| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Susanne Henningsson, Jacqueline Borg, Johan Lundberg, Jessica Bah, Mats Lindström, Erik Ryding, Hristina Jovanovic, Tomoyuki Saijo, Makoto Inoue, Ingmar Rosén, Lil Träskman-Bendz, Lars Farde, Elias Eriksso. Genetic variation in brain-derived neurotrophic factor is associated with serotonin transporter but not serotonin-1A receptor availability in men. Biological psychiatry. vol 66. issue 5. 2009-10-21. PMID:19500776. |
the serotonergic system, including the serotonin transporter (5-htt), which is the target of many antidepressants, seems to be influenced by brain-derived neurotrophic factor (bdnf). |
2009-10-21 |
2023-08-12 |
Not clear |
| M Aguilera, B Arias, M Wichers, N Barrantes-Vidal, J Moya, H Villa, J van Os, M I Ibáñez, M A Ruipérez, G Ortet, L Fañaná. Early adversity and 5-HTT/BDNF genes: new evidence of gene-environment interactions on depressive symptoms in a general population. Psychological medicine. vol 39. issue 9. 2009-10-20. PMID:19215635. |
serotonin transporter (5-htt) and brain-derived neurotrophic factor (bdnf) modulate the effect of childhood adversity on adult depression, although inconsistencies across studies have been found. |
2009-10-20 |
2023-08-12 |
Not clear |
| Christopher G Beevers, Tony T Wells, John E McGear. The BDNF Val66Met polymorphism is associated with rumination in healthy adults. Emotion (Washington, D.C.). vol 9. issue 4. 2009-09-28. PMID:19653783. |
this study examined associations between the tendency to ruminate and 2 polymorphisms: the val66met polymorphism in the brain-derived neurotrophic factor (bdnf) gene and 5-httlpr polymorphism in the serotonin transporter gene (slc6a4). |
2009-09-28 |
2023-08-12 |
human |
| Stefan Ehrlich, Harriet Salbach-Andrae, Sarah Eckart, Julia V Merle, Roland Burghardt, Ernst Pfeiffer, Leonora Franke, Ralf Uebelhack, Ulrike Lehmkuhl, Rainer Hellwe. Serum brain-derived neurotrophic factor and peripheral indicators of the serotonin system in underweight and weight-recovered adolescent girls and women with anorexia nervosa. Journal of psychiatry & neuroscience : JPN. vol 34. issue 4. 2009-09-10. PMID:19568484. |
animal and cell-culture experiments suggest multiple interrelations between bdnf and the serotonin (5-ht) system. |
2009-09-10 |
2023-08-12 |
mouse |
| Reiji Yoshimura, Hikaru Hori, Atsuko Ikenouchi-Sugita, Wakako Umene-Nakano, Nobuhisa Ueda, Jun Nakamur. Higher plasma interleukin-6 (IL-6) level is associated with SSRI- or SNRI-refractory depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 4. 2009-08-10. PMID:19332097. |
in the present study, we compared plasma levels of interleukin-6 (il-6), tumor necrosis factor-alpha(tnfalpha), and brain-derived neurotrophic factor (bdnf) among selective serotonin reuptake inhibitor (ssri)- or serotonin noradrenaline reuptake inhibitor (snri)-responsive depressed patients (n=31), ssri- or snri-refractory depressed patients (n=20), and healthy controls (n=30). |
2009-08-10 |
2023-08-12 |
Not clear |
| S B Pinnock, S E Lazic, H T Wong, I H W Wong, J Herber. Synergistic effects of dehydroepiandrosterone and fluoxetine on proliferation of progenitor cells in the dentate gyrus of the adult male rat. Neuroscience. vol 158. issue 4. 2009-05-20. PMID:19068226. |
this synergistic action does not appear to be mediated by alterations in brain-derived neurotrophic factor (bdnf) gene expression; or by trkb, mineralocorticoid, glucocorticoid, or 5-ht (5ht1a) receptor expression in the dentate gyrus; or by altered levels of plasma corticosterone. |
2009-05-20 |
2023-08-12 |
rat |
| Antonio Drago, Diana De Ronchi, Alessandro Serrett. Pharmacogenetics of antidepressant response: an update. Human genomics. vol 3. issue 3. 2009-05-14. PMID:19403460. |
some replicated findings in the literature have suggested the serotonin transporter promoter (5-httlpr), serotonin receptor 1a (htr1a), serotonin receptor 2a (htr2a), brain derived neurotrophic factor (bdnf), corticotropin releasing hormone receptor 1 (crhr1) and fk506 binding protein 5 (fkbp5) as putative regulators of the antidepressant response. |
2009-05-14 |
2023-08-12 |
Not clear |
| Zofia Rogóz, Grazyna Skuza, Beata Legutk. Repeated co-treatment with fluoxetine and amantadine induces brain-derived neurotrophic factor gene expression in rats. Pharmacological reports : PR. vol 60. issue 6. 2009-04-23. PMID:19211973. |
the obtained results suggest that the enhancement of bdnf gene expression may be essential for the therapeutic effect of the co-administration of flu and ama in drug-resistant depressed patients, and that among other mechanisms, 5-ht(1a) and 5-ht(2) receptors may play some role in this effect. |
2009-04-23 |
2023-08-12 |
rat |
| Geza Nagy, Zsolt Ronai, Aniko Somogyi, Maria Sasvari-Szekely, Omar Abdul Rahman, Attila Mate, Timea Varga, Zsofia Nemod. P2RX7 Gln460Arg polymorphism is associated with depression among diabetic patients. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 8. 2009-04-15. PMID:18801407. |
in the present study, candidate polymorphisms of the serotonin transporter, the tryptophan hydroxylase 2 (tph2) genes, as well as of the brain-derived neurotrophic factor bdnf, and the p2rx7 purinergic receptor genes were analyzed in hungarian diabetic population. |
2009-04-15 |
2023-08-12 |
Not clear |
| T Deltheil, B P Guiard, J Cerdan, D J David, K F Tanaka, C Repérant, J-P Guilloux, F Coudoré, R Hen, A M Gardie. Behavioral and serotonergic consequences of decreasing or increasing hippocampus brain-derived neurotrophic factor protein levels in mice. Neuropharmacology. vol 55. issue 6. 2009-04-14. PMID:18761360. |
although these data suggest a positive regulation of 5-ht on the expression of the gene coding for bdnf, the reciprocal effects of bdnf on brain 5-ht neurotransmission remains poorly documented. |
2009-04-14 |
2023-08-12 |
mouse |
| T Deltheil, B P Guiard, J Cerdan, D J David, K F Tanaka, C Repérant, J-P Guilloux, F Coudoré, R Hen, A M Gardie. Behavioral and serotonergic consequences of decreasing or increasing hippocampus brain-derived neurotrophic factor protein levels in mice. Neuropharmacology. vol 55. issue 6. 2009-04-14. PMID:18761360. |
(1) in heterozygous bdnf+/- mice in which brain bdnf protein levels were decreased by half, an enhancement of basal extracellular 5-ht levels (5-htext) that induced a down-regulation of sert, i.e., a decrease in its capacity to reuptake 5-ht, was found in the hippocampus. |
2009-04-14 |
2023-08-12 |
mouse |
| T Deltheil, B P Guiard, J Cerdan, D J David, K F Tanaka, C Repérant, J-P Guilloux, F Coudoré, R Hen, A M Gardie. Behavioral and serotonergic consequences of decreasing or increasing hippocampus brain-derived neurotrophic factor protein levels in mice. Neuropharmacology. vol 55. issue 6. 2009-04-14. PMID:18761360. |
interestingly, using in situ hybridization experiments indicated that trkb receptor mrna was expressed in the hippocampus and dorsal raphe nucleus in adult mice suggesting that the neurochemical and behavioral effects of intra-hippocampal bdnf injection can mobilize both pre- and post-synaptic elements of the brain 5-ht neurotransmission. |
2009-04-14 |
2023-08-12 |
mouse |
| Eric Mick, Janet Wozniak, Timothy E Wilens, Joseph Biederman, Stephen V Faraon. Family-based association study of the BDNF, COMT and serotonin transporter genes and DSM-IV bipolar-I disorder in children. BMC psychiatry. vol 9. 2009-04-02. PMID:19193231. |
family-based association study of the bdnf, comt and serotonin transporter genes and dsm-iv bipolar-i disorder in children. |
2009-04-02 |
2023-08-12 |
Not clear |
| Eric Mick, Janet Wozniak, Timothy E Wilens, Joseph Biederman, Stephen V Faraon. Family-based association study of the BDNF, COMT and serotonin transporter genes and DSM-IV bipolar-I disorder in children. BMC psychiatry. vol 9. 2009-04-02. PMID:19193231. |
in this report we test for association with genes coding brain-derived neurotrophic factor (bdnf), the serotonin transporter (slc6a4), and catechol-o-methyltransferase (comt). |
2009-04-02 |
2023-08-12 |
Not clear |
| Hymie Anisma. Cascading effects of stressors and inflammatory immune system activation: implications for major depressive disorder. Journal of psychiatry & neuroscience : JPN. vol 34. issue 1. 2009-03-12. PMID:19125209. |
in this review, i provide synopses of the effects of traditional stressors on the release of corticotropin-releasing hormones at hypothalamic and extrahypothalamic sites, variations of serotonin and its receptors and changes of brain-derived neurotrophic factor (bdnf). |
2009-03-12 |
2023-08-12 |
Not clear |
| Smita Thakker-Varia, Janet Alde. Neuropeptides in depression: role of VGF. Behavioural brain research. vol 197. issue 2. 2009-02-23. PMID:18983874. |
one class of genes regulated by both bdnf and serotonin (5-ht) are neuropeptides including vgf (non-acryonimic) which has a novel role in depression. |
2009-02-23 |
2023-08-12 |
Not clear |
| Michal Reichenstein, Moshe Rehavi, Albert Pinhaso. Involvement of pituitary adenylate cyclase activating polypeptide (PACAP) and its receptors in the mechanism of antidepressant action. Journal of molecular neuroscience : MN. vol 36. issue 1-3. 2009-02-17. PMID:18592413. |
in rat hippocampal neurons, prolonged (72-hour) treatment with selective serotonin reuptake inhibitors paroxetine and citalopram significantly up-regulated bdnf and pacap expression and down-regulated pacap receptor (pac1 and vpac2) expression; the tricyclic antidepressant imipramine had an opposite effect. |
2009-02-17 |
2023-08-12 |
rat |
| Palmiero Monteleone, Mario Ma. Genetic susceptibility to eating disorders: associated polymorphisms and pharmacogenetic suggestions. Pharmacogenomics. vol 9. issue 10. 2009-02-13. PMID:18855537. |
although, at present, no convincing evidence for associations of candidate genes with eds has been provided, the 5-ht(2a) receptor gene and the bdnf gene seem to be promising candidates for genetic influences on an, since polymorphic variants of these genes have been found quite consistently, although not specifically, linked to an restricting subtype in large sample studies. |
2009-02-13 |
2023-08-12 |
Not clear |
| Teresa F Ackermann, Heide Hörtnagl, David P Wolfer, Giovanni Colacicco, Reinhard Sohr, Florian Lang, Rainer Hellweg, Undine E Lan. Phosphatidylinositide dependent kinase deficiency increases anxiety and decreases GABA and serotonin abundance in the amygdala. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 22. issue 5-6. 2009-02-10. PMID:19088455. |
further we analyzed the brain substrate underlying this phenotype and found significantly decreased gaba, taurine and serotonin concentrations in the amygdala and olfactory bulb of pdk1(hm) mice, while bdnf and nerve growth factor (ngf) concentrations were not significantly different between pdk1(hm) and pdk1(wt) mice. |
2009-02-10 |
2023-08-12 |
mouse |
| Jiansong Zhou, Lingjiang Li, Shaojun Tang, Xia Cao, Zexuan Li, Weihui Li, Changqi Li, Xianghui Zhan. Effects of serotonin depletion on the hippocampal GR/MR and BDNF expression during the stress adaptation. Behavioural brain research. vol 195. issue 1. 2009-01-12. PMID:18601957. |
effects of serotonin depletion on the hippocampal gr/mr and bdnf expression during the stress adaptation. |
2009-01-12 |
2023-08-12 |
rat |