| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ning Jiang, Jing-Wei Lv, Hai-Xia Wang, Cong Lu, Qiong Wang, Tian-Ji Xia, Yu Bao, Shan-Shan Li, Xin-Min Li. Dammarane sapogenins alleviates depression-like behaviours induced by chronic social defeat stress in mice through the promotion of the BDNF signalling pathway and neurogenesis in the hippocampus. Brain research bulletin. vol 153. 2020-09-24. PMID:31542427. |
in addition, an impairment in hippocampal neurogenesis that paralleled a reduced bdnf level in the hippocampus was observed in the mice that were subjected with csds for 3 weeks, while treatment with ds reversed these changes. |
2020-09-24 |
2023-08-13 |
mouse |
| Ning Jiang, Jing-Wei Lv, Hai-Xia Wang, Cong Lu, Qiong Wang, Tian-Ji Xia, Yu Bao, Shan-Shan Li, Xin-Min Li. Dammarane sapogenins alleviates depression-like behaviours induced by chronic social defeat stress in mice through the promotion of the BDNF signalling pathway and neurogenesis in the hippocampus. Brain research bulletin. vol 153. 2020-09-24. PMID:31542427. |
moreover, ds treatment significantly upregulated bdnf, ptrkb/trkb, pakt/akt, ppi3k/pi3k, pcreb/creb, perk1/2/erk1/2 and pmtor/mtor protein expression in the hippocampus. |
2020-09-24 |
2023-08-13 |
mouse |
| Ning Jiang, Jing-Wei Lv, Hai-Xia Wang, Cong Lu, Qiong Wang, Tian-Ji Xia, Yu Bao, Shan-Shan Li, Xin-Min Li. Dammarane sapogenins alleviates depression-like behaviours induced by chronic social defeat stress in mice through the promotion of the BDNF signalling pathway and neurogenesis in the hippocampus. Brain research bulletin. vol 153. 2020-09-24. PMID:31542427. |
in conclusion, our results showed that ds exerts antidepressant-like effects in mice with csds-induced depression, that the effects may be mediated by the normalization of monoamine neurotransmitter levels, the prevention of hpa axis dysfunction and the impairment of hippocampal neurogenesis, and that this occurs partly through the ability of ds to enhance bdnf expression by increasing the trkb/creb/erk pathway and the pi3k/akt/mtor pathway. |
2020-09-24 |
2023-08-13 |
mouse |
| Javad Riyahi, Behrouz Abdoli, Abbas Haghparast, Laura Petrosin. Intergenerational effect of parental spatial training on offspring learning: Evidence for sex differences in memory function. Brain research bulletin. vol 153. 2020-09-24. PMID:31585156. |
also, erk1/2, bdnf, syt1 and h3k14ac levels in the hippocampus of offspring were analyzed. |
2020-09-24 |
2023-08-13 |
Not clear |
| Javad Riyahi, Behrouz Abdoli, Abbas Haghparast, Laura Petrosin. Intergenerational effect of parental spatial training on offspring learning: Evidence for sex differences in memory function. Brain research bulletin. vol 153. 2020-09-24. PMID:31585156. |
we observed that father's spatial training increased acetylated h3k14 in male offspring's hippocampus, suggesting that histone acetylation may upregulate the expression of bdnf and phosphorylated erk1/2 in the male offspring of father trained and thus contribute to the enhancement of spatial learning and memory. |
2020-09-24 |
2023-08-13 |
Not clear |
| Daniela Velasquez de Oliveira, Tuany Caroline Bernardi, Silvana Regina de Melo, Jacqueline Godinho, Rúbia Maria Weffort de Oliveira, Humberto Milan. Postischemic fish oil treatment restores dendritic integrity and synaptic proteins levels after transient, global cerebral ischemia in rats. Journal of chemical neuroanatomy. vol 101. 2020-09-22. PMID:31499173. |
the neun and bdnf protein levels were reduced in both the hippocampus and pfc, which were recovered by fo treatment. |
2020-09-22 |
2023-08-13 |
rat |
| Bruk Getachew, Yousef Tizab. Antidepressant effects of moxidectin, an antiparasitic drug, in a rat model of depression. Behavioural brain research. vol 376. 2020-09-22. PMID:31513828. |
we undertook this study to determine whether mox would actually show antidepressant-like properties in an animal model of depression and whether it would affect the hippocampal and frontal cortex levels of brain-derived neurotrophic factor (bdnf) or tumor necrosis factor (tnf)-alpha, peptides that have been implicated in pathogenesis of depression and effectiveness of various antidepressants. |
2020-09-22 |
2023-08-13 |
rat |
| Bruk Getachew, Yousef Tizab. Antidepressant effects of moxidectin, an antiparasitic drug, in a rat model of depression. Behavioural brain research. vol 376. 2020-09-22. PMID:31513828. |
concomitant with the 24 h behavioral effects, the levels of hippocampal and frontal cortical bdnf were significantly increased, whereas the levels of tnf-alpha in both these areas were significantly decreased. |
2020-09-22 |
2023-08-13 |
rat |
| Jusik Park, Wookwang Cheon, Kijin Ki. Effects of Long-Term Endurance Exercise and Lithium Treatment on Neuroprotective Factors in Hippocampus of Obese Rats. International journal of environmental research and public health. vol 17. issue 9. 2020-09-22. PMID:32397675. |
to investigate the effects of long-term lithium treatment and low intensity endurance exercise on brain-derived neurotrophic factor (bdnf) expression and glycogen synthase kinase 3 beta (gsk3β) activity in the hippocampus of obese rats. |
2020-09-22 |
2023-08-13 |
rat |
| Abeer M Rababa'h, Afrah N Mardini, Karem H Alzoubi, Mera A Ababneh, Rabaa Y Athamne. The effect of cilostazol on hippocampal memory and oxidative stress biomarkers in rat model of diabetes mellitus. Brain research. vol 1715. 2020-09-18. PMID:30914251. |
bdnf protein, tbars levels and different antioxidant biomarkers were assessed after dissection of the hippocampus. |
2020-09-18 |
2023-08-13 |
rat |
| Can Sun, Jian Fu, Zhenzhen Qu, Dongxiao Li, Peipei Si, Qi Qiao, Wenlin Zhang, Yan Xue, Junli Zhen, Weiping Wan. Chronic mild hypoxia promotes hippocampal neurogenesis involving Notch1 signaling in epileptic rats. Brain research. vol 1714. 2020-09-17. PMID:30768929. |
moreover, mild hypoxia reversed the suppression of hippocampal neurogenesis and the downregulation of nt-3 and bdnf expression in hippocampus and cortex of epileptic rats. |
2020-09-17 |
2023-08-13 |
rat |
| Bruno Lima Giacobbo, Betânia Souza de Freitas, Kelem Vedovelli, Lívia Machado Schlemmer, Vivian Naziaseno Pires, Vinicius Antoniazzi, Cristophod de Souza Dos Santos, Leticia Paludo, Juliano Viana Borges, Daiane Borba de Lima, Nadja Schröder, Erik F J de Vries, Elke Bromber. Long-term environmental modifications affect BDNF concentrations in rat hippocampus, but not in serum. Behavioural brain research. vol 372. 2020-09-17. PMID:31125621. |
long-term environmental modifications affect bdnf concentrations in rat hippocampus, but not in serum. |
2020-09-17 |
2023-08-13 |
rat |
| Luiza P Géa, Rafael Colombo, Eduarda D da Rosa, Bárbara Antqueviezc, Érica Z de Aguiar, Gabriel Henrique Hizo, Gabriela Barella Schmidt, Larissa F de Oliveira, Dirson João Stein, Adriane R Ros. Anhedonic-like behavior correlates with IFNγ serum levels in a two-hit model of depression. Behavioural brain research. vol 373. 2020-09-14. PMID:31284015. |
brain-derived neurotrophic factor (bdnf) levels were decreased in the serum of cums + animals, while no differences were found in the hippocampus and on lipid peroxidation levels. |
2020-09-14 |
2023-08-13 |
rat |
| Gustavo C Dal-Pont, Marco T S Jório, Wilson R Resende, Fernanda F Gava, Jorge M Aguiar-Geraldo, Taise Possamai-Della, Jefté Peper-Nascimento, João Quevedo, Samira S Valvassor. Effects of lithium and valproate on behavioral parameters and neurotrophic factor levels in an animal model of mania induced by paradoxical sleep deprivation. Journal of psychiatric research. vol 119. 2020-09-14. PMID:31574363. |
psd decreased bdnf, ngf, and gdnf levels in the frontal cortex and hippocampus of mice. |
2020-09-14 |
2023-08-13 |
mouse |
| Krishna L Bharani, Aurélie Ledreux, Anah Gilmore, Steven L Carroll, Ann-Charlotte Granhol. Serum pro-BDNF levels correlate with phospho-tau staining in Alzheimer's disease. Neurobiology of aging. vol 87. 2020-09-14. PMID:31882186. |
we used postmortem brain and fluid samples from 20 patients with variable severity of ad and 11 controls to investigate whether bdnf levels in serum and brain tissue correlated with hippocampal pathology. |
2020-09-14 |
2023-08-13 |
Not clear |
| Krishna L Bharani, Aurélie Ledreux, Anah Gilmore, Steven L Carroll, Ann-Charlotte Granhol. Serum pro-BDNF levels correlate with phospho-tau staining in Alzheimer's disease. Neurobiology of aging. vol 87. 2020-09-14. PMID:31882186. |
histological markers for ad pathology, the bdnf cognate receptor (trkb), and glia were measured in the hippocampus (hip). |
2020-09-14 |
2023-08-13 |
Not clear |
| Krishna L Bharani, Aurélie Ledreux, Anah Gilmore, Steven L Carroll, Ann-Charlotte Granhol. Serum pro-BDNF levels correlate with phospho-tau staining in Alzheimer's disease. Neurobiology of aging. vol 87. 2020-09-14. PMID:31882186. |
total bdnf levels in cortical regions were also negatively correlated with amylo-glo staining in the hip suggesting that reduced bdnf cortical levels might influence hippocampal amyloid accumulation. |
2020-09-14 |
2023-08-13 |
Not clear |
| Ghaffar Shokouhi, Morteza Kosari-Nasab, Ali-Akbar Salar. Silymarin sex-dependently improves cognitive functions and alters TNF-α, BDNF, and glutamate in the hippocampus of mice with mild traumatic brain injury. Life sciences. vol 257. 2020-09-14. PMID:32634430. |
silymarin sex-dependently improves cognitive functions and alters tnf-α, bdnf, and glutamate in the hippocampus of mice with mild traumatic brain injury. |
2020-09-14 |
2023-08-13 |
mouse |
| Ismail O Ishola, Mmesomachukwu O Osele, Micah C Chijioke, Olufunmilayo O Adeyem. Isorhamnetin enhanced cortico-hippocampal learning and memory capability in mice with scopolamine-induced amnesia: Role of antioxidant defense, cholinergic and BDNF signaling. Brain research. vol 1712. 2020-09-11. PMID:30772273. |
one hour after probe test (mwm task) on day 7, the brains were isolated to assay for oxidative stress, cholinesterase activity and brain derived neurotrophic factor (bdnf) levels in the prefrontal cortex (pfc) and hippocampus (hippo). |
2020-09-11 |
2023-08-13 |
mouse |
| Ismail O Ishola, Mmesomachukwu O Osele, Micah C Chijioke, Olufunmilayo O Adeyem. Isorhamnetin enhanced cortico-hippocampal learning and memory capability in mice with scopolamine-induced amnesia: Role of antioxidant defense, cholinergic and BDNF signaling. Brain research. vol 1712. 2020-09-11. PMID:30772273. |
in addition, irn attenuates scopolamine induced cholinesterase activity and bdnf level in the prefrontal cortex and hippocampus of mice. |
2020-09-11 |
2023-08-13 |
mouse |