| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C T Correia, A M Coutinho, A F Sequeira, I G Sousa, L Lourenço Venda, J P Almeida, R L Abreu, C Lobo, T S Miguel, J Conroy, L Cochrane, L Gallagher, M Gill, S Ennis, G G Oliveira, A M Vicent. Increased BDNF levels and NTRK2 gene association suggest a disruption of BDNF/TrkB signaling in autism. Genes, brain, and behavior. vol 9. issue 7. 2011-02-08. PMID:20662941. |
we found that bdnf levels in autistic children (n = 146) were significantly higher (t = 6.82; p < 0.0001) than in control children (n = 50) and were positively correlated with platelet serotonin distribution (r = 0.22; p = 0.004). |
2011-02-08 |
2023-08-12 |
Not clear |
| Sangmoon Shin, Robert Stewart, Cleusa P Ferri, Jae-Min Kim, Il-Seon Shin, Sung-Wan Kim, Su-Jin Yang, Jin-Sang Yoo. An investigation of associations between alcohol use disorder and polymorphisms on ALDH2, BDNF, 5-HTTLPR, and MTHFR genes in older Korean men. International journal of geriatric psychiatry. vol 25. issue 5. 2011-01-26. PMID:19637400. |
this study aimed to investigate the association of alcohol use disorder (aud) with four candidate genes in older korean men: aldehyde dehydrogenase 2 (aldh2, 1/2), brain-derived neurotrophic factor (bdnf, val66met), serotonin transporter gene linked polymorphic region (5-httlpr, s/l), and methylenetetrahydrofolate reductase (mthfr, c.677c > t). |
2011-01-26 |
2023-08-12 |
Not clear |
| Plínio Cabrera Casarotto, Valquiria Camin de Bortoli, Fernando Morgan de Aguiar Corrêa, Leonardo Barbosa Moraes Resstel, Hélio Zangross. Panicolytic-like effect of BDNF in the rat dorsal periaqueductal grey matter: the role of 5-HT and GABA. The international journal of neuropsychopharmacology. vol 13. issue 5. 2011-01-25. PMID:20047714. |
panicolytic-like effect of bdnf in the rat dorsal periaqueductal grey matter: the role of 5-ht and gaba. |
2011-01-25 |
2023-08-12 |
rat |
| Shashwath A Meda, Kanchana Jagannathan, Joel Gelernter, Vince D Calhoun, Jingyu Liu, Michael C Stevens, Godfrey D Pearlso. A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia. NeuroImage. vol 53. issue 3. 2011-01-03. PMID:19944766. |
the fmri components, along with their significant genetic profile (dominant snp) correlations were as follows: (1) inferior frontal-anterior/posterior cingulate-thalamus-caudate with snps from brain derived neurotropic factor (bdnf) and dopamine transporter (dat) [r=-0.51; p<0.0001], (2) superior/middle temporal gyrus-cingulate-premotor with slc6a4_pr and slc6a4_pr_ag (serotonin transporter promoter; 5httlpr) [r=0.27; p=0.03], and (3) default mode-fronto-temporal gyrus with brain derived neurotropic factor and dopamine transporter (bdnf, dat) [r=-0.25; p=0.04]. |
2011-01-03 |
2023-08-12 |
human |
| Tony T Wells, Christopher G Beevers, John E McGear. Serotonin transporter and BDNF genetic variants interact to predict cognitive reactivity in healthy adults. Journal of affective disorders. vol 126. issue 1-2. 2010-12-27. PMID:20398943. |
serotonin transporter and bdnf genetic variants interact to predict cognitive reactivity in healthy adults. |
2010-12-27 |
2023-08-12 |
Not clear |
| A B Klein, M A Santini, S Aznar, G M Knudsen, M Rio. Changes in 5-HT2A-mediated behavior and 5-HT2A- and 5-HT1A receptor binding and expression in conditional brain-derived neurotrophic factor knock-out mice. Neuroscience. vol 169. issue 3. 2010-12-16. PMID:20576498. |
5-ht(2a) ([(3)h]-mdl100907) and 5-ht(1a) ([(3)h]-way100635) receptor autoradiography revealed site-specific alterations in bdnf mutant mice. |
2010-12-16 |
2023-08-12 |
mouse |
| A B Klein, M A Santini, S Aznar, G M Knudsen, M Rio. Changes in 5-HT2A-mediated behavior and 5-HT2A- and 5-HT1A receptor binding and expression in conditional brain-derived neurotrophic factor knock-out mice. Neuroscience. vol 169. issue 3. 2010-12-16. PMID:20576498. |
additionally, 5-ht(1a) receptor binding was decreased in hippocampus of bdnf mutants, but unchanged in frontal cortex. |
2010-12-16 |
2023-08-12 |
mouse |
| A B Klein, M A Santini, S Aznar, G M Knudsen, M Rio. Changes in 5-HT2A-mediated behavior and 5-HT2A- and 5-HT1A receptor binding and expression in conditional brain-derived neurotrophic factor knock-out mice. Neuroscience. vol 169. issue 3. 2010-12-16. PMID:20576498. |
molecular analysis indicated corresponding changes in 5-ht(2a) and 5-ht(1a) mrna expression but normal 5-ht(2c) content in these brain regions in bdnf(2l/2lck-cre) mice. |
2010-12-16 |
2023-08-12 |
mouse |
| A B Klein, M A Santini, S Aznar, G M Knudsen, M Rio. Changes in 5-HT2A-mediated behavior and 5-HT2A- and 5-HT1A receptor binding and expression in conditional brain-derived neurotrophic factor knock-out mice. Neuroscience. vol 169. issue 3. 2010-12-16. PMID:20576498. |
bdnf(2l/2lck-cre) mutants treated with the 5-ht(2a) receptor agonist (+/-)-2,5-dimethoxy-4-iodoamphetamine (doi) showed a clearly diminished esr but no differences in htr compared to wildtypes. |
2010-12-16 |
2023-08-12 |
mouse |
| A B Klein, M A Santini, S Aznar, G M Knudsen, M Rio. Changes in 5-HT2A-mediated behavior and 5-HT2A- and 5-HT1A receptor binding and expression in conditional brain-derived neurotrophic factor knock-out mice. Neuroscience. vol 169. issue 3. 2010-12-16. PMID:20576498. |
these findings illustrate the context-dependent effects of deficient bdnf signaling on the 5-ht receptor system and 5-ht(2a)-receptor functional output. |
2010-12-16 |
2023-08-12 |
mouse |
| V E Golimbet, O S Brusov, M I Factor, G P Zlobina, T V Lezheĭko, O M Lavrushina, E A Petrova, M A Savina, V I Skvortsov. [Interaction effect of serotonin transporter gene and brain-derived neurotrophic factor on the platelet serotonin content in stroke patients]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 110. issue 4 Suppl 2. 2010-12-10. PMID:20738025. |
we studied the association between two polymorphisms (5-httlpr and val66met bdnf) and the platelet serotonin content in 47 patients with stroke. |
2010-12-10 |
2023-08-12 |
Not clear |
| Anders Bue Klein, Viktorija Trajkovska, David Erritzoe, Steven Haugbol, Jacob Madsen, William Baaré, Susana Aznar, Gitte M Knudse. Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 30. issue 11. 2010-11-29. PMID:20736957. |
cerebral 5-ht2a receptor and serotonin transporter binding in humans are not affected by the val66met bdnf polymorphism status or blood bdnf levels. |
2010-11-29 |
2023-08-12 |
human |
| Anders Bue Klein, Viktorija Trajkovska, David Erritzoe, Steven Haugbol, Jacob Madsen, William Baaré, Susana Aznar, Gitte M Knudse. Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 30. issue 11. 2010-11-29. PMID:20736957. |
in this study, we investigated whether the bdnf val66met polymorphism or blood bdnf levels are associated with cerebral 5-hydroxytryptamine 2a (5-ht(2a)) receptor or serotonin transporter (sert) binding in healthy subjects. |
2010-11-29 |
2023-08-12 |
human |
| Anders Bue Klein, Viktorija Trajkovska, David Erritzoe, Steven Haugbol, Jacob Madsen, William Baaré, Susana Aznar, Gitte M Knudse. Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 30. issue 11. 2010-11-29. PMID:20736957. |
no statistically significant differences in 5-ht(2a) receptor or sert binding were found between the val/val and met carriers, nor were blood bdnf values associated with sert binding or 5-ht(2a) receptor binding. |
2010-11-29 |
2023-08-12 |
human |
| Anders Bue Klein, Viktorija Trajkovska, David Erritzoe, Steven Haugbol, Jacob Madsen, William Baaré, Susana Aznar, Gitte M Knudse. Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 30. issue 11. 2010-11-29. PMID:20736957. |
moreover, bdnf levels in blood do not correlate with either 5-ht(2a) or sert binding. |
2010-11-29 |
2023-08-12 |
human |
| Angela M Devlin, Ursula Brain, Jehannine Austin, Tim F Oberlande. Prenatal exposure to maternal depressed mood and the MTHFR C677T variant affect SLC6A4 methylation in infants at birth. PloS one. vol 5. issue 8. 2010-11-04. PMID:20808944. |
the methylation status of slc6a4, which encodes the transmembrane serotonin transporter, and bdnf, which encodes brain derived neurotrophic factor, were assessed because of their potential role in behaviour. |
2010-11-04 |
2023-08-12 |
Not clear |
| Wen-Jing Li, Hui Yu, Jian-Min Yang, Jing Gao, Hong Jiang, Min Feng, Yu-Xia Zhao, Zhe-Yu Che. Anxiolytic effect of music exposure on BDNFMet/Met transgenic mice. Brain research. vol 1347. 2010-11-02. PMID:20515664. |
the humanized bdnf(met/met) knock-in transgenic mice exhibited increased anxiety-related behaviors that were unresponsive to serotonin reuptake inhibitors, fluoxetine. |
2010-11-02 |
2023-08-12 |
mouse |
| Laura Baroncelli, Alessandro Sale, Alessandro Viegi, José Fernando Maya Vetencourt, Roberto De Pasquale, Sara Baldini, Lamberto Maffe. Experience-dependent reactivation of ocular dominance plasticity in the adult visual cortex. Experimental neurology. vol 226. issue 1. 2010-10-28. PMID:20713044. |
we also found that ee leads to a reduced intracortical gabaergic inhibition and an increased bdnf expression and that the modulation of these molecular factors is neutralized by cortical infusion of the 5-ht synthesis inhibitor pcpa. |
2010-10-28 |
2023-08-12 |
rat |
| Eleni Païzanis, Thibault Renoir, Vincent Lelievre, Françoise Saurini, Maxette Melfort, Cecilia Gabriel, Nicholas Barden, Elisabeth Mocaër, Michel Hamon, Laurence Lanfume. Behavioural and neuroplastic effects of the new-generation antidepressant agomelatine compared to fluoxetine in glucocorticoid receptor-impaired mice. The international journal of neuropsychopharmacology. vol 13. issue 6. 2010-09-29. PMID:19775499. |
glucocorticoid receptor-impaired (gr-i) mice, a transgenic model for affective disorders with hypothalamic-pituitary-adrenal (hpa) axis feedback control deficit, were used to assess the antidepressant-like effects of the mixed melatonin receptor agonist/5-ht(2c) receptor antagonist, agomelatine, compared to the selective 5-ht reuptake inhibitor (ssri), fluoxetine, on hippocampal neurogenesis, gr and bdnf expression and antidepressant-responsive behaviour (tail suspension test, tst). |
2010-09-29 |
2023-08-12 |
mouse |
| Chad E Beyer, Jason M Dwyer, Michael J Piesla, Brian J Platt, Ru Shen, Zia Rahman, Karen Chan, Melissa T Manners, Tarek A Samad, Jeffrey D Kennedy, Brendan Bingham, Garth T Whitesid. Depression-like phenotype following chronic CB1 receptor antagonism. Neurobiology of disease. vol 39. issue 2. 2010-09-10. PMID:20381618. |
additionally, chronic treatment with rimonabant produced decreases in frontal cortex serotonin levels, marked reductions in hippocampal cell proliferation, survival, and bdnf levels, and elevations in the concentrations of pro-inflammatory cytokines including interferon gamma and tnf alpha. |
2010-09-10 |
2023-08-12 |
rat |