| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kyoji Morita, Song He. Progesterone pretreatment enhances serotonin-stimulated BDNF gene expression in rat c6 glioma cells through production of 5alpha-reduced neurosteroids. Journal of molecular neuroscience : MN. vol 34. issue 3. 2008-06-20. PMID:18219447. |
on the other hand, the stimulation of the glioma cells with serotonin has been reported to enhance brain-derived neurotrophic factor (bdnf) gene expression, which may be closely related to the beneficial effects of antidepressant drugs. |
2008-06-20 |
2023-08-12 |
rat |
| Kyoji Morita, Song He. Progesterone pretreatment enhances serotonin-stimulated BDNF gene expression in rat c6 glioma cells through production of 5alpha-reduced neurosteroids. Journal of molecular neuroscience : MN. vol 34. issue 3. 2008-06-20. PMID:18219447. |
in the present study, to evaluate bdnf expression in differentiated glial cells, the glioma cells were pretreated with progesterone, and the effect of serotonin on bdnf messenger rna levels in these cells was examined. |
2008-06-20 |
2023-08-12 |
rat |
| Kyoji Morita, Song He. Progesterone pretreatment enhances serotonin-stimulated BDNF gene expression in rat c6 glioma cells through production of 5alpha-reduced neurosteroids. Journal of molecular neuroscience : MN. vol 34. issue 3. 2008-06-20. PMID:18219447. |
progesterone pretreatment enhanced the stimulatory action of serotonin on bdnf gene expression, and the enhancement of serotonin action observed in the cells pretreated with progesterone was almost completely abolished by finasteride, an inhibitor of the enzyme involved in the production of 5alpha-reduced neurosteroids. |
2008-06-20 |
2023-08-12 |
rat |
| Tanel Mällo, Kadri Kõiv, Indrek Koppel, Karita Raudkivi, Ain Uustare, Ago Rinken, Tõnis Timmusk, Jaanus Harr. Regulation of extracellular serotonin levels and brain-derived neurotrophic factor in rats with high and low exploratory activity. Brain research. vol 1194. 2008-05-30. PMID:18177844. |
serotonin (5-ht) system has a significant role in anxiety- and depression-related states and may be influenced by brain-derived neurotrophic factor (bdnf). |
2008-05-30 |
2023-08-12 |
rat |
| Tanel Mällo, Kadri Kõiv, Indrek Koppel, Karita Raudkivi, Ain Uustare, Ago Rinken, Tõnis Timmusk, Jaanus Harr. Regulation of extracellular serotonin levels and brain-derived neurotrophic factor in rats with high and low exploratory activity. Brain research. vol 1194. 2008-05-30. PMID:18177844. |
this study examined extracellular 5-ht levels and expression of bdnf in rats with persistently low or high levels of exploratory activity (le and he, respectively). |
2008-05-30 |
2023-08-12 |
rat |
| Megan E Kozisek, David Middlemas, David B Bylun. The differential regulation of BDNF and TrkB levels in juvenile rats after four days of escitalopram and desipramine treatment. Neuropharmacology. vol 54. issue 2. 2008-05-12. PMID:18048068. |
in the present study we report parallel measurements of bdnf mrna and protein in the frontal cortex and hippocampus after four days of twice daily treatments with escitalopram, a selective serotonin reuptake inhibitor, and desipramine, a tricyclic antidepressant. |
2008-05-12 |
2023-08-12 |
rat |
| R Christensen, A B Marcussen, G Wörtwein, G M Knudsen, S Azna. Abeta(1-42) injection causes memory impairment, lowered cortical and serum BDNF levels, and decreased hippocampal 5-HT(2A) levels. Experimental neurology. vol 210. issue 1. 2008-05-02. PMID:18053988. |
abeta(1-42) injection causes memory impairment, lowered cortical and serum bdnf levels, and decreased hippocampal 5-ht(2a) levels. |
2008-05-02 |
2023-08-12 |
rat |
| R Christensen, A B Marcussen, G Wörtwein, G M Knudsen, S Azna. Abeta(1-42) injection causes memory impairment, lowered cortical and serum BDNF levels, and decreased hippocampal 5-HT(2A) levels. Experimental neurology. vol 210. issue 1. 2008-05-02. PMID:18053988. |
in patients with ad, reduced levels of serum brain derived neurotrophic factor (bdnf) and cortical 5-ht(2a) receptor binding has recently been reported but it is unknown how these changes are related to beta-amyloid accumulation. |
2008-05-02 |
2023-08-12 |
rat |
| R Christensen, A B Marcussen, G Wörtwein, G M Knudsen, S Azna. Abeta(1-42) injection causes memory impairment, lowered cortical and serum BDNF levels, and decreased hippocampal 5-HT(2A) levels. Experimental neurology. vol 210. issue 1. 2008-05-02. PMID:18053988. |
in this study we examined in rats the effect of intrahippocampal injections of aggregated abeta(1-42) (1 microg/microl) on serum and brain bdnf or 5-ht(2a) receptor levels. |
2008-05-02 |
2023-08-12 |
rat |
| R Christensen, A B Marcussen, G Wörtwein, G M Knudsen, S Azna. Abeta(1-42) injection causes memory impairment, lowered cortical and serum BDNF levels, and decreased hippocampal 5-HT(2A) levels. Experimental neurology. vol 210. issue 1. 2008-05-02. PMID:18053988. |
in the abeta(1-42) injected animals we saw an abolished increase in serum bdnf levels that was accompanied by significant lower bdnf levels in frontal cortex and by an 8.5% reduction in hippocampal 5-ht(2a) receptor levels. |
2008-05-02 |
2023-08-12 |
rat |
| R Christensen, A B Marcussen, G Wörtwein, G M Knudsen, S Azna. Abeta(1-42) injection causes memory impairment, lowered cortical and serum BDNF levels, and decreased hippocampal 5-HT(2A) levels. Experimental neurology. vol 210. issue 1. 2008-05-02. PMID:18053988. |
these results indicate that the abeta(1-42) associated memory deficit is associated with an impaired bdnf regulation, which is reflected in lower cortical bdnf levels, and changes in hippocampal 5-ht(2a) receptor levels. |
2008-05-02 |
2023-08-12 |
rat |
| Qi Peng, Naoki Masuda, Mali Jiang, Qing Li, Ming Zhao, Christopher A Ross, Wenzhen Dua. The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntington's disease mouse model. Experimental neurology. vol 210. issue 1. 2008-05-02. PMID:18096160. |
antidepressants selectively blocking serotonin reuptake can increase bdnf levels, and also may increase neurogenesis. |
2008-05-02 |
2023-08-12 |
mouse |
| Bruno P Guiard, Denis J P David, Thierry Deltheil, Franck Chenu, Erwan Le Maître, Thibault Renoir, Isabelle Leroux-Nicollet, Pierre Sokoloff, Laurence Lanfumey, Michel Hamon, Anne M Andrews, René Hen, Alain M Gardie. Brain-derived neurotrophic factor-deficient mice exhibit a hippocampal hyperserotonergic phenotype. The international journal of neuropsychopharmacology. vol 11. issue 1. 2008-04-15. PMID:17559709. |
heterozygous mutants bdnf +/- mice were utilized to investigate the influence of bdnf on the serotonin (5-ht) system and the activity of the serotonin transporter (sert) in the hippocampus. |
2008-04-15 |
2023-08-12 |
mouse |
| Bruno P Guiard, Denis J P David, Thierry Deltheil, Franck Chenu, Erwan Le Maître, Thibault Renoir, Isabelle Leroux-Nicollet, Pierre Sokoloff, Laurence Lanfumey, Michel Hamon, Anne M Andrews, René Hen, Alain M Gardie. Brain-derived neurotrophic factor-deficient mice exhibit a hippocampal hyperserotonergic phenotype. The international journal of neuropsychopharmacology. vol 11. issue 1. 2008-04-15. PMID:17559709. |
the zero net flux method of quantitative microdialysis revealed that bdnf +/- heterozygous mice have increased basal extracellular 5-ht levels in the hippocampus and decreased 5-ht reuptake capacity. |
2008-04-15 |
2023-08-12 |
mouse |
| Bruno P Guiard, Denis J P David, Thierry Deltheil, Franck Chenu, Erwan Le Maître, Thibault Renoir, Isabelle Leroux-Nicollet, Pierre Sokoloff, Laurence Lanfumey, Michel Hamon, Anne M Andrews, René Hen, Alain M Gardie. Brain-derived neurotrophic factor-deficient mice exhibit a hippocampal hyperserotonergic phenotype. The international journal of neuropsychopharmacology. vol 11. issue 1. 2008-04-15. PMID:17559709. |
in keeping with these results, the selective serotonin reuptake inhibitor paroxetine failed to increase hippocampal extracellular 5-ht levels in bdnf +/- mice while it produced robust effects in wild-type littermates. |
2008-04-15 |
2023-08-12 |
mouse |
| Bruno P Guiard, Denis J P David, Thierry Deltheil, Franck Chenu, Erwan Le Maître, Thibault Renoir, Isabelle Leroux-Nicollet, Pierre Sokoloff, Laurence Lanfumey, Michel Hamon, Anne M Andrews, René Hen, Alain M Gardie. Brain-derived neurotrophic factor-deficient mice exhibit a hippocampal hyperserotonergic phenotype. The international journal of neuropsychopharmacology. vol 11. issue 1. 2008-04-15. PMID:17559709. |
using in-vitro autoradiography and synaptosome techniques, we investigated the causes of attenuated 5-ht reuptake in bdnf +/- mice. |
2008-04-15 |
2023-08-12 |
mouse |
| b' Astrid Bj\\xc3\\xb8rnebekk, Aleksander A Math\\xc3\\xa9, Susanne H M Gruber, Stefan Bren\\xc3\\xa. Social isolation increases number of newly proliferated cells in hippocampus in female flinders sensitive line rats. Hippocampus. vol 17. issue 12. 2008-02-29. PMID:17879375.' |
in an animal model of depression, flinders sensitive line rats, and sprague dawley controls we analyzed if 7 weeks of social isolation of adult animals affect the number of newly proliferated cells in the dentate gyrus or mrnas of neuropeptide y (npy), the npy-y1 receptor, nociceptin, bdnf, and the serotonin 5ht1a and 5ht2a receptors, which are molecules involved in hippocampal plasticity. |
2008-02-29 |
2023-08-12 |
rat |
| b' Astrid Bj\\xc3\\xb8rnebekk, Aleksander A Math\\xc3\\xa9, Susanne H M Gruber, Stefan Bren\\xc3\\xa. Social isolation increases number of newly proliferated cells in hippocampus in female flinders sensitive line rats. Hippocampus. vol 17. issue 12. 2008-02-29. PMID:17879375.' |
group housed sprague dawley rats had a higher expression of bdnf, npy, and the serotonin 5ht2a receptor mrna than "depressed" flinders sensitive line. |
2008-02-29 |
2023-08-12 |
rat |
| Nicolas P Lapointe, Roth-Visal Ung, Pierre A Guerti. Plasticity in sublesionally located neurons following spinal cord injury. Journal of neurophysiology. vol 98. issue 5. 2008-02-25. PMID:17881483. |
some of these modifications include changes in the expression of immediate early genes (e.g., c-fos and nor-1), tnf-alpha, preprodynorphin, neurotrophic factors (e.g., bdnf and nt-3), and several subtypes of transmembranal receptors (e.g., 5-ht(1a) and 5-ht(2a)). |
2008-02-25 |
2023-08-12 |
Not clear |
| Jens R Wendland, Matthew R Kruse, Kiara R Cromer, Kiara C Cromer, Dennis L Murph. A large case-control study of common functional SLC6A4 and BDNF variants in obsessive-compulsive disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 12. 2008-02-14. PMID:17375136. |
both serotonin transporter (slc6a4) and brain-derived neurotrophic factor (bdnf) genes have shown positive associations with obsessive-compulsive disorder (ocd) and some other psychiatric disorders, but these results have not been consistently replicated. |
2008-02-14 |
2023-08-12 |
Not clear |