht) neurons from the drn. |
2021-05-14 |
2023-08-13 |
mouse |
| Fantao Meng, Jing Liu, Juanjuan Dai, Min Wu, Wentao Wang, Cuilan Liu, Di Zhao, Hongcai Wang, Jingyan Zhang, Min Li, Chen L. Brain-derived neurotrophic factor in 5-HT neurons regulates susceptibility to depression-related behaviors induced by subchronic unpredictable stress. Journal of psychiatric research. vol 126. 2021-05-14. PMID:32416387. |
selective deletion of bdnf in 5-ht neurons alone could not induce anhedonia and behavioral despair in male or female mice, as indicated by the unchanged female urine sniffing time and preference for sucrose/saccharin. |
2021-05-14 |
2023-08-13 |
mouse |
| Fantao Meng, Jing Liu, Juanjuan Dai, Min Wu, Wentao Wang, Cuilan Liu, Di Zhao, Hongcai Wang, Jingyan Zhang, Min Li, Chen L. Brain-derived neurotrophic factor in 5-HT neurons regulates susceptibility to depression-related behaviors induced by subchronic unpredictable stress. Journal of psychiatric research. vol 126. 2021-05-14. PMID:32416387. |
furtherly, total bdnf mrna levels in drn were correlated with depression-related behaviors of female, but not male 5-ht neurons specific bdnf knockout mice. |
2021-05-14 |
2023-08-13 |
mouse |
| Fantao Meng, Jing Liu, Juanjuan Dai, Min Wu, Wentao Wang, Cuilan Liu, Di Zhao, Hongcai Wang, Jingyan Zhang, Min Li, Chen L. Brain-derived neurotrophic factor in 5-HT neurons regulates susceptibility to depression-related behaviors induced by subchronic unpredictable stress. Journal of psychiatric research. vol 126. 2021-05-14. PMID:32416387. |
our results indicate that bdnf might act on 5-ht neurons to regulate depression-related behaviors and stress vulnerability in a sex-dependent manner. |
2021-05-14 |
2023-08-13 |
mouse |
| Yang Li, Tong Liu, Weifeng Lu. Botulinum Neurotoxin Therapy for Depression: Therapeutic Mechanisms and Future Perspective. Frontiers in psychiatry. vol 12. 2021-05-13. PMID:33967844. |
notably, we recently identified that the anti-depressant effects of bont/a associated with up-regulation of 5-ht levels and brain-derived neurotrophic factor (bdnf) expression in the hippocampus in a preclinical mouse model. |
2021-05-13 |
2023-08-13 |
mouse |
| Hang Xu, Xiang Yang Zhang, Wei Wen Wang, Jiesi Wan. Hydroxychloroquine Increased Anxiety-Like Behaviors and Disrupted the Expression of Some Related Genes in the Mouse Brain. Frontiers in pharmacology. vol 12. 2021-05-08. PMID:33953673. |
furthermore, hcq decreased the mrna expression of interleukin-1beta, corticotropin-releasing hormone (crh), a serotonin transporter (slc6a4), and a microglia maker (aif1) in the hippocampus and decreased the mrna expression of brain-derived neurotrophic factor (bdnf) in both the hippocampus and amygdala. |
2021-05-08 |
2023-08-13 |
mouse |
| Merve Demirbugen Oz, Bora Baskak, Zuhal Uckun, Nazan Yuce Artun, Hatice Ozdemir, Tugba Kizil Ozel, Halise Devrimci Ozguven, H Sinan Suze. Association between serotonin 2A receptor (HTR2A), serotonin transporter (SLC6A4) and brain-derived neurotrophic factor (BDNF) gene polymorphisms and citalopram/sertraline induced sexual dysfunction in MDD patients. The pharmacogenomics journal. vol 20. issue 3. 2021-05-07. PMID:31792367. |
association between serotonin 2a receptor (htr2a), serotonin transporter (slc6a4) and brain-derived neurotrophic factor (bdnf) gene polymorphisms and citalopram/sertraline induced sexual dysfunction in mdd patients. |
2021-05-07 |
2023-08-13 |
human |
| Merve Demirbugen Oz, Bora Baskak, Zuhal Uckun, Nazan Yuce Artun, Hatice Ozdemir, Tugba Kizil Ozel, Halise Devrimci Ozguven, H Sinan Suze. Association between serotonin 2A receptor (HTR2A), serotonin transporter (SLC6A4) and brain-derived neurotrophic factor (BDNF) gene polymorphisms and citalopram/sertraline induced sexual dysfunction in MDD patients. The pharmacogenomics journal. vol 20. issue 3. 2021-05-07. PMID:31792367. |
the present study aimed to determine the relationship between serotonin-2a receptor (htr2a) gene -1438a/g and 102t/c polymorphisms, serotonin transporter gene (slc6a4) 5-htt-linked polymorphic region (5-httlpr) insertion/deletion variant and brain-derived neurotrophic factor (bdnf) gene val66met polymorphisms and the occurrence of sd adverse effect in major depressive disorder patients treated with citalopram (cit) or sertraline (sert). |
2021-05-07 |
2023-08-13 |
human |