| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Natalie Groves, Imogen O'Keeffe, Wendy Lee, Alexandra Toft, Daniel Blackmore, Saurabh Bandhavkar, Elizabeth J Coulson, Perry F Bartlett, Dhanisha J Jhaver. Blockade of TrkB but not p75 Developmental neurobiology. vol 79. issue 9-10. 2020-06-11. PMID:31886631. |
blockade of trkb but not p75 brain-derived neurotrophic factor (bdnf) signaling plays a major role in the regulation of hippocampal neurogenesis in the adult brain. |
2020-06-11 |
2023-08-13 |
Not clear |
| Linlin Fan, Lingling Chen, Zhi Liang, Hongkun Bao, Dan Wang, Yilong Dong, Shangyong Zheng, Chunjie Xiao, Jing Du, Hongliang L. A Polysaccharide Extract from Maitake Culinary-Medicinal Mushroom, Grifola frondosa (Agaricomycetes) Ameliorates Learning and Memory Function in Aluminum Chloride-Induced Amnesia in Mice. International journal of medicinal mushrooms. vol 21. issue 11. 2020-06-10. PMID:32450016. |
furthermore, pgm treatment significantly enhanced the level of ampar and bdnf in the hippocampus, while suppressing the tau protein hyperphosphorylation at the ser396 site. |
2020-06-10 |
2023-08-13 |
mouse |
| Durany, Michel, Kurt, Cruz-Sánchez, Cervós-Navarro, Riedere. Brain-derived neurotrophic factor and neurotrophin-3 levels in Alzheimer's disease brains. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 18. issue 8. 2020-06-01. PMID:11154850. |
in the present study, we investigated the levels of brain-derived neurotrophic factor (bdnf) and neurotrophin-3 (nt-3) in post-mortem brain tissue of alzheimer's disease (ad) patients, and we observed a significant increase of bdnf concentration in hippocampus and parietal cortex of ad patients, as well as a negative correlation between nt-3 levels and age in hippocampus and putamen of control subjects, and for bdnf in frontal cortex. |
2020-06-01 |
2023-08-12 |
human |
| Pamela Lopes da Cunha, Maria Eugenia Villar, Fabricio Ballarini, Ramiro Tintorelli, Haydée Ana María Viol. Spatial object recognition memory formation under acute stress. Hippocampus. vol 29. issue 6. 2020-06-01. PMID:30295349. |
the effect induced by stress was dependent on the activation of glucocorticoid- and mineralocorticoid-receptors, brain-derived neurotrophic factor (bdnf) and protein synthesis in the dorsal hippocampus. |
2020-06-01 |
2023-08-13 |
rat |
| Nona Sakhaie, Farshid Sadegzadeh, Alireza Mohammadnia, Masoumeh Dadkhah, Hakimeh Saadat. Sex-dependent effects of postweaning exposure to an enriched environment on novel objective recognition memory and anxiety-like behaviors: The role of hippocampal BDNF level. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2020-05-31. PMID:32416621. |
sex-dependent effects of postweaning exposure to an enriched environment on novel objective recognition memory and anxiety-like behaviors: the role of hippocampal bdnf level. |
2020-05-31 |
2023-08-13 |
rat |
| Nona Sakhaie, Farshid Sadegzadeh, Alireza Mohammadnia, Masoumeh Dadkhah, Hakimeh Saadat. Sex-dependent effects of postweaning exposure to an enriched environment on novel objective recognition memory and anxiety-like behaviors: The role of hippocampal BDNF level. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2020-05-31. PMID:32416621. |
exposure to enriched environment (ee) has been indicated to enhance cognitive functions, hippocampal neural plasticity, neurogenesis, long-term potentiation, and levels of the brain-derived neurotrophic factor (bdnf) in laboratory animals. |
2020-05-31 |
2023-08-13 |
rat |
| Nona Sakhaie, Farshid Sadegzadeh, Alireza Mohammadnia, Masoumeh Dadkhah, Hakimeh Saadat. Sex-dependent effects of postweaning exposure to an enriched environment on novel objective recognition memory and anxiety-like behaviors: The role of hippocampal BDNF level. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2020-05-31. PMID:32416621. |
therefore, the present study was designed to compare the effects of ee during adolescence (pnd21-pnd60) on novel objective recognition memory (norm), anxiety-like behaviors, and hippocampal bdnf mrna level in the adult male and female rats. |
2020-05-31 |
2023-08-13 |
rat |
| Nona Sakhaie, Farshid Sadegzadeh, Alireza Mohammadnia, Masoumeh Dadkhah, Hakimeh Saadat. Sex-dependent effects of postweaning exposure to an enriched environment on novel objective recognition memory and anxiety-like behaviors: The role of hippocampal BDNF level. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2020-05-31. PMID:32416621. |
additionally, our results indicated an augmented bdnf level in the hippocampus of male and female rats. |
2020-05-31 |
2023-08-13 |
rat |
| Nona Sakhaie, Farshid Sadegzadeh, Alireza Mohammadnia, Masoumeh Dadkhah, Hakimeh Saadat. Sex-dependent effects of postweaning exposure to an enriched environment on novel objective recognition memory and anxiety-like behaviors: The role of hippocampal BDNF level. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2020-05-31. PMID:32416621. |
in conclusion, adolescent exposure to ee has sex-dependent effects on cognitive functions and anxiety-like behaviors and increases bdnf mrna expression in the hippocampus of both male and female rats; thus, bdnf is an important factor that can mediate the beneficial effects of ee and running exercise on cognitive functions and psychiatric traits. |
2020-05-31 |
2023-08-13 |
rat |
| Masaaki Tanichi, Kunio Shimizu, Shingo Enomoto, Minori Koga, Hiroyuki Toda, Masanori Nagamine, Eiji Suzuki, Masashi Nibuy. The effects of eicosapentaenoic acid dietary supplementation on behavioral parameters and expression of hippocampal brain-derived neurotrophic factor in an animal model of post-traumatic stress disorder. European journal of pharmacology. vol 865. 2020-05-20. PMID:31654623. |
additionally, western blot analyses using brain-derived neurotrophic factor (bdnf) monoclonal antibody revealed a decreased expression of bdnf protein, in the hippocampal region of the rats, due to foot-shock traumatization and a significantly increased expression of bdnf protein after oral epa supplementation. |
2020-05-20 |
2023-08-13 |
rat |
| Masaaki Tanichi, Kunio Shimizu, Shingo Enomoto, Minori Koga, Hiroyuki Toda, Masanori Nagamine, Eiji Suzuki, Masashi Nibuy. The effects of eicosapentaenoic acid dietary supplementation on behavioral parameters and expression of hippocampal brain-derived neurotrophic factor in an animal model of post-traumatic stress disorder. European journal of pharmacology. vol 865. 2020-05-20. PMID:31654623. |
the results indicate a possibility that alteration of the numbing/avoidance behavior parallels the expression of hippocampal bdnf in the rat brain. |
2020-05-20 |
2023-08-13 |
rat |
| Yue Han, Lijuan Zhang, Qiaozhi Wang, Dingding Zhang, Qiuying Zhao, Jinqiang Zhang, Lei Xie, Guangyi Liu, Zili Yo. Minocycline inhibits microglial activation and alleviates depressive-like behaviors in male adolescent mice subjected to maternal separation. Psychoneuroendocrinology. vol 107. 2020-05-18. PMID:31078757. |
these changes in inflammatory processes correlated with changes in neurogenesis and bdnf expression in the hippocampus. |
2020-05-18 |
2023-08-13 |
mouse |
| Yi-Yung Hung, Ya-Ling Huang, Chawnshang Chang, Hong-Yo Kan. Deficiency in Androgen Receptor Aggravates the Depressive-Like Behaviors in Chronic Mild Stress Model of Depression. Cells. vol 8. issue 9. 2020-05-14. PMID:31480771. |
adding the antiandrogen flutamide with the stress hormone corticosterone can additively decrease bdnf mrna in mouse hippocampus mhippoe-14 cells, which can then be reversed via down-regulating the mir-204-5p expression. |
2020-05-14 |
2023-08-13 |
mouse |
| Paulo Wagner Linhares Lima Filho, Adriano José Maia Chaves Filho, Charliene Freire Xavier Vieira, Tatiana de Queiroz Oliveira, Michelle Verde Ramo Soares, Paloma Marinho Jucá, Joao Quevedo, Tatiana Barichello, Danielle Macedo, Francisco das Chagas Medeiro. Peritoneal endometriosis induces time-related depressive- and anxiety-like alterations in female rats: involvement of hippocampal pro-oxidative and BDNF alterations. Metabolic brain disease. vol 34. issue 3. 2020-05-11. PMID:30798429. |
peritoneal endometriosis induces time-related depressive- and anxiety-like alterations in female rats: involvement of hippocampal pro-oxidative and bdnf alterations. |
2020-05-11 |
2023-08-13 |
rat |
| Paulo Wagner Linhares Lima Filho, Adriano José Maia Chaves Filho, Charliene Freire Xavier Vieira, Tatiana de Queiroz Oliveira, Michelle Verde Ramo Soares, Paloma Marinho Jucá, Joao Quevedo, Tatiana Barichello, Danielle Macedo, Francisco das Chagas Medeiro. Peritoneal endometriosis induces time-related depressive- and anxiety-like alterations in female rats: involvement of hippocampal pro-oxidative and BDNF alterations. Metabolic brain disease. vol 34. issue 3. 2020-05-11. PMID:30798429. |
corticosterone stress reactivity, oxidative stress markers - reduced glutathione (gsh), lipid peroxidation, activity of superoxide dismutase (sod) and myeloperoxidase (mpo) - and brain-derived-neurotrophic factor (bdnf) levels in the hippocampus were also evaluated. |
2020-05-11 |
2023-08-13 |
rat |
| Vishnu N Thakare, Rajesh R Patil, Anupama A Suralkar, Valmik D Dhakane, Bhoomika M Pate. Protocatechuic acid attenuate depressive-like behavior in olfactory bulbectomized rat model: behavioral and neurobiochemical investigations. Metabolic brain disease. vol 34. issue 3. 2020-05-11. PMID:30848471. |
behavioral (ambulatory and rearing activity and immobility time), neurochemical [serotonin (5-ht), dopamine (da), norepinephrine (ne) and brain derived neurotrophic factor (bdnf) expression], biochemical (mda formation, il-6, tnf-α and antioxidants) changes in hippocampus and cerebral cortex along with serum corticosterone were investigated. |
2020-05-11 |
2023-08-13 |
rat |
| Vishnu N Thakare, Rajesh R Patil, Anupama A Suralkar, Valmik D Dhakane, Bhoomika M Pate. Protocatechuic acid attenuate depressive-like behavior in olfactory bulbectomized rat model: behavioral and neurobiochemical investigations. Metabolic brain disease. vol 34. issue 3. 2020-05-11. PMID:30848471. |
experimental findings reveals that obx subjected rats showed alteration in behaviors like, increase in immobility time, ambulatory and rearing behaviors significantly, reduced bdnf level, 5-ht, da,ne and antioxidant parameters along with increased serum corticosterone, mda formation, il-6, and tnf-α in hippocampus and cerebral cortex compared to sham operated rats. |
2020-05-11 |
2023-08-13 |
rat |
| Vishnu N Thakare, Rajesh R Patil, Anupama A Suralkar, Valmik D Dhakane, Bhoomika M Pate. Protocatechuic acid attenuate depressive-like behavior in olfactory bulbectomized rat model: behavioral and neurobiochemical investigations. Metabolic brain disease. vol 34. issue 3. 2020-05-11. PMID:30848471. |
administration of pca significantly attenuated behavioral and neurobiochemical alterations, thus, its antidepressant-like activity is largely mediated through modulation of neurotransmitter, endocrine and immunologic systems, mainly by improvements of bdnf, 5-ht, da, ne, reduced mda, il-6, and tnf-α in hippocampus and cerebral cortex. |
2020-05-11 |
2023-08-13 |
rat |
| Jing-Jing Zhang, Ting-Ting Gao, Yuan Wang, Jin-Liang Wang, Wei Guan, Ying-Jie Wang, Cheng-Niu Wang, Jian-Feng Liu, Bo Jian. Andrographolide Exerts Significant Antidepressant-Like Effects Involving the Hippocampal BDNF System in Mice. The international journal of neuropsychopharmacology. vol 22. issue 9. 2020-05-11. PMID:31181145. |
andrographolide exerts significant antidepressant-like effects involving the hippocampal bdnf system in mice. |
2020-05-11 |
2023-08-13 |
mouse |
| Kuan-Ming Chiu, Tzu-Yu Lin, Ming-Yi Lee, Cheng-Wei Lu, Ming-Jiuh Wang, Su-Jane Wan. Dexmedetomidine protects neurons from kainic acid-induced excitotoxicity by activating BDNF signaling. Neurochemistry international. vol 129. 2020-05-11. PMID:31220473. |
the results suggest that dexmedetomidine protected rat brains from ka-induced excitotoxic damage by reducing glutamate levels, suppressing caspase-3 activation and mapks phosphorylation, and enhancing bcl-2, nrf2, bdnf and trkb expression in the hippocampus. |
2020-05-11 |
2023-08-13 |
rat |