| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Teresa F Burke, Tushar Advani, Megumi Adachi, Lisa M Monteggia, Julie G Hensle. Sensitivity of hippocampal 5-HT1A receptors to mild stress in BDNF-deficient mice. The international journal of neuropsychopharmacology. vol 16. issue 3. 2013-10-31. PMID:22575584. |
decreases in hippocampal 5-ht(1a) receptor function induced by mild stress in bdnf-deficient mice were prevented by administration of the selective serotonin reuptake inhibitor fluoxetine, which increased activation of trkb, the high affinity receptor for bdnf, in wild-type and bdnf(+/-) mice. |
2013-10-31 |
2023-08-12 |
mouse |
| Teresa F Burke, Tushar Advani, Megumi Adachi, Lisa M Monteggia, Julie G Hensle. Sensitivity of hippocampal 5-HT1A receptors to mild stress in BDNF-deficient mice. The international journal of neuropsychopharmacology. vol 16. issue 3. 2013-10-31. PMID:22575584. |
in hippocampal cultures, bdnf increased the capacity of 5-ht(1a) receptors to activate g proteins, an effect eliminated by the knockout of trkb, confirming trkb activation increases 5-ht(1a) receptor function. |
2013-10-31 |
2023-08-12 |
mouse |
| Teresa F Burke, Tushar Advani, Megumi Adachi, Lisa M Monteggia, Julie G Hensle. Sensitivity of hippocampal 5-HT1A receptors to mild stress in BDNF-deficient mice. The international journal of neuropsychopharmacology. vol 16. issue 3. 2013-10-31. PMID:22575584. |
the mechanisms underlying the sensitivity of hippocampal 5-ht(1a) receptors to mild stress and decreased bdnf expression remain to be elucidated and may have important implications for the emotional and cognitive impairments associated with stress-related mental illness. |
2013-10-31 |
2023-08-12 |
mouse |
| Young-Min Park, Seung-Hwan Lee, Heon-Jeong Lee, Seung-Gul Kang, Jung-Ah Min, Jeong-Ho Cha. Association between BDNF gene polymorphisms and serotonergic activity using loudness dependence of auditory evoked potentials in healthy subjects. PloS one. vol 8. issue 4. 2013-10-22. PMID:23593198. |
serotonin levels and turnover are also increased by brain-derived neurotrophic factor (bdnf). |
2013-10-22 |
2023-08-12 |
human |
| Ari Illi, Merja Viikki, Outi Poutanen, Eija Setälä-Soikkeli, Timo Nuolivirta, Olli Kampman, Esa Leinonen, Heini Huhtala, Nina Mononen, Terho Lehtimäk. No support for a role for BDNF gene polymorphisms rs11030101 and rs61888800 in major depressive disorder or antidepressant response in patients of Finnish origin. Psychiatric genetics. vol 23. issue 1. 2013-09-20. PMID:23250003. |
the aim of the present study was to examine the role of two bdnf gene polymorphisms (rs11030101 and rs61888800) in relation to the response to selective serotonin reuptake inhibitor medication in 106 patients of finnish origin suffering from major depression. |
2013-09-20 |
2023-08-12 |
Not clear |
| Ari Illi, Merja Viikki, Outi Poutanen, Eija Setälä-Soikkeli, Timo Nuolivirta, Olli Kampman, Esa Leinonen, Heini Huhtala, Nina Mononen, Terho Lehtimäk. No support for a role for BDNF gene polymorphisms rs11030101 and rs61888800 in major depressive disorder or antidepressant response in patients of Finnish origin. Psychiatric genetics. vol 23. issue 1. 2013-09-20. PMID:23250003. |
we did not find any significant differences in the distribution of these two bdnf gene polymorphisms in our patient population in relation to remission or response to treatment with selective serotonin reuptake inhibitor. |
2013-09-20 |
2023-08-12 |
Not clear |
| Janusz K Rybakowsk. Genetic influences on response to mood stabilizers in bipolar disorder: current status of knowledge. CNS drugs. vol 27. issue 3. 2013-09-13. PMID:23378337. |
the genes studied for their association with lithium response have been those connected with neurotransmitters (serotonin, dopamine and glutamate), second messengers (phosphatidyl inositol [pi], cyclic adenosine-monophosphate [camp] and protein kinase c [pkc] pathways), substances involved in neuroprotection (brain-derived neurotrophic factor [bdnf] and glycogen synthase kinase 3-β [gsk-3β]) and a number of other miscellaneous genes. |
2013-09-13 |
2023-08-12 |
Not clear |
| Dennis L Murphy, Pablo R Moya, Meredith A Fox, Liza M Rubenstein, Jens R Wendland, Kiara R Timpan. Anxiety and affective disorder comorbidity related to serotonin and other neurotransmitter systems: obsessive-compulsive disorder as an example of overlapping clinical and genetic heterogeneity. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 368. issue 1615. 2013-09-12. PMID:23440468. |
the serotonin transporter gene (slc6a4), the brain-derived neurotrophic factor (bdnf) gene), and rare variants in genes/chromosomal abnormalities (e.g. |
2013-09-12 |
2023-08-12 |
Not clear |
| Evan J Kyzar, Mimi Pham, Andrew Roth, Jonathan Cachat, Jeremy Green, Siddharth Gaikwad, Allan V Kaluef. Alterations in grooming activity and syntax in heterozygous SERT and BDNF knockout mice: the utility of behavior-recognition tools to characterize mutant mouse phenotypes. Brain research bulletin. vol 89. issue 5-6. 2013-08-16. PMID:22951260. |
serotonin transporter (sert) and brain-derived neurotrophic factor (bdnf) are key modulators of molecular signaling, cognition and behavior. |
2013-08-16 |
2023-08-12 |
mouse |
| Masatoshi Tomi, Yuanzi Zhao, Shanthie Thamotharan, Bo-Chul Shin, Sherin U Devaska. Early life nutrient restriction impairs blood-brain metabolic profile and neurobehavior predisposing to Alzheimer's disease with aging. Brain research. vol 1495. 2013-07-22. PMID:23228723. |
in addition increased brain glucose transporters, glut1 & glut3, greater brain derived neurotrophic factor (bdnf), reduced glut4, with unchanged serotonin transporter concentrations were noted in (f) (pn50-60). |
2013-07-22 |
2023-08-12 |
rat |
| A Ferrés-Coy, F Pilar-Cuellar, R Vidal, V Paz, M Masana, R Cortés, M C Carmona, L Campa, A Pazos, A Montefeltro, E M Valdizán, F Artigas, A Bortolozz. RNAi-mediated serotonin transporter suppression rapidly increases serotonergic neurotransmission and hippocampal neurogenesis. Translational psychiatry. vol 3. 2013-07-04. PMID:23321808. |
moreover, short-term sert-sirna treatment modified mouse brain variables considered to be key markers of antidepressant action: reduced expression and function of 5-ht(1a)-autoreceptors, elevated extracellular serotonin in forebrain and increased neurogenesis and expression of plasticity-related genes (bdnf, vegf, arc) in hippocampus. |
2013-07-04 |
2023-08-12 |
mouse |
| T Hochstrasser, D Ehrlich, B Sperner-Unterweger, C Humpe. Antidepressants and anti-inflammatory drugs differentially reduce the release of NGF and BDNF from rat platelets. Pharmacopsychiatry. vol 46. issue 1. 2013-06-28. PMID:22699957. |
platelets store serotonin and brain-derived neurotrophic factor (bdnf) as well as amyloid precursor protein and nerve growth factor (ngf), thus platelets are of special interest in depression and alzheimer's disease, respectively. |
2013-06-28 |
2023-08-12 |
rat |
| Sinead M Gibney, Barry McGuinness, Christine Prendergast, Andrew Harkin, Thomas J Conno. Poly I:C-induced activation of the immune response is accompanied by depression and anxiety-like behaviours, kynurenine pathway activation and reduced BDNF expression. Brain, behavior, and immunity. vol 28. 2013-06-28. PMID:23201589. |
furthermore, the ability of poly i:c to deplete central tryptophan and serotonin via induction of indolamine 2,3 dioxygenase (ido), and also the ability of poly i:c to impact upon expression of the neurotrophin bdnf and its receptor trkb were examined as potential mechanisms to link inflammation to depression. |
2013-06-28 |
2023-08-12 |
rat |
| Sinead M Gibney, Barry McGuinness, Christine Prendergast, Andrew Harkin, Thomas J Conno. Poly I:C-induced activation of the immune response is accompanied by depression and anxiety-like behaviours, kynurenine pathway activation and reduced BDNF expression. Brain, behavior, and immunity. vol 28. 2013-06-28. PMID:23201589. |
these findings suggest that depressive and anxiety-like behaviours elicited by poly i:c are associated with a reduction in bdnf signalling, and activation of the kynurenine pathway, but not a reduction in serotonin. |
2013-06-28 |
2023-08-12 |
rat |
| S S Daftary, G Calderon, M Rio. Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala. Neuroscience. vol 224. 2013-06-17. PMID:22917617. |
examination of bdnf(2l/2lck-cre) mutant mice with brain-selective depletion of bdnf revealed mild decreases in serotonin content in the bla. |
2013-06-17 |
2023-08-12 |
mouse |
| S S Daftary, G Calderon, M Rio. Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala. Neuroscience. vol 224. 2013-06-17. PMID:22917617. |
notably, whole cell recordings in bla pyramidal cells uncovered significant alterations in 5-ht(2)-mediated regulation of gabaergic and glutamatergic transmission in bdnf(2l/2lck-cre) mutant mice that result in a hyperexcitable circuit. |
2013-06-17 |
2023-08-12 |
mouse |
| S S Daftary, G Calderon, M Rio. Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala. Neuroscience. vol 224. 2013-06-17. PMID:22917617. |
collectively, the results indicate a required role of bdnf in serotonin transmission in the bla. |
2013-06-17 |
2023-08-12 |
mouse |
| M S Hoffman, N L Nichols, P M Macfarlane, G S Mitchel. Phrenic long-term facilitation after acute intermittent hypoxia requires spinal ERK activation but not TrkB synthesis. Journal of applied physiology (Bethesda, Md. : 1985). vol 113. issue 8. 2013-06-17. PMID:22961271. |
pltf requires spinal serotonin receptor-2 activation, the synthesis of new brain-derived neurotrophic factor (bdnf), and the activation of its high-affinity receptor tyrosine kinase, trkb. |
2013-06-17 |
2023-08-12 |
rat |
| Sarah M Rothman, Mark P Mattso. Sleep disturbances in Alzheimer's and Parkinson's diseases. Neuromolecular medicine. vol 14. issue 3. 2013-06-03. PMID:22552887. |
perturbations in neurotransmitter and hormone signaling (e.g., serotonin, norepinephrine and melatonin) and the neurotrophic factor bdnf likely contribute to the disease process. |
2013-06-03 |
2023-08-12 |
Not clear |
| b' Francesca Zoratto, Marco Fiore, Syed F Ali, Giovanni Laviola, Simone Macr\\xc3\\xa. Neonatal tryptophan depletion and corticosterone supplementation modify emotional responses in adult male mice. Psychoneuroendocrinology. vol 38. issue 1. 2013-05-20. PMID:22613034.' |
maternal care was scored throughout treatment and adult offspring were tested for: anhedonia (progressive ratio schedule); anxiety-related behaviour (approach-avoidance conflict paradigm); bdnf, dopamine and serotonin concentrations in selected brain areas. |
2013-05-20 |
2023-08-12 |
mouse |