| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wen Shan Yang, Zhen-Guo Shi, Xian-Zhe Dong, Ping Liu, Meng-Li Chen, Yuan H. Involvement of 5-HT-BDNF signaling axis in mediating synergistic antidepressant-like effects after combined administration of two oligosaccharide esters. Food science & nutrition. vol 9. issue 2. 2021-02-19. PMID:33598202. |
moreover, combined treatment of diss and tfsa also demonstrated enhanced levels of 5-hydroxytryptamine (5-ht), and stronger increase in the phosphorylation levels of creb, bdnf, and crtc1 proteins in the hippocampus. |
2021-02-19 |
2023-08-13 |
Not clear |
| Wen Shan Yang, Zhen-Guo Shi, Xian-Zhe Dong, Ping Liu, Meng-Li Chen, Yuan H. Involvement of 5-HT-BDNF signaling axis in mediating synergistic antidepressant-like effects after combined administration of two oligosaccharide esters. Food science & nutrition. vol 9. issue 2. 2021-02-19. PMID:33598202. |
thus, the antidepressant properties of both these compounds can be attributed to their ability to influence 5-ht and bdnf pathway, and thereby suggesting that this combination strategy can definitely act as alternative therapy for depression disorder with very limited side effects. |
2021-02-19 |
2023-08-13 |
Not clear |
| Xiaoxia Huang, Wu Li, Bangyan You, Wanpei Tang, Tingsheng Gan, Chao Feng, Congfa Li, Ruili Yan. Serum Metabonomic Study on the Antidepressant-like Effects of Ellagic Acid in a Chronic Unpredictable Mild Stress-Induced Mouse Model. Journal of agricultural and food chemistry. vol 68. issue 35. 2021-02-03. PMID:32786855. |
furthermore, ea attenuated the cums-induced hippocampal damage and significantly increased the brain-derived neurotrophic factor (bdnf) and the serotonin (5-ht) levels as well as suppressed the inflammatory response. |
2021-02-03 |
2023-08-13 |
mouse |
| Tao Yang, Xubo Wang, Lei Liu, Hanwen Chen, Na Wan. Ginkgolide-Platinum(II) Complex GPt(II) Exhibits Therapeutic Effect on Depression in Mice via Upregulation of DA and 5-HT Neurotransmitters. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-02-02. PMID:32484164. |
treatment of mice with gpt(ii) significantly elevated dopamine, bdnf, and serotonin levels in hippocampus tissues. |
2021-02-02 |
2023-08-13 |
mouse |
| Tao Yang, Xubo Wang, Lei Liu, Hanwen Chen, Na Wan. Ginkgolide-Platinum(II) Complex GPt(II) Exhibits Therapeutic Effect on Depression in Mice via Upregulation of DA and 5-HT Neurotransmitters. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-02-02. PMID:32484164. |
the levels of dopamine, serotonin, and bdnf were increased from 187.83±8.53, 289.65±10.76, and 7.98±1.87 ng/g, respectively, in the model group to 657.63±24.47, 720.54±28.09, and 22.56±3.11 ng/g, respectively, in the 12 mg/kg gpt(ii) treatment group. |
2021-02-02 |
2023-08-13 |
mouse |
| Hui-Rong Guo, Bai-Ling Huang, Ya-Li Wang, Yan-Yan Zhang, Quan-Gang Ma, Pei-Pei Lv, Yu-Ming Re. Effect of Escitalopram on Serum GDNF and BDNF Levels and 5-HT Level of Brain Tissue of Obsessive-Compulsive Disorder Rats. Cellular and molecular neurobiology. vol 40. issue 6. 2021-01-22. PMID:31927718. |
effect of escitalopram on serum gdnf and bdnf levels and 5-ht level of brain tissue of obsessive-compulsive disorder rats. |
2021-01-22 |
2023-08-13 |
rat |
| Hui-Rong Guo, Bai-Ling Huang, Ya-Li Wang, Yan-Yan Zhang, Quan-Gang Ma, Pei-Pei Lv, Yu-Ming Re. Effect of Escitalopram on Serum GDNF and BDNF Levels and 5-HT Level of Brain Tissue of Obsessive-Compulsive Disorder Rats. Cellular and molecular neurobiology. vol 40. issue 6. 2021-01-22. PMID:31927718. |
the present study aims to discuss the effect of escitalopram in glial cell line-derived neurotrophic factor (gdnf), brain-derived neurotrophic factor (bdnf) levels, and 5-hydroxytryptamine (5-ht) in obsessive-compulsive disorder rats. |
2021-01-22 |
2023-08-13 |
rat |
| Hui-Rong Guo, Bai-Ling Huang, Ya-Li Wang, Yan-Yan Zhang, Quan-Gang Ma, Pei-Pei Lv, Yu-Ming Re. Effect of Escitalopram on Serum GDNF and BDNF Levels and 5-HT Level of Brain Tissue of Obsessive-Compulsive Disorder Rats. Cellular and molecular neurobiology. vol 40. issue 6. 2021-01-22. PMID:31927718. |
in addition, western blot was used to determine the brain tissue protein levels of gdnf and bdnf and high-performance liquid chromatography + electrochemistry method to determine the 5-ht level of brain tissue. |
2021-01-22 |
2023-08-13 |
rat |
| Hui-Rong Guo, Bai-Ling Huang, Ya-Li Wang, Yan-Yan Zhang, Quan-Gang Ma, Pei-Pei Lv, Yu-Ming Re. Effect of Escitalopram on Serum GDNF and BDNF Levels and 5-HT Level of Brain Tissue of Obsessive-Compulsive Disorder Rats. Cellular and molecular neurobiology. vol 40. issue 6. 2021-01-22. PMID:31927718. |
escitalopram could increase gdnf and bdnf levels and 5-ht content in serum and brain tissue in obsessive-compulsive disorder rats, which contributes to a function on the treatment of obsessive-compulsive disorder. |
2021-01-22 |
2023-08-13 |
rat |
| Brittany E Dong, Hao Chen, Kazuko Sakat. BDNF deficiency and enriched environment treatment affect neurotransmitter gene expression differently across ages. Journal of neurochemistry. vol 154. issue 1. 2020-12-04. PMID:32222968. |
high-throughput quantitative reverse transcription polymerase chain reaction measured expression of 81 genes for dopamine, adrenaline, serotonin, gamma aminobutyric acid, glutamate, acetylcholine, and bdnf systems in the frontal cortex (fc) and hippocampus. |
2020-12-04 |
2023-08-13 |
mouse |
| Christopher B German. The Psilocybin-Telomere Hypothesis: An empirically falsifiable prediction concerning the beneficial neuropsychopharmacological effects of psilocybin on genetic aging. Medical hypotheses. vol 134. 2020-11-23. PMID:31634774. |
in order to substantiate the 'psilocybin-telomere hypothesis' potential neuropsychopharmacological, endocrinological, and genetic mechanisms of action are discussed (e.g., hpa-axis reactivity, hippocampal neurogenesis, neurotropic growth factors such as bdnf, 5-ht |
2020-11-23 |
2023-08-13 |
human |
| Hajer Jasim, Bijar Ghafouri, Björn Gerdle, Britt Hedenberg-Magnusson, Malin Ernber. Altered levels of salivary and plasma pain related markers in temporomandibular disorders. The journal of headache and pain. vol 21. issue 1. 2020-11-23. PMID:32842964. |
the aims of the current study were to compare concentration of glutamate, serotonin (5-ht), nerve growth factor (ngf), brain-derived neurotrophic factor (bdnf), and substance p (sp) in saliva and plasma from a well-defined group of patients with chronic temporomandibular disorders myalgia (tmd-myalgia) with a group of pain-free controls, and further investigate the relationship between these markers and clinical characteristics. |
2020-11-23 |
2023-08-13 |
Not clear |
| Aaveri Sengupta, Ujjal Das, Krishnendu Manna, Sushobhan Biswas, Siddhartha Datta, Amitava Khan, Tuhin Bhattacharya, Samrat Saha, Tapashi Mitra, Swapan Mukherjee, Anup K Sadhu, Suhrita Paul, Saurabh Ghosh, Rakhi Dey Sharma, Sanjit De. An association study of severity of intellectual disability with peripheral biomarkers of disabled children in a rehabilitation home, Kolkata, India. Scientific reports. vol 9. issue 1. 2020-10-28. PMID:31541143. |
the lipid peroxidation of pbmc and rbc membranes, levels of serum glutamate, serotonin, homocysteine, ros, lactate and ldh-a expression increased significantly with severity of id whereas changes in rbc membrane β-actin, serum bdnf, tnf-α and il-6 was found non-significant. |
2020-10-28 |
2023-08-13 |
human |
| Valeria Salinas, Juana Villarroel, Hernán Silva, Luisa Herrera, Sonia Jerez, Alejandra Zazueta, Cristián Montes, Rodrigo Nieto, M Leonor Bustamant. SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorder. BMC research notes. vol 13. issue 1. 2020-10-26. PMID:32033618. |
we studied 76 patients diagnosed with borderline personality disorder (bpd), characterized by extreme levels of personality traits, especially neuroticism (n), in which we genotyped two polymorphisms, the 5httlpr of the serotonin transporter (sert) gene, and the val66met of the brain-derived neurotrophic factor (bdnf) gene. |
2020-10-26 |
2023-08-13 |
Not clear |
| Yingying Zhou, Xinyi Wang, Yuhang Zhao, Aihua Liu, Tong Zhao, Yuanyuan Zhang, Zhongyan Shan, Weiping Ten. Elevated Thyroid Peroxidase Antibody Increases Risk of Post-partum Depression by Decreasing Prefrontal Cortex BDNF and 5-HT Levels in Mice. Frontiers in cellular neuroscience. vol 10. 2020-10-01. PMID:28119573. |
elevated thyroid peroxidase antibody increases risk of post-partum depression by decreasing prefrontal cortex bdnf and 5-ht levels in mice. |
2020-10-01 |
2023-08-13 |
mouse |
| Yingying Zhou, Xinyi Wang, Yuhang Zhao, Aihua Liu, Tong Zhao, Yuanyuan Zhang, Zhongyan Shan, Weiping Ten. Elevated Thyroid Peroxidase Antibody Increases Risk of Post-partum Depression by Decreasing Prefrontal Cortex BDNF and 5-HT Levels in Mice. Frontiers in cellular neuroscience. vol 10. 2020-10-01. PMID:28119573. |
furthermore, in the prefrontal cortex, the mrna and protein expression levels of brain-derived neurotrophic factor (bdnf) were measured, serotonin (5-ht) levels were measured by ultra-high-performance liquid chromatography-tandem mass-spectrometry (uhplc-ms/ms), and total thyroxine (tt4) levels were determined by elisa. |
2020-10-01 |
2023-08-13 |
mouse |
| Yingying Zhou, Xinyi Wang, Yuhang Zhao, Aihua Liu, Tong Zhao, Yuanyuan Zhang, Zhongyan Shan, Weiping Ten. Elevated Thyroid Peroxidase Antibody Increases Risk of Post-partum Depression by Decreasing Prefrontal Cortex BDNF and 5-HT Levels in Mice. Frontiers in cellular neuroscience. vol 10. 2020-10-01. PMID:28119573. |
compared with the controls, the mice immunized with mtpo-ad displayed depressive behaviors, with a significantly lower sucrose preference (sp) at the 12-h time point and a longer immobility time in the fst and tst, which were accompanied by a lower expression of bdnf and 5-ht but no change in the tt4 concentration in the prefrontal cortex. |
2020-10-01 |
2023-08-13 |
mouse |
| Yingying Zhou, Xinyi Wang, Yuhang Zhao, Aihua Liu, Tong Zhao, Yuanyuan Zhang, Zhongyan Shan, Weiping Ten. Elevated Thyroid Peroxidase Antibody Increases Risk of Post-partum Depression by Decreasing Prefrontal Cortex BDNF and 5-HT Levels in Mice. Frontiers in cellular neuroscience. vol 10. 2020-10-01. PMID:28119573. |
together, these findings suggest that elevated tpoab may increase the risk of subsequent ppd and decrease the concentration of bdnf and 5-ht in the prefrontal cortex. |
2020-10-01 |
2023-08-13 |
mouse |
| Walter J Lukiw, Evgeny I Rogae. Genetics of Aggression in Alzheimer's Disease (AD). Frontiers in aging neuroscience. vol 9. 2020-10-01. PMID:28443016. |
interestingly, (i) the expression of three of these six genes (comt, dbh, nos1) are highly variable; (ii) three of these six genes (comt, dbh, tph1) are involved in da or serotonin metabolism, biosynthesis and/or neurotransmission; and (iii) five of these six genes (ar, bdnf, comt, dbh, nos1) have been implicated in the development, onset and/or propagation of schizophrenia. |
2020-10-01 |
2023-08-13 |
human |
| Yi-Lu Ye, Kai Zhong, Dan-Dan Liu, Jing Xu, Bei-Bei Pan, Xiang Li, Yue-Ping Yu, Qi Zhan. Huanglian-Jie-Du-Tang Extract Ameliorates Depression-Like Behaviors through BDNF-TrkB-CREB Pathway in Rats with Chronic Unpredictable Stress. Evidence-based complementary and alternative medicine : eCAM. vol 2017. 2020-10-01. PMID:28694833. |
5-hydroxytryptamine (5-ht) and dopamine (da) contents, microglial activation, proinflammatory cytokines, and brain derived neurotrophic factor (bdnf), tropomyosin receptor kinases b (trkb), and camp-responsive element binding protein (creb) expression were investigated. |
2020-10-01 |
2023-08-13 |
rat |