| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Olaf Schulte-Herbrüggen, Sabine Chourbaji, Stephanie Ridder, Christiane Brandwein, Peter Gass, Heide Hörtnagl, Rainer Hellwe. Stress-resistant mice overexpressing glucocorticoid receptors display enhanced BDNF in the amygdala and hippocampus with unchanged NGF and serotonergic function. Psychoneuroendocrinology. vol 31. issue 10. 2007-03-19. PMID:17098367. |
here, we analyzed gr overexpressing mice for morning and evening content of nerve growth factor (ngf), brain-derived neurotrophic factor (bdnf) and the tissue levels of serotonin and its metabolite 5-hydroxyindoleacetic acid) in brain areas suspected to be involved in stress adaptation. |
2007-03-19 |
2023-08-12 |
mouse |
| Shih-Jen Tsa. The P11, tPA/plasminogen system and brain-derived neurotrophic factor: Implications for the pathogenesis of major depression and the therapeutic mechanism of antidepressants. Medical hypotheses. vol 68. issue 1. 2007-01-30. PMID:16890384. |
evidence from animal and human studies suggests that a disturbance in serotonergic (5-ht) activity and/or brain-derived neurotrophic factor (bdnf) signaling may be implicated in the pathogenesis of mdd. |
2007-01-30 |
2023-08-12 |
mouse |
| Rainer Hellweg, Maha Zueger, Katharina Fink, Heide Hörtnagl, Peter Gas. Olfactory bulbectomy in mice leads to increased BDNF levels and decreased serotonin turnover in depression-related brain areas. Neurobiology of disease. vol 25. issue 1. 2007-01-23. PMID:16990008. |
olfactory bulbectomy in mice leads to increased bdnf levels and decreased serotonin turnover in depression-related brain areas. |
2007-01-23 |
2023-08-12 |
mouse |
| Rebeca Martínez-Turrillas, Sonia Moyano, Joaquín Del Río, Diana Frechill. Differential effects of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") on BDNF mRNA expression in rat frontal cortex and hippocampus. Neuroscience letters. vol 402. issue 1-2. 2007-01-16. PMID:16644117. |
the differential regulation of bdnf mrna expression in the two brain regions examined appears to account for the enhanced tph expression and the recovery of 5-ht levels in the frontal cortex, but not in the hippocampus, after neurotoxin treatment. |
2007-01-16 |
2023-08-12 |
rat |
| Hiroki Koizumi, Kenji Hashimoto, Masaomi Iy. Dietary restriction changes behaviours in brain-derived neurotrophic factor heterozygous mice: role of serotonergic system. The European journal of neuroscience. vol 24. issue 8. 2006-12-21. PMID:17074054. |
after carrying out a behavioural evaluation, we determined the bdnf mrna levels, as well as mrna levels for subtypes (5-ht(1a), 5-ht(1b), 5-ht(2a) and 5-ht(2c)) of the 5-ht receptor and 5-ht transporter (5-htt), protein levels of bdnf and concentrations of 5-ht and 5-hiaa in the hypothalamus, hippocampus and frontal cortex. |
2006-12-21 |
2023-08-12 |
mouse |
| Hiroki Koizumi, Kenji Hashimoto, Masaomi Iy. Dietary restriction changes behaviours in brain-derived neurotrophic factor heterozygous mice: role of serotonergic system. The European journal of neuroscience. vol 24. issue 8. 2006-12-21. PMID:17074054. |
the concentrations of 5-ht and 5-hiaa in the frontal cortex, and 5-ht in the hippocampus, of bdnf(+/-) mice were significantly lower than those of wild-type mice. |
2006-12-21 |
2023-08-12 |
mouse |
| Hiroki Koizumi, Kenji Hashimoto, Masaomi Iy. Dietary restriction changes behaviours in brain-derived neurotrophic factor heterozygous mice: role of serotonergic system. The European journal of neuroscience. vol 24. issue 8. 2006-12-21. PMID:17074054. |
interestingly, dr significantly increased the levels of 5-ht and 5-hiaa in the frontal cortex of bdnf(+/-) mice. |
2006-12-21 |
2023-08-12 |
mouse |
| J P Chan, T J Unger, J Byrnes, M Rio. Examination of behavioral deficits triggered by targeting Bdnf in fetal or postnatal brains of mice. Neuroscience. vol 142. issue 1. 2006-12-20. PMID:16844311. |
interestingly, depletion of bdnf from the fetal brain had more pronounced effects on aggressive and depressive-like behaviors and led to deficits in 5-ht(2a) receptor content in the medial frontal cortex, highlighting the importance of this neurotrophin during development. |
2006-12-20 |
2023-08-12 |
mouse |
| Damijana Mojca Juric, Spela Miklic, Marija Carman-Krza. Monoaminergic neuronal activity up-regulates BDNF synthesis in cultured neonatal rat astrocytes. Brain research. vol 1108. issue 1. 2006-12-06. PMID:16828062. |
because brain-derived neurotrophic factor (bdnf) is produced by astrocytes, in addition to neurons, we focused our present study on the regulatory effects of monoamines noradrenaline (na), serotonin (5-ht), and dopamine (da) on the synthesis of bdnf protein in rat neonatal astrocytes from specific brain regions (cortex, cerebellum). |
2006-12-06 |
2023-08-12 |
rat |
| Damijana Mojca Juric, Spela Miklic, Marija Carman-Krza. Monoaminergic neuronal activity up-regulates BDNF synthesis in cultured neonatal rat astrocytes. Brain research. vol 1108. issue 1. 2006-12-06. PMID:16828062. |
in cultured cortical astrocytes, na (1 microm; 6 h) elevates bdnf levels by a 4-fold, 5-ht (1 microm; 4 h) by a 2.3-fold, and da (150 microm; 4 h) by a 2.2-fold. |
2006-12-06 |
2023-08-12 |
rat |
| Damijana Mojca Juric, Spela Miklic, Marija Carman-Krza. Monoaminergic neuronal activity up-regulates BDNF synthesis in cultured neonatal rat astrocytes. Brain research. vol 1108. issue 1. 2006-12-06. PMID:16828062. |
in cerebellar astrocytes, na (1 microm; 4 h) increases bdnf content by a 4.7-fold, 5-ht (1 microm; 4 h) by a 1.7-fold, and da (150 microm; 4 h) by a 1.4-fold. |
2006-12-06 |
2023-08-12 |
rat |
| Damijana Mojca Juric, Spela Miklic, Marija Carman-Krza. Monoaminergic neuronal activity up-regulates BDNF synthesis in cultured neonatal rat astrocytes. Brain research. vol 1108. issue 1. 2006-12-06. PMID:16828062. |
the initial increase in the bdnf levels return to basal levels when incubation with monoamines is extended beyond 12 h (for 5-ht) or 24 h (for na and da). |
2006-12-06 |
2023-08-12 |
rat |
| Jacob P R Jacobsen, Arne Mør. Chronic corticosterone decreases brain-derived neurotrophic factor (BDNF) mRNA and protein in the hippocampus, but not in the frontal cortex, of the rat. Brain research. vol 1110. issue 1. 2006-12-06. PMID:16876769. |
because evidence suggests that bdnf is an important determinant of the function of the 5-hydroxytryptamine (5-ht) system, we also quantified tissue levels of 5-ht and its major metabolite, 5-hydroxyindoleacetic acid (5-hiaa), to investigate if changes in bdnf mrna and protein paralleled changes in the 5-ht system. |
2006-12-06 |
2023-08-12 |
rat |
| Jacob P R Jacobsen, Arne Mør. Chronic corticosterone decreases brain-derived neurotrophic factor (BDNF) mRNA and protein in the hippocampus, but not in the frontal cortex, of the rat. Brain research. vol 1110. issue 1. 2006-12-06. PMID:16876769. |
combined, these data suggests that the effects of corticosterone on the bdnf system are not linked to the effects on the 5-ht systems. |
2006-12-06 |
2023-08-12 |
rat |
| Leandro Michelon, Ivanor Meira-Lima, Quirino Cordeiro, Karen Miguita, Gerome Breen, David Collier, Homero Vallad. Association study of the INPP1, 5HTT, BDNF, AP-2beta and GSK-3beta GENE variants and restrospectively scored response to lithium prophylaxis in bipolar disorder. Neuroscience letters. vol 403. issue 3. 2006-09-01. PMID:16787706. |
association study of the inpp1, 5htt, bdnf, ap-2beta and gsk-3beta gene variants and restrospectively scored response to lithium prophylaxis in bipolar disorder. |
2006-09-01 |
2023-08-12 |
Not clear |
| Prakasham Rumajogee, Daniel Vergé, Michel Hamon, Marie-Christine Mique. Somato-dendritic distribution of 5-HT(1A) and 5-HT(1B) autoreceptors in the BDNF- and cAMP-differentiated RN46A serotoninergic raphe cell line. Brain research. vol 1085. issue 1. 2006-08-10. PMID:16579976. |
in conclusion, both bdnf and camp-differentiated rn46a cells towards a neuronal serotoninergic-like phenotype without the typical differential targeting of the 5-ht(1) autoreceptors, an interesting model to study the molecular mechanisms ensuing the targeting of 5-ht(1) autoreceptors to somas and dendrites. |
2006-08-10 |
2023-08-12 |
rat |
| Marek Lommatzsch, Katharina Hornych, Christiana Zingler, Peter Schuff-Werner, Jacqueline Höppner, J Christian Vircho. Maternal serum concentrations of BDNF and depression in the perinatal period. Psychoneuroendocrinology. vol 31. issue 3. 2006-06-08. PMID:16289360. |
bdnf correlated with decreased serotonin (5-ht) levels in serum (r>0.6 and p<0.001 at all time points). |
2006-06-08 |
2023-08-12 |
human |
| Marek Lommatzsch, Katharina Hornych, Christiana Zingler, Peter Schuff-Werner, Jacqueline Höppner, J Christian Vircho. Maternal serum concentrations of BDNF and depression in the perinatal period. Psychoneuroendocrinology. vol 31. issue 3. 2006-06-08. PMID:16289360. |
there was a trend to a decrease of bdnf and 5-ht levels in cases of maternal depression (as compared to cases without depression), but this was not significant. |
2006-06-08 |
2023-08-12 |
human |
| Beth A Luellen, Matthew E Szapacs, Christopher K Materese, Anne M Andrew. The neurotoxin 2'-NH2-MPTP degenerates serotonin axons and evokes increases in hippocampal BDNF. Neuropharmacology. vol 50. issue 3. 2006-05-24. PMID:16288930. |
the neurotoxin 2'-nh2-mptp degenerates serotonin axons and evokes increases in hippocampal bdnf. |
2006-05-24 |
2023-08-12 |
mouse |
| Maribel Rios, Evelyn K Lambe, Rongjian Liu, Sarah Teillon, JinHong Liu, Schahram Akbarian, Suzanne Roffler-Tarlov, Rudolf Jaenisch, George K Aghajania. Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant mice. Journal of neurobiology. vol 66. issue 4. 2006-04-28. PMID:16408297. |
bdnf is thought to provide critical trophic support for serotonin neurons. |
2006-04-28 |
2023-08-12 |
mouse |