| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patrick Nasrallah, Edwina Abou Haidar, Joseph S Stephan, Lauretta El Hayek, Nabil Karnib, Mohamad Khalifeh, Nour Barmo, Vanessa Jabre, Rouba Houbeika, Anthony Ghanem, Jason Nasser, Nadine Zeeni, Maya Bassil, Sama F Sleima. Branched-chain amino acids mediate resilience to chronic social defeat stress by activating BDNF/TRKB signaling. Neurobiology of stress. vol 11. 2020-09-28. PMID:31193350. |
bcaa promoted resilience to chronic stress, rescued social avoidance behaviors and increased hippocampal bdnf levels and trkb activation. |
2020-09-28 |
2023-08-13 |
mouse |
| Patrick Nasrallah, Edwina Abou Haidar, Joseph S Stephan, Lauretta El Hayek, Nabil Karnib, Mohamad Khalifeh, Nour Barmo, Vanessa Jabre, Rouba Houbeika, Anthony Ghanem, Jason Nasser, Nadine Zeeni, Maya Bassil, Sama F Sleima. Branched-chain amino acids mediate resilience to chronic social defeat stress by activating BDNF/TRKB signaling. Neurobiology of stress. vol 11. 2020-09-28. PMID:31193350. |
interestingly, we found that bcaa activate the exercise-regulated pgc1a/fndc5 pathway known to induce hippocampal bdnf signaling. |
2020-09-28 |
2023-08-13 |
mouse |
| Paula M Q Bellozi, Renan Pelição, Matheus C Santos, Isabel V A Lima, Soraya W Saliba, Érica L M Vieira, Alline C Campos, Antônio L Teixeira, Antônio C P de Oliveira, Ester M Nakamura-Palacios, Lívia C M Rodrigue. URB597 ameliorates the deleterious effects induced by binge alcohol consumption in adolescent rats. Neuroscience letters. vol 711. 2020-09-28. PMID:31374324. |
the chronic binge alcohol administration increased the interferon (ifn)-γ and tumor necrosis factor (tnf)-α levels in the pfc and hippocampus and the interleukin (il)-10 and bdnf levels in the pfc, and these effects were prevented by urb597. |
2020-09-28 |
2023-08-13 |
rat |
| Nathaniel Bohm-Levine, Alexander R Goldberg, Monica Mariani, Maya Frankfurt, Janice Thornto. Reducing luteinizing hormone levels after ovariectomy improves spatial memory: Possible role of brain-derived neurotrophic factor. Hormones and behavior. vol 118. 2020-09-28. PMID:31593698. |
estrogens appear to exert some of their effects on memory by increasing levels of brain-derived neurotrophic factor (bdnf) in the hippocampus. |
2020-09-28 |
2023-08-13 |
human |
| Nathaniel Bohm-Levine, Alexander R Goldberg, Monica Mariani, Maya Frankfurt, Janice Thornto. Reducing luteinizing hormone levels after ovariectomy improves spatial memory: Possible role of brain-derived neurotrophic factor. Hormones and behavior. vol 118. 2020-09-28. PMID:31593698. |
immunohistochemical analysis revealed that both antide and estradiol increased bdnf expression in the hippocampus. |
2020-09-28 |
2023-08-13 |
human |
| Nathaniel Bohm-Levine, Alexander R Goldberg, Monica Mariani, Maya Frankfurt, Janice Thornto. Reducing luteinizing hormone levels after ovariectomy improves spatial memory: Possible role of brain-derived neurotrophic factor. Hormones and behavior. vol 118. 2020-09-28. PMID:31593698. |
these results provide evidence for a relationship between lh and bdnf in the hippocampus and demonstrate that estrogen-increasing and lh-lowering treatments may both require bdnf signaling in order to improve spatial memory. |
2020-09-28 |
2023-08-13 |
human |
| Maryam Hoseindoost, Mohammad Reza Alipour, Fereshteh Farajdokht, Roghayeh Diba, Parvin Bayandor, Keyvan Mehri, Sepehr Nayebi Rad, Shirin Babr. Effects of troxerutin on inflammatory cytokines and BDNF levels in male offspring of high-fat diet fed rats. Avicenna journal of phytomedicine. vol 9. issue 6. 2020-09-28. PMID:31763218. |
in the present study, we aimed to examine the effect of troxerutin treatment on levels of brain-derived neurotrophic factor (bdnf), and tumor necrosis factor-alpha (tnf-α) and interleukin-6 (il-6), as pro-inflammatory cytokines, in the blood and hippocampus of high-fat diet (hfd) fed dams and their male offspring. |
2020-09-28 |
2023-08-13 |
rat |
| Gyeong Joon Moon, Sehwan Kim, Min-Tae Jeon, Kea Joo Lee, Il-Sung Jang, Michiko Nakamura, Sang Ryong Ki. Therapeutic Potential of AAV1-Rheb(S16H) Transduction Against Alzheimer's Disease. Journal of clinical medicine. vol 8. issue 12. 2020-09-28. PMID:31766645. |
rheb(s16h) transduction of hippocampal neurons in the 5xfad mice increased the levels of neurotrophic signaling molecules, including brain-derived neurotrophic factor (bdnf) and ciliary neurotrophic factor (cntf), and their corresponding receptors, tropomyosin receptor kinase b (trkb) and cntf receptor α subunit (cntfrα), respectively. |
2020-09-28 |
2023-08-13 |
mouse |
| Anna O Giarratana, Shavonne Teng, Sahithi Reddi, Cynthia Zheng, Derek Adler, Smita Thakker-Varia, Janet Alde. BDNF Val66Met Genetic Polymorphism Results in Poor Recovery Following Repeated Mild Traumatic Brain Injury in a Mouse Model and Treatment With AAV-BDNF Improves Outcomes. Frontiers in neurology. vol 10. 2020-09-28. PMID:31787925. |
in order to determine the mechanism for these differences, we investigated levels of the apoptotic-inducing pro bdnf and survival-inducing mature bdnf isoforms and found that met carriers had less total bdnf in the cortex and a higher pro/mature ratio of bdnf in the hippocampus. |
2020-09-28 |
2023-08-13 |
mouse |
| Bo Dam Lee, Jae-Myung Yoo, Seong Yeon Baek, Fu Yi Li, Dai-Eun Sok, Mee Ree Ki. 3,3'-Diindolylmethane Promotes BDNF and Antioxidant Enzyme Formation via TrkB/Akt Pathway Activation for Neuroprotection against Oxidative Stress-Induced Apoptosis in Hippocampal Neuronal Cells. Antioxidants (Basel, Switzerland). vol 9. issue 1. 2020-09-28. PMID:31861353. |
3,3'-diindolylmethane promotes bdnf and antioxidant enzyme formation via trkb/akt pathway activation for neuroprotection against oxidative stress-induced apoptosis in hippocampal neuronal cells. |
2020-09-28 |
2023-08-13 |
mouse |
| Yang Zong, Ting Chen, Hongli Dong, Lijing Zhu, Wenzheng J. Si-Ni-San Prevents Reserpine-Induced Depression by Inhibiting Inflammation and Regulating CYP450 Enzymatic Activity. Frontiers in pharmacology. vol 10. 2020-09-28. PMID:32009949. |
furthermore, the key proteins nf-κb, bdnf, and trkb were analyzed by western blot (wb) analysis in the hippocampus. |
2020-09-28 |
2023-08-13 |
rat |
| Yang Zong, Ting Chen, Hongli Dong, Lijing Zhu, Wenzheng J. Si-Ni-San Prevents Reserpine-Induced Depression by Inhibiting Inflammation and Regulating CYP450 Enzymatic Activity. Frontiers in pharmacology. vol 10. 2020-09-28. PMID:32009949. |
the levels of nf-κb, bdnf, and trkb in the hippocampus of depressive rats were also altered. |
2020-09-28 |
2023-08-13 |
rat |
| Ke Fang, Hua-Rong Li, Xing-Xing Chen, Xin-Ran Gao, Ling-Ling Huang, An-Qi Du, Chuan Jiang, Hua Li, Jin-Fang G. Quercetin Alleviates LPS-Induced Depression-Like Behavior in Rats Frontiers in pharmacology. vol 10. 2020-09-28. PMID:32009956. |
results of western blot showed that the expression levels of bdnf, copine 6, p-trkb, and the triggering receptors expressed on myeloid cells (trem) 1 were decreased in both the hippocampus and the prefrontal cortex (pfc) of lps-challenged rats, while the expression of trem2 was increased. |
2020-09-28 |
2023-08-13 |
mouse |
| Osvaldo Flores-Bastías, Alfredo Adriasola-Carrasco, Eduardo Karahania. Activation of Melanocortin-4 Receptor Inhibits Both Neuroinflammation Induced by Early Exposure to Ethanol and Subsequent Voluntary Alcohol Intake in Adulthood in Animal Models: Is BDNF the Key Mediator? Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32063838. |
we hypothesize that ethanol exposure during adolescence decreases the expression of α-msh and hence mc4r signaling in the hippocampus, leading to a lower bdnf activity that causes dramatic changes in the brain (e.g., neuroinflammation and decreased neurogenesis) that predispose to maintain alcohol abuse until adulthood. |
2020-09-28 |
2023-08-13 |
rat |
| Christoph Linnemann, Undine E Lan. Pathways Connecting Late-Life Depression and Dementia. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32231570. |
fourthly, the neurotrophin bdnf is highly expressed in the central nervous system, especially in the hippocampus, where it plays a key role in the proliferation, differentiation and the maintenance of neuronal integrity throughout lifespan. |
2020-09-28 |
2023-08-13 |
Not clear |
| Dongyoung Yun, Min-Tae Jeon, Hyung-Jun Kim, Gyeong Joon Moon, Shinrye Lee, Chang Man Ha, Minsang Shin, Sang Ryong Ki. Induction of GDNF and GFRα-1 Following AAV1-Rheb(S16H) Administration in the Hippocampus Experimental neurobiology. vol 29. issue 2. 2020-09-28. PMID:32408406. |
herein, we report that hippocampal transduction of adeno-associated virus serotype 1 (aav1) with a constitutively active form of ras homolog enriched in brain [rheb(s16h)], which can stimulate the production of brain-derived neurotrophic factor (bdnf) in hippocampal neurons, induces the increases in expression of gdnf and gdnf family receptor α-1 (gfrα-1), in neurons and astrocytes in the hippocampus of rat brain |
2020-09-28 |
2023-08-13 |
rat |
| Quentin Delmotte, Diabe Diabira, Yasmine Belaidouni, Mira Hamze, Marine Kochmann, Aurélie Montheil, Jean-Luc Gaiarsa, Christophe Porcher, Yesser H Belgace. Sonic Hedgehog Signaling Agonist (SAG) Triggers BDNF Secretion and Promotes the Maturation of GABAergic Networks in the Postnatal Rat Hippocampus. Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32425757. |
sonic hedgehog signaling agonist (sag) triggers bdnf secretion and promotes the maturation of gabaergic networks in the postnatal rat hippocampus. |
2020-09-28 |
2023-08-13 |
rat |
| John R Kershne. Dyslexia as an adaptation to cortico-limbic stress system reactivity. Neurobiology of stress. vol 12. 2020-09-28. PMID:32435671. |
stress exceeding an individual's range of resilience: (1) reduces levels of tfeb and bdnf, gene regulatory factors prolonging maturation and neuroplasticity; (2) interferes with the insular cortex, amygdala and hippocampus in coordinating afferent visceral signals with cognitive performance; (3) over-recruits the brain's default mode network; and (4) amplifies release from the locus coeruleus/norepinephrine system which impairs the entrainment of oscillations in the lower phonological frequencies of speech. |
2020-09-28 |
2023-08-13 |
Not clear |
| Jonathas Rodrigo Dos Santos, Mariza Bortolanza, Gustavo Duarte Ferrari, Guilherme Pauperio Lanfredi, Glauce Crivelaro do Nascimento, Ana Elisa Calereiro Seixas Azzolini, Elaine Del Bel, Alline Cristina de Campos, Vitor Marcel Faça, Anderson Vulczak, Luciane Carla Alberic. One-Week High-Intensity Interval Training Increases Hippocampal Plasticity and Mitochondrial Content without Changes in Redox State. Antioxidants (Basel, Switzerland). vol 9. issue 5. 2020-09-28. PMID:32455608. |
the mass spectrometry analyses showed that one-week of hiit increased minichromosome maintenance complex component 2 (mcm2), brain derived neutrophic factor (bdnf), doublecortin (dcx) and voltage-dependent anion-selective channel protein 2 (vdac), and decreased mitochondrial superoxide dismutase 2 (sod 2) in the hippocampus. |
2020-09-28 |
2023-08-13 |
mouse |
| Shanyan Hong, Honghong Huang, Meili Yang, Haining Wu, Lingxing Wan. Enriched Environment Decreases Cognitive Impairment in Elderly Rats With Prenatal Mobile Phone Exposure. Frontiers in aging neuroscience. vol 12. 2020-09-28. PMID:32581772. |
the results demonstrated that prenatal long-term but not short-term exposure to mobile phone lead to cognitive impairment, morphological changes in the hippocampal cells, reduced synaptic number, decreased syn, psd-95, and bdnf expression in elderly offspring, which were alleviated by postnatal ee housing. |
2020-09-28 |
2023-08-13 |
rat |