| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giuseppe Musumeci, Paola Castrogiovanni, Sergio Castorina, Rosa Imbesi, Marta Anna Szychlinska, Soraya Scuderi, Carla Loreto, Salvatore Giunt. Changes in serotonin (5-HT) and brain-derived neurotrophic factor (BDFN) expression in frontal cortex and hippocampus of aged rat treated with high tryptophan diet. Brain research bulletin. vol 119. issue Pt A. 2016-08-29. PMID:26444078. |
interestingly, immunohistochemical analyses confirmed that high trp diet significantly elevates the number of 5-ht immunoreactive fibers in both brain areas tested and this correlated with bdnf increase in the fc and hippocampal regions ca1, ca2, ca3 and a strikingly down-regulation of neurotrophin levels in the dentate gyrus (dg) of aged rats. |
2016-08-29 |
2023-08-13 |
rat |
| Giuseppe Musumeci, Paola Castrogiovanni, Sergio Castorina, Rosa Imbesi, Marta Anna Szychlinska, Soraya Scuderi, Carla Loreto, Salvatore Giunt. Changes in serotonin (5-HT) and brain-derived neurotrophic factor (BDFN) expression in frontal cortex and hippocampus of aged rat treated with high tryptophan diet. Brain research bulletin. vol 119. issue Pt A. 2016-08-29. PMID:26444078. |
altogether, these finding provide evidence that enhanced trp intake and the consequent increase in 5-ht neurotransmission may act as a modulator of bdnf system suggesting a possible mechanism for the protective role of serotonergic system on memory impairment occurring along normal aging process. |
2016-08-29 |
2023-08-13 |
rat |
| Jing Sun, Fangyan Wang, Guangliang Hong, Mengqi Pang, Hailing Xu, Haixiao Li, Feng Tian, Renchi Fang, Ye Yao, Jiaming Li. Antidepressant-like effects of sodium butyrate and its possible mechanisms of action in mice exposed to chronic unpredictable mild stress. Neuroscience letters. vol 618. 2016-08-22. PMID:26957230. |
then changes of nissl's body in the hippocampus, brain serotonin (5-ht) concentration, brain-derived neurotrophic factor (bdnf) and tight junctions (tjs) proteins level were assessed to explore the antidepressant mechanisms. |
2016-08-22 |
2023-08-13 |
mouse |
| Jing Sun, Fangyan Wang, Guangliang Hong, Mengqi Pang, Hailing Xu, Haixiao Li, Feng Tian, Renchi Fang, Ye Yao, Jiaming Li. Antidepressant-like effects of sodium butyrate and its possible mechanisms of action in mice exposed to chronic unpredictable mild stress. Neuroscience letters. vol 618. 2016-08-22. PMID:26957230. |
our results showed that cums caused significant depression-like behaviors, neuropathological changes, and decreased brain 5-ht concentration, tjs protein levels and bdnf expression in the hippocampus. |
2016-08-22 |
2023-08-13 |
mouse |
| Jing Sun, Fangyan Wang, Guangliang Hong, Mengqi Pang, Hailing Xu, Haixiao Li, Feng Tian, Renchi Fang, Ye Yao, Jiaming Li. Antidepressant-like effects of sodium butyrate and its possible mechanisms of action in mice exposed to chronic unpredictable mild stress. Neuroscience letters. vol 618. 2016-08-22. PMID:26957230. |
however, nab treatment significantly ameliorated behavioral deficits of the cums-induced mice, increased 5-ht concentration, increased bdnf expression, and up-regulated occludin and zonula occludens-1(zo-1) protein levels in the hippocampus, which demonstrated that nab could partially restore cums-induced blood-brain barrier (bbb) impairments. |
2016-08-22 |
2023-08-13 |
mouse |
| Jing Sun, Fangyan Wang, Guangliang Hong, Mengqi Pang, Hailing Xu, Haixiao Li, Feng Tian, Renchi Fang, Ye Yao, Jiaming Li. Antidepressant-like effects of sodium butyrate and its possible mechanisms of action in mice exposed to chronic unpredictable mild stress. Neuroscience letters. vol 618. 2016-08-22. PMID:26957230. |
in conclusion, these results demonstrated that nab significantly improved depression-like behaviors in cums-induced mice and its antidepressant actions might be related with, at least in part, the increasing brain 5-ht concentration and bdnf expression and restoring bbb impairments. |
2016-08-22 |
2023-08-13 |
mouse |
| Ana Carolina de Moura, Virgínia Meneghini Lazzari, Roberta Oriques Becker, Mirela Severo Gil, Carina Anicet Ruthschilling, Grasiela Agnes, Silvana Almeida, Ana Beatriz Gorini da Veiga, Aldo Bolten Lucion, Márcia Giovenard. Gene expression in the CNS of lactating rats with different patterns of maternal behavior. Neuroscience research. vol 99. 2016-08-19. PMID:26003743. |
this study aimed to analyze the gene expression of the receptors for dopamine (drd1a), prolactin (prlr), serotonin (htr1a, htr1b), estrogen (esr1, esr2), and of bdnf in the olfactory bulb (ob), hippocampus (hp), prefrontal cortex (pfc), and striatum (st) of wistar rats from three groups: ll (n = 8); hl (n = 8); virgin females in diestrus (d; n = 6). |
2016-08-19 |
2023-08-13 |
rat |
| S Liang, T Wang, X Hu, J Luo, W Li, X Wu, Y Duan, F Ji. Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress. Neuroscience. vol 310. 2016-08-15. PMID:26408987. |
l. helveticus ns8 also resulted in lower plasma corticosterone (cort) and adrenocorticotropic hormone (acth) levels, higher plasma interleukin-10 (il-10) levels, restored hippocampal serotonin (5-ht) and norepinephrine (ne) levels, and more hippocampal brain-derived neurotrophic factor (bdnf) mrna expression than in chronic stress rats. |
2016-08-15 |
2023-08-13 |
rat |
| Henk Temmingh, Dan J Stei. Anxiety in Patients with Schizophrenia: Epidemiology and Management. CNS drugs. vol 29. issue 10. 2016-08-15. PMID:26482261. |
recent findings implicate the serotonin transporter (sert) genes, brain-derived neurotropic factor (bdnf) genes, and the serotonin 1a (5ht1a) receptor, but are preliminary and in need of replication. |
2016-08-15 |
2023-08-13 |
Not clear |
| Sören Enge, Monika Fleischhauer, Anne Gärtner, Andreas Reif, Klaus-Peter Lesch, Matthias Kliegel, Alexander Strobe. Brain-Derived Neurotrophic Factor (Val66Met) and Serotonin Transporter (5-HTTLPR) Polymorphisms Modulate Plasticity in Inhibitory Control Performance Over Time but Independent of Inhibitory Control Training. Frontiers in human neuroscience. vol 10. 2016-08-15. PMID:27524961. |
because serotonin (5-ht) signaling and the interplay of bdnf and 5-ht are known to critically mediate brain plasticity, genetic variation in the 5-htt gene-linked polymorphic region (5-httlpr) was also addressed. |
2016-08-15 |
2023-08-13 |
Not clear |
| A R Mesquita, J Belsky, Z Li, J Baptista, E Carvalho-Correia, P Maciel, I Soare. Institutionalization and indiscriminate social behavior: Differential-susceptibility versus diathesis-stress models for the 5-HTTLPR and BDNF genotypes. Physiology & behavior. vol 152. issue Pt A. 2016-08-08. PMID:26386404. |
in seeking to extend work in this area, this research on gene x environment (gxe) interplay investigated whether the serotonin transporter (5-httlpr) and val66met brain-derived neurotrophic factor (bdnf) polymorphisms moderated the effect of institutional care on indiscriminate behavior in preschoolers. |
2016-08-08 |
2023-08-13 |
human |
| N Jennifer Klinedinst, Barbara Resnick, Laura M Yerges-Armstrong, Susan G Dorse. The Interplay of Genetics, Behavior, and Pain with Depressive Symptoms in the Elderly. The Gerontologist. vol 55 Suppl 1. 2016-07-11. PMID:26055783. |
commonly studied candidate genes associated with depression include those that influence serotonin (slc6a4), dopamine (comt), or neuroplasticity (bdnf, ntrk3). |
2016-07-11 |
2023-08-13 |
Not clear |
| Francesco S Bersani, Daniel Lindqvist, Synthia H Mellon, Brenda W J H Penninx, Josine E Verhoeven, Dóra Révész, Victor I Reus, Owen M Wolkowit. Telomerase activation as a possible mechanism of action for psychopharmacological interventions. Drug discovery today. vol 20. issue 11. 2016-06-17. PMID:26166813. |
the modulation of intracellular wnt/β-catenin or pi3k/akt signalling pathways, the interaction with bdnf and 5-ht, and the antioxidant properties could represent possible mechanisms by which the different types of psychiatric medications could modulate telomerase activity. |
2016-06-17 |
2023-08-13 |
Not clear |
| Brendan J Dougherty, Daryl P Fields, Gordon S Mitchel. Mammalian target of rapamycin is required for phrenic long-term facilitation following severe but not moderate acute intermittent hypoxia. Journal of neurophysiology. vol 114. issue 3. 2016-06-17. PMID:26224775. |
moderate aih (maih; three 5-min episodes, pao2 ∼35-55 mmhg) elicits pltf by a serotonin (5-ht)-dependent mechanism that requires new synthesis of brain-derived neurotrophic factor (bdnf), activation of its high-affinity receptor (trkb), and erk mapk signaling. |
2016-06-17 |
2023-08-13 |
rat |
| Aurora Szentágotai-Tătar, Adina Chiș, Romana Vulturar, Anca Dobrean, Diana Mirela Cândea, Andrei C Mi. Shame and Guilt-Proneness in Adolescents: Gene-Environment Interactions. PloS one. vol 10. issue 7. 2016-05-03. PMID:26230319. |
this study investigated the effects of early traumatic events and functional polymorphisms in the brain-derived neurotrophic factor (bdnf) gene and the serotonin transporter gene promoter (5-httlpr) on shame and guilt in adolescents. |
2016-05-03 |
2023-08-13 |
Not clear |
| A Young Min, Choon Nan Doo, Eun Jung Son, Nak Yun Sung, Kun Jong Lee, Dai-Eun Sok, Mee Ree Ki. N-palmitoyl serotonin alleviates scopolamine-induced memory impairment via regulation of cholinergic and antioxidant systems, and expression of BDNF and p-CREB in mice. Chemico-biological interactions. vol 242. 2016-05-03. PMID:26408985. |
n-palmitoyl serotonin alleviates scopolamine-induced memory impairment via regulation of cholinergic and antioxidant systems, and expression of bdnf and p-creb in mice. |
2016-05-03 |
2023-08-13 |
mouse |
| Jennilee Davidson, Michael D Cusimano, William G Benden. Post-Traumatic Brain Injury: Genetic Susceptibility to Outcome. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 21. issue 4. 2016-04-14. PMID:25059577. |
to provide health care workers with the basic information for clinical management we summarize and compare the data on post-tbi outcome with regard to the impact of genetic variation: apolipoprotein e (apoe), brain-derived neurotrophic factor (bdnf), calcium channel, voltage dependent p/q type, catechol-o-methyltransferase (comt), dopamine receptor d2 and ankyrin repeat and kinase domain containing 1 (drd2 and ankk1), interleukin-1 (il-1), interleukin-6 (il-6), kidney and brain expressed protein (kibra), neurofilament, heavy polypeptide (nefh), endothelial nitric oxide synthase 3 (nos3), poly (adp-ribose) polymerase-1 (parp-1), protein phosphatase 3, catalytic subunit, gamma isozyme (ppp3cc), the serotonin transporter (5-htt) gene solute carrier family 6 member (slc6a4) and tumor protein 53 (tp53). |
2016-04-14 |
2023-08-13 |
human |
| César Augusto Brüning, Franciele Martini, Suelen Mendonça Soares, Tuane Bazanella Sampaio, Bibiana Mozzaquatro Gai, Marta M M F Duarte, Cristina Wayne Nogueir. m-Trifluoromethyl-diphenyl diselenide, a multi-target selenium compound, prevented mechanical allodynia and depressive-like behavior in a mouse comorbid pain and depression model. Progress in neuro-psychopharmacology & biological psychiatry. vol 63. 2016-04-08. PMID:26025319. |
(m-cf3-phse)2 also increased the bdnf levels and reduced glutamate release and 5-ht uptake altered by psnl. |
2016-04-08 |
2023-08-13 |
mouse |
| Michelle S Antunes, Jossana Rodrigues Ruff, Dieniffer de Oliveira Espinosa, Manuela Bastos Piegas, Maicon Lenon Otenio de Brito, Kellen Athaíde Rocha, Marcelo Gomes de Gomes, André Tiago Rossito Goes, Leandro Cattelan Souza, Franciele Donato, Silvana Peterini Boeira, Cristiano R Jess. Neuropeptide Y administration reverses tricyclic antidepressant treatment-resistant depression induced by ACTH in mice. Hormones and behavior. vol 73. 2016-04-06. PMID:26122290. |
the levels of serum corticosterone, tryptophan (trp), kynurenine (kyn), serotonin (5-ht), 5-hydroxyindoleacetic acid (5-hiaa), brain-derived neurotrophic factor (bdnf), nerve growth factor (ngf) and indoleamine 2,3-dioxygenase (ido) activity in the hippocampus were analyzed. |
2016-04-06 |
2023-08-13 |
mouse |
| Elizabeth D Dalton, Constance L Hammen, Jake M Najman, Patricia A Brenna. Genetic susceptibility to family environment: BDNF Val66met and 5-HTTLPR influence depressive symptoms. Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43). vol 28. issue 6. 2016-04-05. PMID:25347540. |
functional genetic polymorphisms associated with brain-derived neurotrophic factor (bdnf) and serotonin (5-httlpr) have demonstrated associations with depression in interaction with environmental stressors. |
2016-04-05 |
2023-08-13 |
Not clear |