| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Martin J Lan, R Todd Ogden, Yung-Yu Huang, Maria A Oquendo, Gregory M Sullivan, Jeffrey Miller, Matthew Milak, J John Mann, Ramin V Parse. Genetic variation in brain-derived neurotrophic factor val66met allele is associated with altered serotonin-1A receptor binding in human brain. NeuroImage. vol 94. 2015-02-06. PMID:24607934. |
bdnf affects serotonin signaling, increases serotonin levels in brain tissue and prevents degeneration of serotonin neurons. |
2015-02-06 |
2023-08-12 |
human |
| Martin J Lan, R Todd Ogden, Yung-Yu Huang, Maria A Oquendo, Gregory M Sullivan, Jeffrey Miller, Matthew Milak, J John Mann, Ramin V Parse. Genetic variation in brain-derived neurotrophic factor val66met allele is associated with altered serotonin-1A receptor binding in human brain. NeuroImage. vol 94. 2015-02-06. PMID:24607934. |
we examined the relationship of the functional val66met polymorphism of the bdnf gene to serotonin 1a (5-ht(1a)) receptor binding in vivo. |
2015-02-06 |
2023-08-12 |
human |
| Xiaofang Lan, Meng Zhang, Wan Yang, Zongju Zheng, Yuan Wu, Qian Zeng, Shudong Liu, Ke Liu, Guangqin L. Effect of treadmill exercise on 5-HT, 5-HT1A receptor and brain derived neurophic factor in rats after permanent middle cerebral artery occlusion. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 35. issue 5. 2015-01-27. PMID:24326625. |
this study aimed to discuss the effect of treadmill exercise on expression levels of 5-ht, 5-ht1a receptor (5-ht1ar) and brain derived neurophic factor (bdnf) in rat brains after permanent middle cerebral artery occlusion (pmcao). |
2015-01-27 |
2023-08-12 |
rat |
| Xiaofang Lan, Meng Zhang, Wan Yang, Zongju Zheng, Yuan Wu, Qian Zeng, Shudong Liu, Ke Liu, Guangqin L. Effect of treadmill exercise on 5-HT, 5-HT1A receptor and brain derived neurophic factor in rats after permanent middle cerebral artery occlusion. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 35. issue 5. 2015-01-27. PMID:24326625. |
these results indicate that treadmill exercise improves neurologic function, enhances neuronal plasticity and upregulates the levels of 5-ht, 5-ht1ar and bdnf in rats with pmcao. |
2015-01-27 |
2023-08-12 |
rat |
| Aki Takahashi, Isabel M Quadros, Rosa M M de Almeida, Klaus A Micze. Behavioral and pharmacogenetics of aggressive behavior. Current topics in behavioral neurosciences. vol 12. 2015-01-20. PMID:22297576. |
studies of aggression in genetically modified mice identified several molecules that affect the 5-ht system directly (e.g., tph2, 5-ht1b, 5-ht transporter, pet1, maoa) or indirectly[e.g., bdnf, neuronal nitric oxide (nnos), acamkii, neuropeptide y].the future agenda delineates specific receptor subpopulations for gaba, glutamate and neuropeptides as they modulate the canonical aminergic neurotransmitters in brainstem, limbic and cortical regions with the ultimate outcome of attenuating or escalating aggressive behavior. |
2015-01-20 |
2023-08-12 |
mouse |
| Qiong-Qiong Lv, Wen-Jie Wu, Xiao-Liang Guo, Rui-Li Liu, Yu-Ping Yang, Du-Shuang Zhou, Ji-Xia Zhang, Ju-Yuan Li. Antidepressant activity of astilbin: involvement of monoaminergic neurotransmitters and BDNF signal pathway. Biological & pharmaceutical bulletin. vol 37. issue 6. 2015-01-20. PMID:24681540. |
our findings suggest that ast has antidepressant activities and the mechanisms, at least in part, relate to up-regulation of monoaminergic neurotransmitters (5-ht and da) and activation of the bdnf signaling pathway. |
2015-01-20 |
2023-08-12 |
mouse |
| Young-Min Park, Bun-Hee Lee, Tae Hyun Um, Sollip Ki. Serum BDNF levels in relation to illness severity, suicide attempts, and central serotonin activity in patients with major depressive disorder: a pilot study. PloS one. vol 9. issue 3. 2015-01-15. PMID:24663244. |
serum bdnf levels in relation to illness severity, suicide attempts, and central serotonin activity in patients with major depressive disorder: a pilot study. |
2015-01-15 |
2023-08-12 |
human |
| Young-Min Park, Bun-Hee Lee, Tae Hyun Um, Sollip Ki. Serum BDNF levels in relation to illness severity, suicide attempts, and central serotonin activity in patients with major depressive disorder: a pilot study. PloS one. vol 9. issue 3. 2015-01-15. PMID:24663244. |
the question of whether there is a difference in bdnf levels between depressive patients according to their illness severity, history of suicide attempts, and central serotonin activity was also addressed. |
2015-01-15 |
2023-08-12 |
human |
| Zhang Tianzhu, Yang Shihai, Du Jua. Antidepressant-like effects of cordycepin in a mice model of chronic unpredictable mild stress. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2015-01-14. PMID:25587342. |
then the serotonin (5-ht) and noradrenaline (ne) concentrations in hippocampal were evaluated by hplc; tumor necrosis factor-α (tnf-α) and interleukin-6 (il-6) in hippocampal were evaluated, and the proteins of tnf-α, il-6, nf-κbp65 5-ht2a receptor (5-ht2ar), and brain-derived neurotrophic factor (bdnf) in hippocampal were evaluated by western blot. |
2015-01-14 |
2023-08-13 |
mouse |
| Zhang Tianzhu, Yang Shihai, Du Jua. Antidepressant-like effects of cordycepin in a mice model of chronic unpredictable mild stress. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2015-01-14. PMID:25587342. |
our results indicated that 6 weeks of cums exposure induced significant depression-like behavior, with low 5-ht and ne levels, high tnf-α and il-6 in brain and high hippocampal tnf-α, il-6, p-nf-κbp65, and 5-ht2ar levels, and low bdnf expression levels. |
2015-01-14 |
2023-08-13 |
mouse |
| Hsiu-Chuan Lee, Hsiang-Kai Ko, Brian E T-G Huang, Yan-Hwa Chu, Shih-Yi Huan. Antidepressant-like effects of Perilla frutescens seed oil during a forced swimming test. Food & function. vol 5. issue 5. 2014-12-19. PMID:24651157. |
levels of brain-derived neurotrophic factor (bdnf), serotonin, and dopamine in the pfc were also determined. |
2014-12-19 |
2023-08-12 |
rat |
| Hsiu-Chuan Lee, Hsiang-Kai Ko, Brian E T-G Huang, Yan-Hwa Chu, Shih-Yi Huan. Antidepressant-like effects of Perilla frutescens seed oil during a forced swimming test. Food & function. vol 5. issue 5. 2014-12-19. PMID:24651157. |
levels of bdnf in the p. frutescens seed oil-rich group and levels of serotonin in the epa-rich group were significantly (p < 0.05) higher than those of the control group. |
2014-12-19 |
2023-08-12 |
rat |
| Valentina Vaghi, Alessio Polacchini, Gabriele Baj, Vera L M Pinheiro, Annalisa Vicario, Enrico Tongiorg. Pharmacological profile of brain-derived neurotrophic factor (BDNF) splice variant translation using a novel drug screening assay: a "quantitative code". The Journal of biological chemistry. vol 289. issue 40. 2014-12-17. PMID:25074925. |
however, constructs with either a 5'utr or a 3'utr alone showed poor translation modulation by bdnf, kcl, dihydroxyphenylglycine, ampa, nmda, dopamine, acetylcholine, norepinephrine, or serotonin. |
2014-12-17 |
2023-08-13 |
human |
| L Musazzi, J M Rimland, A Ieraci, G Racagni, E Domenici, M Popol. Pharmacological characterization of BDNF promoters I, II and IV reveals that serotonin and norepinephrine input is sufficient for transcription activation. The international journal of neuropsychopharmacology. vol 17. issue 5. 2014-12-01. PMID:24451568. |
pharmacological characterization of bdnf promoters i, ii and iv reveals that serotonin and norepinephrine input is sufficient for transcription activation. |
2014-12-01 |
2023-08-12 |
rat |
| L Musazzi, J M Rimland, A Ieraci, G Racagni, E Domenici, M Popol. Pharmacological characterization of BDNF promoters I, II and IV reveals that serotonin and norepinephrine input is sufficient for transcription activation. The international journal of neuropsychopharmacology. vol 17. issue 5. 2014-12-01. PMID:24451568. |
we generated a gene reporter system based on hippocampal and cortical neuronal cultures, in which the transcription of luciferase is regulated by bdnf promoters i, ii, iv or by camp response element (cre), to investigate the activation of selected promoters induced by monoaminergic antidepressants and by serotonin or noradrenaline agonists. |
2014-12-01 |
2023-08-12 |
rat |
| L Musazzi, J M Rimland, A Ieraci, G Racagni, E Domenici, M Popol. Pharmacological characterization of BDNF promoters I, II and IV reveals that serotonin and norepinephrine input is sufficient for transcription activation. The international journal of neuropsychopharmacology. vol 17. issue 5. 2014-12-01. PMID:24451568. |
on the other hand, the incubation of cultures with selective agonists of serotonin or noradrenaline receptors induced a specific and distinct profile of activation of bdnf promoters i, ii, iv and cre, suggesting that the monoaminergic input, absent in dissociated cultures, is essential for the modulation of bdnf expression. |
2014-12-01 |
2023-08-12 |
rat |
| Hortensia Alonso-Navarro, Felix Javier Jimenez-Jimenez, Elena Garcia-Martin, Jose A G Agunde. Genomic and pharmacogenomic biomarkers of Parkinson's disease. Current drug metabolism. vol 15. issue 2. 2014-11-24. PMID:24694231. |
nor did polymorphisms in genes related to dopamine or serotonin drd, dat, th, ddc, dbh, mao, comt, slc6a4, mtr, mthfr, oxidative stress noq1, noq2, mephx, hfe, gpx, cat, mnsod, hfe, ho-1, ho-2, nfe2l2, keap1, inflammatory processes, ils, tnf, act, nos, hnmt, abp1, hrhs, trophic and growth factors bdnf, fgf, or mitochondrial metabolism and function. |
2014-11-24 |
2023-08-13 |
cat |
| Chih-Jen Hung, Chih-Cheng Wu, Wen-Ying Chen, Cheng-Yi Chang, Yu-Hsiang Kuan, Hung-Chuan Pan, Su-Lan Liao, Chun-Jung Che. Depression-like effect of prenatal buprenorphine exposure in rats. PloS one. vol 8. issue 12. 2014-10-08. PMID:24367510. |
neurobehavioral changes were accompanied by elevation of oxidative stress, reduction of plasma levels of brain-derived neurotrophic factor (bdnf) and serotonin, and attenuation of tropomyosin-related kinase receptor type b (trkb) phosphorylation, extracellular signal-regulated kinase (erk) phosphorylation, protein kinase a activity, camp response element-binding protein (creb) phosphorylation, and creb dna-binding activity. |
2014-10-08 |
2023-08-12 |
rat |
| Chih-Jen Hung, Chih-Cheng Wu, Wen-Ying Chen, Cheng-Yi Chang, Yu-Hsiang Kuan, Hung-Chuan Pan, Su-Lan Liao, Chun-Jung Che. Depression-like effect of prenatal buprenorphine exposure in rats. PloS one. vol 8. issue 12. 2014-10-08. PMID:24367510. |
since bdnf/serotonin and creb signaling could orchestrate a positive feedback loop, our findings suggest that the induction of oxidative stress, reduction of bdnf and serotonin expression, and attenuation of creb signaling induced by prenatal exposure to supra-therapeutic dose of buprenorphine provide evidence of potential mechanism for the development of depression-like neurobehavior. |
2014-10-08 |
2023-08-12 |
rat |
| Guang Yue Su, Jing Yu Yang, Fang Wang, Jie Ma, Kuo Zhang, Ying Xu Dong, Shao Jiang Song, Xiu Mei Lu, Chun Fu W. Antidepressant-like effects of Xiaochaihutang in a rat model of chronic unpredictable mild stress. Journal of ethnopharmacology. vol 152. issue 1. 2014-10-06. PMID:24440317. |
the present study was designed to confirm the antidepressant effect of xcht using a chronic unpredictable mild stress (cums) model and explore its potential mechanism of action by investigating the monoamine neurotransmitters (dopamine and 5-hydroxytryptamine) and neurotrophins (bdnf and ngf). |
2014-10-06 |
2023-08-12 |
rat |