| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nina K Popova, Vladimir S Naumenk. Neuronal and behavioral plasticity: the role of serotonin and BDNF systems tandem. Expert opinion on therapeutic targets. vol 23. issue 3. 2020-03-06. PMID:30661441. |
understanding the function of the members of bdnf system in response to challenges of the environment and the interaction with different 5-ht receptors in health and disease will one day lead to new classes of drugs. |
2020-03-06 |
2023-08-13 |
Not clear |
| Ankit Uniyal, Raghunath Singh, Ansab Akhtar, Yashika Bansal, Anurag Kuhad, Sangeeta Pilkhwal Sa. Co-treatment of piracetam with risperidone rescued extinction deficits in experimental paradigms of post-traumatic stress disorder by restoring the physiological alterations in cortex and hippocampus. Pharmacology, biochemistry, and behavior. vol 185. 2020-02-26. PMID:31445955. |
neurotransmitters (dopamine and serotonin and their metabolites), bdnf, proinflammatory cytokines (tnf-α, il-6), caspase-3, and markers for oxidative stress were assessed in the hippocampus and cortex while corticosterone and nitrite levels were estimated in plasma. |
2020-02-26 |
2023-08-13 |
rat |
| Atef Tadros Fahim, Amal Ahmed Abd El-Fattah, Nermin Abdel Hamid Sadik, Bassam Mohamed Al. Resveratrol and dimethyl fumarate ameliorate testicular dysfunction caused by chronic unpredictable mild stress-induced depression in rats. Archives of biochemistry and biophysics. vol 665. 2020-02-14. PMID:30904419. |
cums-induced depressive-like behaviours in rats were evidenced by increased serum corticosterone levels and decreased serum and hippocampal serotonin levels as well as decreased hippocampal bdnf levels. |
2020-02-14 |
2023-08-13 |
rat |
| Xinnan Zhao, Fengrui Cao, Qing Liu, Xinsheng Li, Guoyang Xu, Gang Liu, Yanli Zhang, Xiaohan Yang, Shansong Yi, Fenghua Xu, Kai Fan, Jianmei M. Behavioral, inflammatory and neurochemical disturbances in LPS and UCMS-induced mouse models of depression. Behavioural brain research. vol 364. 2020-02-13. PMID:28572058. |
the decrease of 5-ht and bdnf was detected only in hippocampus of lps-stressed mice, but in overall all the brain areas assessed in ucms-stressed mice as compared to control. |
2020-02-13 |
2023-08-13 |
mouse |
| Joshua Loewenstern, Xiaozhen You, Junaid Merchant, Evan M Gordon, Melanie Stollstorff, Joseph Devaney, Chandan J Vaidy. Interactive effect of 5-HTTLPR and BDNF polymorphisms on amygdala intrinsic functional connectivity and anxiety. Psychiatry research. Neuroimaging. vol 285. 2020-02-11. PMID:30711709. |
the serotonin transporter (5-httlpr) and brain-derived neurotrophic factor (bdnf) gene polymorphisms have been associated with risk for affective disorders and functional variability of the amygdala. |
2020-02-11 |
2023-08-13 |
Not clear |
| M Neus Fullana, Esther Ruiz-Bronchal, Albert Ferrés-Coy, Elena Juárez-Escoto, Francesc Artigas, Analia Bortolozz. Regionally selective knockdown of astroglial glutamate transporters in infralimbic cortex induces a depressive phenotype in mice. Glia. vol 67. issue 6. 2019-12-30. PMID:30635928. |
intra-il glast or glt-1 knockdown markedly reduced serotonin (5-ht) release in the dorsal raphe nucleus (dr) and induced an overall reduction of brain-derived neurotrophic factor (bdnf) expression in ipsilateral and contralateral hemispheres. |
2019-12-30 |
2023-08-13 |
mouse |
| M Neus Fullana, Esther Ruiz-Bronchal, Albert Ferrés-Coy, Elena Juárez-Escoto, Francesc Artigas, Analia Bortolozz. Regionally selective knockdown of astroglial glutamate transporters in infralimbic cortex induces a depressive phenotype in mice. Glia. vol 67. issue 6. 2019-12-30. PMID:30635928. |
egr-1 (early growth response protein-1) labeling suggests that both sirnas enhance the gabaergic tone onto dr 5-ht neurons, leading to an overall decrease of 5-ht function, likely related to the widespread reduction on bdnf expression. |
2019-12-30 |
2023-08-13 |
mouse |
| Xuan Liu, Junjian Zhang, Dong Sun, Yuanteng Fan, Hongbin Zhou, Binfang F. Fluoxetine enhances Brain Derived Neurotropic Factor Serum Concentration and Cognition in Patients with Vascular Dementia. Current neurovascular research. 2019-11-20. PMID:23962390. |
selective serotonin reuptake inhibitors (ssris) improve cognition in patients with stroke and increase the expression of brain-derived neurotrophic factor (bdnf) in the rat hippocampus. |
2019-11-20 |
2023-08-12 |
rat |
| Xuan Liu, Junjian Zhang, Dong Sun, Yuanteng Fan, Hongbin Zhou, Binfang F. Fluoxetine enhances Brain Derived Neurotropic Factor Serum Concentration and Cognition in Patients with Vascular Dementia. Current neurovascular research. 2019-11-20. PMID:23962390. |
we performed an open-label study to investigate the effects of fluoxetine, a selective serotonin reuptake inhibitor, on mini-mental state examination (mmse) score and serum bdnf level in vad patients. |
2019-11-20 |
2023-08-12 |
rat |
| Kalsea J Koss, E Mark Cummings, Patrick T Davies, Susan Hetzel, Dante Cicchett. Harsh Parenting and Serotonin Transporter and BDNF Val66Met Polymorphisms as Predictors of Adolescent Depressive Symptoms. Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53. vol 47. issue sup1. 2019-11-20. PMID:27736236. |
harsh parenting and serotonin transporter and bdnf val66met polymorphisms as predictors of adolescent depressive symptoms. |
2019-11-20 |
2023-08-13 |
human |
| Undurti N Da. Is There a Role for Bioactive Lipids in the Pathobiology of Diabetes Mellitus? Frontiers in endocrinology. vol 8. 2019-11-20. PMID:28824543. |
inflammation, decreased levels of circulating endothelial nitric oxide (eno) and brain-derived neurotrophic factor (bdnf), altered activity of hypothalamic neurotransmitters (including serotonin and vagal tone) and gut hormones, increased concentrations of free radicals, and imbalance in the levels of bioactive lipids and their pro- and anti-inflammatory metabolites have been suggested to play a role in diabetes mellitus (dm). |
2019-11-20 |
2023-08-13 |
Not clear |
| Sheng Wei, Xinyang Xiao, Jieqiong Wang, Shiguang Sun, Zifa Li, Kaiyong Xu, Fang Li, Jie Gao, Dehao Zhu, Mingqi Qia. Impact of anger emotional stress before pregnancy on adult male offspring. Oncotarget. vol 8. issue 58. 2019-11-20. PMID:29228731. |
the monoaminergic system was significantly altered in pre-gestationally stressed offspring, and the expression of phosphorylated cyclic adenosine monophosphate response element binding protein (p-creb), brain-derived neurotrophic factor (bdnf), and serotonin transporter (sert) levels in pre-gestational stressed offspring were altered in some brain regions. |
2019-11-20 |
2023-08-13 |
rat |
| Stefano Porcelli, Agnese Marsano, Elisabetta Caletti, Michela Sala, Vera Abbiati, Marcella Bellani, Cinzia Perlini, Maria Gloria Rossetti, Gian Mario Mandolini, Alessandro Pigoni, Riccardo Augusto Paoli, Sara Piccin, Matteo Lazzaretti, Dora Fabbro, Giuseppe Damante, Carolina Bonivento, Clarissa Ferrari, Roberta Rossi, Laura Pedrini, Alessandro Serretti, Paolo Brambill. Temperament and Character Inventory in Bipolar Disorder versus Healthy Controls and Modulatory Effects of 3 Key Functional Gene Variants. Neuropsychobiology. vol 76. issue 4. 2019-11-20. PMID:30041166. |
several studies investigated the genetic basis of temperament and character, identifying catechol-o-methyltransferase (comt), brain derived neurotrophic factor (bdnf), and serotonin transporter (5-htt) gene variants as strong candidates. |
2019-11-20 |
2023-08-13 |
Not clear |
| Vishnu N Thakare, Rajesh R Patil, Rajesh J Oswal, Valmik D Dhakane, Manoj K Aswar, Bhoomika M Pate. Therapeutic potential of silymarin in chronic unpredictable mild stress induced depressive-like behavior in mice. Journal of psychopharmacology (Oxford, England). vol 32. issue 2. 2019-10-24. PMID:29215318. |
in addition, neurobiochemical alterations, mainly monoamines, 5-ht, ne, da, neurotrophic factor bdnf, and cytokines, il-6, tnf-α, oxidant-antioxidant parameters by determining the malondialdehyde formation (an index of lipid peroxidation process), superoxide dismutase (sod) and catalase (cat) activity in hippocampus and cerebral cortex along with serum corticosterone were investigated. |
2019-10-24 |
2023-08-13 |
mouse |
| Vishnu N Thakare, Rajesh R Patil, Rajesh J Oswal, Valmik D Dhakane, Manoj K Aswar, Bhoomika M Pate. Therapeutic potential of silymarin in chronic unpredictable mild stress induced depressive-like behavior in mice. Journal of psychopharmacology (Oxford, England). vol 32. issue 2. 2019-10-24. PMID:29215318. |
our findings reveal that mice subjected to cums exhibited lower sucrose preference, increase immobility time without affecting general locomotion of the animals, and reduce bdnf, 5-ht, ne, and da level, increased serum corticosterone, il-6 and tnf-α along with an oxidant-antioxidant imbalance in the hippocampus and cerebral cortex. |
2019-10-24 |
2023-08-13 |
mouse |
| Vishnu N Thakare, Rajesh R Patil, Rajesh J Oswal, Valmik D Dhakane, Manoj K Aswar, Bhoomika M Pate. Therapeutic potential of silymarin in chronic unpredictable mild stress induced depressive-like behavior in mice. Journal of psychopharmacology (Oxford, England). vol 32. issue 2. 2019-10-24. PMID:29215318. |
thus, the possible mechanism involved in the antidepressant-like activity of silymarin is correlated to the alleviation of monoaminergic, neurogenesis (enhancing 5-ht, ne, and bdnf levels), and attenuation of inflammatory cytokines system and oxidative stress by modulation of corticosterone response, restoration of antioxidant defense system in cerebral cortex and hippocampus. |
2019-10-24 |
2023-08-13 |
mouse |
| A Pietrelli, L Matković, M Vacotto, J J Lopez-Costa, N Basso, A Brusc. Aerobic exercise upregulates the BDNF-Serotonin systems and improves the cognitive function in rats. Neurobiology of learning and memory. vol 155. 2019-09-23. PMID:29800645. |
serotonin (5-ht) and brain-derived neurotrophic factor (bdnf) are known to mediate and shape cognitive processes. |
2019-09-23 |
2023-08-13 |
rat |
| A Pietrelli, L Matković, M Vacotto, J J Lopez-Costa, N Basso, A Brusc. Aerobic exercise upregulates the BDNF-Serotonin systems and improves the cognitive function in rats. Neurobiology of learning and memory. vol 155. 2019-09-23. PMID:29800645. |
both systems share some actions: bdnf is involved in the maturation and function of 5-ht neurons. |
2019-09-23 |
2023-08-13 |
rat |
| A Pietrelli, L Matković, M Vacotto, J J Lopez-Costa, N Basso, A Brusc. Aerobic exercise upregulates the BDNF-Serotonin systems and improves the cognitive function in rats. Neurobiology of learning and memory. vol 155. 2019-09-23. PMID:29800645. |
in turn, 5-ht is involved in neuroplasticity phenomena mediated by bdnf and stimulated by exercise. |
2019-09-23 |
2023-08-13 |
rat |
| A Pietrelli, L Matković, M Vacotto, J J Lopez-Costa, N Basso, A Brusc. Aerobic exercise upregulates the BDNF-Serotonin systems and improves the cognitive function in rats. Neurobiology of learning and memory. vol 155. 2019-09-23. PMID:29800645. |
the levels and expression of bdnf, 5-ht, serotonin transporter (sert) and 5-ht |
2019-09-23 |
2023-08-13 |
rat |