| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kimia Alizadeh, Hamid Moghimi, Ali Golbabaei, Sakineh Alijanpour, Ameneh Rezayo. Post-Weaning Treatment with Probiotic Inhibited Stress-Induced Amnesia in Adulthood Rats: The Mediation of GABAergic System and BDNF/c-Fos Signaling Pathways. Neurochemical research. 2022-05-26. PMID:35618945. |
the muscimol response was compounded with the decreased levels of bdnf and c-fos in the pfc and the hippocampus. |
2022-05-26 |
2023-08-13 |
rat |
| Keren Nitzan, Dekel David, Motty Franko, Roni Toledano, Sharon Fidelman, Yaarit Simchon Tenenbaum, Maya Blonder, Shir Armoza-Eilat, Alon Shamir, Moshe Rehavi, Yair Ben-Chaim, Ravid Doro. Anxiolytic and antidepressants' effect of Crataegus pinnatifida (Shan Zha): biochemical mechanisms. Translational psychiatry. vol 12. issue 1. 2022-05-19. PMID:35589704. |
we show here that shan zha is sufficient to produce an anxiolytic and antidepressant-like effect similar to nht or the escitalopram through activation of 5-ht1a receptor and an elevation in bdnf levels in the hippocampus and pre-frontal cortex (pfc). |
2022-05-19 |
2023-08-13 |
mouse |
| Hanxue Wu, Jinzhu Zhuang, Jiawei Wang, Shenglan Yuan, Hui Sun, Jiaxi X. AT FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556110. |
in both prefrontal cortex and hippocampus, the mrna levels of bdnf (brain-derived neurotrophic factor) and pi4kiiiβ (phosphatidylinositol 4-kinase iiiβ) were found to be significantly lower in hypertensive nt mice. |
2022-05-13 |
2023-08-13 |
mouse |
| Faezeh Kazemi, Shirin Babri, Parisa Keyhanmehr, Mahsa Farid-Habibi, Sepehr Nayebi Rad, Fereshteh Farajdokh. Maternal vitamin D supplementation and treadmill exercise attenuated vitamin D deficiency-induced anxiety-and depressive-like behaviors in adult male offspring rats. Nutritional neuroscience. 2022-04-26. PMID:35470763. |
this study examined the effect of maternal vitamin d dietary manipulations and treadmill exercise on anxiety-and depressive-related behaviors, pro-inflammatory cytokines, and prefrontal cortex (pfc) protein levels of brain-derived neurotrophic factor (bdnf) and vitamin d receptor (vdr) in adult male offspring born to vitamin d-deficient diet (vdd)-fed dams. |
2022-04-26 |
2023-08-13 |
rat |
| Basma Youssef, Kholoud S Ramadan, Shaimaa ElShebiney, Ehab A Ibrahi. Antidepressant-like effects of aqueous extracts of miswak (Salvadora persica) and date palm (Phoenix dactylifera) on depression-like behaviors using CUMS model in male rats. Journal of food biochemistry. 2022-03-29. PMID:35348229. |
in the prefrontal cortex, cums decreased the expression of creb and bdnf mrna. |
2022-03-29 |
2023-08-13 |
rat |
| Basma Youssef, Kholoud S Ramadan, Shaimaa ElShebiney, Ehab A Ibrahi. Antidepressant-like effects of aqueous extracts of miswak (Salvadora persica) and date palm (Phoenix dactylifera) on depression-like behaviors using CUMS model in male rats. Journal of food biochemistry. 2022-03-29. PMID:35348229. |
furthermore, the studied extracts improved the levels of plasma pro-inflammatory cytokines and creb and bdnf mrna expression in the prefrontal cortex. |
2022-03-29 |
2023-08-13 |
rat |
| Antonia Giacco, Federica Cioffi, Arianna Cuomo, Roberta Simiele, Rosalba Senese, Elena Silvestri, Angela Amoresano, Carolina Fontanarosa, Giuseppe Petito, Maria Moreno, Antonia Lanni, Assunta Lombardi, Pieter de Lang. Mild Endurance Exercise during Fasting Increases Gastrocnemius Muscle and Prefrontal Cortex Thyroid Hormone Levels through Differential BHB and BCAA-Mediated BDNF-mTOR Signaling in Rats. Nutrients. vol 14. issue 6. 2022-03-26. PMID:35334826. |
thus, a subset of male wistar rats housed at thermoneutrality that were fed or fasted was submitted to 30-min-mild treadmill exercise bouts (five in total, twice daily, 15 m/min, 0° inclination) over a period of 66 h. prefrontal cortex and gastrocnemius muscle bhb, bcaa, and thyroid hormone were measured by lc-ms/ms analysis and were related to bdnf and mammalian target of rapamycin (mtor) signaling. |
2022-03-26 |
2023-08-13 |
rat |
| Antonia Giacco, Federica Cioffi, Arianna Cuomo, Roberta Simiele, Rosalba Senese, Elena Silvestri, Angela Amoresano, Carolina Fontanarosa, Giuseppe Petito, Maria Moreno, Antonia Lanni, Assunta Lombardi, Pieter de Lang. Mild Endurance Exercise during Fasting Increases Gastrocnemius Muscle and Prefrontal Cortex Thyroid Hormone Levels through Differential BHB and BCAA-Mediated BDNF-mTOR Signaling in Rats. Nutrients. vol 14. issue 6. 2022-03-26. PMID:35334826. |
mild endurance exercise during fasting did not increase prefrontal cortex bhb levels nor was bdnf activated, whereas increased leucine levels were associated with akt-independent increased phosphorylation of the mtorc1 target p70s6k. |
2022-03-26 |
2023-08-13 |
rat |
| Yaping Chen, Mengxin Shen, Xu Liu, Jiangping Xu, Chuang Wan. The Regulation of Glutamate Transporter 1 in the Rapid Antidepressant-Like Effect of Ketamine in Mice. Frontiers in behavioral neuroscience. vol 16. 2022-03-21. PMID:35309681. |
moreover, inhibition of l-vdcc significantly blocked the upregulation of glt1 and bdnf in the pfc of mice. |
2022-03-21 |
2023-08-13 |
mouse |
| Shengying Pan, Yaoying Ma, Rongrong Yang, Xu Lu, Qingsheng You, Ting Ye, Chao Huan. Indole-3-Carbinol Selectively Prevents Chronic Stress-Induced Depression-but not Anxiety-Like Behaviors via Suppressing Pro-Inflammatory Cytokine Production and Oxido-Nitrosative Stress in the Brain. Frontiers in pharmacology. vol 13. 2022-03-04. PMID:35242039. |
further analysis showed that repeated i3c treatment (60 mg/kg, 10 days) prevented csds-induced increases in levels of nitrite and malondialdehyde (mda), decreases in contents of glutathione (gsh), and decreases in levels of brain derived neurotrophic factor (bdnf) protein in the hippocampus and prefrontal cortex. |
2022-03-04 |
2023-08-13 |
mouse |
| Zofia Rogóż, Kinga Kamińska, Marta Anna Lech, Elżbieta Lorenc-Koc. N-Acetylcysteine and Aripiprazole Improve Social Behavior and Cognition and Modulate Brain BDNF Levels in a Rat Model of Schizophrenia. International journal of molecular sciences. vol 23. issue 4. 2022-02-26. PMID:35216241. |
the aim of our study was to compare the efficacy of chronic administration of the atypical antipsychotic drug aripiprazole (7-{4-[4-(2,3-dichlorophenyl)-1-piperazinyl] butoxy}-3,4-dihydro-2(1h)-quinolinone; ari) and the well-known antioxidant n-acetylcysteine (nac) both in alleviating schizophrenia-like social and cognitive deficits and in reducing the decreases in the levels of the brain-derived neurotrophic factor (bdnf) in the prefrontal cortex (pfc) and hippocampus (hip) of adult sprague-dawley rats, that have been induced by chronic administration of the model compound l-buthionine-(s, r)-sulfoximine (bso) during the early postnatal development (p5-p16). |
2022-02-26 |
2023-08-13 |
rat |
| Zofia Rogóż, Kinga Kamińska, Marta Anna Lech, Elżbieta Lorenc-Koc. N-Acetylcysteine and Aripiprazole Improve Social Behavior and Cognition and Modulate Brain BDNF Levels in a Rat Model of Schizophrenia. International journal of molecular sciences. vol 23. issue 4. 2022-02-26. PMID:35216241. |
both doses of nac and 0.3 mg/kg of ari increased the expression of bdnf mrna in the pfc, while all doses of these drugs and their combinations enhanced the levels of bdnf protein in this brain structure. |
2022-02-26 |
2023-08-13 |
rat |
| Zofia Rogóż, Kinga Kamińska, Marta Anna Lech, Elżbieta Lorenc-Koc. N-Acetylcysteine and Aripiprazole Improve Social Behavior and Cognition and Modulate Brain BDNF Levels in a Rat Model of Schizophrenia. International journal of molecular sciences. vol 23. issue 4. 2022-02-26. PMID:35216241. |
these data show that in the rat bso-induced neurodevelopmental model of schizophrenia, ari and nac differently modulated bdnf levels in the pfc and hip. |
2022-02-26 |
2023-08-13 |
rat |
| Minja Aleksic, Zeljka Brkic, Zorica Petrovic, Ester Francija, Iva Lukic, Miroslav Adzi. Sex-specific contribution of glucocorticoid receptor alpha isoforms to anxiety and depressive-like behavior in mice. Journal of neuroscience research. 2022-02-20. PMID:35184325. |
we analyzed corticosterone concentrations in serum, levels of grα isoforms (95, 67, 50, 40, and 25 kda), and mrna levels of gr-responsive genes (gr, fkbp5, bdnf, and il-1β) in the hippocampus and the prefrontal cortex (pfc). |
2022-02-20 |
2023-08-13 |
mouse |
| Minja Aleksic, Zeljka Brkic, Zorica Petrovic, Ester Francija, Iva Lukic, Miroslav Adzi. Sex-specific contribution of glucocorticoid receptor alpha isoforms to anxiety and depressive-like behavior in mice. Journal of neuroscience research. 2022-02-20. PMID:35184325. |
changes in gene expression revealed that female depressive-like behavior could be related to increased levels of il-1β in hippocampus and reduced bdnf levels in both hippocampus and pfc. |
2022-02-20 |
2023-08-13 |
mouse |
| Minja Aleksic, Zeljka Brkic, Zorica Petrovic, Ester Francija, Iva Lukic, Miroslav Adzi. Sex-specific contribution of glucocorticoid receptor alpha isoforms to anxiety and depressive-like behavior in mice. Journal of neuroscience research. 2022-02-20. PMID:35184325. |
however, in males, adolescent cus increased expression of gr in adult hippocampus and bdnf in pfc. |
2022-02-20 |
2023-08-13 |
mouse |
| Sarah Thomas Broome, Alessandro Castorin. The Anxiolytic Drug Buspirone Prevents Rotenone-Induced Toxicity in a Mouse Model of Parkinson's Disease. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163768. |
buspirone attenuated the induction of interleukin-1β and interleukin-6 expression by rotenone, and this was paralleled by the upregulation of arginase-1, brain-derived neurotrophic factor (bdnf), and activity-dependent neuroprotective protein (adnp) in the midbrain, striatum, prefrontal cortex, amygdala, and hippocampus. |
2022-02-15 |
2023-08-13 |
mouse |
| Jing Gao, Ming-Yin Lai, Thi Tanh-Tam Mai, Wen Fu, Meng-Yu Wang, Bai-le Ning, Wen-Bin F. [Effects of electroacupuncture on BNDF/mTORC1 signaling pathway and synaptic plasticity in prefrontal cortex of rats exposed to chronic unpredictable mild stress]. Zhen ci yan jiu = Acupuncture research. vol 47. issue 1. 2022-02-07. PMID:35128865. |
to investigate the effects of electroacupuncture (ea) on the expression of related proteins in the brain-derived neurotrophic factor (bdnf)/mammalian target of rapamycin complex 1 (mtorc1) signaling pathway and synapse-associated proteins and the density of dendrite spines in the prefrontal cortex (pfc) of depression model rats, and to reveal the underlying mechanism by which ea regulates the synaptic plasticity to improve depressive symptoms. |
2022-02-07 |
2023-08-13 |
rat |
| Kohei Takahashi, Kazuhiro Kurokawa, Lihua Hong, Kazuya Miyagawa, Atsumi Mochida-Saito, Masahiro Iwasa, Hiroyuki Iwasa, Osamu Nakagawasai, Takeshi Tadano, Hiroshi Takeda, Minoru Tsuj. Antidepressant effects of Enterococcus faecalis 2001 through the regulation of prefrontal cortical myelination via the enhancement of CREB/BDNF and NF-κB p65/LIF/STAT3 pathways in olfactory bulbectomized mice. Journal of psychiatric research. vol 148. 2022-02-05. PMID:35123326. |
further, ef-2001 treatment increased brain-derived neurotrophic factor (bdnf) and leukemia inhibitory factor (lif) in the pfc. |
2022-02-05 |
2023-08-13 |
mouse |
| Alessandro Virtuoso, Pernille Tveden-Nyborg, Anne Marie Voigt Schou-Pedersen, Jens Lykkesfeldt, Heidi Kaastrup Müller, Betina Elfving, Dorte Bratbo Sørense. A Long-Term Energy-Rich Diet Increases Prefrontal BDNF in Sprague-Dawley Rats. Nutrients. vol 14. issue 1. 2022-01-11. PMID:35011001. |
findings of the effect of high-fat feeding including "cafeteria diets" (caf) on brain-derived neurotrophic factor (bdnf) in the hippocampus (hip) and prefrontal cortex (pfc) in rodents are conflicting. |
2022-01-11 |
2023-08-13 |
human |