| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rebecca A Lundwall, James L Dannemiller, H Hill Goldsmit. Genetic associations with reflexive visual attention in infancy and childhood. Developmental science. vol 20. issue 3. 2018-01-03. PMID:26613685. |
the genetic markers (single nucleotide polymorphisms and variable number tandem repeats on the genes apoe, bdnf, chrna4, comt, drd4, htr4, igf2, maoa, slc5a7, slc6a3, and snap25) are related to brain development and/or to the availability of neurotransmitters such as acetylcholine, dopamine, or serotonin. |
2018-01-03 |
2023-08-13 |
Not clear |
| Troy A Roepke, Jennifer A Yang, Ali Yasrebi, Kyle J Mamounis, Elif Oruc, Aparna Mahakali Zama, Mehmet Uzumc. Regulation of arcuate genes by developmental exposures to endocrine-disrupting compounds in female rats. Reproductive toxicology (Elmsford, N.Y.). vol 62. 2018-01-01. PMID:27103539. |
bdnf (brain-derived neurotropic factor), igf1 (insulin-like growth factor 1), htr2c (5-hydroxytryptamine receptor), and cck2r (cholescystokinin 2 receptor) were impacted. |
2018-01-01 |
2023-08-13 |
rat |
| Andiara E Freitas, Javier Egea, Izaskun Buendia, Vanessa Gómez-Rangel, Esther Parada, Elisa Navarro, Ana Isabel Casas, Aneta Wojnicz, José Avendaño Ortiz, Antonio Cuadrado, Ana Ruiz-Nuño, Ana Lúcia S Rodrigues, Manuela G Lope. Agmatine, by Improving Neuroplasticity Markers and Inducing Nrf2, Prevents Corticosterone-Induced Depressive-Like Behavior in Mice. Molecular neurobiology. vol 53. issue 5. 2017-12-25. PMID:25966970. |
agmatine treatment for 21 days was able to abolish the corticosterone-induced depressive-like behavior and the alterations in the immunocontent of mature bdnf and synaptotagmin i, and in the serotonin and glutamate levels. |
2017-12-25 |
2023-08-13 |
mouse |
| Andiara E Freitas, Javier Egea, Izaskun Buendia, Vanessa Gómez-Rangel, Esther Parada, Elisa Navarro, Ana Isabel Casas, Aneta Wojnicz, José Avendaño Ortiz, Antonio Cuadrado, Ana Ruiz-Nuño, Ana Lúcia S Rodrigues, Manuela G Lope. Agmatine, by Improving Neuroplasticity Markers and Inducing Nrf2, Prevents Corticosterone-Induced Depressive-Like Behavior in Mice. Molecular neurobiology. vol 53. issue 5. 2017-12-25. PMID:25966970. |
in addition, agmatine treatment in control mice increased noradrenaline, serotonin, and dopamine levels, creb phosphorylation, mature bdnf and synaptotagmin i immunocontents, and reduced pro-bdnf immunocontent in the hippocampus. |
2017-12-25 |
2023-08-13 |
mouse |
| Marina Sagud, Matea Nikolac Perkovic, Bjanka Vuksan-Cusa, Anja Maravic, Dubravka Svob Strac, Alma Mihaljevic Peles, Maja Zivkovic, Zorana Kusevic, Nela Piva. A prospective, longitudinal study of platelet serotonin and plasma brain-derived neurotrophic factor concentrations in major depression: effects of vortioxetine treatment. Psychopharmacology. vol 233. issue 17. 2017-12-12. PMID:27356518. |
various antidepressants occupy brain serotonin transporter (sert), decrease platelet serotonin (5-ht) concentration, and normalize reduced plasma brain-derived neurotrophic factor (bdnf) concentrations in depressed patients. |
2017-12-12 |
2023-08-13 |
Not clear |
| Marina Sagud, Matea Nikolac Perkovic, Bjanka Vuksan-Cusa, Anja Maravic, Dubravka Svob Strac, Alma Mihaljevic Peles, Maja Zivkovic, Zorana Kusevic, Nela Piva. A prospective, longitudinal study of platelet serotonin and plasma brain-derived neurotrophic factor concentrations in major depression: effects of vortioxetine treatment. Psychopharmacology. vol 233. issue 17. 2017-12-12. PMID:27356518. |
to further elucidate its mechanism of action, we have investigated the effects of vortioxetine on platelet 5-ht and plasma bdnf concentrations in patients with major depression. |
2017-12-12 |
2023-08-13 |
Not clear |
| Junfei Zhou, Fang Wang, Chang Xu, Zipeng Zhou, Wei Zhan. The histone demethylase JMJD2A regulates the expression of BDNF and mediates neuropathic pain in mice. Experimental cell research. vol 361. issue 1. 2017-12-12. PMID:29054488. |
jmjd2a responded to 5-hydroxytryptamine (5-ht) and promoted the expression of the brain-derived neurotrophic factor (bdnf), which is a protein critically involved in neuropathic pain. |
2017-12-12 |
2023-08-13 |
mouse |
| Erica L Tatham, Rajamannar Ramasubbu, Ismael Gaxiola-Valdez, Filomeno Cortese, Darren Clark, Bradley Goodyear, Jane Foster, Geoffrey B Hal. White matter integrity in major depressive disorder: Implications of childhood trauma, 5-HTTLPR and BDNF polymorphisms. Psychiatry research. Neuroimaging. vol 253. 2017-12-07. PMID:27261564. |
this study examined the impact of childhood neglect, serotonin transporter (5-httlpr) and brain derived neurotrophic factor (bdnf) polymorphisms on white matter (wm) integrity in major depressive disorder (mdd) using diffusion tensor imaging (dti). |
2017-12-07 |
2023-08-13 |
human |
| Ana Paula Pesarico, Gláubia Sartori, César A Brüning, Anderson C Mantovani, Thiago Duarte, Gilson Zeni, Cristina Wayne Nogueir. A novel isoquinoline compound abolishes chronic unpredictable mild stress-induced depressive-like behavior in mice. Behavioural brain research. vol 307. 2017-11-28. PMID:27036647. |
the synaptosomal [(3)h] serotonin (5-ht) uptake, nuclear factor (nf)-κb, tyrosine kinase receptor (trkb) and pro-brain-derived neurotrophic factor (bdnf) levels were determined in the mouse prefrontal cortex. |
2017-11-28 |
2023-08-13 |
mouse |
| Sara Agnafors, Gunilla Sydsjö, Erika Comasco, Marie Bladh, Lars Oreland, Carl Göran Svedi. Early predictors of behavioural problems in pre-schoolers - a longitudinal study of constitutional and environmental main and interaction effects. BMC pediatrics. vol 16. 2017-11-27. PMID:27267363. |
gene-by-environment studies investigating the impact of the serotonin transporter gene-linked polymorphic region (5-httlpr) and the brain derived neurotrophic factor (bdnf) val66met polymorphisms by life events on mental health and behaviour problems have been inconclusive. |
2017-11-27 |
2023-08-13 |
Not clear |
| Rubén García-Cabrerizo, M Julia García-Fuste. Comparative effects of amphetamine-like psychostimulants on rat hippocampal cell genesis at different developmental ages. Neurotoxicology. vol 56. 2017-11-20. PMID:27373168. |
moreover, the present results, in line with previous data, suggest a possible role for the neuroplasticity marker bdnf and serotonin in regulating cell survival, as mbdnf protein regulation paralleled hippocampal cell survival and 5-ht |
2017-11-20 |
2023-08-13 |
rat |
| P M Fisher, B Ozenne, C Svarer, D Adamsen, S Lehel, W F C Baaré, P S Jensen, G M Knudse. BDNF val66met association with serotonin transporter binding in healthy humans. Translational psychiatry. vol 7. issue 2. 2017-11-16. PMID:28195567. |
bdnf val66met association with serotonin transporter binding in healthy humans. |
2017-11-16 |
2023-08-13 |
Not clear |
| Mahmoud M Said, Marwa M Abd Rab. Neuroprotective effects of eugenol against aluminiuminduced toxicity in the rat brain. Arhiv za higijenu rada i toksikologiju. vol 68. issue 1. 2017-11-08. PMID:28365674. |
in addition, al enhanced brain acetylcholinesterase activity (ache) (46.22±4.90 u mg-1 protein, p<0.001), tumour necrosis factor alpha (tnf-α) (118.72±11.32 pg mg-1 protein, p<0.001), and caspase 3 (casp-3) (8.77±1.26 ng mg-1 protein, p<0.001) levels, and in contrast significantly suppressed brain-derived neurotrophic factor (bdnf) (82.74±14.53 pg mg-1 protein, p<0.002) and serotonin (5-ht) (1.54±0.12 ng mg-1 tissue, p<0.01) levels. |
2017-11-08 |
2023-08-13 |
rat |
| Mahmoud M Said, Marwa M Abd Rab. Neuroprotective effects of eugenol against aluminiuminduced toxicity in the rat brain. Arhiv za higijenu rada i toksikologiju. vol 68. issue 1. 2017-11-08. PMID:28365674. |
on the other hand, co-administration of dietary eugenol with al intoxication restored brain bdnf (108.76±2.64 pg mg-1 protein) and 5-ht (2.13±0.27 ng mg-1 tissue) to normal levels, enhanced brain tas (13.43±0.24 μmol g-1 tissue, p<0.05), with a concomitant significant reduction in tnf-α (69.98±4.74 pg mg-1 protein) and casp-3 (3.80±0.37 ng mg-1 protein) levels (p<0.001), as well as ache activity (24.50±3.25 u mg-1 protein, p<0.001), and increased striatal gfap immunoreactivity, compared with al-treated rats. |
2017-11-08 |
2023-08-13 |
rat |
| L Zhou, S L Ma, P K K Yeung, Y H Wong, K W K Tsim, K F So, L C W Lam, S K Chun. Anxiety and depression with neurogenesis defects in exchange protein directly activated by cAMP 2-deficient mice are ameliorated by a selective serotonin reuptake inhibitor, Prozac. Translational psychiatry. vol 6. issue 9. 2017-11-07. PMID:27598965. |
fluoxetine, a selective serotonin reuptake inhibitor (ssri) also known as prozac, is widely used against depression, potentially by activating camp response element-binding protein (creb) and increasing brain-derived neurotrophic factor (bdnf) through protein kinase a (pka). |
2017-11-07 |
2023-08-13 |
mouse |
| Tianheng Hou, Xiaobo Li, Chongsheng Pen. Borneol enhances the antidepressant effects of asiaticoside by promoting its distribution into the brain. Neuroscience letters. vol 646. 2017-10-10. PMID:28263826. |
hippocampal 5-ht, ne, bdnf, and tnf-α levels were detected, and pathological changes were observed by h&e staining. |
2017-10-10 |
2023-08-13 |
rat |
| Tianheng Hou, Xiaobo Li, Chongsheng Pen. Borneol enhances the antidepressant effects of asiaticoside by promoting its distribution into the brain. Neuroscience letters. vol 646. 2017-10-10. PMID:28263826. |
furthermore, fab upregulated bdnf and 5-ht more significantly compared with as, which revealed a possible multi-mechanism of action. |
2017-10-10 |
2023-08-13 |
rat |
| Cecilia Csölle, Mária Baranyi, Gabriella Zsilla, Agnes Kittel, Flóra Gölöncsér, Peter Illes, Edit Papp, E Sylvester Vizi, Beáta Sperlág. Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors. PloS one. vol 8. issue 6. 2017-10-06. PMID:23805233. |
in conclusion there are several potential mechanisms for the antidepressant phenotype of p2rx7-/- mice, such as the absence of p2rx7-mediated glutamate release, elevated basal bdnf production, enhanced neurogenesis and increased 5-ht bioavailability in the hippocampus. |
2017-10-06 |
2023-08-12 |
mouse |
| Elisabetta Tronci, Francesco Napolitano, Ana Muñoz, Camino Fidalgo, Francesca Rossi, Anders Björklund, Alessandro Usiello, Manolo Cart. BDNF over-expression induces striatal serotonin fiber sprouting and increases the susceptibility to l-DOPA-induced dyskinesia in 6-OHDA-lesioned rats. Experimental neurology. vol 297. 2017-10-05. PMID:28757258. |
bdnf over-expression induces striatal serotonin fiber sprouting and increases the susceptibility to l-dopa-induced dyskinesia in 6-ohda-lesioned rats. |
2017-10-05 |
2023-08-13 |
rat |
| Elisabetta Tronci, Francesco Napolitano, Ana Muñoz, Camino Fidalgo, Francesca Rossi, Anders Björklund, Alessandro Usiello, Manolo Cart. BDNF over-expression induces striatal serotonin fiber sprouting and increases the susceptibility to l-DOPA-induced dyskinesia in 6-OHDA-lesioned rats. Experimental neurology. vol 297. 2017-10-05. PMID:28757258. |
in addition to its role in neuronal survival, the brain neurotrophic factor (bdnf) has been shown to influence serotonin transmission and synaptic plasticity, events strongly implicated in the appearance of l-dopa-induced dyskinesia (lid), a motor complication occurring in parkinsonian patients after long-term treatment with the dopamine precursor. |
2017-10-05 |
2023-08-13 |
rat |