| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alessandro Virtuoso, Pernille Tveden-Nyborg, Anne Marie Voigt Schou-Pedersen, Jens Lykkesfeldt, Heidi Kaastrup Müller, Betina Elfving, Dorte Bratbo Sørense. A Long-Term Energy-Rich Diet Increases Prefrontal BDNF in Sprague-Dawley Rats. Nutrients. vol 14. issue 1. 2022-01-11. PMID:35011001. |
this study investigated the effects of a chronic, restricted access to caf on bdnf, monoamine neurotransmitters, and redox imbalance in hip and pfc in male rats. |
2022-01-11 |
2023-08-13 |
human |
| Alessandro Virtuoso, Pernille Tveden-Nyborg, Anne Marie Voigt Schou-Pedersen, Jens Lykkesfeldt, Heidi Kaastrup Müller, Betina Elfving, Dorte Bratbo Sørense. A Long-Term Energy-Rich Diet Increases Prefrontal BDNF in Sprague-Dawley Rats. Nutrients. vol 14. issue 1. 2022-01-11. PMID:35011001. |
our results show that caf induced bdnf and its receptor trkb in pfc compared to the controls ( |
2022-01-11 |
2023-08-13 |
human |
| Yuan Zhou, Shao-Fu Li, Li-Sha Deng, Yong-Kang Ma, Gang Lei, Yong-Hui Dan. HINT1 deficiency in aged mice reduces anxiety-like and depression-like behaviours and enhances cognitive performances. Experimental gerontology. 2022-01-07. PMID:34995725. |
in addition, hint1 ko mice also showed increased gsh-px and superoxide dismutase, and decreased malondialdehyde, together with enhanced bdnf and trk-b expression in the hippocampus and pfc. |
2022-01-07 |
2023-08-13 |
mouse |
| Yulia V Vakhitova, Tatiana S Kalinina, Liana F Zainullina, Anastasiya Yu Lusta, Anna V Volkova, Nikita V Kudryashov, Tatiana A Gudasheva, Alexander A Shimshirt, Ilya A Kadnikov, Mikhail V Voronin, Sergei B Seredeni. Analysis of Antidepressant-like Effects and Action Mechanisms of GSB-106, a Small Molecule, Affecting the TrkB Signaling. International journal of molecular sciences. vol 22. issue 24. 2021-12-24. PMID:34948177. |
in addition, chronic per os administration of gsb-106 resulted in an increase in bdnf levels, which were found to be decreased in the prefrontal cortex and hippocampus of mice after ucms. |
2021-12-24 |
2023-08-13 |
mouse |
| Jing Gao, Mingyin Lai, Wen Fu, Mengyu Wang, Thi Thanh Tam Mai, Baile Ning, Wenbin F. Electroacupuncture Ameliorates Depressive-Like State and Synaptic Deficits Induced by Hyper-Cholinergic Tone During Chronic Stress in Rats. Medical science monitor : international medical journal of experimental and clinical research. vol 27. 2021-12-20. PMID:34924558. |
consistent with the behavior tests and cholinergic tones, there were increased spine density and expressions of synaptic proteins, including brain-derived neurotrophic factor (bdnf), glutamate receptor 1 (glur1), glutamate receptor 2 (glur2), postsynaptic density protein 95 (psd95), and synapsin i in the pfc. |
2021-12-20 |
2023-08-13 |
rat |
| J Blair Price, Clarissa G Yates, Brooke A Morath, Sam K Van De Wakker, Nathanael J Yates, Kim Butters, Mark A Frye, Sean L McGee, Susannah J Ty. Lithium augmentation of ketamine increases insulin signaling and antidepressant-like active stress coping in a rodent model of treatment-resistant depression. Translational psychiatry. vol 11. issue 1. 2021-12-11. PMID:34824208. |
prefrontal oxygen consumption rate (ocr) and extracellular acidification rates (ecar) were also determined in anterior pfc tissue at rest and following stimulation with brain-derived neurotrophic factor (bdnf) and tumor necrosis factor α (tnfα). |
2021-12-11 |
2023-08-13 |
human |
| Ehsan Asadi, Fariba Khodagholi, Sareh Asadi, Hamed Mohammadi Kamsorkh, Neda Kaveh, Ali Malek. Quality of early-life maternal care predicts empathy-like behavior in adult male rats: Linking empathy to BDNF gene expression in associated brain regions. Brain research. vol 1767. 2021-12-09. PMID:34192516. |
additionally, gene expression of bdnf was measured in the amygdala, hippocampus, insula, anterior cingulate cortex, prefrontal cortex, and striatum in these adult male rats. |
2021-12-09 |
2023-08-13 |
rat |
| Vandreza Cardoso Bortolotto, Stífani Machado Araujo, Franciane Cabral Pinheiro, Márcia Rósula Poetini, Luana Barreto Meichtry, Mariana G Fronza, Silvana Peterini Boeira, Lucielli Savegnago, Marina Prigo. Chrysin restores memory deficit in hypothyroidism mice: Behavioral, neurochemical and computational approaches involving the neurotrophinergic system. Journal of psychiatric research. vol 144. 2021-12-07. PMID:34700210. |
then, the levels of neurotrophins (bdnf and ngf) in the hippocampus and prefrontal cortex were measured and tested the affinity of chrysin with neurotrophinergic receptors through molecular docking. |
2021-12-07 |
2023-08-13 |
mouse |
| Vandreza Cardoso Bortolotto, Stífani Machado Araujo, Franciane Cabral Pinheiro, Márcia Rósula Poetini, Luana Barreto Meichtry, Mariana G Fronza, Silvana Peterini Boeira, Lucielli Savegnago, Marina Prigo. Chrysin restores memory deficit in hypothyroidism mice: Behavioral, neurochemical and computational approaches involving the neurotrophinergic system. Journal of psychiatric research. vol 144. 2021-12-07. PMID:34700210. |
hypothyroid mice showed memory deficit in the mwm and reduced neurotrophins levels in the hippocampus and prefrontal cortex, meanwhile, the chrysin treatment was able to reversed the deficit of spatial memory function and increased the levels of bdnf in hipocamppus and ngf in both structures. |
2021-12-07 |
2023-08-13 |
mouse |
| Joko Poleksic, Milan Aksic, Slobodan Kapor, Dubravka Aleksic, Tihomir Stojkovic, Marina Radovic, Vuk Djulejic, Branka Markovic, Antonios Stamataki. Effects of Maternal Deprivation on the Prefrontal Cortex of Male Rats: Cellular, Neurochemical, and Behavioral Outcomes. Frontiers in behavioral neuroscience. vol 15. 2021-11-26. PMID:34819843. |
furthermore, md induced upregulation of brain-derived neurotrophic factor (bdnf), while it did not affect the overall expression of iba1 in neonatal or young adult pfc as measured by western blot, however, microglial activation in young adult md rats was detected immunohistochemically in deep layers of mo and infralimbic cortex (il). |
2021-11-26 |
2023-08-13 |
rat |
| Hakimeh Saadati, Farshid Sadegzadeh, Nona Sakhaie, Hamdollah Panahpour, Mohsen Sagh. Serotonin depletion during the postnatal developmental period causes behavioral and cognitive alterations and decreases BDNF level in the brain of rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 81. issue 2. 2021-11-18. PMID:33404066. |
therefore, in the present study, we examined the effects of postnatal days (pnd 10-20) administration of para-chlorophenylalanine (pcpa, 100 mg/kg, s.c) a 5-ht synthesis inhibitor, on anxiety-related behaviors, pain sensitivity, short-term recognition memory, and hippocampal and prefrontal cortex (pfc) brain-derived neurotrophic factor (bdnf) mrna expression in adult male and female rats. |
2021-11-18 |
2023-08-13 |
rat |
| Hakimeh Saadati, Farshid Sadegzadeh, Nona Sakhaie, Hamdollah Panahpour, Mohsen Sagh. Serotonin depletion during the postnatal developmental period causes behavioral and cognitive alterations and decreases BDNF level in the brain of rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 81. issue 2. 2021-11-18. PMID:33404066. |
novel object recognition memory (norm) and behavioral parameters (anxiety-like behaviors and pain sensitivity) were evaluated in early adulthood and after that, the hippocampi and pfc of the rat's brain were removed for the determination of bdnf mrna expression. |
2021-11-18 |
2023-08-13 |
rat |
| Hakimeh Saadati, Farshid Sadegzadeh, Nona Sakhaie, Hamdollah Panahpour, Mohsen Sagh. Serotonin depletion during the postnatal developmental period causes behavioral and cognitive alterations and decreases BDNF level in the brain of rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 81. issue 2. 2021-11-18. PMID:33404066. |
in addition, postnatal days serotonin depletion decreased bdnf level in the hippocampus and pfc of both male and female rats. |
2021-11-18 |
2023-08-13 |
rat |
| Shuang Zhao, Chengbo Rong, Yi Gao, Linfeng Wu, Xiaoheng Luo, Shuang Song, Yu Liu, Jack Ho Wong, Hexiang Wang, Litao Yi, Tzibun N. Antidepressant-like effect of Ganoderma lucidum spore polysaccharide-peptide mediated by upregulation of prefrontal cortex brain-derived neurotrophic factor. Applied microbiology and biotechnology. vol 105. issue 23. 2021-11-16. PMID:34716786. |
pgl decreased serum corticosterone levels and increased bdnf mrna and protein levels and increased synapsin i and psd95 levels in the prefrontal cortex. |
2021-11-16 |
2023-08-13 |
mouse |
| Shuang Zhao, Chengbo Rong, Yi Gao, Linfeng Wu, Xiaoheng Luo, Shuang Song, Yu Liu, Jack Ho Wong, Hexiang Wang, Litao Yi, Tzibun N. Antidepressant-like effect of Ganoderma lucidum spore polysaccharide-peptide mediated by upregulation of prefrontal cortex brain-derived neurotrophic factor. Applied microbiology and biotechnology. vol 105. issue 23. 2021-11-16. PMID:34716786. |
this effect was completely blocked by pretreatment with the bdnf antagonist k252a, indicating that pgl increased synaptic proteins in a bdnf-dependent manner.key points• an antidepressive polysaccharide-peptide pgl was isolated from g. lucidum spores.• pgl protected pc12 nerve cells from the toxicity of corticosterone.• pgl upregulated bdnf expression and influenced key factors in the prefrontal cortex. |
2021-11-16 |
2023-08-13 |
mouse |
| Yufang Si, Xing Xue, Si Liu, Caixia Feng, Huiping Zhang, Sisi Zhang, Yating Ren, Hengyu Ma, Yankai Dong, Hui Li, Longshan Xie, Zhongliang Zh. CRTC1 signaling involvement in depression-like behavior of prenatally stressed offspring rat. Behavioural brain research. vol 399. 2021-11-15. PMID:33161032. |
it was also found decreased levels of total crtc1, nuclear crtc1, calcineurin, brain-derived neurotrophic factor (bdnf) and c-fos, but increased cytoplasmic p-crtc1 in the hippocampus (hip) and prefrontal cortex (pfc) of the offspring rats. |
2021-11-15 |
2023-08-13 |
rat |
| Laura Martínez-Drudis, Laura Amorós-Aguilar, Meritxell Torras-Garcia, Bruna Serra-Elias, David Costa-Miserachs, Isabel Portell-Cortés, Margalida Coll-Andre. Delayed voluntary physical exercise restores "when" and "where" object recognition memory after traumatic brain injury. Behavioural brain research. vol 400. 2021-11-15. PMID:33279639. |
the aims of this work were to: 1) assess whether voluntary physical exercise can reduce the deficits associated with traumatic brain injury (tbi) in two different components of episodic-like memory based on object recognition, temporal order memory ("when"), and object location memory ("where"); and 2) determine whether changes in levels of brain-derived neurotrophic factor (bdnf) in the hippocampus and prefrontal cortex, as well as alterations in hippocampal cytokines, insulin-like growth factor-1 (igf-1) and vascular endothelial growth factor (vegf), may influence the effects exercise has on either or both tasks. |
2021-11-15 |
2023-08-13 |
rat |
| Laura Martínez-Drudis, Laura Amorós-Aguilar, Meritxell Torras-Garcia, Bruna Serra-Elias, David Costa-Miserachs, Isabel Portell-Cortés, Margalida Coll-Andre. Delayed voluntary physical exercise restores "when" and "where" object recognition memory after traumatic brain injury. Behavioural brain research. vol 400. 2021-11-15. PMID:33279639. |
physical exercise restored the "when" and "where" memories, which had been impaired by the tbi, and increased the concentration of bdnf in the hippocampus, but not the prefrontal cortex. |
2021-11-15 |
2023-08-13 |
rat |
| Mingyue Zhao, Zemeng Zhu, Haonan Li, Wei Wang, Shuyue Cheng, Xiaqing Qin, Huiran Wu, Dexiang Liu, Fang Pa. Effects of traumatic stress in adolescence on PTSD-like behaviors, dendrite development, and H3K9me2/BDNF expression in the amygdala of male rats. Journal of affective disorders. vol 296. 2021-11-15. PMID:34619155. |
in a previous experiment, we demonstrated that traumatic stress in adolescence triggers changes in the expression of the epigenetic marker h3k9me2 in the hippocampus and prefrontal cortex of adolescent and adult rats, which suppresses transcription of the brain-derived neurotrophic factor (bdnf) gene that promotes dendrite development and synaptic growth. |
2021-11-15 |
2023-08-13 |
rat |
| Isabella A Heinrich, Andiara E Freitas, Ingrid A V Wolin, Ana Paula M Nascimento, Roger Walz, Ana Lúcia S Rodrigues, Rodrigo B Lea. Neuronal activity regulated pentraxin (narp) and GluA4 subunit of AMPA receptor may be targets for fluoxetine modulation. Metabolic brain disease. vol 36. issue 4. 2021-11-12. PMID:33528752. |
fluoxetine 10 mg/kg increased creb phosphorylation and bdnf expression in the prefrontal cortex and hippocampus. |
2021-11-12 |
2023-08-13 |
mouse |