| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Scott E Hemby, Scot McIntos. Chronic haloperidol administration downregulates select BDNF transcript and protein levels in the dorsolateral prefrontal cortex of rhesus monkeys. Frontiers in psychiatry. vol 14. 2023-02-23. PMID:36816400. |
chronic haloperidol administration downregulates select bdnf transcript and protein levels in the dorsolateral prefrontal cortex of rhesus monkeys. |
2023-02-23 |
2023-08-14 |
monkey |
| Scott E Hemby, Scot McIntos. Chronic haloperidol administration downregulates select BDNF transcript and protein levels in the dorsolateral prefrontal cortex of rhesus monkeys. Frontiers in psychiatry. vol 14. 2023-02-23. PMID:36816400. |
post-mortem studies in the prefrontal cortex and hippocampal formation from schizophrenia patients have revealed significant disruptions in the expression molecules associated with cytoarchitecture, synaptic structure, function, and plasticity, known to be regulated in part by brain derived neurotrophic factor (bdnf). |
2023-02-23 |
2023-08-14 |
monkey |
| Shuyue Cheng, Jingjing Xu, Wei Wang, Rui Wang, Haonan Li, Zhijun Jiang, Dexiang Liu, Fang Pa. Inhibition of mGluR5 alters BDNF/TrkB and GLT-1 expression in the prefrontal cortex and hippocampus and ameliorates PTSD-like behavior in rats. Psychopharmacology. 2023-02-01. PMID:36725696. |
this study aims to explore the effects of inhibiting mglur5 on ptsd-like behaviors and bdnf, trkb, and glt-1 expression in the hip and pfc of inevitable foot shock (ifs)-treated rats. |
2023-02-01 |
2023-08-14 |
rat |
| Samuel C Woodburn, Helina S Asrat, James K Flurer, Hana C Schwierling, Justin L Bollinger, Lauren L Vollmer, Eric S Wohle. Depletion of microglial BDNF increases susceptibility to the behavioral and synaptic effects of chronic unpredictable stress. Brain, behavior, and immunity. 2023-01-21. PMID:36681359. |
adding to this, our work showed that 14 days of chronic unpredictable stress (cus) reduced bdnf transcript in pfc microglia, evincing its relevance in the effects of stress. |
2023-01-21 |
2023-08-14 |
mouse |
| Atilla Topcu, Sinan Saral, Aykut Ozturk, Ozlem Saral, Ali Koray Kay. The effect of the calcium channel blocker nimodipine on hippocampal BDNF/Ach levels in rats with experimental cognitive impairment. Neurological research. 2023-01-04. PMID:36598971. |
nimodipine appears to possess the potential to reverse cognitive impairment-induced dysfunction in learning and memory through its regulatory effect on the brain-derived neurotrophic factor (bdnf), acetylcholine (ach), and acetylcholinesterase (ache) pathway in the hippocampus and prefrontal cortex. |
2023-01-04 |
2023-08-14 |
rat |
| Mengxin Shen, Dan Lv, Xinya Liu, Chuang Wan. ERK/mTOR signaling may underlying the antidepressant actions of rapastinel in mice. Translational psychiatry. vol 12. issue 1. 2022-12-22. PMID:36550125. |
produced antidepressant-like actions dependent on the increase in extracellular regulated protein kinase (erk)/mammalian target of rapamycin (mtor) signaling and downstream substrates p70s6 kinase (p70s6k) and the eukaryotic initiation factor 4e-binding protein 1 (4e-bp1), which may induce the expression of vgf and bdnf in the hippocampus and prefrontal cortex of mice. |
2022-12-22 |
2023-08-14 |
mouse |
| Maria Pina Serra, Francesco Sanna, Marianna Boi, Laura Poddighe, Lorenzo Secci, Marcello Trucas, Alberto Fernández-Teruel, Maria Giuseppa Corda, Osvaldo Giorgi, Marina Quart. Acute Stress Induces Different Changes on the Expression of BDNF and trkB in the Mesocorticolimbic System of Two Lines of Rats Differing in Their Response to Stressors. International journal of molecular sciences. vol 23. issue 23. 2022-12-11. PMID:36499323. |
the present work was undertaken to investigate the effects of acute forced swimming (fs) on the levels of brain-derived neurotrophic factor (bdnf) and tyrosine kinase receptor b (trkb) proteins in: the ventral tegmental area (vta); the nucleus accumbens (acb) shell and core compartments; and the anterior cingulate (acg), prelimbic (pl) and infralimbic (il) territories of the prefrontal cortex of genetic models of vulnerability (rla, roman low-avoidance rats) and resistance (rha, roman high-avoidance rats) to stress-induced depression. |
2022-12-11 |
2023-08-14 |
rat |
| Shuyue Cheng, Wei Wang, Zemeng Zhu, Mingyue Zhao, Hannao Li, Dexiang Liu, Fang Pa. Involvement of brain-derived neurotrophic factor methylation in the prefrontal cortex and hippocampus induced by chronic unpredictable mild stress in male mice. Journal of neurochemistry. 2022-12-01. PMID:36453259. |
depression-like behaviors, bdnf promoter iv methylation, expression of dna methyltransferases (dnmts), demethylation machinery enzymes, bdnf protein levels, and neuronal development in the prefrontal cortex (pfc) and hippocampus (hip) were assessed in adolescent and adult mice. |
2022-12-01 |
2023-08-14 |
mouse |
| Leandro Garbossa, Larissa Joaquim, Lucineia Gainski Danielski, Mariana Pereira de Souza Goldim, Richard Simon Machado, Kiuanne Metzker, Gabriela Bernades, Everton Lanzzarin, Erick Bagio, Adriele de Farias, Naiana da Rosa, Fabiana Durante de Medeiros, Raquel Jaconi de Carli, Bruna Hoffman Oliveira, Nivaldo Correia Ferreira, Juliete Palandi, Franciane Bobinski, Daniel Fernandes Martins, Jucelia Jeremias Fortunato, Tatiana Barichello, Fabricia Petronilh. The effect of modafinil on passive avoidance memory, brain level of BDNF and oxidative stress markers in sepsis survivor rats. The International journal of neuroscience. 2022-11-30. PMID:36448768. |
the nitrite and nitrate (n/n) concentration, myeloperoxidase (mpo) and catalase (cat) activity, lipid and protein oxidative damage, and brain-derived neurotrophic factor (bdnf) levels were measured in the prefrontal cortex and hippocampus. |
2022-11-30 |
2023-08-14 |
rat |
| Leandro Garbossa, Larissa Joaquim, Lucineia Gainski Danielski, Mariana Pereira de Souza Goldim, Richard Simon Machado, Kiuanne Metzker, Gabriela Bernades, Everton Lanzzarin, Erick Bagio, Adriele de Farias, Naiana da Rosa, Fabiana Durante de Medeiros, Raquel Jaconi de Carli, Bruna Hoffman Oliveira, Nivaldo Correia Ferreira, Juliete Palandi, Franciane Bobinski, Daniel Fernandes Martins, Jucelia Jeremias Fortunato, Tatiana Barichello, Fabricia Petronilh. The effect of modafinil on passive avoidance memory, brain level of BDNF and oxidative stress markers in sepsis survivor rats. The International journal of neuroscience. 2022-11-30. PMID:36448768. |
decreased n/n concentration and mpo activity were verified in the prefrontal cortex of rats submitted to clp and md treatment, as well as reduced protein and lipid oxidative damage in the hippocampus, which was accompanied by increased cat activity and bdnf levels. |
2022-11-30 |
2023-08-14 |
rat |
| Wei Sun, Zhenzhong Lu, Xiao Chen, Yang, Yazi Mei, Xiaoliang Li, Lei A. Aluminum Oxide Nanoparticles Impair Working Memory and Neuronal Activity through the GSK3β/BDNF Signaling Pathway of Prefrontal Cortex in Rats. ACS chemical neuroscience. 2022-11-29. PMID:36444509. |
here, alumina nps (10 or 20 μg/kg of body weight) were bilaterally injected into the medial pfc (mpfc) of adult rats, and the levels of glycogen synthase kinase 3β (gsk3β) and the brain-derived neurotrophic factor (bdnf) were detected. |
2022-11-29 |
2023-08-14 |
rat |
| Satoshi Deyama, Katsuyuki Kaned. Role of neurotrophic and growth factors in the rapid and sustained antidepressant actions of ketamine. Neuropharmacology. 2022-11-20. PMID:36403852. |
the neurotrophic hypothesis of depression proposes that reduced levels of brain-derived neurotrophic factor (bdnf) and vascular endothelial growth factor (vegf) contribute to neuronal atrophy or loss in the prefrontal cortex (pfc) and hippocampus and impaired hippocampal adult neurogenesis, which are associated with depressive symptoms. |
2022-11-20 |
2023-08-14 |
mouse |
| Satoshi Deyama, Katsuyuki Kaned. Role of neurotrophic and growth factors in the rapid and sustained antidepressant actions of ketamine. Neuropharmacology. 2022-11-20. PMID:36403852. |
rodent studies have revealed that ketamine rapidly increases bdnf and vegf release and/or expression in the pfc and hippocampus, which in turn increases the number and function of spine synapses in the pfc and hippocampal neurogenesis. |
2022-11-20 |
2023-08-14 |
mouse |
| Álvaro de Oliveira Franco, Guilherme de Oliveira Venturini, Camila Fernanda da Silveira Alves, Rael Lopes Alves, Paul Vicuña, Leticia Ramalho, Rafaela Tomedi, Samara Machado Bruck, Iraci L S Torres, Felipe Fregni, Wolnei Caum. Functional connectivity response to acute pain assessed by fNIRS is associated with BDNF genotype in fibromyalgia: an exploratory study. Scientific reports. vol 12. issue 1. 2022-11-06. PMID:36336706. |
in this cross-sectional imaging genetics study, we investigated fibromyalgia, the relationship between bdnf val66met heterozygous genotypes (val/met), and the functional connectivity (fc) response pattern to acute pain stimulus in the motor (mc) and prefrontal (pfc) cortex assessed by near-infrared spectroscopy (fnirs) before and after a cold pressor test utilizing water (0-1 °c). |
2022-11-06 |
2023-08-14 |
Not clear |
| Álvaro de Oliveira Franco, Guilherme de Oliveira Venturini, Camila Fernanda da Silveira Alves, Rael Lopes Alves, Paul Vicuña, Leticia Ramalho, Rafaela Tomedi, Samara Machado Bruck, Iraci L S Torres, Felipe Fregni, Wolnei Caum. Functional connectivity response to acute pain assessed by fNIRS is associated with BDNF genotype in fibromyalgia: an exploratory study. Scientific reports. vol 12. issue 1. 2022-11-06. PMID:36336706. |
here we show that fibromyalgia patients carrying the val/met bdnf genotype presented an increased Δfc across mc and pfc in response to acute pain associated with differences in acute pain perception and fibromyalgia symptoms. |
2022-11-06 |
2023-08-14 |
Not clear |
| Junhui He, Dongmei Li, Jie Wei, Sheng Wang, Shifeng Chu, Zhao Zhang, Fei He, Dongmei Wei, Yi Li, Jiaxiu Xie, Kedao Lai, Naihong Chen, Guining We. Mahonia Alkaloids (MA) Ameliorate Depression Induced Gap Junction Dysfunction by miR-205/Cx43 Axis. Neurochemical research. 2022-10-12. PMID:36222958. |
the concentrations of neurotransmitters were measured by elisa, the expression of connexin 43 (cx43) protein was measured by immunohistochemistry and western-blot, brain derived neurotrophic factor (bdnf), camp-response element binding protein (creb) proteins were measured by western-blot, the pathological changes of prefrontal cortex were observed by hematoxylin-eosin (h&e) staining. |
2022-10-12 |
2023-08-14 |
human |
| Francisco de Borja Belloch, María Cortés-Erice, Etienne Herzog, Xiao Min Zhang, Teresa Díaz-Perdigon, Elena Puerta, Rosa M Torder. Fast antidepressant action of ketamine in mouse models requires normal VGLUT1 levels from prefrontal cortex neurons. Progress in neuro-psychopharmacology & biological psychiatry. 2022-10-09. PMID:36209771. |
pre-clinical studies suggest that de novo synthesis of the brain-derived neurotrophic factor (bdnf) in the pfc might be involved in the rapid antidepressant action of ketamine. |
2022-10-09 |
2023-08-14 |
mouse |
| Li Ma, Long Wang, Lijia Chang, Jiajing Shan, Youge Qu, Xingming Wang, Xiayun Wan, Yuko Fujita, Kenji Hashimot. A key role of miR-132-5p in the prefrontal cortex for persistent prophylactic actions of (R)-ketamine in mice. Translational psychiatry. vol 12. issue 1. 2022-09-28. PMID:36171191. |
quantitative rt-pcr confirmed that (r)-ketamine significantly attenuated altered expression of mir-132-5p and its regulated genes (bdnf, mecp2, tgfb1, tgfbr2) in the pfc of crs-exposed mice. |
2022-09-28 |
2023-08-14 |
mouse |
| Li Ma, Long Wang, Lijia Chang, Jiajing Shan, Youge Qu, Xingming Wang, Xiayun Wan, Yuko Fujita, Kenji Hashimot. A key role of miR-132-5p in the prefrontal cortex for persistent prophylactic actions of (R)-ketamine in mice. Translational psychiatry. vol 12. issue 1. 2022-09-28. PMID:36171191. |
furthermore, (r)-ketamine significantly attenuated altered expression of bdnf, mecp2, tgf-β1 (transforming growth factor β1), and synaptic proteins (psd-95, and glua1) in the pfc of crs-exposed mice. |
2022-09-28 |
2023-08-14 |
mouse |
| Li Ma, Long Wang, Lijia Chang, Jiajing Shan, Youge Qu, Xingming Wang, Xiayun Wan, Yuko Fujita, Kenji Hashimot. A key role of miR-132-5p in the prefrontal cortex for persistent prophylactic actions of (R)-ketamine in mice. Translational psychiatry. vol 12. issue 1. 2022-09-28. PMID:36171191. |
administration of agomir-132-5p decreased the expression of bdnf and tgfb1 in the pfc, resulting in depression-like behaviors. |
2022-09-28 |
2023-08-14 |
mouse |