| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elizabeth D Dalton, Constance L Hammen, Jake M Najman, Patricia A Brenna. Genetic susceptibility to family environment: BDNF Val66met and 5-HTTLPR influence depressive symptoms. Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43). vol 28. issue 6. 2016-04-05. PMID:25347540. |
in light of evidence for biological connections between bdnf and serotonin, it is prudent to consider genetic epistasis between variants in these genes in the development of depressive symptoms. |
2016-04-05 |
2023-08-13 |
Not clear |
| Yingcong Yu, Shujuan Wu, Jianxin Li, Renye Wang, Xupei Xie, Xuefeng Yu, Jianchun Pan, Ying Xu, Liang Zhen. The effect of curcumin on the brain-gut axis in rat model of irritable bowel syndrome: involvement of 5-HT-dependent signaling. Metabolic brain disease. vol 30. issue 1. 2016-03-17. PMID:24807589. |
our study found that ibs rats showed depression- and anxiety-like behaviors associated with decreased 5-ht (serotonin), bdnf (brain-derived neurotrophic factor) and pcreb (phosphorylation of camp response element-binding protein) expression in the hippocampus after chronic acute combining stress (cas). |
2016-03-17 |
2023-08-13 |
rat |
| Yingcong Yu, Shujuan Wu, Jianxin Li, Renye Wang, Xupei Xie, Xuefeng Yu, Jianchun Pan, Ying Xu, Liang Zhen. The effect of curcumin on the brain-gut axis in rat model of irritable bowel syndrome: involvement of 5-HT-dependent signaling. Metabolic brain disease. vol 30. issue 1. 2016-03-17. PMID:24807589. |
moreover, curcumin increased serotonin, bdnf and pcreb levels in the hippocampus, but they were decreased in the colonic of cas rats. |
2016-03-17 |
2023-08-13 |
rat |
| Yingcong Yu, Shujuan Wu, Jianxin Li, Renye Wang, Xupei Xie, Xuefeng Yu, Jianchun Pan, Ying Xu, Liang Zhen. The effect of curcumin on the brain-gut axis in rat model of irritable bowel syndrome: involvement of 5-HT-dependent signaling. Metabolic brain disease. vol 30. issue 1. 2016-03-17. PMID:24807589. |
5-ht(1a) receptor antagonist nan-190 reversed the effects of curcumin on behaviors and the changes of intestine, pcreb and bdnf expression, which are related to ibs. |
2016-03-17 |
2023-08-13 |
rat |
| Lingpeng Zhu, Tingting Wei, Jing Gao, Xiayun Chang, He He, Mingxing Miao, Tianhua Ya. Salidroside attenuates lipopolysaccharide (LPS) induced serum cytokines and depressive-like behavior in mice. Neuroscience letters. vol 606. 2016-03-01. PMID:26300543. |
levels of neurotransmitters like norepinephrine (ne) and 5-hydroxytryptamine (5-ht) in the prefrontal cortex were detected by hplc-ms. further, brain-derived neurotrophic factor (bdnf), tropomyosin-related kinase b (trkb) and nuclear factor-κb (nf-κb) in hippocampal was determined by western blot analysis. |
2016-03-01 |
2023-08-13 |
mouse |
| Plinio C Casarotto, Paula C dos Santos, Guilherme A Lucas, Caroline Biojone, Roger L H Pobbe, Heloisa H Vilela-Costa, Samia R L Joca, Francisco S Guimarães, Hélio Zangross. BDNF-TRKB signaling system of the dorsal periaqueductal gray matter is implicated in the panicolytic-like effect of antidepressant drugs. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 6. 2016-02-16. PMID:25840741. |
only longterm treatment with the selective serotonin reuptake inhibitor fluoxetine was able to increase bdnf levels in this structure. |
2016-02-16 |
2023-08-13 |
rat |
| Kerri S Rawson, David Dixon, Petra Nowotny, William M Ricci, Ellen F Binder, Thomas L Rodebaugh, Leah Wendleton, Peter Doré, Eric J Lenz. Association of functional polymorphisms from brain-derived neurotrophic factor and serotonin-related genes with depressive symptoms after a medical stressor in older adults. PloS one. vol 10. issue 3. 2016-02-04. PMID:25781924. |
we examined the valine (val) to methionine (met) polymorphism in brain-derived neurotrophic factor (bdnf), serotonin 1a receptor (5ht1a-rs6295) polymorphism, and the serotonin transporter-linked polymorphic region (5httlpr) interaction with the rs25531 a to g single nucleotide polymorphism (5httlpr-rs25531) as predictors of depressive symptoms. |
2016-02-04 |
2023-08-13 |
human |
| N Singewald, C Schmuckermair, N Whittle, A Holmes, K J Ressle. Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders. Pharmacology & therapeutics. vol 149. 2015-12-15. PMID:25550231. |
the purpose of this review is to outline the literature showing how pharmacological interventions targeting neurotransmitter systems including serotonin, dopamine, noradrenaline, histamine, glutamate, gaba, cannabinoids, neuropeptides (oxytocin, neuropeptides y and s, opioids) and other targets (neurotrophins bdnf and fgf2, glucocorticoids, l-type-calcium channels, epigenetic modifications) as well as their downstream signaling pathways, can augment fear extinction and strengthen extinction memory persistently in preclinical models. |
2015-12-15 |
2023-08-13 |
Not clear |
| Kent W Nilsson, Erika Comasco, Sheilagh Hodgins, Lars Oreland, Cecilia Åslun. Genotypes do not confer risk for delinquency but rather alter susceptibility to positive and negative environmental factors: gene-environmentinteractions of BDNF Val66Met, 5-HTTLPR, and MAOA-uVNTR [corrected]. The international journal of neuropsychopharmacology. vol 18. issue 5. 2015-12-08. PMID:25522433. |
the present study investigated interactions between the brain-derived neurotrophic factor gene (bdnf val66met), the serotonin transporter gene-linked polymorphic region (5-httlpr), the monoamine oxidase a (maoa-uvntr) polymorphisms, family conflict, sexual abuse, the quality of the child-parent relationship, and teenage delinquency. |
2015-12-08 |
2023-08-13 |
Not clear |
| Christoph Kraus, Pia Baldinger, Christina Rami-Mark, Gregor Gryglewski, Gregor Gryglewsky, Georg S Kranz, Daniela Haeusler, Andreas Hahn, Wolfgang Wadsak, Markus Mitterhauser, Dan Rujescu, Siegfried Kasper, Rupert Lanzenberge. Exploring the impact of BDNF Val66Met genotype on serotonin transporter and serotonin-1A receptor binding. PloS one. vol 9. issue 9. 2015-12-07. PMID:25188405. |
exploring the impact of bdnf val66met genotype on serotonin transporter and serotonin-1a receptor binding. |
2015-12-07 |
2023-08-13 |
Not clear |
| Christoph Kraus, Pia Baldinger, Christina Rami-Mark, Gregor Gryglewski, Gregor Gryglewsky, Georg S Kranz, Daniela Haeusler, Andreas Hahn, Wolfgang Wadsak, Markus Mitterhauser, Dan Rujescu, Siegfried Kasper, Rupert Lanzenberge. Exploring the impact of BDNF Val66Met genotype on serotonin transporter and serotonin-1A receptor binding. PloS one. vol 9. issue 9. 2015-12-07. PMID:25188405. |
the brain-derived neurotrophic factor (bdnf) val66met polymorphism (rs6265) may impact on the in-vivo binding of important serotonergic structures such as the serotonin transporter (5-htt) and the serotonin-1a (5-ht1a) receptor. |
2015-12-07 |
2023-08-13 |
Not clear |
| Sang Jun Lee, Jun-Hyung Baek, Young-Hoon Ki. Brain-derived Neurotrophic Factor Is Associated with Cognitive Impairment in Elderly Korean Individuals. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology. vol 13. issue 3. 2015-11-24. PMID:26598587. |
the present study measured serum bdnf levels to investigate the associations of the bdnf val66met and 5-hydroxytryptamine transporter linked promoter region (5-httlpr) polymorphisms with cognitive function in elderly korean individuals. |
2015-11-24 |
2023-08-13 |
Not clear |
| F Nees, S H Witt, R Dinu-Biringer, A Lourdusamy, J Tzschoppe, S Vollstädt-Klein, S Millenet, C Bach, L Poustka, T Banaschewski, G J Barker, A L W Bokde, U Bromberg, C Büchel, P J Conrod, J Frank, V Frouin, J Gallinat, H Garavan, P Gowland, A Heinz, B Ittermann, K Mann, J-L Martinot, T Paus, Z Pausova, T W Robbins, M N Smolka, M Rietschel, G Schumann, H Flo. BDNF Val66Met and reward-related brain function in adolescents: role for early alcohol consumption. Alcohol (Fayetteville, N.Y.). vol 49. issue 2. 2015-11-20. PMID:25650137. |
the nonsynonymous single nucleotide polymorphism in the brain-derived neurotrophic factor (bdnf) gene (rs6265/val66met) modulates the central nervous system activity of neurotransmitters involved in reward processing such as serotonin, dopamine, and glutamate. |
2015-11-20 |
2023-08-13 |
rat |
| Magdalene C Jawahar, Chris Murgatroyd, Emma L Harrison, Bernhard T Baun. Epigenetic alterations following early postnatal stress: a review on novel aetiological mechanisms of common psychiatric disorders. Clinical epigenetics. vol 7. 2015-11-20. PMID:26583053. |
however, epigenetic changes in other candidate genes such as brain-derived neurotrophic factor (bdnf) and serotonin transporter are also implicated in early life stress (els) and susceptibility to adult psychiatric disorders. |
2015-11-20 |
2023-08-13 |
human |
| Toshizo Ishikawa, Seiko Yasuda, Seiji Minoda, Takae Ibuki, Kayoko Fukuhara, Yasutake Iwanaga, Toru Ariyoshi, Hironori Sasak. Neurotropin(®) ameliorates chronic pain via induction of brain-derived neurotrophic factor. Cellular and molecular neurobiology. vol 35. issue 2. 2015-11-17. PMID:25283187. |
changes in perk1/2 and pcreb (immunohistochemistry), 5-ht, and bdnf protein level (elisa) and bdnf mrna (rt-pcr) were measured in the anterior cingulate cortex (acc) and in the rostral ventromedial medulla (rvm) 14 days after injury. |
2015-11-17 |
2023-08-13 |
rat |
| Maira J Maturana, Cláudia Pudell, Adriano D S Targa, Laís S Rodrigues, Ana Carolina D Noseda, Mariana H Fortes, Patrícia Dos Santos, Cláudio Da Cunha, Sílvio M Zanata, Anete C Ferraz, Marcelo M S Lim. REM sleep deprivation reverses neurochemical and other depressive-like alterations induced by olfactory bulbectomy. Molecular neurobiology. vol 51. issue 1. 2015-10-20. PMID:24826915. |
remsd triggered antidepressant mechanisms such as the increment of brain-derived neurotrophic factor (bdnf) levels, within the substantia nigra pars compacta (snpc), which were strongly correlated to the swimming time (r = 0.83; p < 0.0001) and hippocampal serotonin (5-ht) content (r = 0.66; p = 0.004). |
2015-10-20 |
2023-08-13 |
rat |
| Maira J Maturana, Cláudia Pudell, Adriano D S Targa, Laís S Rodrigues, Ana Carolina D Noseda, Mariana H Fortes, Patrícia Dos Santos, Cláudio Da Cunha, Sílvio M Zanata, Anete C Ferraz, Marcelo M S Lim. REM sleep deprivation reverses neurochemical and other depressive-like alterations induced by olfactory bulbectomy. Molecular neurobiology. vol 51. issue 1. 2015-10-20. PMID:24826915. |
we suggested that the neurochemical complexity inflicted by the obx model, counteracted by remsd, is directly correlated to the nigral bdnf expression and hippocampal 5-ht levels. |
2015-10-20 |
2023-08-13 |
rat |
| Indira Mendez-David, Laurent Tritschler, Zeina El Ali, Marie-Hélène Damiens, Marc Pallardy, Denis J David, Saadia Kerdine-Römer, Alain M Gardie. Nrf2-signaling and BDNF: A new target for the antidepressant-like activity of chronic fluoxetine treatment in a mouse model of anxiety/depression. Neuroscience letters. vol 597. 2015-10-19. PMID:25916883. |
taken together, these data suggest that nrf2 signaling contributes to fluoxetine-induced neuroprotection via an unexpected mechanism involving 5-ht transporter sert blockade, and not through enhancement of bdnf expression. |
2015-10-19 |
2023-08-13 |
mouse |
| Q-S Wang, J-S Tian, Y-L Cui, S Ga. Genipin is active via modulating monoaminergic transmission and levels of brain-derived neurotrophic factor (BDNF) in rat model of depression. Neuroscience. vol 275. 2015-10-15. PMID:24972301. |
the mrna expressions of 5-hydroxytryptamine 1a receptor (5-ht1ar), camp response element binding protein (creb) and brain-derived neurotrophic factor (bdnf) in rats were decreased exposed to cums, which were reversed by genipin-treated rats exposed to cums. |
2015-10-15 |
2023-08-13 |
rat |
| Q-S Wang, J-S Tian, Y-L Cui, S Ga. Genipin is active via modulating monoaminergic transmission and levels of brain-derived neurotrophic factor (BDNF) in rat model of depression. Neuroscience. vol 275. 2015-10-15. PMID:24972301. |
these results suggest that the possible mechanism of antidepressant-like effects on genipin, at least in one part, resulted from monoaminergic neurotransmitter system and the potential dysfunctional regulation of the post-receptor signaling pathway, which particularly affected the 5-ht(1a)r, 5-ht(2a)r and bdnf levels in the hippocampus. |
2015-10-15 |
2023-08-13 |
rat |