| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li Ma, Long Wang, Lijia Chang, Jiajing Shan, Youge Qu, Xingming Wang, Xiayun Wan, Yuko Fujita, Kenji Hashimot. A key role of miR-132-5p in the prefrontal cortex for persistent prophylactic actions of (R)-ketamine in mice. Translational psychiatry. vol 12. issue 1. 2022-09-28. PMID:36171191. |
in contrast, administration of antagomir-132-5p blocked the increased expression of mir-132-5p and decreased expression of bdnf in the pfc of crs-exposed mice, resulting in antidepressant-like effects. |
2022-09-28 |
2023-08-14 |
mouse |
| Silvia Hoirisch-Clapauc. The Fibrinolytic System in Peripartum Depression. Seminars in thrombosis and hemostasis. 2022-09-16. PMID:36113504. |
brain-derived neurotrophic factor (bdnf), synthesized as a precursor that is activated through cleavage by tissue plasminogen activator and plasmin, influences adult neurogenesis and neuronal plasticity in the hippocampus and prefrontal cortex. |
2022-09-16 |
2023-08-14 |
Not clear |
| Nikita S Persaud, Hannah M Cate. The Epigenetics of Anxiety Pathophysiology: A DNA Methylation and Histone Modification Focused Review. eNeuro. 2022-08-23. PMID:35998298. |
in this review, we summarize and discuss a plethora of dna methylation, histone modification, and associated gene expression differences underscoring the anxiety phenotype.findings we outline include expression changes of various dmnts and changes in histone modifications that affect the hypothalamic pituitary adrenal axis and stress response as well as gaba, glutamate, and bdnf signaling in the pfc, amygdala, hypothalamus, and hippocampus. |
2022-08-23 |
2023-08-14 |
Not clear |
| Camila Espasandín, Sofía Rivero, Laura Bengoa, Karina Cal, Gerardo Romanelli, Juan Claudio Benech, Juan Pablo Damiá. CaMKIV/CREB/BDNF signaling pathway expression in prefrontal cortex, amygdala, hippocampus and hypothalamus in streptozotocin-induced diabetic mice with anxious-like behavior. Experimental brain research. 2022-08-19. PMID:35984483. |
the objective of this study was to determine whether mice with type 1 diabetes (t1dm) induced with streptozotocin show a profile of anxious-type behaviors and alterations in the expression/activity of camkiv, creb, pcreb and bdnf in different regions of the brain (prefrontal cortex, amygdala, hippocampus and hypothalamus) in comparison to non-diabetic mice (ndb). |
2022-08-19 |
2023-08-14 |
mouse |
| Naghmeh Saadati, Maryam Bananej, Fatemeh Khakpai, Mohammad-Reza Zarrindast, Hengameh Alibei. Synergistic antidepressant effects of citalopram and SB-334867 in the REM sleep-deprived mice: Possible role of BDNF. Pharmacology, biochemistry, and behavior. 2022-08-16. PMID:35973584. |
this study was done to evaluate the effect of co-treatment of orexin agents along with citalopram on the modulation of depression-like behavior and the expression of bdnf in the prefrontal cortex (pfc) of sleep-deprived male mice. |
2022-08-16 |
2023-08-14 |
mouse |
| Naghmeh Saadati, Maryam Bananej, Fatemeh Khakpai, Mohammad-Reza Zarrindast, Hengameh Alibei. Synergistic antidepressant effects of citalopram and SB-334867 in the REM sleep-deprived mice: Possible role of BDNF. Pharmacology, biochemistry, and behavior. 2022-08-16. PMID:35973584. |
furthermore, we used the open-field test (oft), forced swim test (fst), tail suspension test (tst), and splash test for recording depression-like behavior as well as real-time pcr amplification for assessing the expression of bdnf in the pfc of rem sleep-deprived mice. |
2022-08-16 |
2023-08-14 |
mouse |
| Naghmeh Saadati, Maryam Bananej, Fatemeh Khakpai, Mohammad-Reza Zarrindast, Hengameh Alibei. Synergistic antidepressant effects of citalopram and SB-334867 in the REM sleep-deprived mice: Possible role of BDNF. Pharmacology, biochemistry, and behavior. 2022-08-16. PMID:35973584. |
however, the expression of bdnf was decreased in the pfc. |
2022-08-16 |
2023-08-14 |
mouse |
| Naghmeh Saadati, Maryam Bananej, Fatemeh Khakpai, Mohammad-Reza Zarrindast, Hengameh Alibei. Synergistic antidepressant effects of citalopram and SB-334867 in the REM sleep-deprived mice: Possible role of BDNF. Pharmacology, biochemistry, and behavior. 2022-08-16. PMID:35973584. |
furthermore, our results showed that injection of citalopram alone or with sb-334867 increased the mrna expression level of bdnf in the pfc of rem sleep-deprived mice. |
2022-08-16 |
2023-08-14 |
mouse |
| Sarah G M Benevenuto, Marlise D Domenico, Victor Y Yariwake, Clarissa Tavares Dias, Cristiano Mendes-da-Silva, Nilmara de O Alves, Sofia Ellen da S Caumo, Pérola Vasconcellos, Damila R Morais, Marilia S Cardoso, Janaína Ianicelli, Dunia Waked, Gavin P Davey, Fabio Boylan, Jose L Costa, Mariana Matera Vera. Prenatal exposure to Cannabis smoke induces early and lasting damage to the brain. Neurochemistry international. 2022-08-15. PMID:35970295. |
mice at pnd 60 presented an increase in mature bdnf in the prefrontal cortex (pfc) in the exposed group and a higher cb1 receptor expression in the pfc. |
2022-08-15 |
2023-08-14 |
mouse |
| Yang Yang, Akihiro Mouri, Qiaohui Lu, Kazuo Kunisawa, Hisayoshi Kubota, Masaya Hasegawa, Mami Hirakawa, Yuko Mori, Zou Libo, Kuniaki Saito, Toshitaka Nabeshim. Loureirin C and Xanthoceraside Prevent Abnormal Behaviors Associated with Downregulation of Brain Derived Neurotrophic Factor and AKT/mTOR/CREB Signaling in the Prefrontal Cortex Induced by Chronic Corticosterone Exposure in Mice. Neurochemical research. 2022-07-24. PMID:35871433. |
chronic cort administration decreased the expression levels of bdnf and the phosphorylation of protein kinase b (akt), mammalian target of rapamycin (mtor), and the camp response element binding protein (creb) in the prefrontal cortex. |
2022-07-24 |
2023-08-14 |
mouse |
| Yang Yang, Akihiro Mouri, Qiaohui Lu, Kazuo Kunisawa, Hisayoshi Kubota, Masaya Hasegawa, Mami Hirakawa, Yuko Mori, Zou Libo, Kuniaki Saito, Toshitaka Nabeshim. Loureirin C and Xanthoceraside Prevent Abnormal Behaviors Associated with Downregulation of Brain Derived Neurotrophic Factor and AKT/mTOR/CREB Signaling in the Prefrontal Cortex Induced by Chronic Corticosterone Exposure in Mice. Neurochemical research. 2022-07-24. PMID:35871433. |
lou c and xan dose-dependently prevented the abnormal behaviors and decreased the expression levels of bdnf and in phosphorylation of akt, mtor, and creb in the prefrontal cortex of cort mice. |
2022-07-24 |
2023-08-14 |
mouse |
| V Begni, I Pisano, M Marizzoni, F Marchisella, K C Creutzberg, F De Rosa, A Cattaneo, P Gruca, E Litwa, M Papp, M A Riv. Exposure to chronic stress impairs the ability to cope with an acute challenge: Modulation by lurasidone treatment. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 61. 2022-07-13. PMID:35830759. |
we found that exposure to as produced an upregulation of brain derived neurotrophic factor (bdnf) in the prefrontal cortex of controls animals. |
2022-07-13 |
2023-08-14 |
rat |
| Muhammad S Aldhshan, Tooru M Mizun. Effect of environmental enrichment on aggression and the expression of brain-derived neurotrophic factor transcript variants in group-housed male mice. Behavioural brain research. 2022-07-07. PMID:35798208. |
ee increased levels of bdnf mrna variant i (bdnf i) in the amygdala while it reduced levels of bdnf i in the hypothalamus, hippocampus, prefrontal cortex, parietal cortex, and brainstem. |
2022-07-07 |
2023-08-14 |
mouse |
| Fabiana Festucci, Eugenia Annunzi, Martina Pepe, Giuseppe Curcio, Claudio D'Addario, Walter Adrian. Dopamine-transporter heterozygous rats carrying maternal wild-type allele are more vulnerable to the development of compulsive behavior. Synapse (New York, N.Y.). 2022-06-30. PMID:35772468. |
regarding the prefrontal cortex (pfc), d2r correlates with y-maze "perseverance" in addition to bdnf; considering the amygdala (amy), both d3r and oxtr correlate with sip "licks". |
2022-06-30 |
2023-08-14 |
human |
| Fabiana Festucci, Eugenia Annunzi, Martina Pepe, Giuseppe Curcio, Claudio D'Addario, Walter Adrian. Dopamine-transporter heterozygous rats carrying maternal wild-type allele are more vulnerable to the development of compulsive behavior. Synapse (New York, N.Y.). 2022-06-30. PMID:35772468. |
indeed, compulsivity may be linked to d2r and bdnf in pfc, while extreme anxiety in mat-het rats may be associated with d3r and oxtr in the amygdala. |
2022-06-30 |
2023-08-14 |
human |
| Yann Dromard, Margarita Arango-Lievano, Amelie Borie, Maheva Dedin, Pierre Fontanaud, Joan Torrent, Michael J Garabedian, Stephen D Ginsberg, Freddy Jeannetea. Loss of glucocorticoid receptor phosphorylation contributes to cognitive and neurocentric damages of the amyloid-β pathway. Acta neuropathologica communications. vol 10. issue 1. 2022-06-22. PMID:35733193. |
parallel studies in postmortem human prefrontal cortex revealed ad subjects had downregulated bdnf signaling and concomitant upregulated cortisol pathway activation, which correlated with cognitive decline. |
2022-06-22 |
2023-08-14 |
mouse |
| Solange de Souza Stork, Marcos Hübner, Erica Biehl, Lucineia Gainski Danielski, Sandra Bonfante, Larissa Joaquim, Tais Denicol, Thaina Cidreira, Anita Pacheco, Erick Bagio, Everton Lanzzarin, Gabriela Bernades, Mariana Pacheco de Oliveira, Larissa Espindola da Silva, Josiel M Mack, Franciane Bobinski, Gislaine Tezza Rezin, Tatiana Barichello, Emilio Luiz Streck, Fabricia Petronilh. Diabetes Exacerbates Sepsis-Induced Neuroinflammation and Brain Mitochondrial Dysfunction. Inflammation. 2022-06-10. PMID:35689164. |
levels of il-6, il-10, brain-derived neurotrophic factor (bdnf), nerve growth factor (ngf), and mitochondrial respiratory chain complexes were evaluated in the hippocampus and prefrontal cortex 24 h after sepsis by cecal ligation and perforation (clp) in wistar rats induced to type 1 diabetes by alloxan (150 mg/kg). |
2022-06-10 |
2023-08-14 |
rat |
| Xiaoyan Ma, Shuo Yang, Zhaoxiang Zhang, Luping Liu, Wenli Shi, Sungchil Yang, Shupeng Li, Xiang Cai, Qiang Zho. Rapid and sustained restoration of astrocytic functions by ketamine in depression model mice. Biochemical and biophysical research communications. vol 616. 2022-06-02. PMID:35653826. |
these behavioral anti-depressant effects are associated with normalized expression of glutamate transporter-1(glt-1), glial fibrillary acidic protein (gfap), brain-derived neurotrophic factor (bdnf) and eukaryotic elongation factor 2 phosphorylation (p-eef2) in the prelimbic prefrontal cortex (prl-pfc). |
2022-06-02 |
2023-08-14 |
mouse |
| Kimia Alizadeh, Hamid Moghimi, Ali Golbabaei, Sakineh Alijanpour, Ameneh Rezayo. Post-Weaning Treatment with Probiotic Inhibited Stress-Induced Amnesia in Adulthood Rats: The Mediation of GABAergic System and BDNF/c-Fos Signaling Pathways. Neurochemical research. 2022-05-26. PMID:35618945. |
the hippocampal and prefrontal cortical (pfc) expression levels of bdnf and c-fos were also assessed to show whether the treatments affect the memory-related signaling pathway. |
2022-05-26 |
2023-08-13 |
rat |
| Kimia Alizadeh, Hamid Moghimi, Ali Golbabaei, Sakineh Alijanpour, Ameneh Rezayo. Post-Weaning Treatment with Probiotic Inhibited Stress-Induced Amnesia in Adulthood Rats: The Mediation of GABAergic System and BDNF/c-Fos Signaling Pathways. Neurochemical research. 2022-05-26. PMID:35618945. |
the expression levels of bdnf and c-fos in the pfc and the hippocampus were significantly decreased in the stress animal group. |
2022-05-26 |
2023-08-13 |
rat |