| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sung-Wuk Jang, Xia Liu, Sompol Pradoldej, Gianluca Tosini, Qiang Chang, P Michael Iuvone, Keqiang Y. N-acetylserotonin activates TrkB receptor in a circadian rhythm. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 8. 2010-04-05. PMID:20133677. |
bdnf and serotonin often function in a cooperative manner to regulate neuronal plasticity, neurogenesis, and neuronal survival. |
2010-04-05 |
2023-08-12 |
mouse |
| Atsuko Ikenouchi-Sugita, Yumiko Toyohira, Reiji Yoshimura, Susumu Ueno, Masato Tsutsui, Jun Nakamura, Nobuyuki Yanagihar. Opposite effects of milnacipran, a serotonin norepinephrine reuptake inhibitor, on the levels of nitric oxide and brain-derived neurotrophic factor in mouse brain cortex. Naunyn-Schmiedeberg's archives of pharmacology. vol 380. issue 6. 2010-03-30. PMID:19894036. |
we report here the effects of subchronic treatment of mice with milnacipran, a serotonin norepinephrine reuptake inhibitor, on the levels of no and bdnf in mice. |
2010-03-30 |
2023-08-12 |
mouse |
| Miho Nakano, Kenichi Osada, Atsushi Misonoo, Keisuke Fujiwara, Miho Takahashi, Yuriko Ogawa, Toshiaki Haga, Shigeto Kanai, Daisuke Tanaka, Yasuo Sasuga, Takuyoh Yanagida, Mikio Asakura, Noboru Yamaguch. Fluvoxamine and sigma-1 receptor agonists dehydroepiandrosterone (DHEA)-sulfate induces the Ser473-phosphorylation of Akt-1 in PC12 cells. Life sciences. vol 86. issue 9-10. 2010-03-18. PMID:19995565. |
the expression of brain-derived neurotrophic factor (bdnf) may be a downstream target of a variety of antidepressant treatments, and selective serotonin reuptake inhibitors (ssris) are used clinically for the treatment of depression. |
2010-03-18 |
2023-08-12 |
Not clear |
| Gonzalo Laje, Roy H Perlis, A John Rush, Francis J McMaho. Pharmacogenetics studies in STAR*D: strengths, limitations, and results. Psychiatric services (Washington, D.C.). vol 60. issue 11. 2010-01-15. PMID:19880459. |
other findings in pde11a and bdnf were not successfully replicated, and reports of potential confounders in previous associations with serotonin transporter variation (slc6a4) were identified. |
2010-01-15 |
2023-08-12 |
Not clear |
| Takeshi Otowa, Takafumi Shimada, Yoshiya Kawamura, Xiaoxi Liu, Ken Inoue, Nagisa Sugaya, Takanobu Minato, Ryoichi Nakagami, Mamoru Tochigi, Tadashi Umekage, Kiyoto Kasai, Nobumasa Kato, Hisashi Tanii, Yuji Okazaki, Hisanobu Kaiya, Tsukasa Sasak. No association between the brain-derived neurotrophic factor gene and panic disorder in Japanese population. Journal of human genetics. vol 54. issue 8. 2009-12-15. PMID:19461660. |
brain-derived neurotrophic factor (bdnf) gene, which has regulatory effects on neurotransmitter systems such as serotonin and dopamine, is a candidate for susceptibility locus of pd. |
2009-12-15 |
2023-08-12 |
Not clear |
| Vera Golimbet, Margarita Alfimova, Galina Korovaitseva, Lilia I Abramova, Vasily G Kale. Emotional distress in parents of psychotic patients is modified by serotonin transporter gene (5-HTTLPR)--brain-derived neurotrophic factor gene interactions. The Spanish journal of psychology. vol 12. issue 2. 2009-12-03. PMID:19899670. |
there is growing evidence that sensitivity of individuals to depressogenic effects of stressful factor is moderated by genetic variants of serotonin transporter (sert) and brain-derived neurotrophic factors (bdnf). |
2009-12-03 |
2023-08-12 |
Not clear |
| Gillian M Mackay, Caroline M Forrest, John Christofides, Michala A Bridel, Susan Mitchell, Richard Cowlard, Trevor W Stone, L Gail Darlingto. Kynurenine metabolites and inflammation markers in depressed patients treated with fluoxetine or counselling. Clinical and experimental pharmacology & physiology. vol 36. issue 4. 2009-11-24. PMID:19018805. |
concentrations of 5-hydroxytryptamine (5-ht; serotonin), 5-hydroxyindoleacetic acid (5-hiaa), oxidized tryptophan metabolites, brain-derived neurotrophic factor (bdnf) and inflammatory mediators (interleukin (il)-2, c-reactive protein (crp), neopterin) were measured in peripheral blood during an 18 week period of treatment with fluoxetine, fluoxetine plus tri-iodothyronine (t(3)) or psychiatric counselling. |
2009-11-24 |
2023-08-12 |
Not clear |
| Eva Real, Mònica Gratacòs, Virginia Soria, Geòrgia Escaramís, Pino Alonso, Cinto Segalàs, Mònica Bayés, Rafael de Cid, José M Menchón, Xavier Estivil. A brain-derived neurotrophic factor haplotype is associated with therapeutic response in obsessive-compulsive disorder. Biological psychiatry. vol 66. issue 7. 2009-11-23. PMID:19589503. |
furthermore, there is strong evidence of a role for the serotonergic system in the pathophysiology and treatment of ocd, and upregulation of bdnf has been observed with various classes of antidepressants, including selective serotonin reuptake inhibitors (ssri). |
2009-11-23 |
2023-08-12 |
Not clear |
| V Trajkovska, M A Santini, A B Marcussen, M S Thomsen, H H Hansen, J D Mikkelsen, L Arneberg, M Kokaia, G M Knudsen, S Azna. BDNF downregulates 5-HT(2A) receptor protein levels in hippocampal cultures. Neurochemistry international. vol 55. issue 7. 2009-11-17. PMID:19563850. |
bdnf downregulates 5-ht(2a) receptor protein levels in hippocampal cultures. |
2009-11-17 |
2023-08-12 |
mouse |
| V Trajkovska, M A Santini, A B Marcussen, M S Thomsen, H H Hansen, J D Mikkelsen, L Arneberg, M Kokaia, G M Knudsen, S Azna. BDNF downregulates 5-HT(2A) receptor protein levels in hippocampal cultures. Neurochemistry international. vol 55. issue 7. 2009-11-17. PMID:19563850. |
both brain-derived neurotrophic factor (bdnf) and the serotonin receptor 2a (5-ht(2a)) have been related to depression pathology. |
2009-11-17 |
2023-08-12 |
mouse |
| V Trajkovska, M A Santini, A B Marcussen, M S Thomsen, H H Hansen, J D Mikkelsen, L Arneberg, M Kokaia, G M Knudsen, S Azna. BDNF downregulates 5-HT(2A) receptor protein levels in hippocampal cultures. Neurochemistry international. vol 55. issue 7. 2009-11-17. PMID:19563850. |
specific 5-ht(2a) receptor changes seen in bdnf conditional mutant mice suggest that bdnf regulates the 5-ht(2a) receptor level. |
2009-11-17 |
2023-08-12 |
mouse |
| V Trajkovska, M A Santini, A B Marcussen, M S Thomsen, H H Hansen, J D Mikkelsen, L Arneberg, M Kokaia, G M Knudsen, S Azna. BDNF downregulates 5-HT(2A) receptor protein levels in hippocampal cultures. Neurochemistry international. vol 55. issue 7. 2009-11-17. PMID:19563850. |
here we show a direct effect of bdnf on 5-ht(2a) receptor protein levels in primary hippocampal neuronal and mature hippocampal organotypic cultures exposed to different bdnf concentrations for either 1, 3, 5 or 7 days. |
2009-11-17 |
2023-08-12 |
mouse |
| V Trajkovska, M A Santini, A B Marcussen, M S Thomsen, H H Hansen, J D Mikkelsen, L Arneberg, M Kokaia, G M Knudsen, S Azna. BDNF downregulates 5-HT(2A) receptor protein levels in hippocampal cultures. Neurochemistry international. vol 55. issue 7. 2009-11-17. PMID:19563850. |
in vivo effects of bdnf on hippocampal 5-ht(2a) receptor levels were further corroborated in (bdnf +/-) mice with reduced bdnf levels. |
2009-11-17 |
2023-08-12 |
mouse |
| V Trajkovska, M A Santini, A B Marcussen, M S Thomsen, H H Hansen, J D Mikkelsen, L Arneberg, M Kokaia, G M Knudsen, S Azna. BDNF downregulates 5-HT(2A) receptor protein levels in hippocampal cultures. Neurochemistry international. vol 55. issue 7. 2009-11-17. PMID:19563850. |
in primary neuronal cultures, 7 days exposure to 25 and 50ng/ml bdnf resulted in downregulation of 5-ht(2a), but not of 5-ht(1a), receptor protein levels. |
2009-11-17 |
2023-08-12 |
mouse |
| V Trajkovska, M A Santini, A B Marcussen, M S Thomsen, H H Hansen, J D Mikkelsen, L Arneberg, M Kokaia, G M Knudsen, S Azna. BDNF downregulates 5-HT(2A) receptor protein levels in hippocampal cultures. Neurochemistry international. vol 55. issue 7. 2009-11-17. PMID:19563850. |
the bdnf-associated downregulation of 5-ht(2a) receptor levels was also observed in mature hippocampal organotypic cultures, excluding confounding effects of bdnf on immature tissue. |
2009-11-17 |
2023-08-12 |
mouse |
| V Trajkovska, M A Santini, A B Marcussen, M S Thomsen, H H Hansen, J D Mikkelsen, L Arneberg, M Kokaia, G M Knudsen, S Azna. BDNF downregulates 5-HT(2A) receptor protein levels in hippocampal cultures. Neurochemistry international. vol 55. issue 7. 2009-11-17. PMID:19563850. |
bdnf +/- mice showed significant increased 5-ht(2a) receptor levels in hippocampus confirming the association between 5-ht(2a) receptor and bdnf levels in vivo. |
2009-11-17 |
2023-08-12 |
mouse |
| J D Cooke, L M Grover, P R Spangle. Venlafaxine treatment stimulates expression of brain-derived neurotrophic factor protein in frontal cortex and inhibits long-term potentiation in hippocampus. Neuroscience. vol 162. issue 4. 2009-11-10. PMID:19464349. |
we hypothesized that the 5-ht and norepinephrine reuptake inhibitor, venlafaxine, would stimulate bdnf expression and alter ltp more effectively than the selective 5-ht reuptake inhibitor, citalopram. |
2009-11-10 |
2023-08-12 |
rat |
| Susanne Henningsson, Jacqueline Borg, Johan Lundberg, Jessica Bah, Mats Lindström, Erik Ryding, Hristina Jovanovic, Tomoyuki Saijo, Makoto Inoue, Ingmar Rosén, Lil Träskman-Bendz, Lars Farde, Elias Eriksso. Genetic variation in brain-derived neurotrophic factor is associated with serotonin transporter but not serotonin-1A receptor availability in men. Biological psychiatry. vol 66. issue 5. 2009-10-21. PMID:19500776. |
the serotonergic system, including the serotonin transporter (5-htt), which is the target of many antidepressants, seems to be influenced by brain-derived neurotrophic factor (bdnf). |
2009-10-21 |
2023-08-12 |
Not clear |
| M Aguilera, B Arias, M Wichers, N Barrantes-Vidal, J Moya, H Villa, J van Os, M I Ibáñez, M A Ruipérez, G Ortet, L Fañaná. Early adversity and 5-HTT/BDNF genes: new evidence of gene-environment interactions on depressive symptoms in a general population. Psychological medicine. vol 39. issue 9. 2009-10-20. PMID:19215635. |
serotonin transporter (5-htt) and brain-derived neurotrophic factor (bdnf) modulate the effect of childhood adversity on adult depression, although inconsistencies across studies have been found. |
2009-10-20 |
2023-08-12 |
Not clear |
| Christopher G Beevers, Tony T Wells, John E McGear. The BDNF Val66Met polymorphism is associated with rumination in healthy adults. Emotion (Washington, D.C.). vol 9. issue 4. 2009-09-28. PMID:19653783. |
this study examined associations between the tendency to ruminate and 2 polymorphisms: the val66met polymorphism in the brain-derived neurotrophic factor (bdnf) gene and 5-httlpr polymorphism in the serotonin transporter gene (slc6a4). |
2009-09-28 |
2023-08-12 |
human |