| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiansong Zhou, Lingjiang Li, Shaojun Tang, Xia Cao, Zexuan Li, Weihui Li, Changqi Li, Xianghui Zhan. Effects of serotonin depletion on the hippocampal GR/MR and BDNF expression during the stress adaptation. Behavioural brain research. vol 195. issue 1. 2009-01-12. PMID:18601957. |
the para-chloroamphetamine (p-pca) was used to deplete 5-ht in the rat prior to repeated restraint stress (6h/day for 10 days), and determined the consequences of 5-ht depletion on stress-induced alterations of animal behaviors, hippocampal corticosteroid receptor immunoreactivity and the brain-derived neurotrophic factor (bdnf) mrna expression. |
2009-01-12 |
2023-08-12 |
rat |
| Jiansong Zhou, Lingjiang Li, Shaojun Tang, Xia Cao, Zexuan Li, Weihui Li, Changqi Li, Xianghui Zhan. Effects of serotonin depletion on the hippocampal GR/MR and BDNF expression during the stress adaptation. Behavioural brain research. vol 195. issue 1. 2009-01-12. PMID:18601957. |
the study suggest that 5-ht deficiency in the adult hippocampus may impair stress adaptation by suppressing hippocampal gr and bdnf expression. |
2009-01-12 |
2023-08-12 |
rat |
| Olaf Schulte-Herbrüggen, Heide Hörtnagl, Gerald Ponath, Matthias Rothermundt, Rainer Hellwe. Distinct regulation of brain-derived neurotrophic factor and noradrenaline in S100B knockout mice. Neuroscience letters. vol 442. issue 2. 2008-12-12. PMID:18638525. |
therefore we investigated levels of serotonin (5-ht) and its metabolite 5-hydroxyindoleacetic acid (5-hiaa), noradrenaline (na), dopamine (da), brain-derived neurotrophic factor (bdnf) and nerve growth factor (ngf) in the hippocampus, frontal cortex and residual neocortex in s100b knock out (s100b ko) mice compared to wildtype controls. |
2008-12-12 |
2023-08-12 |
mouse |
| Wenzhen Duan, Qi Peng, Naoki Masuda, Eric Ford, Erik Tryggestad, Bruce Ladenheim, Ming Zhao, Jean Lud Cadet, John Wong, Christopher A Ros. Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington's disease. Neurobiology of disease. vol 30. issue 3. 2008-11-07. PMID:18403212. |
to identify neuroprotective compound (s) that can slow down disease progression and can be administered long term with few side effects in huntington's disease, we investigated the effect of sertraline, a selective serotonin reuptake inhibitor (ssri) which has been shown to upregulate bdnf levels in rodent brains. |
2008-11-07 |
2023-08-12 |
mouse |
| Pablo Salazar-Colocho, Joaquín Del Río, Diana Frechill. Neuroprotective effects of serotonin 5-HT 1A receptor activation against ischemic cell damage in gerbil hippocampus: Involvement of NMDA receptor NR1 subunit and BDNF. Brain research. vol 1199. 2008-09-29. PMID:18269931. |
neuroprotective effects of serotonin 5-ht 1a receptor activation against ischemic cell damage in gerbil hippocampus: involvement of nmda receptor nr1 subunit and bdnf. |
2008-09-29 |
2023-08-12 |
Not clear |
| Ilona Vincze, Nader Perroud, Catherine Buresi, Patrick Baud, Frank Bellivier, Bruno Etain, Claire Fournier, Felicien Karege, Marie-Louise Matthey, Martin Preisig, Marion Leboyer, Alain Malafoss. Association between brain-derived neurotrophic factor gene and a severe form of bipolar disorder, but no interaction with the serotonin transporter gene. Bipolar disorders. vol 10. issue 5. 2008-09-25. PMID:18657242. |
several family and population-based studies have reported associations between the bdnf gene and serotonin-related genes, specifically the serotonin transporter (5htt) gene, with bipolar disorder (bd) and sb. |
2008-09-25 |
2023-08-12 |
Not clear |
| Ilona Vincze, Nader Perroud, Catherine Buresi, Patrick Baud, Frank Bellivier, Bruno Etain, Claire Fournier, Felicien Karege, Marie-Louise Matthey, Martin Preisig, Marion Leboyer, Alain Malafoss. Association between brain-derived neurotrophic factor gene and a severe form of bipolar disorder, but no interaction with the serotonin transporter gene. Bipolar disorders. vol 10. issue 5. 2008-09-25. PMID:18657242. |
however, despite the fact that gene-by-gene interaction between bdnf and 5htt has been demonstrated in monoamine deficiencies in animals, this kind of interaction has never been tested in humans. |
2008-09-25 |
2023-08-12 |
Not clear |
| Ilona Vincze, Nader Perroud, Catherine Buresi, Patrick Baud, Frank Bellivier, Bruno Etain, Claire Fournier, Felicien Karege, Marie-Louise Matthey, Martin Preisig, Marion Leboyer, Alain Malafoss. Association between brain-derived neurotrophic factor gene and a severe form of bipolar disorder, but no interaction with the serotonin transporter gene. Bipolar disorders. vol 10. issue 5. 2008-09-25. PMID:18657242. |
our hypothesis is that some bdnf and 5htt polymorphisms might confer increased risk for bd and sb and that both genes may interact with each other. |
2008-09-25 |
2023-08-12 |
Not clear |
| Saloua Benmansour, Thierry Deltheil, Jonathan Piotrowski, Lorelei Nicolas, Christelle Reperant, Alain M Gardier, Alan Frazer, Denis J Davi. Influence of brain-derived neurotrophic factor (BDNF) on serotonin neurotransmission in the hippocampus of adult rodents. European journal of pharmacology. vol 587. issue 1-3. 2008-08-25. PMID:18474368. |
influence of brain-derived neurotrophic factor (bdnf) on serotonin neurotransmission in the hippocampus of adult rodents. |
2008-08-25 |
2023-08-12 |
mouse |
| Saloua Benmansour, Thierry Deltheil, Jonathan Piotrowski, Lorelei Nicolas, Christelle Reperant, Alain M Gardier, Alan Frazer, Denis J Davi. Influence of brain-derived neurotrophic factor (BDNF) on serotonin neurotransmission in the hippocampus of adult rodents. European journal of pharmacology. vol 587. issue 1-3. 2008-08-25. PMID:18474368. |
a single bdnf injection (either intracerebroventricularly or directly into the ca3 region of hippocampus) decreased the signal amplitude and clearance rate produced by exogenously applied 5-ht compared to what was measured in control rats, shown using in vivo chronoamperometry. |
2008-08-25 |
2023-08-12 |
mouse |
| Saloua Benmansour, Thierry Deltheil, Jonathan Piotrowski, Lorelei Nicolas, Christelle Reperant, Alain M Gardier, Alan Frazer, Denis J Davi. Influence of brain-derived neurotrophic factor (BDNF) on serotonin neurotransmission in the hippocampus of adult rodents. European journal of pharmacology. vol 587. issue 1-3. 2008-08-25. PMID:18474368. |
in awake freely moving mice, acute intrahippocampal injection of bdnf decreased extracellular levels of 5-ht in the hippocampus, as measured using microdialysis. |
2008-08-25 |
2023-08-12 |
mouse |
| Saloua Benmansour, Thierry Deltheil, Jonathan Piotrowski, Lorelei Nicolas, Christelle Reperant, Alain M Gardier, Alan Frazer, Denis J Davi. Influence of brain-derived neurotrophic factor (BDNF) on serotonin neurotransmission in the hippocampus of adult rodents. European journal of pharmacology. vol 587. issue 1-3. 2008-08-25. PMID:18474368. |
in addition, perfusion with bdnf decreased kcl-evoked elevations of 5-ht. |
2008-08-25 |
2023-08-12 |
mouse |
| Scarlett B Pinnock, Joe Herber. Brain-derived neurotropic factor and neurogenesis in the adult rat dentate gyrus: interactions with corticosterone. The European journal of neuroscience. vol 27. issue 10. 2008-08-20. PMID:18547240. |
this, together with our previous findings, suggests that corticoid rhythms permit both serotonin and no access to bdnf, and the latter to regulate progenitor cell activity. |
2008-08-20 |
2023-08-12 |
rat |
| Luisella Bocchio-Chiavetto, Carlo Miniussi, Roberta Zanardini, Anna Gazzoli, Stefano Bignotti, Claudia Specchia, Massimo Gennarell. 5-HTTLPR and BDNF Val66Met polymorphisms and response to rTMS treatment in drug resistant depression. Neuroscience letters. vol 437. issue 2. 2008-08-18. PMID:18450378. |
according to this rationale, we investigated the role of two functional polymorphisms in the genes coding for the serotonin transporter (5-httlpr) and the brain-derived neurotrophic factor (bdnf val66met), and rtms response in a group of 36 drug resistant patients affected by mood disorders. |
2008-08-18 |
2023-08-12 |
Not clear |
| L Pezawas, A Meyer-Lindenberg, A L Goldman, B A Verchinski, G Chen, B S Kolachana, M F Egan, V S Mattay, A R Hariri, D R Weinberge. Evidence of biologic epistasis between BDNF and SLC6A4 and implications for depression. Molecular psychiatry. vol 13. issue 7. 2008-08-13. PMID:18347599. |
5-httlpr and bdnf val66met, functional polymorphisms of the serotonin (5-ht) transporter (slc6a4) and brain-derived neurotrophic factor (bdnf) gene, impact on two distinct, but interacting signaling systems, which have been related to depression and to the modulation of neurogenesis and plasticity of circuitries of emotion processing. |
2008-08-13 |
2023-08-12 |
mouse |
| L Pezawas, A Meyer-Lindenberg, A L Goldman, B A Verchinski, G Chen, B S Kolachana, M F Egan, V S Mattay, A R Hariri, D R Weinberge. Evidence of biologic epistasis between BDNF and SLC6A4 and implications for depression. Molecular psychiatry. vol 13. issue 7. 2008-08-13. PMID:18347599. |
here we show, using anatomical neuroimaging techniques in a sample of healthy subjects (n=111), that the bdnf met allele, which is predicted to have reduced responsivity to 5-ht signaling, protects against 5-httlpr s allele-induced effects on a brain circuitry encompassing the amygdala and the subgenual portion of the anterior cingulate (rac). |
2008-08-13 |
2023-08-12 |
mouse |
| Thierry Deltheil, Bruno P Guiard, Jean-Philippe Guilloux, Lorelei Nicolas, Claudine Deloménie, Christelle Repérant, Erwan Le Maitre, Isabelle Leroux-Nicollet, Saloua Benmansour, François Coudoré, Denis J David, Alain M Gardie. Consequences of changes in BDNF levels on serotonin neurotransmission, 5-HT transporter expression and function: studies in adult mice hippocampus. Pharmacology, biochemistry, and behavior. vol 90. issue 2. 2008-08-12. PMID:17980409. |
consequences of changes in bdnf levels on serotonin neurotransmission, 5-ht transporter expression and function: studies in adult mice hippocampus. |
2008-08-12 |
2023-08-12 |
mouse |
| Thierry Deltheil, Bruno P Guiard, Jean-Philippe Guilloux, Lorelei Nicolas, Claudine Deloménie, Christelle Repérant, Erwan Le Maitre, Isabelle Leroux-Nicollet, Saloua Benmansour, François Coudoré, Denis J David, Alain M Gardie. Consequences of changes in BDNF levels on serotonin neurotransmission, 5-HT transporter expression and function: studies in adult mice hippocampus. Pharmacology, biochemistry, and behavior. vol 90. issue 2. 2008-08-12. PMID:17980409. |
indeed, although the elevation of 5-ht outflow induced by chronic administration of selective serotonin reuptake inhibitors (ssris) causes an increase in bdnf protein levels and expression (mrna) in the hippocampus of rodents, the reciprocal interaction has not been demonstrated yet. |
2008-08-12 |
2023-08-12 |
mouse |
| Thierry Deltheil, Bruno P Guiard, Jean-Philippe Guilloux, Lorelei Nicolas, Claudine Deloménie, Christelle Repérant, Erwan Le Maitre, Isabelle Leroux-Nicollet, Saloua Benmansour, François Coudoré, Denis J David, Alain M Gardie. Consequences of changes in BDNF levels on serotonin neurotransmission, 5-HT transporter expression and function: studies in adult mice hippocampus. Pharmacology, biochemistry, and behavior. vol 90. issue 2. 2008-08-12. PMID:17980409. |
thus, the neurochemical sight of this question will be addressed here by examining the consequences of either a constitutive decrease or increase in brain bdnf protein levels on hippocampal extracellular levels of 5-ht in conscious mice. |
2008-08-12 |
2023-08-12 |
mouse |
| Claudio Mannari, Nicola Origlia, Alessia Scatena, Alessandro Del Debbio, Mario Catena, Grazia Dell'agnello, Alessandra Barraco, Luca Giovannini, Liliana Dell'osso, Luciano Domenici, Armando Piccinn. BDNF level in the rat prefrontal cortex increases following chronic but not acute treatment with duloxetine, a dual acting inhibitor of noradrenaline and serotonin re-uptake. Cellular and molecular neurobiology. vol 28. issue 3. 2008-08-11. PMID:18172756. |
bdnf level in the rat prefrontal cortex increases following chronic but not acute treatment with duloxetine, a dual acting inhibitor of noradrenaline and serotonin re-uptake. |
2008-08-11 |
2023-08-12 |
rat |