| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maarten J A Van Den Bossche, Louise Emsell, Annemiek Dols, Kristof Vansteelandt, François-Laurent De Winter, Jan Van den Stock, Pascal Sienaert, Max L Stek, Filip Bouckaert, Mathieu Vandenbulck. Hippocampal volume change following ECT is mediated by rs699947 in the promotor region of VEGF. Translational psychiatry. vol 9. issue 1. 2020-02-28. PMID:31431610. |
we hypothesized that two regulatory snps in the vegf and bdnf gene influence the changes in hippocampal volume following ect. |
2020-02-28 |
2023-08-13 |
Not clear |
| Ankit Uniyal, Raghunath Singh, Ansab Akhtar, Yashika Bansal, Anurag Kuhad, Sangeeta Pilkhwal Sa. Co-treatment of piracetam with risperidone rescued extinction deficits in experimental paradigms of post-traumatic stress disorder by restoring the physiological alterations in cortex and hippocampus. Pharmacology, biochemistry, and behavior. vol 185. 2020-02-26. PMID:31445955. |
neurotransmitters (dopamine and serotonin and their metabolites), bdnf, proinflammatory cytokines (tnf-α, il-6), caspase-3, and markers for oxidative stress were assessed in the hippocampus and cortex while corticosterone and nitrite levels were estimated in plasma. |
2020-02-26 |
2023-08-13 |
rat |
| Ankit Uniyal, Raghunath Singh, Ansab Akhtar, Yashika Bansal, Anurag Kuhad, Sangeeta Pilkhwal Sa. Co-treatment of piracetam with risperidone rescued extinction deficits in experimental paradigms of post-traumatic stress disorder by restoring the physiological alterations in cortex and hippocampus. Pharmacology, biochemistry, and behavior. vol 185. 2020-02-26. PMID:31445955. |
risperidone and piracetam were found to be effective alone, while their high dose combination, produced potentiating effect in reversing the extinction deficit, behavioral alterations, altered cortical and hippocampal bdnf, il-6, tnf-α, caspase-3, oxidative stress markers, and neurotransmitter levels. |
2020-02-26 |
2023-08-13 |
rat |
| Joseph A Hippensteel, Brian J Anderson, James E Orfila, Sarah A McMurtry, Robert M Dietz, Guowei Su, Joshay A Ford, Kaori Oshima, Yimu Yang, Fuming Zhang, Xiaorui Han, Yanlei Yu, Jian Liu, Robert J Linhardt, Nuala J Meyer, Paco S Herson, Eric P Schmid. Circulating heparan sulfate fragments mediate septic cognitive dysfunction. The Journal of clinical investigation. vol 129. issue 4. 2020-02-25. PMID:30720464. |
memory impairment occurred despite preserved hippocampal bdnf content and could be reversed by stimulation of bdnf signaling, suggesting the presence of a local bdnf inhibitor. |
2020-02-25 |
2023-08-13 |
mouse |
| Tingxu Yan, Yingying Sun, Feng Xiao, Bo Wu, Kaishun Bi, Bosai He, Ying Ji. Schisandrae Chinensis Fructus inhibits behavioral deficits induced by sleep deprivation and chronic unpredictable mild stress via increased signaling of brain-derived neurotrophic factor. Phytotherapy research : PTR. vol 33. issue 12. 2020-02-20. PMID:31468620. |
in addition, the bdnf level in hippocampus was elevated by sd (12 hr) and scf treatment and together with the upregulation of trkb/creb/erk and pi3k/akt/gsk3β/mtor signaling pathways. |
2020-02-20 |
2023-08-13 |
Not clear |
| Yang Li, Jing Liu, Xu Liu, Cun-Jin Su, Qi-Lin Zhang, Zhi-Hong Wang, Lei-Fang Cao, Xue-Yan Guo, Ya Huang, Weifeng Luo, Tong Li. Antidepressant-Like Action of Single Facial Injection of Botulinum Neurotoxin A is Associated with Augmented 5-HT Levels and BDNF/ERK/CREB Pathways in Mouse Brain. Neuroscience bulletin. vol 35. issue 4. 2020-02-18. PMID:30900142. |
furthermore, bont/a significantly increased the expression of brain-derived neurotrophic factor (bdnf) in the hippocampus, hypothalamus, prefrontal cortex, and amygdala, which were decreased in srs mice. |
2020-02-18 |
2023-08-13 |
mouse |
| Atef Tadros Fahim, Amal Ahmed Abd El-Fattah, Nermin Abdel Hamid Sadik, Bassam Mohamed Al. Resveratrol and dimethyl fumarate ameliorate testicular dysfunction caused by chronic unpredictable mild stress-induced depression in rats. Archives of biochemistry and biophysics. vol 665. 2020-02-14. PMID:30904419. |
cums-induced depressive-like behaviours in rats were evidenced by increased serum corticosterone levels and decreased serum and hippocampal serotonin levels as well as decreased hippocampal bdnf levels. |
2020-02-14 |
2023-08-13 |
rat |
| Fen Xue, Shan-Shan Xue, Ling Liu, Han-Fei Sang, Quan-Rui Ma, Qing-Rong Tan, Hua-Ning Wang, Cui-Hong Zhou, Zheng-Wu Pen. Early intervention with electroacupuncture prevents PTSD-like behaviors in rats through enhancing hippocampal endocannabinoid signaling. Progress in neuro-psychopharmacology & biological psychiatry. vol 93. 2020-02-14. PMID:30946940. |
in the present study, we used an enhanced single prolonged stress (esps) model to access the effects of early ea intervention on the prevention of anxiety-like and fear learning behaviors, as well as the influence of the expression of post-synaptic density protein 95 (psd95), synaptophysin (syn), brain derived neurotrophic factor (bdnf), diacylglycerol lipase alpha (daglα) and cannabinoid type 1 receptor (cb1r) in the hippocampus with or without daglα or cb1r knockdown by a short hairpin rna (shrna) in the hippocampus. |
2020-02-14 |
2023-08-13 |
rat |
| Fen Xue, Shan-Shan Xue, Ling Liu, Han-Fei Sang, Quan-Rui Ma, Qing-Rong Tan, Hua-Ning Wang, Cui-Hong Zhou, Zheng-Wu Pen. Early intervention with electroacupuncture prevents PTSD-like behaviors in rats through enhancing hippocampal endocannabinoid signaling. Progress in neuro-psychopharmacology & biological psychiatry. vol 93. 2020-02-14. PMID:30946940. |
the results showed that early ea intervention improved hippocampal synaptic plasticity and ameliorated ptsd-like behaviors and also increased expression of bdnf, daglα and cb1r. |
2020-02-14 |
2023-08-13 |
rat |
| Fuencisla Pilar-Cuellar, Elena Castro, Sylvie Bretin, Elisabeth Mocaer, Ángel Pazos, Álvaro Día. S 47445 counteracts the behavioral manifestations and hippocampal neuroplasticity changes in bulbectomized mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 93. 2020-02-14. PMID:30980840. |
afterwards, the expression levels of bdnf, mtor, phospho-mtor, 4ebp1 and phospho-4ebp1 were evaluated in hippocampus and prefrontal cortex. |
2020-02-14 |
2023-08-13 |
mouse |
| Fuencisla Pilar-Cuellar, Elena Castro, Sylvie Bretin, Elisabeth Mocaer, Ángel Pazos, Álvaro Día. S 47445 counteracts the behavioral manifestations and hippocampal neuroplasticity changes in bulbectomized mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 93. 2020-02-14. PMID:30980840. |
chronic administration of s 47445 reversed ob-induced changes in bdnf and phopho-mtor expression in hippocampus but not in prefrontal cortex. |
2020-02-14 |
2023-08-13 |
mouse |
| Fuencisla Pilar-Cuellar, Elena Castro, Sylvie Bretin, Elisabeth Mocaer, Ángel Pazos, Álvaro Día. S 47445 counteracts the behavioral manifestations and hippocampal neuroplasticity changes in bulbectomized mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 93. 2020-02-14. PMID:30980840. |
associated with the reversal of ob-induced changes in hippocampal bdnf and mtor signaling pathways. |
2020-02-14 |
2023-08-13 |
mouse |
| Yun Wang, Jing Ni, Ce Gao, Liming Xie, Lingyan Zhai, Guiyun Cui, Xiaoxing Yi. Mitochondrial transplantation attenuates lipopolysaccharide- induced depression-like behaviors. Progress in neuro-psychopharmacology & biological psychiatry. vol 93. 2020-02-14. PMID:31022424. |
besides, the neurogenesis, expression of brain-derived neurotrophic factor (bdnf), glial activation, neuroinflammation, oxidative stress and atp production were determined in the hippocampus. |
2020-02-14 |
2023-08-13 |
mouse |
| Yue Jia, Haoran Li, Hongkun Bao, Dandan Zhang, Lei Feng, Yuhuan Xiao, Keming Zhu, Yangyang Hou, Shaolei Luo, Yaping Zhang, Le Xiao, Xu Chen, Jiaojiao Zhou, Changming Wang, Gang Wang, Haijing Yu, Chunjie Xiao, Jing D. Cordycepin (3'-deoxyadenosine) promotes remyelination via suppression of neuroinflammation in a cuprizone-induced mouse model of demyelination. International immunopharmacology. vol 75. 2020-02-14. PMID:31357085. |
pro-inflammatory cytokine expression (il-1β and il-6) was inhibited while anti-inflammatory cytokine il-4 and neurotrophic factor bdnf release was elevated in the corpus callosum and hippocampus after cordycepin treatment. |
2020-02-14 |
2023-08-13 |
mouse |
| Daiyue Chang, Jinghua Zhao, Xintong Zhang, HuiMin Lian, XueMan Du, Rui Yuan, Yajing Wen, Li Ga. Effect of ketamine combined with DHA on lipopolysaccharide-induced depression-like behavior in rats. International immunopharmacology. vol 75. 2020-02-14. PMID:31377587. |
the combination of ketamine and dha significantly decreased the levels of il-1, il-6 and tnf-ɑin hippocampus and pc12 cells and increased the content of bdnf. |
2020-02-14 |
2023-08-13 |
rat |
| Daiyue Chang, Jinghua Zhao, Xintong Zhang, HuiMin Lian, XueMan Du, Rui Yuan, Yajing Wen, Li Ga. Effect of ketamine combined with DHA on lipopolysaccharide-induced depression-like behavior in rats. International immunopharmacology. vol 75. 2020-02-14. PMID:31377587. |
western blot results showed that ketamine combined with dha can effectively inhibit the expression of nf-kb in hippocampus and pc12 cells, and increase the expression of p-creb and bdnf. |
2020-02-14 |
2023-08-13 |
rat |
| Xinnan Zhao, Fengrui Cao, Qing Liu, Xinsheng Li, Guoyang Xu, Gang Liu, Yanli Zhang, Xiaohan Yang, Shansong Yi, Fenghua Xu, Kai Fan, Jianmei M. Behavioral, inflammatory and neurochemical disturbances in LPS and UCMS-induced mouse models of depression. Behavioural brain research. vol 364. 2020-02-13. PMID:28572058. |
the decrease of 5-ht and bdnf was detected only in hippocampus of lps-stressed mice, but in overall all the brain areas assessed in ucms-stressed mice as compared to control. |
2020-02-13 |
2023-08-13 |
mouse |
| Paola Brivio, Giulia Corsini, Marco Andrea Riva, Francesca Calabres. Chronic vortioxetine treatment improves the responsiveness to an acute stress acting through the ventral hippocampus in a glucocorticoid-dependent way. Pharmacological research. vol 142. 2020-02-13. PMID:30735803. |
we found that prolonged vortioxetine administration significantly increased total bdnf expression in the dorsal and ventral hippocampus of adult male rats and affected the stress-induced modulation of the immediate early genes arc and zif268, mainly in the ventral sub-region. |
2020-02-13 |
2023-08-13 |
rat |
| Rebecca Ward, Weiguo Li, Yasir Abdul, LaDonya Jackson, Guangkuo Dong, Sarah Jamil, Jessica Filosa, Susan C Fagan, Adviye Ergu. NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia. Pharmacological research. vol 142. 2020-02-13. PMID:30818045. |
bdnf was measured in endothelial and hippocampal neuronal cultures under hypoxic and diabetes-mimicking condition with and without nlrp3 inhibition. |
2020-02-13 |
2023-08-13 |
rat |
| K Gawlinska, D Gawlinski, E Przegalinski, M Fili. Maternal high-fat diet during pregnancy and lactation provokes depressive-like behavior and influences the irisin/brain-derived neurotrophic factor axis and inflammatory factors in male and female offspring in rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 70. issue 3. 2020-02-13. PMID:31539886. |
the aim of the present study was to evaluate the influence of a maternal hfd during pregnancy and lactation on depressive-like behavior, serum irisin concentration and hippocampal levels of irisin, bdnf and inflammatory factors (interleukin-1α, interleukin-6 and tumor necrosis factor-α) in adolescent and adult male and female offspring. |
2020-02-13 |
2023-08-13 |
rat |