| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pingyuan Gong, Zijian Zheng, Wanyu Chi, Xu Lei, Xiaodong Wu, Dongmei Chen, Kejin Zhang, Anyun Zheng, Xiaocai Gao, Fuchang Zhan. An association study of the genetic polymorphisms in 13 neural plasticity-related genes with semantic and episodic memories. Journal of molecular neuroscience : MN. vol 46. issue 2. 2012-09-14. PMID:21728060. |
however, the functional variations in bdnf, comt, dbh, drd ( 2 ), drd ( 3 ), drd ( 4 ), maoa, tph ( 2 ), 5-ht ( 2a ), grm ( 1 ), and grin2b had no observable effects on the memories. |
2012-09-14 |
2023-08-12 |
human |
| YeeWen Candace Wu, Rachel A Hill, Maren Klug, Maarten van den Buus. Sex-specific and region-specific changes in BDNF-TrkB signalling in the hippocampus of 5-HT1A receptor and BDNF single and double mutant mice. Brain research. vol 1452. 2012-09-14. PMID:22464183. |
brain-derived neurotrophic factor (bdnf) and serotonin 5-ht1a receptors are implicated in the pathophysiology of depression and the mechanism of action of antidepressant drugs. |
2012-09-14 |
2023-08-12 |
mouse |
| Mauricio Schüler Nin, Luis A Martinez, Fabio Pibiri, Marianela Nelson, Graziano Pinn. Neurosteroids reduce social isolation-induced behavioral deficits: a proposed link with neurosteroid-mediated upregulation of BDNF expression. Frontiers in endocrinology. vol 2. 2012-08-23. PMID:22649384. |
the pharmacological action of selective serotonin reuptake inhibitor antidepressants may include a normalization of the decreased brain levels of the brain-derived neurotrophic factor (bdnf) and of neurosteroids such as the progesterone metabolite allopregnanolone, which are decreased in patients with depression and posttraumatic stress disorders (ptsd). |
2012-08-23 |
2023-08-12 |
mouse |
| Aparecida Vines, Ana Marcia Delattre, Marcelo M S Lima, Laís Soares Rodrigues, Deborah Suchecki, Ricardo B Machado, Sergio Tufik, Sofia I R Pereira, Sílvio M Zanata, Anete Curte Ferra. The role of 5-HT₁A receptors in fish oil-mediated increased BDNF expression in the rat hippocampus and cortex: a possible antidepressant mechanism. Neuropharmacology. vol 62. issue 1. 2012-08-13. PMID:21740919. |
the present study was performed to evaluate the involvement of serotonin (5-ht) receptors, particularly of 5-ht(1a), and hippocampal brain-derived neurotrophic factor (bdnf) expression in the antidepressant effect of ω-3 pufa supplementation. |
2012-08-13 |
2023-08-12 |
rat |
| Aparecida Vines, Ana Marcia Delattre, Marcelo M S Lima, Laís Soares Rodrigues, Deborah Suchecki, Ricardo B Machado, Sergio Tufik, Sofia I R Pereira, Sílvio M Zanata, Anete Curte Ferra. The role of 5-HT₁A receptors in fish oil-mediated increased BDNF expression in the rat hippocampus and cortex: a possible antidepressant mechanism. Neuropharmacology. vol 62. issue 1. 2012-08-13. PMID:21740919. |
in experiment 2, cortical and hippocampal contents of bdnf, 5-ht, dopamine (da) and its metabolites, 5-hydroxyindoleacetic acid (5-hiaa), and 3,4-dihydroxyphenylacetic acid (dopac), were determined in animals subjected to the same protocol. |
2012-08-13 |
2023-08-12 |
rat |
| Galina T Shishkina, Tatyana S Kalinina, Inna V Berezova, Nikolay N Dygal. Stress-induced activation of the brainstem Bcl-xL gene expression in rats treated with fluoxetine: correlations with serotonin metabolism and depressive-like behavior. Neuropharmacology. vol 62. issue 1. 2012-08-13. PMID:21740920. |
here we investigated 5-ht markers and expression of genes for brain-derived neurotrophic factor (bdnf) and apoptotic proteins in the brainstem in relation to swim stress-induced behavioral despair. |
2012-08-13 |
2023-08-12 |
rat |
| Janusz K Rybakowski, Piotr Czerski, Monika Dmitrzak-Weglarz, Sebastian Kliwicki, Anna Leszczynska-Rodziewicz, Agnieszka Permoda-Osip, Maria Skibinska, Aleksandra Suwalska, Aleksandra Szczepankiewicz, Joanna Hause. Clinical and pathogenic aspects of candidate genes for lithium prophylactic efficacy. Journal of psychopharmacology (Oxford, England). vol 26. issue 3. 2012-08-03. PMID:21890592. |
some association with lithium prophylactic efficacy was found for the polymorphisms of 5htt, drd1, comt, bdnf and fyn genes, but not for 5ht2a, 5ht2c, drd2, drd3, drd4, gsk-3, ntrk2, grin2b and mmp-9. |
2012-08-03 |
2023-08-12 |
Not clear |
| Lin Gao, Xiao-Ning Zeng, Hong-Ming Guo, Xu-Ming Wu, Hui-Juan Chen, Rong-Ke Di, Ying W. Cognitive and neurochemical alterations in hyperhomocysteinemic rat. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 33. issue 1. 2012-07-19. PMID:21647626. |
the high-methionine diet group presented longer mean latency of escape and lesser time in target quadrant in morris maze test, lower level of serotonin and dopamine in cortex homogenates and lower level of bdnf in csf. |
2012-07-19 |
2023-08-12 |
rat |
| Gianluigi Guidotti, Francesca Calabrese, Francesca Auletta, Jocelien Olivier, Giorgio Racagni, Judith Homberg, Marco A Riv. Developmental influence of the serotonin transporter on the expression of npas4 and GABAergic markers: modulation by antidepressant treatment. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 3. 2012-07-19. PMID:22012473. |
genetic deletion of the serotonin transporter (sert) in rodents leads to an anxious and depressive phenotype, and is associated with reduced neuronal plasticity as indicated by decreased brain-derived neurotrophic factor (bdnf) expression levels. |
2012-07-19 |
2023-08-12 |
rat |
| B Arias, M Aguilera, J Moya, P A Sáiz, H Villa, M I Ibáñez, M P García-Portillo, J Bobes, G Ortet, L Fañaná. The role of genetic variability in the SLC6A4, BDNF and GABRA6 genes in anxiety-related traits. Acta psychiatrica Scandinavica. vol 125. issue 3. 2012-06-01. PMID:21902679. |
the aims of this study were to test the individual association of the serotonin transporter gene (slc6a4), the brain-derived neurotrophic factor gene (bdnf) and the gaba(a) α(6) receptor subunit gene (gabra6) with anxiety-related traits and to explore putative gene-gene interactions in a spanish healthy sample. |
2012-06-01 |
2023-08-12 |
Not clear |
| Olaf Schulte-Herbrüggen, Miriam A Vogt, Heide Hörtnagl, Peter Gass, Rainer Hellwe. Pramipexole is active in depression tests and modulates monoaminergic transmission, but not brain levels of BDNF in mice. European journal of pharmacology. vol 677. issue 1-3. 2012-05-17. PMID:22206815. |
in a second experiment dosages of pramipexole shown to be effective were used and candidate brain regions including hippocampus, frontal cortex and striatum were analyzed for levels of 5-hydroxytryptamine (5-ht), noradrenaline and dopamine and their metabolites as well as brain-derived neurotrophic factor (bdnf) to investigate possible neurochemical correlates of behavioral changes. |
2012-05-17 |
2023-08-12 |
mouse |
| C Gómez, G G Curto, F C Baltanás, J Valero, E O'Shea, M I Colado, D Díaz, E Weruaga, J R Alons. Changes in the serotonergic system and in brain-derived neurotrophic factor distribution in the main olfactory bulb of pcd mice before and after mitral cell loss. Neuroscience. vol 201. 2012-05-14. PMID:22133893. |
studies of the amount of 5-ht and its metabolite, 5-hydroxyindole acetic acid (5-hiaa), were performed by means of high-performance liquid chromatography (hplc), and the relative amounts of brain-derived neurotrophin factor, bdnf, and its major receptor, tropomyosin-related kinase b (trkb), were measured by western blot. |
2012-05-14 |
2023-08-12 |
mouse |
| Hans Jörgen Grabe, Christian Schwahn, Jessie Mahler, Katja Appel, Andrea Schulz, Carsten Spitzer, Kristin Fenske, Sven Barnow, Harald Jürgen Freyberger, Alexander Teumer, Astrid Petersmann, Reiner Biffar, Dieter Rosskopf, Ulrich John, Henry Völzk. Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse. Progress in neuro-psychopharmacology & biological psychiatry. vol 36. issue 2. 2012-05-08. PMID:21996278. |
based on biological interactions between the serotonergic system and the brain-derived neurotrophic factor (bdnf), bdnf is a plausible candidate for a gene-gene-environment interaction moderating the interaction between the s/l- promoter polymorphism of the serotonin transporter (5-httlpr) and childhood abuse. |
2012-05-08 |
2023-08-12 |
Not clear |
| Shiho Arakawa, Yukihiko Shirayama, Yuko Fujita, Tamaki Ishima, Mao Horio, Katsumasa Muneoka, Masaomi Iyo, Kenji Hashimot. Minocycline produced antidepressant-like effects on the learned helplessness rats with alterations in levels of monoamine in the amygdala and no changes in BDNF levels in the hippocampus at baseline. Pharmacology, biochemistry, and behavior. vol 100. issue 3. 2012-05-04. PMID:21967886. |
lh rats showed significantly higher serotonin turnover in the orbitofrontal cortex and lower levels of brain-derived neurotrophic factor (bdnf) in the hippocampus than control rats. |
2012-05-04 |
2023-08-12 |
rat |
| Shiho Arakawa, Yukihiko Shirayama, Yuko Fujita, Tamaki Ishima, Mao Horio, Katsumasa Muneoka, Masaomi Iyo, Kenji Hashimot. Minocycline produced antidepressant-like effects on the learned helplessness rats with alterations in levels of monoamine in the amygdala and no changes in BDNF levels in the hippocampus at baseline. Pharmacology, biochemistry, and behavior. vol 100. issue 3. 2012-05-04. PMID:21967886. |
however, these alterations in serotonin turnover and bdnf expression remained unchanged after treatment with minocycline. |
2012-05-04 |
2023-08-12 |
rat |
| Jae-Min Kim, Sung-Wan Kim, Robert Stewart, Seon-Young Kim, Il-Seon Shin, Min-Ho Park, Jung-Han Yoon, Ji-Shin Lee, Sung-Woo Park, Young-Hoon Kim, Jin-Sang Yoo. Serotonergic and BDNF genes associated with depression 1 week and 1 year after mastectomy for breast cancer. Psychosomatic medicine. vol 74. issue 1. 2012-04-24. PMID:22210241. |
polymorphisms of serotonin transporter (5-htt) and brain-derived neurotrophic factor (bdnf) genes have been investigated as candidate genes for depression occurring in medical disorders. |
2012-04-24 |
2023-08-12 |
Not clear |
| Erika Comasco, Sara M Sylvén, Fotios C Papadopoulos, Lars Oreland, Inger Sundström-Poromaa, Alkistis Skalkido. Postpartum depressive symptoms and the BDNF Val66Met functional polymorphism: effect of season of delivery. Archives of women's mental health. vol 14. issue 6. 2012-04-12. PMID:21997575. |
candidate genes, such as those encoding for the brain-derived neurotrophic factor (bdnf), serotonin transporter (5-htt), and period2 (per2), have been associated with depression and seasonal disorders. |
2012-04-12 |
2023-08-12 |
Not clear |
| Kelli Hiio, Liis Merenäkk, Niklas Nordquist, Jüri Parik, Lars Oreland, Toomas Veidebaum, Jaanus Harr. Effects of serotonin transporter promoter and BDNF Val66Met genotype on personality traits in a population representative sample of adolescents. Psychiatric genetics. vol 21. issue 5. 2012-04-06. PMID:21206400. |
effects of serotonin transporter promoter and bdnf val66met genotype on personality traits in a population representative sample of adolescents. |
2012-04-06 |
2023-08-12 |
Not clear |
| Elisabet Cuyàs, Antonio Verdejo-García, Ana Beatriz Fagundo, Olha Khymenets, Joan Rodríguez, Aida Cuenca, Susana de Sola Llopis, Klaus Langohr, Jordi Peña-Casanova, Marta Torrens, Rocío Martín-Santos, Magí Farré, Rafael de la Torr. The influence of genetic and environmental factors among MDMA users in cognitive performance. PloS one. vol 6. issue 11. 2012-03-26. PMID:22110616. |
participants were also genotyped for polymorphisms within the 5htt, 5htr2a, comt, cyp2d6, bdnf, and grin2b genes using polymerase chain reaction and taqman polymerase assays. |
2012-03-26 |
2023-08-12 |
human |
| M L Molendijk, B A A Bus, Ph Spinhoven, B W J H Penninx, G Kenis, J Prickaerts, R C Oude Voshaar, B M Elzing. Serum levels of brain-derived neurotrophic factor in major depressive disorder: state-trait issues, clinical features and pharmacological treatment. Molecular psychiatry. vol 16. issue 11. 2012-03-05. PMID:20856249. |
the antidepressant associated upregulation of serum bdnf in depressed patients was confined to selective serotonin reuptake inhibitors (ssris) (p=0.003) and st john's wort (p=0.03). |
2012-03-05 |
2023-08-12 |
Not clear |