| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Atef Tadros Fahim, Amal Ahmed Abd El-Fattah, Nermin Abdel Hamid Sadik, Bassam Mohamed Al. Resveratrol and dimethyl fumarate ameliorate testicular dysfunction caused by chronic unpredictable mild stress-induced depression in rats. Archives of biochemistry and biophysics. vol 665. 2020-02-14. PMID:30904419. |
cums-induced depressive-like behaviours in rats were evidenced by increased serum corticosterone levels and decreased serum and hippocampal serotonin levels as well as decreased hippocampal bdnf levels. |
2020-02-14 |
2023-08-13 |
rat |
| Fen Xue, Shan-Shan Xue, Ling Liu, Han-Fei Sang, Quan-Rui Ma, Qing-Rong Tan, Hua-Ning Wang, Cui-Hong Zhou, Zheng-Wu Pen. Early intervention with electroacupuncture prevents PTSD-like behaviors in rats through enhancing hippocampal endocannabinoid signaling. Progress in neuro-psychopharmacology & biological psychiatry. vol 93. 2020-02-14. PMID:30946940. |
in the present study, we used an enhanced single prolonged stress (esps) model to access the effects of early ea intervention on the prevention of anxiety-like and fear learning behaviors, as well as the influence of the expression of post-synaptic density protein 95 (psd95), synaptophysin (syn), brain derived neurotrophic factor (bdnf), diacylglycerol lipase alpha (daglα) and cannabinoid type 1 receptor (cb1r) in the hippocampus with or without daglα or cb1r knockdown by a short hairpin rna (shrna) in the hippocampus. |
2020-02-14 |
2023-08-13 |
rat |
| Fen Xue, Shan-Shan Xue, Ling Liu, Han-Fei Sang, Quan-Rui Ma, Qing-Rong Tan, Hua-Ning Wang, Cui-Hong Zhou, Zheng-Wu Pen. Early intervention with electroacupuncture prevents PTSD-like behaviors in rats through enhancing hippocampal endocannabinoid signaling. Progress in neuro-psychopharmacology & biological psychiatry. vol 93. 2020-02-14. PMID:30946940. |
the results showed that early ea intervention improved hippocampal synaptic plasticity and ameliorated ptsd-like behaviors and also increased expression of bdnf, daglα and cb1r. |
2020-02-14 |
2023-08-13 |
rat |
| Fuencisla Pilar-Cuellar, Elena Castro, Sylvie Bretin, Elisabeth Mocaer, Ángel Pazos, Álvaro Día. S 47445 counteracts the behavioral manifestations and hippocampal neuroplasticity changes in bulbectomized mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 93. 2020-02-14. PMID:30980840. |
afterwards, the expression levels of bdnf, mtor, phospho-mtor, 4ebp1 and phospho-4ebp1 were evaluated in hippocampus and prefrontal cortex. |
2020-02-14 |
2023-08-13 |
mouse |
| Fuencisla Pilar-Cuellar, Elena Castro, Sylvie Bretin, Elisabeth Mocaer, Ángel Pazos, Álvaro Día. S 47445 counteracts the behavioral manifestations and hippocampal neuroplasticity changes in bulbectomized mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 93. 2020-02-14. PMID:30980840. |
chronic administration of s 47445 reversed ob-induced changes in bdnf and phopho-mtor expression in hippocampus but not in prefrontal cortex. |
2020-02-14 |
2023-08-13 |
mouse |
| Fuencisla Pilar-Cuellar, Elena Castro, Sylvie Bretin, Elisabeth Mocaer, Ángel Pazos, Álvaro Día. S 47445 counteracts the behavioral manifestations and hippocampal neuroplasticity changes in bulbectomized mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 93. 2020-02-14. PMID:30980840. |
associated with the reversal of ob-induced changes in hippocampal bdnf and mtor signaling pathways. |
2020-02-14 |
2023-08-13 |
mouse |
| Yun Wang, Jing Ni, Ce Gao, Liming Xie, Lingyan Zhai, Guiyun Cui, Xiaoxing Yi. Mitochondrial transplantation attenuates lipopolysaccharide- induced depression-like behaviors. Progress in neuro-psychopharmacology & biological psychiatry. vol 93. 2020-02-14. PMID:31022424. |
besides, the neurogenesis, expression of brain-derived neurotrophic factor (bdnf), glial activation, neuroinflammation, oxidative stress and atp production were determined in the hippocampus. |
2020-02-14 |
2023-08-13 |
mouse |
| Yue Jia, Haoran Li, Hongkun Bao, Dandan Zhang, Lei Feng, Yuhuan Xiao, Keming Zhu, Yangyang Hou, Shaolei Luo, Yaping Zhang, Le Xiao, Xu Chen, Jiaojiao Zhou, Changming Wang, Gang Wang, Haijing Yu, Chunjie Xiao, Jing D. Cordycepin (3'-deoxyadenosine) promotes remyelination via suppression of neuroinflammation in a cuprizone-induced mouse model of demyelination. International immunopharmacology. vol 75. 2020-02-14. PMID:31357085. |
pro-inflammatory cytokine expression (il-1β and il-6) was inhibited while anti-inflammatory cytokine il-4 and neurotrophic factor bdnf release was elevated in the corpus callosum and hippocampus after cordycepin treatment. |
2020-02-14 |
2023-08-13 |
mouse |
| Daiyue Chang, Jinghua Zhao, Xintong Zhang, HuiMin Lian, XueMan Du, Rui Yuan, Yajing Wen, Li Ga. Effect of ketamine combined with DHA on lipopolysaccharide-induced depression-like behavior in rats. International immunopharmacology. vol 75. 2020-02-14. PMID:31377587. |
the combination of ketamine and dha significantly decreased the levels of il-1, il-6 and tnf-ɑin hippocampus and pc12 cells and increased the content of bdnf. |
2020-02-14 |
2023-08-13 |
rat |
| Daiyue Chang, Jinghua Zhao, Xintong Zhang, HuiMin Lian, XueMan Du, Rui Yuan, Yajing Wen, Li Ga. Effect of ketamine combined with DHA on lipopolysaccharide-induced depression-like behavior in rats. International immunopharmacology. vol 75. 2020-02-14. PMID:31377587. |
western blot results showed that ketamine combined with dha can effectively inhibit the expression of nf-kb in hippocampus and pc12 cells, and increase the expression of p-creb and bdnf. |
2020-02-14 |
2023-08-13 |
rat |
| Xinnan Zhao, Fengrui Cao, Qing Liu, Xinsheng Li, Guoyang Xu, Gang Liu, Yanli Zhang, Xiaohan Yang, Shansong Yi, Fenghua Xu, Kai Fan, Jianmei M. Behavioral, inflammatory and neurochemical disturbances in LPS and UCMS-induced mouse models of depression. Behavioural brain research. vol 364. 2020-02-13. PMID:28572058. |
the decrease of 5-ht and bdnf was detected only in hippocampus of lps-stressed mice, but in overall all the brain areas assessed in ucms-stressed mice as compared to control. |
2020-02-13 |
2023-08-13 |
mouse |
| Paola Brivio, Giulia Corsini, Marco Andrea Riva, Francesca Calabres. Chronic vortioxetine treatment improves the responsiveness to an acute stress acting through the ventral hippocampus in a glucocorticoid-dependent way. Pharmacological research. vol 142. 2020-02-13. PMID:30735803. |
we found that prolonged vortioxetine administration significantly increased total bdnf expression in the dorsal and ventral hippocampus of adult male rats and affected the stress-induced modulation of the immediate early genes arc and zif268, mainly in the ventral sub-region. |
2020-02-13 |
2023-08-13 |
rat |
| Rebecca Ward, Weiguo Li, Yasir Abdul, LaDonya Jackson, Guangkuo Dong, Sarah Jamil, Jessica Filosa, Susan C Fagan, Adviye Ergu. NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia. Pharmacological research. vol 142. 2020-02-13. PMID:30818045. |
bdnf was measured in endothelial and hippocampal neuronal cultures under hypoxic and diabetes-mimicking condition with and without nlrp3 inhibition. |
2020-02-13 |
2023-08-13 |
rat |
| K Gawlinska, D Gawlinski, E Przegalinski, M Fili. Maternal high-fat diet during pregnancy and lactation provokes depressive-like behavior and influences the irisin/brain-derived neurotrophic factor axis and inflammatory factors in male and female offspring in rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 70. issue 3. 2020-02-13. PMID:31539886. |
the aim of the present study was to evaluate the influence of a maternal hfd during pregnancy and lactation on depressive-like behavior, serum irisin concentration and hippocampal levels of irisin, bdnf and inflammatory factors (interleukin-1α, interleukin-6 and tumor necrosis factor-α) in adolescent and adult male and female offspring. |
2020-02-13 |
2023-08-13 |
rat |
| Tatiana A Gudasheva, Polina Povarnina, Alexey V Tarasiuk, Sergey B Seredeni. The Low Molecular Weight Brain-derived Neurotrophic Factor Mimetics with Antidepressant-like Activity. Current pharmaceutical design. vol 25. issue 6. 2020-02-10. PMID:30931847. |
bdnf is a key regulator of neuroplasticity in the hippocampus and the prefrontal cortex, the dysfunction of which is considered to be the main pathophysiological hallmark of this disorder. |
2020-02-10 |
2023-08-13 |
Not clear |
| San-Juan Yang, Zhu-Jin Song, Xun-Cui Wang, Zheng-Rong Zhang, Sheng-Bing Wu, Guo-Qi Zh. Curculigoside facilitates fear extinction and prevents depression-like behaviors in a mouse learned helplessness model through increasing hippocampal BDNF. Acta pharmacologica Sinica. vol 40. issue 10. 2020-02-10. PMID:31028292. |
curculigoside facilitates fear extinction and prevents depression-like behaviors in a mouse learned helplessness model through increasing hippocampal bdnf. |
2020-02-10 |
2023-08-13 |
mouse |
| Kuang-Dai Li, Kuo Yan, Qiang-Song Wang, Jun-Sheng Tian, Dong Xu, Wen-Yan Zhang, Yuan-Lu Cu. Antidepressant-like effects of dietary gardenia blue pigment derived from genipin and tyrosine. Food & function. vol 10. issue 8. 2020-02-05. PMID:31264676. |
besides, gtd increased plasma testosterone and hippocampal brain-derived neurotrophic factor (bdnf) levels in cums rats. |
2020-02-05 |
2023-08-13 |
mouse |
| Narumi Hashikawa-Hobara, Ami Otsuka, Risa Ishikawa, Naoya Hashikaw. Roman chamomile inhalation combined with clomipramine treatment improves treatment-resistant depression-like behavior in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 118. 2020-02-05. PMID:31369988. |
next, we examined the hippocampal mrna levels of two cytokines, tumor necrosis factor (tnf) alpha and interleukin-6 (il-6); a neurotrophic factor, brain derived-neurotrophic factor (bdnf); and nerve growth factor (ngf). |
2020-02-05 |
2023-08-13 |
mouse |
| Narumi Hashikawa-Hobara, Ami Otsuka, Risa Ishikawa, Naoya Hashikaw. Roman chamomile inhalation combined with clomipramine treatment improves treatment-resistant depression-like behavior in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 118. 2020-02-05. PMID:31369988. |
tnf alpha, il-6 and bdnf mrna levels did not change in the hippocampus of stressed mice. |
2020-02-05 |
2023-08-13 |
mouse |
| Supawadee Daodee, Orawan Monthakantirat, Kanlaya Ruengwinitwong, Kankrittanon Gatenakorn, Juthamart Maneenet, Charinya Khamphukdee, Nazim Sekeroglu, Yaowared Chulikhit, Anake Kijjo. Effects of the Ethanol Extract of Dipterocarpus alatus Leaf on the Unpredictable Chronic Mild Stress-Induced Depression in ICR Mice and Its Possible Mechanism of Action. Molecules (Basel, Switzerland). vol 24. issue 18. 2020-02-05. PMID:31540539. |
the extract not only decreased the elevation of serum corticosterone level and the index of over-activation of the hypothalamic-pituitary-adrenal (hpa) axis, caused by ucms, but also ameliorated ucms-induced up-regulation of serum- and glucocorticoid-inducible kinase 1 (sgk1) mrna expression and down-regulation of cyclic amp-responsive element binding (creb) and brain-derived neurotrophic factor (bdnf) mrnas in frontal cortex and hippocampus. |
2020-02-05 |
2023-08-13 |
mouse |