| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Enzo Pérez-Valenzuela, Roger Hudson, Taygun Uzuneser, Marta De Felice, Hanna Szkudlarek, Walter Rushlow, Steven R Laviolett. Sex-Dependent Synergism of an Edible THC: CBD Formulation in Reducing Anxiety and Depressive-like Symptoms Following Chronic Stress. Current neuropharmacology. 2023-09-13. PMID:37702237. |
these synergistic effects are associated with alterations in akt/gsk3 and d2-r expression in nac and bdnf expression in pfc. |
2023-09-13 |
2023-10-07 |
rat |
| Mandana Shekarchian, Maghsoud Peeri, Mohammad Ali Azarbayjan. Physical activity in a swimming pool attenuates memory impairment by reducing glutamate and inflammatory cytokines and increasing BDNF in the brain of mice with type 2 diabetes. Brain research bulletin. 2023-08-05. PMID:37543294. |
we also measured inflammatory cytokines (interleukin (il)-6, il-1β, and tumor-necrosis-factor (tnf)-α), an anti-inflammatory cytokine (il-10), and brain-derived-neurotrophic-factor (bdnf), and glutamate levels in the hippocampus or prefrontal cortex of mice. |
2023-08-05 |
2023-08-14 |
mouse |
| Mandana Shekarchian, Maghsoud Peeri, Mohammad Ali Azarbayjan. Physical activity in a swimming pool attenuates memory impairment by reducing glutamate and inflammatory cytokines and increasing BDNF in the brain of mice with type 2 diabetes. Brain research bulletin. 2023-08-05. PMID:37543294. |
while higher physical activity was associated with reduced body weight, glucose, and insulin resistance, attenuated memory impairment, il-6, il-1β, tnf-α, and glutamate, and increased bdnf levels in the hippocampus and prefrontal cortex of diabetic mice. |
2023-08-05 |
2023-08-14 |
mouse |
| Cailian Lu, Shan Li, Lin Kang, Qianqian Li, Hongxu Chen, Yanwen Lin, Han Zhang, Ziling Tang, Meiyan Bai, Peng Xion. Aripiprazole combined with nerve growth factor improves cognitive function in mice with schizophrenia model. Neuroscience letters. 2023-07-26. PMID:37495071. |
the results showed that ari alone or in combination with ngf can improve increased spontaneous activity and spatial learning memory deficits in model mice by elevating bdnf expression levels in prefrontal cortex (pfc) and hippocampus (hip). |
2023-07-26 |
2023-08-14 |
mouse |
| Tahmineh Mokhtari, Min Lu, Ayman El-Meghawry El-Kenaw. Potential anxiolytic and antidepressant-like effects of luteolin in a chronic constriction injury rat model of neuropathic pain: Role of oxidative stress, neurotrophins, and inflammatory factors. International immunopharmacology. vol 122. 2023-07-21. PMID:37478667. |
levels of glial cell-derived neurotrophic factor (gdnf), brain-derived neurotrophic factor (bdnf), b-cell lymphoma-2 (bcl2), superoxide dismutase (sod), catalase (cat), and nuclear factor erythroid-2-related factor 2 (nrf2) were reduced in the hippocampus (hpc) and prefrontal cortex (pfc). |
2023-07-21 |
2023-08-14 |
rat |
| Gabriel Araújo Costa, Nívea Karla de Gusmão Taveiros Silva, Priscila Marianno, Priti Chivers, Alexis Bailey, Rosana Camarin. Environmental enrichment increased Bdnf transcripts in the prefrontal cortex: implications for an epigenetically controlled mechanism. Neuroscience. 2023-07-07. PMID:37419403. |
environmental enrichment increased bdnf transcripts in the prefrontal cortex: implications for an epigenetically controlled mechanism. |
2023-07-07 |
2023-08-14 |
mouse |
| Gabriel Araújo Costa, Nívea Karla de Gusmão Taveiros Silva, Priscila Marianno, Priti Chivers, Alexis Bailey, Rosana Camarin. Environmental enrichment increased Bdnf transcripts in the prefrontal cortex: implications for an epigenetically controlled mechanism. Neuroscience. 2023-07-07. PMID:37419403. |
this study aimed to dissect the transcriptional and epigenetic regulatory effect of 54-day exposure to ee on bdnf by analysing individual bdnf exons mrna expression and the dna methylation profile of a key transcriptional regulator of the bdnf gene, exon iv, in the prefrontal cortex (pfc) of c57bl/6 male mice (sample size=33). |
2023-07-07 |
2023-08-14 |
mouse |
| Gabriel Araújo Costa, Nívea Karla de Gusmão Taveiros Silva, Priscila Marianno, Priti Chivers, Alexis Bailey, Rosana Camarin. Environmental enrichment increased Bdnf transcripts in the prefrontal cortex: implications for an epigenetically controlled mechanism. Neuroscience. 2023-07-07. PMID:37419403. |
bdnf exons ii, iv, vi and ix mrna expression were upregulated and methylation levels at two cpg sites of exon iv were reduced in the pfc of ee mice. |
2023-07-07 |
2023-08-14 |
mouse |
| Gabriel Araújo Costa, Nívea Karla de Gusmão Taveiros Silva, Priscila Marianno, Priti Chivers, Alexis Bailey, Rosana Camarin. Environmental enrichment increased Bdnf transcripts in the prefrontal cortex: implications for an epigenetically controlled mechanism. Neuroscience. 2023-07-07. PMID:37419403. |
the findings of this study contribute to the current literature by dissecting the bdnf gene topology in the pfc where transcriptional and epigenetic regulatory effect of ee takes place. |
2023-07-07 |
2023-08-14 |
mouse |
| Manuela Dicarlo, Patrizia Pignataro, Roberta Zerlotin, Clelia Suriano, Chiara Zecca, Maria Teresa Dell'Abate, Giuseppina Storlino, Angela Oranger, Lorenzo Sanesi, Giorgio Mori, Maria Grano, Graziana Colaianni, Silvia Colucc. Short-Term Irisin Treatment Enhanced Neurotrophin Expression Differently in the Hippocampus and the Prefrontal Cortex of Young Mice. International journal of molecular sciences. vol 24. issue 11. 2023-06-11. PMID:37298063. |
we found significantly increased mrna levels of nerve growth factor (ngf) and fibroblast growth factor 2 (fgf-2) in the hippocampus and brain-derived growth factor (bdnf) in the pfc. |
2023-06-11 |
2023-08-14 |
mouse |
| Manuela Dicarlo, Patrizia Pignataro, Roberta Zerlotin, Clelia Suriano, Chiara Zecca, Maria Teresa Dell'Abate, Giuseppina Storlino, Angela Oranger, Lorenzo Sanesi, Giorgio Mori, Maria Grano, Graziana Colaianni, Silvia Colucc. Short-Term Irisin Treatment Enhanced Neurotrophin Expression Differently in the Hippocampus and the Prefrontal Cortex of Young Mice. International journal of molecular sciences. vol 24. issue 11. 2023-06-11. PMID:37298063. |
except for bdnf in the pfc, two-way anova analysis did not reveal sex differences in the expression of the tested genes. |
2023-06-11 |
2023-08-14 |
mouse |
| Emily J Jaehne, Emily J Antolasic, Kerstin C Creutzberg, Veronica Begni, Marco A Riva, Maarten van den Buus. Impaired fear memory in a rat model of the Brain-Derived Neurotrophic Factor Val66Met polymorphism is reversed by chronic exercise. Neurobiology of learning and memory. 2023-06-03. PMID:37269900. |
exercise furthermore led to increased expression of bdnf in the prefrontal cortex of females and its isoforms in both sexes, as well as increased expression of fk506 binding protein 51 (fkpb5) in females and decreased expression of serum/glucocorticoid-regulated kinase (sgk1) in males independent of genotype. |
2023-06-03 |
2023-08-14 |
rat |
| Seda Kose, Meltem Donmez Kutlu, Samet Kara, Sait Polat, Kubra Akilliogl. Investıgatıon of the protectıve effect of long-term exercıse on molecular pathways and behavıours ın scopolamıne ınduced alzheımer's dısease-lıke condıtıon. Brain research. 2023-06-03. PMID:37269967. |
hippocampus and prefrontal cortex of mice were isolated, and levels of bdnf, trkb, and p-gsk3ß |
2023-06-03 |
2023-08-14 |
mouse |
| Mark D Underwood, Hanga Galfalvy, Shu-Chi Hsiung, Yan Liu, Norman R Simpson, Mihran J Bakalian, Gorazd B Rosoklija, Andrew J Dwork, Victoria Arango, J John Man. A Stress Protein Based Suicide Prediction Score and relationship to reported Early Life Adversity and Recent Life Stress. The international journal of neuropsychopharmacology. 2023-05-27. PMID:37243534. |
we examined relationships between reported early life adversity (ela), recent life stress (rls), suicide, and corticotropin releasing hormone (crh), crh binding protein (crhbp), fk506-binding protein (fkbp5), glucocorticoid receptor (gr) and brain-derived neurotrophic factor (bdnf) in postmortem human prefrontal cortex (ba9) and anterior cingulate cortex (ba24). |
2023-05-27 |
2023-08-14 |
human |
| Jing Wang, Jianxing Wang, Yulai Wang, Yiwen Chai, Haochen Li, Deyang Miao, Honggui Liu, Jianhong Li, Jun Ba. Music with Different Tones Affects the Development of Brain Nerves in Mice in Early Life through BDNF and Its Downstream Pathways. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175826. |
in addition, the number of dendritic spines and the number of dendritic spines per unit length were significantly higher than those in group c, and the expressions of synaptic plasticity proteins (syp and psd95) were also significantly elevated over those in group c. compared with group c, the expression levels of bdnf, trkb, creb, pi3k, akt, gs3kβ, plcγ1, pkc, dag, erk and mapk genes and proteins in the hippocampus and prefrontal cortex of mice in the music groups were up-regulated, suggesting that different tones of music could regulate neural development through bdnf and its downstream pathways. |
2023-05-14 |
2023-08-14 |
mouse |
| Timothy C Durazzo, M Windy McNerney, Annika M Hansen, Meng Gu, Matthew D Sacchet, Claudia B Padul. BDNF rs6265 Met carriers with alcohol use disorder show greater age-related decline of N-acetylaspartate in left dorsolateral prefrontal cortex. Drug and alcohol dependence. vol 248. 2023-05-05. PMID:37146499. |
bdnf rs6265 met carriers with alcohol use disorder show greater age-related decline of n-acetylaspartate in left dorsolateral prefrontal cortex. |
2023-05-05 |
2023-08-14 |
Not clear |
| Meltem Donmez Kutlu, Seda Kose, Kubra Akilliogl. GLP-1 agonist Liraglutide prevents MK‑801-induced schizophrenia‑like behaviors and BDNF, CREB, p-CREB, Trk-B expressions in the hippocampus and prefrontal cortex in Balb/c mice. Behavioural brain research. vol 445. 2023-03-22. PMID:36948022. |
glp-1 agonist liraglutide prevents mk‑801-induced schizophrenia‑like behaviors and bdnf, creb, p-creb, trk-b expressions in the hippocampus and prefrontal cortex in balb/c mice. |
2023-03-22 |
2023-08-14 |
mouse |
| Meltem Donmez Kutlu, Seda Kose, Kubra Akilliogl. GLP-1 agonist Liraglutide prevents MK‑801-induced schizophrenia‑like behaviors and BDNF, CREB, p-CREB, Trk-B expressions in the hippocampus and prefrontal cortex in Balb/c mice. Behavioural brain research. vol 445. 2023-03-22. PMID:36948022. |
western blots were performed on mice' hippocampus and pfc for bdnf, trk-b, creb, and p-creb expression. |
2023-03-22 |
2023-08-14 |
mouse |
| Thiago Ângelo Smaniotto, Angela Maria Casaril, Darling de Andrade Lourenço, Fernanda S Sousa, Fabiana K Seixas, Tiago Collares, Rafael Woloski, Luciano da Silva Pinto, Diego Alves, Lucielli Savegnag. Intranasal administration of interleukin-4 ameliorates depression-like behavior and biochemical alterations in mouse submitted to the chronic unpredictable mild stress: modulation of neuroinflammation and oxidative stress. Psychopharmacology. 2023-03-01. PMID:36856802. |
moreover, il-4 restored the expression of nuclear factor erythroid 2-related factor 2 (nrf2), nuclear factor kappa b (nf-kb), interleukin 1 beta (il-1β), il-4, brain derived neurotrophic factor (bdnf), and indoleamine 2,3-dioxygenase (ido) in the pfc and hc and modulated oxidative stress markers in these brain structures in stressed mice. |
2023-03-01 |
2023-08-14 |
mouse |
| Aleksandra Gliwińska, Justyna Czubilińska-Łada, Gniewko Więckiewicz, Elżbieta Świętochowska, Andrzej Badeński, Marta Dworak, Maria Szczepańsk. The Role of Brain-Derived Neurotrophic Factor (BDNF) in Diagnosis and Treatment of Epilepsy, Depression, Schizophrenia, Anorexia Nervosa and Alzheimer's Disease as Highly Drug-Resistant Diseases: A Narrative Review. Brain sciences. vol 13. issue 2. 2023-02-25. PMID:36831706. |
bdnf is the most widely distributed neurotrophin in the central nervous system (cns) and is highly expressed in the prefrontal cortex (pfc) and hippocampus. |
2023-02-25 |
2023-08-14 |
Not clear |