| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhi-Long Zhang, Yu-Gang Gao, Pu Zang, Pei-Pei Gu, Yan Zhao, Zhong-Mei He, Hong-Yan Zh. [Research progress on mechanism of gastrodin and p-hydroxybenzyl alcohol on central nervous system]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 2. 2020-06-23. PMID:32237313. |
they alleviate hippocampal neuronal toxicity mainly by regulating a variety of neurotransmitters, such as acetylcholine, glutamic acid(glu), γ-aminobutyric acid(gaba), serotonin(5-ht), dopamine(da), norepinephrine(ne), 5-indoleacetic acid(5-hiaa), high vanillic acid(hva) and dihydroxyphenylacetic acid(dopac), pro-inflammatory cell growth factors, such as il-1β, il-6 and tnf-α and relevant receptor functions, and exert neuropharmacological effects by effectively increasing mrna expressions of brain neurotrophic factors, such as bdnf and gdnf, and further inhibiting the apoptosis of damaged neurons. |
2020-06-23 |
2023-08-13 |
Not clear |
| Andre R Brunoni, Angel Carracedo, Olalla M Amigo, Ana L Pellicer, Leda Talib, Andre F Carvalho, Paulo A Lotufo, Isabela M Benseñor, Wagner Gattaz, Carolina Capp. Association of BDNF, HTR2A, TPH1, SLC6A4, and COMT polymorphisms with tDCS and escitalopram efficacy: ancillary analysis of a double-blind, placebo-controlled trial. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). vol 42. issue 2. 2020-05-26. PMID:31721892. |
we investigated whether single nucleotide polymorphisms (snps) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (bdnf, rs6265), the serotonin transporter (slc6a4, rs25531), the tryptophan hydroxylase 1 (tph1, rs1800532), the 5-hydroxytryptamine receptor 2a (htr2a, rs6311, rs6313, rs7997012), and the catechol-o-methyltransferase (comt, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tdcs) in major depression. |
2020-05-26 |
2023-08-13 |
Not clear |
| Jodi L Pawluski, Ursula Brain, Geoffrey L Hammond, Tim F Oberlande. Selective serotonin reuptake inhibitor effects on neural biomarkers of perinatal depression. Archives of women's mental health. vol 22. issue 3. 2020-05-11. PMID:30506371. |
the effect of perinatal selective serotonin reuptake inhibitors (ssris) on brain-derived neurotrophic factor (bdnf) and s100 calcium binding protein b (s100b) has not been investigated. |
2020-05-11 |
2023-08-13 |
Not clear |
| Vishnu N Thakare, Rajesh R Patil, Anupama A Suralkar, Valmik D Dhakane, Bhoomika M Pate. Protocatechuic acid attenuate depressive-like behavior in olfactory bulbectomized rat model: behavioral and neurobiochemical investigations. Metabolic brain disease. vol 34. issue 3. 2020-05-11. PMID:30848471. |
behavioral (ambulatory and rearing activity and immobility time), neurochemical [serotonin (5-ht), dopamine (da), norepinephrine (ne) and brain derived neurotrophic factor (bdnf) expression], biochemical (mda formation, il-6, tnf-α and antioxidants) changes in hippocampus and cerebral cortex along with serum corticosterone were investigated. |
2020-05-11 |
2023-08-13 |
rat |
| Vishnu N Thakare, Rajesh R Patil, Anupama A Suralkar, Valmik D Dhakane, Bhoomika M Pate. Protocatechuic acid attenuate depressive-like behavior in olfactory bulbectomized rat model: behavioral and neurobiochemical investigations. Metabolic brain disease. vol 34. issue 3. 2020-05-11. PMID:30848471. |
experimental findings reveals that obx subjected rats showed alteration in behaviors like, increase in immobility time, ambulatory and rearing behaviors significantly, reduced bdnf level, 5-ht, da,ne and antioxidant parameters along with increased serum corticosterone, mda formation, il-6, and tnf-α in hippocampus and cerebral cortex compared to sham operated rats. |
2020-05-11 |
2023-08-13 |
rat |
| Vishnu N Thakare, Rajesh R Patil, Anupama A Suralkar, Valmik D Dhakane, Bhoomika M Pate. Protocatechuic acid attenuate depressive-like behavior in olfactory bulbectomized rat model: behavioral and neurobiochemical investigations. Metabolic brain disease. vol 34. issue 3. 2020-05-11. PMID:30848471. |
administration of pca significantly attenuated behavioral and neurobiochemical alterations, thus, its antidepressant-like activity is largely mediated through modulation of neurotransmitter, endocrine and immunologic systems, mainly by improvements of bdnf, 5-ht, da, ne, reduced mda, il-6, and tnf-α in hippocampus and cerebral cortex. |
2020-05-11 |
2023-08-13 |
rat |
| Mohsen Enayati, Belal Mosaferi, Judith R Homberg, Danielle Mendes Diniz, Ali-Akbar Salar. Prenatal maternal stress alters depression-related symptoms in a strain - and sex-dependent manner in rodent offspring. Life sciences. vol 251. 2020-05-05. PMID:32243926. |
we measured basal and stress-induced corticosterone levels in the serum, and brain-derived-neurotrophic-factor (bdnf), interleukin-1β, tumor necrosis factor-α, glutamate and serotonin in the brain to determine changes in hypothalamic-pituitary-adrenal-(hpa)-axis function, neuroplasticity, neuroinflammation, and neurotransmission. |
2020-05-05 |
2023-08-13 |
mouse |
| Mohsen Enayati, Belal Mosaferi, Judith R Homberg, Danielle Mendes Diniz, Ali-Akbar Salar. Prenatal maternal stress alters depression-related symptoms in a strain - and sex-dependent manner in rodent offspring. Life sciences. vol 251. 2020-05-05. PMID:32243926. |
our findings revealed that prenatal stress increases depression-like behaviour, hpa-axis (re) activity, pro-inflammatory cytokines and glutamate levels, and decreases bdnf and serotonin levels in a strain and sex-dependent manner in rodent offspring. |
2020-05-05 |
2023-08-13 |
mouse |
| Prabesh Bhattarai, Mehmet Ilyas Cosacak, Violeta Mashkaryan, Sevgican Demir, Stanislava Dimitrova Popova, Nambirajan Govindarajan, Kerstin Brandt, Yixin Zhang, Weipang Chang, Konstantinos Ampatzis, Caghan Kizi. Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer's model of adult zebrafish brain. PLoS biology. vol 18. issue 1. 2020-04-24. PMID:31905199. |
nsc proliferation was suppressed by serotonin via down-regulation of brain-derived neurotrophic factor (bdnf)-expression in serotonin-responsive periventricular neurons. |
2020-04-24 |
2023-08-13 |
zebrafish |
| M Dimitriadis, R H S van den Brink, H C Comijs, R C Oude Voshaa. Prognostic effect of serum BDNF levels in late-life depression: Moderated by childhood trauma and SSRI usage? Psychoneuroendocrinology. vol 103. 2020-04-23. PMID:30771710. |
we hypothesize that the predictive value of serum bdnf levels in late-life depression is moderated by selective serotonin reuptake inhibitors (ssri) usage and early traumatization. |
2020-04-23 |
2023-08-13 |
Not clear |
| Kan Gao, Yu Pi, Chun-Long Mu, Aitak Farzi, Zhuang Liu, Wei-Yun Zh. Increasing carbohydrate availability in the hindgut promotes hypothalamic neurotransmitter synthesis: aromatic amino acids linking the microbiota-brain axis. Journal of neurochemistry. vol 149. issue 5. 2020-03-13. PMID:31006109. |
increasing carbohydrate availability by cecal starch infusion led to a decrease in hindgut aaa metabolism, and an increase in systemic aaa availability, central aaa-derived neurotransmitters (5-ht, dopamine), and neurotrophin bdnf in piglets, indicating that hindgut microbiota affect hypothalamic neurochemistry in an aaa-dependent manner. |
2020-03-13 |
2023-08-13 |
mouse |
| Kan Gao, Yu Pi, Chun-Long Mu, Aitak Farzi, Zhuang Liu, Wei-Yun Zh. Increasing carbohydrate availability in the hindgut promotes hypothalamic neurotransmitter synthesis: aromatic amino acids linking the microbiota-brain axis. Journal of neurochemistry. vol 149. issue 5. 2020-03-13. PMID:31006109. |
injection in mice revealed that an increase in circulating tryptophan and tyrosine elevated their concentrations in brain and finally promoted the expressions of 5-ht, dopamine, and bdnf in a time-dependent manner. |
2020-03-13 |
2023-08-13 |
mouse |
| Kan Gao, Yu Pi, Chun-Long Mu, Aitak Farzi, Zhuang Liu, Wei-Yun Zh. Increasing carbohydrate availability in the hindgut promotes hypothalamic neurotransmitter synthesis: aromatic amino acids linking the microbiota-brain axis. Journal of neurochemistry. vol 149. issue 5. 2020-03-13. PMID:31006109. |
neuronal cells treated with single aaas in vitro further demonstrated that tryptophan and tyrosine enhanced 5-ht and dopamine synthesis, respectively, and promoted bdnf expression partly through the 5-ht1a/drd1-creb pathway. |
2020-03-13 |
2023-08-13 |
mouse |
| Nina K Popova, Vladimir S Naumenk. Neuronal and behavioral plasticity: the role of serotonin and BDNF systems tandem. Expert opinion on therapeutic targets. vol 23. issue 3. 2020-03-06. PMID:30661441. |
neuronal and behavioral plasticity: the role of serotonin and bdnf systems tandem. |
2020-03-06 |
2023-08-13 |
Not clear |
| Nina K Popova, Vladimir S Naumenk. Neuronal and behavioral plasticity: the role of serotonin and BDNF systems tandem. Expert opinion on therapeutic targets. vol 23. issue 3. 2020-03-06. PMID:30661441. |
serotonin (5-ht) and brain-derived neurotrophic factor (bdnf) are known as principal players in different kinds of plasticity. |
2020-03-06 |
2023-08-13 |
Not clear |
| Nina K Popova, Vladimir S Naumenk. Neuronal and behavioral plasticity: the role of serotonin and BDNF systems tandem. Expert opinion on therapeutic targets. vol 23. issue 3. 2020-03-06. PMID:30661441. |
area covered: this paper concentrates on the interaction between 5-ht and bdnf systems and its implication in different plasticity levels, from neurons to behavior. |
2020-03-06 |
2023-08-13 |
Not clear |
| Nina K Popova, Vladimir S Naumenk. Neuronal and behavioral plasticity: the role of serotonin and BDNF systems tandem. Expert opinion on therapeutic targets. vol 23. issue 3. 2020-03-06. PMID:30661441. |
this review describes (1) different 5-ht functioning in the embryonic (as neurotrophin) and adult brain (as a neurotransmitter); (2) bdnf as a modulator of 5-ht system and vice versa; (3) the prolonged positive effect of bdnf on genetically and epigenetically defined central nervous system disorders; (4) the 5-ht-bdnf interplay contribution to aggressive behavior, depression, drug addiction, suicide, and stress response; and (5) the role of common second messengers for 5-ht and bdnf signaling in the 5-ht-bdnf interaction. |
2020-03-06 |
2023-08-13 |
Not clear |
| Nina K Popova, Vladimir S Naumenk. Neuronal and behavioral plasticity: the role of serotonin and BDNF systems tandem. Expert opinion on therapeutic targets. vol 23. issue 3. 2020-03-06. PMID:30661441. |
understanding the function of the members of bdnf system in response to challenges of the environment and the interaction with different 5-ht receptors in health and disease will one day lead to new classes of drugs. |
2020-03-06 |
2023-08-13 |
Not clear |
| Ankit Uniyal, Raghunath Singh, Ansab Akhtar, Yashika Bansal, Anurag Kuhad, Sangeeta Pilkhwal Sa. Co-treatment of piracetam with risperidone rescued extinction deficits in experimental paradigms of post-traumatic stress disorder by restoring the physiological alterations in cortex and hippocampus. Pharmacology, biochemistry, and behavior. vol 185. 2020-02-26. PMID:31445955. |
neurotransmitters (dopamine and serotonin and their metabolites), bdnf, proinflammatory cytokines (tnf-α, il-6), caspase-3, and markers for oxidative stress were assessed in the hippocampus and cortex while corticosterone and nitrite levels were estimated in plasma. |
2020-02-26 |
2023-08-13 |
rat |
| Atef Tadros Fahim, Amal Ahmed Abd El-Fattah, Nermin Abdel Hamid Sadik, Bassam Mohamed Al. Resveratrol and dimethyl fumarate ameliorate testicular dysfunction caused by chronic unpredictable mild stress-induced depression in rats. Archives of biochemistry and biophysics. vol 665. 2020-02-14. PMID:30904419. |
cums-induced depressive-like behaviours in rats were evidenced by increased serum corticosterone levels and decreased serum and hippocampal serotonin levels as well as decreased hippocampal bdnf levels. |
2020-02-14 |
2023-08-13 |
rat |