| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ahmad A Khundakar, Tyra S C Zetterströ. Effects of GABAB ligands alone and in combination with paroxetine on hippocampal BDNF gene expression. European journal of pharmacology. vol 671. issue 1-3. 2012-03-01. PMID:21930121. |
the inhibitory action by the selective serotonin re-uptake inhibitor (ssri) paroxetine on hippocampal bdnf mrna was also attenuated by cgp 46381. |
2012-03-01 |
2023-08-12 |
rat |
| J Cole, D R Weinberger, V S Mattay, X Cheng, A W Toga, P M Thompson, G Powell-Smith, S Cohen-Woods, A Simmons, P McGuffin, C H Y F. No effect of 5HTTLPR or BDNF Val66Met polymorphism on hippocampal morphology in major depression. Genes, brain, and behavior. vol 10. issue 7. 2012-02-22. PMID:21692988. |
imaging genetics studies have investigated the influence of the serotonin transporter-linked polymorphic region (5httlpr) and brain-derived neurotrophic factor (bdnf) val66met polymorphism on the hippocampus in healthy individuals and patients with depression (mdd). |
2012-02-22 |
2023-08-12 |
Not clear |
| P C Clasen, T T Wells, V S Knopik, J E McGeary, C G Beever. 5-HTTLPR and BDNF Val66Met polymorphisms moderate effects of stress on rumination. Genes, brain, and behavior. vol 10. issue 7. 2012-02-22. PMID:21745335. |
this study examined whether polymorphisms in the serotonin transporter (slc6a4, 5-httlpr) and brain-derived neurotropic factor (bdnf val66met, rs6265) genes moderate the relationship between life stress and rumination. |
2012-02-22 |
2023-08-12 |
human |
| F F da Rocha, L Malloy-Diniz, N V Lage, H Corrê. The relationship between the Met allele of the BDNF Val66Met polymorphism and impairments in decision making under ambiguity in patients with obsessive-compulsive disorder. Genes, brain, and behavior. vol 10. issue 5. 2012-02-13. PMID:21401876. |
brain-derived neurotrophic factor (bdnf) gene has an important link to neurotransmitter systems, including serotonin, and seems to play a major role in emotional decision making. |
2012-02-13 |
2023-08-12 |
Not clear |
| Sarah J Texel, Simonetta Camandola, Bruce Ladenheim, Sarah M Rothman, Mohamed R Mughal, Erica L Unger, Jean Lud Cadet, Mark P Mattso. Ceruloplasmin deficiency results in an anxiety phenotype involving deficits in hippocampal iron, serotonin, and BDNF. Journal of neurochemistry. vol 120. issue 1. 2012-02-06. PMID:22035068. |
ceruloplasmin deficiency results in an anxiety phenotype involving deficits in hippocampal iron, serotonin, and bdnf. |
2012-02-06 |
2023-08-12 |
mouse |
| Sarah J Texel, Simonetta Camandola, Bruce Ladenheim, Sarah M Rothman, Mohamed R Mughal, Erica L Unger, Jean Lud Cadet, Mark P Mattso. Ceruloplasmin deficiency results in an anxiety phenotype involving deficits in hippocampal iron, serotonin, and BDNF. Journal of neurochemistry. vol 120. issue 1. 2012-02-06. PMID:22035068. |
previous studies provided evidence that anxiety disorders and long-standing stress are associated with reductions in levels of serotonin (5ht) and brain-derived neurotrophic factor (bdnf) in the hippocampus. |
2012-02-06 |
2023-08-12 |
mouse |
| Sarah J Texel, Simonetta Camandola, Bruce Ladenheim, Sarah M Rothman, Mohamed R Mughal, Erica L Unger, Jean Lud Cadet, Mark P Mattso. Ceruloplasmin deficiency results in an anxiety phenotype involving deficits in hippocampal iron, serotonin, and BDNF. Journal of neurochemistry. vol 120. issue 1. 2012-02-06. PMID:22035068. |
we found that levels of 5ht and norepinephrine (ne), and the expression of bdnf and its receptor trkb, are significantly reduced in the hippocampus of cpko mice. |
2012-02-06 |
2023-08-12 |
mouse |
| Sarah J Texel, Simonetta Camandola, Bruce Ladenheim, Sarah M Rothman, Mohamed R Mughal, Erica L Unger, Jean Lud Cadet, Mark P Mattso. Ceruloplasmin deficiency results in an anxiety phenotype involving deficits in hippocampal iron, serotonin, and BDNF. Journal of neurochemistry. vol 120. issue 1. 2012-02-06. PMID:22035068. |
thus, cp deficiency causes an anxiety phenotype by a mechanism that involves decreased levels of iron, 5ht, ne, and bdnf in the hippocampus. |
2012-02-06 |
2023-08-12 |
mouse |
| Leo She. The role of brain-derived neurotrophic factor in the pathophysiology of adolescent suicidal behavior. International journal of adolescent medicine and health. vol 23. issue 3. 2012-01-17. PMID:22191181. |
the serotonin dysfunction found in adolescent and adult suicidal behavior could be related to the low level of bdnf, which impedes the normal development of serotonin neurons during brain development. |
2012-01-17 |
2023-08-12 |
Not clear |
| Nela Pivac, Matea Nikolac, Gordana Nedic, Maja Mustapic, Fran Borovecki, Sanja Hajnsek, Paola Presecki, Mladen Pavlovic, Ninoslav Mimica, Dorotea Muck Sele. Brain derived neurotrophic factor Val66Met polymorphism and psychotic symptoms in Alzheimer's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 35. issue 2. 2011-11-22. PMID:21044653. |
since behavioral disturbances, such as psychotic symptoms, represent a key feature of ad, genes related to dopamine, serotonin and brain derived neurotrophic factor (bdnf), are considered as candidate genes for ad. |
2011-11-22 |
2023-08-12 |
Not clear |
| Charles S Carver, Sheri L Johnson, Jutta Joormann, Joelle Lemoult, Michael L Cuccar. Childhood adversity interacts separately with 5-HTTLPR and BDNF to predict lifetime depression diagnosis. Journal of affective disorders. vol 132. issue 1-2. 2011-11-01. PMID:21420735. |
the serotonin transporter polymorphism (5-httlpr) and the brain-derived neurotrophic factor (bdnf) val66met polymorphism have both been linked to depression symptoms and to depression diagnosis (mdd) in interaction with adversity; there have also been failures to find the effects. |
2011-11-01 |
2023-08-12 |
Not clear |
| Y Mizoguchi, A Monji, T A Kato, H Horikawa, Y Seki, M Kasai, S Kanba, S Yamad. Possible role of BDNF-induced microglial intracellular Ca(2+) elevation in the pathophysiology of neuropsychiatric disorders. Mini reviews in medicinal chemistry. vol 11. issue 7. 2011-10-06. PMID:21699488. |
additionally, selective serotonin reuptake inhibitors (ssris), including paroxetine or sertraline, potentiated the bdnf-induced increase in [ca(2+)]i in rodent microglial cells this article provides a review of recent findings on the role of bdnf in the pathophysiology of neuropsychiatric disorders, especially by focusing on its effect on intracellular ca(2+) signaling in microglial cells. |
2011-10-06 |
2023-08-12 |
Not clear |
| Rachel A Hill, Simon S Murray, Paul G Halley, Michele D Binder, Sally J Martin, Maarten van den Buus. Brain-derived neurotrophic factor expression is increased in the hippocampus of 5-HT(2C) receptor knockout mice. Hippocampus. vol 21. issue 4. 2011-09-28. PMID:20087884. |
several studies have suggested a close interaction between serotonin (5-ht) and bdnf; however, little is known of the specific relationship between bdnf and the 5-ht(2c) receptor. |
2011-09-28 |
2023-08-12 |
mouse |
| Rachel A Hill, Simon S Murray, Paul G Halley, Michele D Binder, Sally J Martin, Maarten van den Buus. Brain-derived neurotrophic factor expression is increased in the hippocampus of 5-HT(2C) receptor knockout mice. Hippocampus. vol 21. issue 4. 2011-09-28. PMID:20087884. |
therefore, in this study we investigated bdnf expression in 5-ht(2c) receptor knockout mice (5-ht(2c) ko). |
2011-09-28 |
2023-08-12 |
mouse |
| Rachel A Hill, Simon S Murray, Paul G Halley, Michele D Binder, Sally J Martin, Maarten van den Buus. Brain-derived neurotrophic factor expression is increased in the hippocampus of 5-HT(2C) receptor knockout mice. Hippocampus. vol 21. issue 4. 2011-09-28. PMID:20087884. |
western blot analysis demonstrated a significant 2.2-fold increase in the expression of the mature form of bdnf in 5-ht(2c) ko mice when compared with wild-type controls (wt) in the hippocampus (p = 0.008), but not frontal cortex or striatum. |
2011-09-28 |
2023-08-12 |
mouse |
| Rachel A Hill, Simon S Murray, Paul G Halley, Michele D Binder, Sally J Martin, Maarten van den Buus. Brain-derived neurotrophic factor expression is increased in the hippocampus of 5-HT(2C) receptor knockout mice. Hippocampus. vol 21. issue 4. 2011-09-28. PMID:20087884. |
no differences in the expression of the pro-bdnf isoform were found, and the ratio of mature/pro bdnf was significantly increased in 5-ht(2c) ko (p = 0.003). |
2011-09-28 |
2023-08-12 |
mouse |
| Rachel A Hill, Simon S Murray, Paul G Halley, Michele D Binder, Sally J Martin, Maarten van den Buus. Brain-derived neurotrophic factor expression is increased in the hippocampus of 5-HT(2C) receptor knockout mice. Hippocampus. vol 21. issue 4. 2011-09-28. PMID:20087884. |
hence, increased mature bdnf levels in 5-ht(2c) ko hippocampus are most likely due to increased extracellular cleavage rates of pro-bdnf to its mature form. |
2011-09-28 |
2023-08-12 |
mouse |
| Rachel A Hill, Simon S Murray, Paul G Halley, Michele D Binder, Sally J Martin, Maarten van den Buus. Brain-derived neurotrophic factor expression is increased in the hippocampus of 5-HT(2C) receptor knockout mice. Hippocampus. vol 21. issue 4. 2011-09-28. PMID:20087884. |
in conclusion, loss of 5-ht(2c) receptor expression leads to a marked and selective increase in levels of the mature form of bdnf in the hippocampus. |
2011-09-28 |
2023-08-12 |
mouse |
| Reiji Yoshimura, Taro Kishi, Akihito Suzuki, Wakako Umene-Nakano, Atsuko Ikenouchi-Sugita, Hikaru Hori, Koichi Otani, Nakao Iwata, Jun Nakamur. The brain-derived neurotrophic factor (BDNF) polymorphism Val66Met is associated with neither serum BDNF level nor response to selective serotonin reuptake inhibitors in depressed Japanese patients. Progress in neuro-psychopharmacology & biological psychiatry. vol 35. issue 4. 2011-09-13. PMID:21338649. |
the brain-derived neurotrophic factor (bdnf) polymorphism val66met is associated with neither serum bdnf level nor response to selective serotonin reuptake inhibitors in depressed japanese patients. |
2011-09-13 |
2023-08-12 |
Not clear |
| Reiji Yoshimura, Taro Kishi, Akihito Suzuki, Wakako Umene-Nakano, Atsuko Ikenouchi-Sugita, Hikaru Hori, Koichi Otani, Nakao Iwata, Jun Nakamur. The brain-derived neurotrophic factor (BDNF) polymorphism Val66Met is associated with neither serum BDNF level nor response to selective serotonin reuptake inhibitors in depressed Japanese patients. Progress in neuro-psychopharmacology & biological psychiatry. vol 35. issue 4. 2011-09-13. PMID:21338649. |
we investigated the relationship between a brain-derived neurotrophic factor (bdnf) polymorphism (val66met) and the clinical response of patients with major depressive disorder to selective serotonin reuptake inhibitors (ssris; here, paroxetine and sertraline). |
2011-09-13 |
2023-08-12 |
Not clear |