| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David S Paterson, Eric G Thompson, Richard A Belliveau, Bobbie A Antalffy, Felicia L Trachtenberg, Dawna D Armstrong, Hannah C Kinne. Serotonin transporter abnormality in the dorsal motor nucleus of the vagus in Rett syndrome: potential implications for clinical autonomic dysfunction. Journal of neuropathology and experimental neurology. vol 64. issue 11. 2005-12-15. PMID:16254496. |
this gene plays a role in regulating neuronal activity-dependent gene expression, including brain-derived neurotrophic factor (bdnf), which is a potent serotonergic (5-ht) neuronal growth factor. |
2005-12-15 |
2023-08-12 |
mouse |
| David S Paterson, Eric G Thompson, Richard A Belliveau, Bobbie A Antalffy, Felicia L Trachtenberg, Dawna D Armstrong, Hannah C Kinne. Serotonin transporter abnormality in the dorsal motor nucleus of the vagus in Rett syndrome: potential implications for clinical autonomic dysfunction. Journal of neuropathology and experimental neurology. vol 64. issue 11. 2005-12-15. PMID:16254496. |
we analyzed selected parameters of the 5-ht system of the medulla in autopsied patients with rett syndrome because of the role of bdnf in 5-ht cell development and because 5-ht plays a key role in modulating autonomic control. |
2005-12-15 |
2023-08-12 |
mouse |
| Shuji Murakami, Hiroki Imbe, Yoshihiro Morikawa, Chiharu Kubo, Emiko Senb. Chronic stress, as well as acute stress, reduces BDNF mRNA expression in the rat hippocampus but less robustly. Neuroscience research. vol 53. issue 2. 2005-11-01. PMID:16024125. |
we investigated bdnf mrna levels there, together with plasma gc levels, gc receptors in the hippocampus/hypothalamus and 5-ht synthesizing enzyme, tryptophan hydroxylase in the raphe nuclei, in animals chronically stressed for 1-3 weeks, using in situ hybridization and immunohistochemistry. |
2005-11-01 |
2023-08-12 |
rat |
| Prakasham Rumajogee, Daniel Vergé, Michèle Darmon, Marie-Jeanne Brisorgueil, Michel Hamon, Marie-Christine Mique. Rapid up-regulation of the neuronal serotoninergic phenotype by brain-derived neurotrophic factor and cyclic adenosine monophosphate: relations with raphe astrocytes. Journal of neuroscience research. vol 81. issue 4. 2005-10-20. PMID:15968642. |
these data suggest that bdnf and camp, but not s100beta, rapidly induce both an up-regulation of the 5-ht neuronal phenotype and modifications of the neighboring astrocytes in a trkb-dependent manner. |
2005-10-20 |
2023-08-12 |
rat |
| Renee F Ren-Patterson, Lauren W Cochran, Andrew Holmes, Suzanne Sherrill, Su-Jan Huang, Teresa Tolliver, Klaus-Peter Lesch, Bai Lu, Dennis L Murph. Loss of brain-derived neurotrophic factor gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities of serotonin transporter knockout mice. Journal of neuroscience research. vol 79. issue 6. 2005-07-15. PMID:15672416. |
to study the neurochemical and behavioral effects of altered brain-derived neurotrophic factor (bdnf) expression on a brain serotonin system with diminished serotonin transport capability, a double-mutant mouse model was developed by interbreeding serotonin transporter (sert) knockout mice with bdnf heterozygous knockout mice (bdnf +/-), producing sert -/- x bdnf +/- (sb) mice. |
2005-07-15 |
2023-08-12 |
mouse |
| Renee F Ren-Patterson, Lauren W Cochran, Andrew Holmes, Suzanne Sherrill, Su-Jan Huang, Teresa Tolliver, Klaus-Peter Lesch, Bai Lu, Dennis L Murph. Loss of brain-derived neurotrophic factor gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities of serotonin transporter knockout mice. Journal of neuroscience research. vol 79. issue 6. 2005-07-15. PMID:15672416. |
these findings support the hypothesis that genetic changes in bdnf expression interact with serotonin and other circuits that modulate anxiety and stress-related behaviors. |
2005-07-15 |
2023-08-12 |
mouse |
| Renee F Ren-Patterson, Lauren W Cochran, Andrew Holmes, Suzanne Sherrill, Su-Jan Huang, Teresa Tolliver, Klaus-Peter Lesch, Bai Lu, Dennis L Murph. Loss of brain-derived neurotrophic factor gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities of serotonin transporter knockout mice. Journal of neuroscience research. vol 79. issue 6. 2005-07-15. PMID:15672416. |
thus, this double-mutant mouse model should prove valuable in studying other gene x gene consequences for brain plasticity as well as in evaluating epistatic interactions of bdnf and serotonin transporter gene polymorphisms in neuropsychiatric disorders. |
2005-07-15 |
2023-08-12 |
mouse |
| A Appert-Collin, F H Duong, P Passilly Degrace, J M Warter, P Poindron, J P Gie. MAPK activation via 5-hydroxytryptamine 1A receptor is involved in the neuroprotective effects of xaliproden. International journal of immunopathology and pharmacology. vol 18. issue 1. 2005-07-14. PMID:15698508. |
morever, 8-oh-dpat, an agonist of 5-hydroxytryptamine 1a receptor, increases the survival of mouse motoneurons but not by the same extent as bdnf or xaliproden. |
2005-07-14 |
2023-08-12 |
mouse |
| S Djalali, M Höltje, G Grosse, T Rothe, T Stroh, J Grosse, D R Deng, R Hellweg, R Grantyn, H Hörtnagl, G Ahnert-Hilge. Effects of brain-derived neurotrophic factor (BDNF) on glial cells and serotonergic neurones during development. Journal of neurochemistry. vol 92. issue 3. 2005-06-24. PMID:15659231. |
their survival and maturation is promoted by a variety of factors, including serotonin itself, brain-derived neurotrophic factor (bdnf) and s100beta, an astrocyte-specific ca(2+) binding protein. |
2005-06-24 |
2023-08-12 |
mouse |
| Mark P Mattson, Stuart Maudsley, Bronwen Marti. A neural signaling triumvirate that influences ageing and age-related disease: insulin/IGF-1, BDNF and serotonin. Ageing research reviews. vol 3. issue 4. 2005-04-12. PMID:15541711. |
a neural signaling triumvirate that influences ageing and age-related disease: insulin/igf-1, bdnf and serotonin. |
2005-04-12 |
2023-08-12 |
Not clear |
| Mark P Mattson, Stuart Maudsley, Bronwen Marti. A neural signaling triumvirate that influences ageing and age-related disease: insulin/IGF-1, BDNF and serotonin. Ageing research reviews. vol 3. issue 4. 2005-04-12. PMID:15541711. |
among such specific signaling modalities are those activated in neurons by insulin-like growth factors (igfs), brain-derived neurotrophic factor (bdnf) and serotonin. |
2005-04-12 |
2023-08-12 |
Not clear |
| Mark P Mattson, Stuart Maudsley, Bronwen Marti. A neural signaling triumvirate that influences ageing and age-related disease: insulin/IGF-1, BDNF and serotonin. Ageing research reviews. vol 3. issue 4. 2005-04-12. PMID:15541711. |
at the molecular level, bdnf, serotonin and igfs can all stimulate the production of proteins involved in cellular stress adaptation, growth and repair, neurogenesis, learning and memory and cell survival. |
2005-04-12 |
2023-08-12 |
Not clear |
| Matthew E Szapacs, Tiffany A Mathews, Lino Tessarollo, W Ernest Lyons, Laura A Mamounas, Anne M Andrew. Exploring the relationship between serotonin and brain-derived neurotrophic factor: analysis of BDNF protein and extraneuronal 5-HT in mice with reduced serotonin transporter or BDNF expression. Journal of neuroscience methods. vol 140. issue 1-2. 2005-04-12. PMID:15589338. |
exploring the relationship between serotonin and brain-derived neurotrophic factor: analysis of bdnf protein and extraneuronal 5-ht in mice with reduced serotonin transporter or bdnf expression. |
2005-04-12 |
2023-08-12 |
mouse |
| Matthew E Szapacs, Tiffany A Mathews, Lino Tessarollo, W Ernest Lyons, Laura A Mamounas, Anne M Andrew. Exploring the relationship between serotonin and brain-derived neurotrophic factor: analysis of BDNF protein and extraneuronal 5-HT in mice with reduced serotonin transporter or BDNF expression. Journal of neuroscience methods. vol 140. issue 1-2. 2005-04-12. PMID:15589338. |
serotonin (5-ht) has been proposed to promote neuronal plasticity during the treatment of mood and anxiety disorders and following neurodegenerative insult by altering the expression of critical genes including brain-derived neurotrophic factor (bdnf). |
2005-04-12 |
2023-08-12 |
mouse |
| Matthew E Szapacs, Tiffany A Mathews, Lino Tessarollo, W Ernest Lyons, Laura A Mamounas, Anne M Andrew. Exploring the relationship between serotonin and brain-derived neurotrophic factor: analysis of BDNF protein and extraneuronal 5-HT in mice with reduced serotonin transporter or BDNF expression. Journal of neuroscience methods. vol 140. issue 1-2. 2005-04-12. PMID:15589338. |
in this study, mice with constitutive reductions in the serotonin transporter (sert) or bdnf were investigated to further assess the functional relationship between serotonin neurotransmission and bdnf expression. |
2005-04-12 |
2023-08-12 |
mouse |
| Matthew E Szapacs, Tiffany A Mathews, Lino Tessarollo, W Ernest Lyons, Laura A Mamounas, Anne M Andrew. Exploring the relationship between serotonin and brain-derived neurotrophic factor: analysis of BDNF protein and extraneuronal 5-HT in mice with reduced serotonin transporter or BDNF expression. Journal of neuroscience methods. vol 140. issue 1-2. 2005-04-12. PMID:15589338. |
in addition to other phenotypic aspects suggestive of altered serotonin neurotransmission, bdnf(+/-) mice show accelerated age-related degeneration of 5-ht forebrain innervation. |
2005-04-12 |
2023-08-12 |
mouse |
| Matthew E Szapacs, Tiffany A Mathews, Lino Tessarollo, W Ernest Lyons, Laura A Mamounas, Anne M Andrew. Exploring the relationship between serotonin and brain-derived neurotrophic factor: analysis of BDNF protein and extraneuronal 5-HT in mice with reduced serotonin transporter or BDNF expression. Journal of neuroscience methods. vol 140. issue 1-2. 2005-04-12. PMID:15589338. |
nevertheless, extracellular 5-ht levels determined by zero net flux microdialysis were similar between bdnf(+/+) and bdnf(+/-) mice in striatum and frontal cortex at 8-12 months of age. |
2005-04-12 |
2023-08-12 |
mouse |
| Matthew E Szapacs, Tiffany A Mathews, Lino Tessarollo, W Ernest Lyons, Laura A Mamounas, Anne M Andrew. Exploring the relationship between serotonin and brain-derived neurotrophic factor: analysis of BDNF protein and extraneuronal 5-HT in mice with reduced serotonin transporter or BDNF expression. Journal of neuroscience methods. vol 140. issue 1-2. 2005-04-12. PMID:15589338. |
these data illustrate that a 50% decrease in bdnf does not appear to be sufficient to cause measurable changes in basal extracellular 5-ht concentrations and, furthermore, that constitutive reductions in sert expression are not associated with altered bdnf protein levels at the ages and in the brain regions examined in this study. |
2005-04-12 |
2023-08-12 |
mouse |
| Ayman H Fanous, M C Neale, R E Straub, B T Webb, A F O'Neill, D Walsh, K S Kendle. Clinical features of psychotic disorders and polymorphisms in HT2A, DRD2, DRD4, SLC6A3 (DAT1), and BDNF: a family based association study. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 125B. issue 1. 2005-03-21. PMID:14755448. |
we tested for the presence of association between clinical features and polymorphisms in the genes for the serotonin 2a receptor (ht2a), dopamine receptor types 2 and 4, dopamine transporter (slc6a3), and brain-derived neurotrophic factor (bdnf). |
2005-03-21 |
2023-08-12 |
Not clear |
| G De Foubert, S L Carney, C S Robinson, E J Destexhe, R Tomlinson, C A Hicks, T K Murray, J P Gaillard, C Deville, V Xhenseval, C E Thomas, M J O'Neill, T S C Zetterströ. Fluoxetine-induced change in rat brain expression of brain-derived neurotrophic factor varies depending on length of treatment. Neuroscience. vol 128. issue 3. 2005-03-04. PMID:15381288. |
the results presented here show that bdnf is expressed differentially depending on length of fluoxetine administration, which could contribute in explaining the slow onset of antidepressant activity observed with selective serotonin reuptake inhibitors. |
2005-03-04 |
2023-08-12 |
rat |