| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tatiana A Gudasheva, Polina Povarnina, Alexey V Tarasiuk, Sergey B Seredeni. The Low Molecular Weight Brain-derived Neurotrophic Factor Mimetics with Antidepressant-like Activity. Current pharmaceutical design. vol 25. issue 6. 2020-02-10. PMID:30931847. |
bdnf is a key regulator of neuroplasticity in the hippocampus and the prefrontal cortex, the dysfunction of which is considered to be the main pathophysiological hallmark of this disorder. |
2020-02-10 |
2023-08-13 |
Not clear |
| San-Juan Yang, Zhu-Jin Song, Xun-Cui Wang, Zheng-Rong Zhang, Sheng-Bing Wu, Guo-Qi Zh. Curculigoside facilitates fear extinction and prevents depression-like behaviors in a mouse learned helplessness model through increasing hippocampal BDNF. Acta pharmacologica Sinica. vol 40. issue 10. 2020-02-10. PMID:31028292. |
curculigoside facilitates fear extinction and prevents depression-like behaviors in a mouse learned helplessness model through increasing hippocampal bdnf. |
2020-02-10 |
2023-08-13 |
mouse |
| Kuang-Dai Li, Kuo Yan, Qiang-Song Wang, Jun-Sheng Tian, Dong Xu, Wen-Yan Zhang, Yuan-Lu Cu. Antidepressant-like effects of dietary gardenia blue pigment derived from genipin and tyrosine. Food & function. vol 10. issue 8. 2020-02-05. PMID:31264676. |
besides, gtd increased plasma testosterone and hippocampal brain-derived neurotrophic factor (bdnf) levels in cums rats. |
2020-02-05 |
2023-08-13 |
mouse |
| Narumi Hashikawa-Hobara, Ami Otsuka, Risa Ishikawa, Naoya Hashikaw. Roman chamomile inhalation combined with clomipramine treatment improves treatment-resistant depression-like behavior in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 118. 2020-02-05. PMID:31369988. |
next, we examined the hippocampal mrna levels of two cytokines, tumor necrosis factor (tnf) alpha and interleukin-6 (il-6); a neurotrophic factor, brain derived-neurotrophic factor (bdnf); and nerve growth factor (ngf). |
2020-02-05 |
2023-08-13 |
mouse |
| Narumi Hashikawa-Hobara, Ami Otsuka, Risa Ishikawa, Naoya Hashikaw. Roman chamomile inhalation combined with clomipramine treatment improves treatment-resistant depression-like behavior in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 118. 2020-02-05. PMID:31369988. |
tnf alpha, il-6 and bdnf mrna levels did not change in the hippocampus of stressed mice. |
2020-02-05 |
2023-08-13 |
mouse |
| Supawadee Daodee, Orawan Monthakantirat, Kanlaya Ruengwinitwong, Kankrittanon Gatenakorn, Juthamart Maneenet, Charinya Khamphukdee, Nazim Sekeroglu, Yaowared Chulikhit, Anake Kijjo. Effects of the Ethanol Extract of Dipterocarpus alatus Leaf on the Unpredictable Chronic Mild Stress-Induced Depression in ICR Mice and Its Possible Mechanism of Action. Molecules (Basel, Switzerland). vol 24. issue 18. 2020-02-05. PMID:31540539. |
the extract not only decreased the elevation of serum corticosterone level and the index of over-activation of the hypothalamic-pituitary-adrenal (hpa) axis, caused by ucms, but also ameliorated ucms-induced up-regulation of serum- and glucocorticoid-inducible kinase 1 (sgk1) mrna expression and down-regulation of cyclic amp-responsive element binding (creb) and brain-derived neurotrophic factor (bdnf) mrnas in frontal cortex and hippocampus. |
2020-02-05 |
2023-08-13 |
mouse |
| Fei Chen, Can-Can Zhou, Yin Yang, Jian-Wen Liu, Chong-Huai Ya. GM1 Ameliorates Lead-Induced Cognitive Deficits and Brain Damage Through Activating the SIRT1/CREB/BDNF Pathway in the Developing Male Rat Hippocampus. Biological trace element research. vol 190. issue 2. 2020-02-04. PMID:30414004. |
furthermore, we found that gm1 upregulated the expression of sirt1, creb phosphorylation, and bdnf, which underlie learning and memory in the lead-treated developing rat hippocampus. |
2020-02-04 |
2023-08-13 |
rat |
| Yong-Hyun Ko, Seung-Hwan Kwon, Seok-Yong Lee, Choon-Gon Jan. Isoorientin improves scopolamine-induced cognitive impairments by restoring the cholinergic system, antioxidant defense, and p-CREB/BDNF signaling in the hippocampus and frontal cortex. Archives of pharmacal research. vol 42. issue 8. 2020-02-03. PMID:31350730. |
moreover, western blot results indicated that iso reversed the decreases in expression of phosphorylated camp response element binding (creb) and brain-derived neurotrophic factor (bdnf) in the hippocampus and frontal cortex of scopolamine-treated mice. |
2020-02-03 |
2023-08-13 |
mouse |
| Nasroallah Moradi-Kor, Ali Ghanbari, Hadi Rashidipour, Behpour Yousefi, Ahmad Reza Bandegi, Ali Rashidy-Pou. Beneficial effects of Spirulina platensis, voluntary exercise and environmental enrichment against adolescent stress induced deficits in cognitive functions, hippocampal BDNF and morphological remolding in adult female rats. Hormones and behavior. vol 112. 2020-01-30. PMID:30917909. |
beneficial effects of spirulina platensis, voluntary exercise and environmental enrichment against adolescent stress induced deficits in cognitive functions, hippocampal bdnf and morphological remolding in adult female rats. |
2020-01-30 |
2023-08-13 |
rat |
| Nasroallah Moradi-Kor, Ali Ghanbari, Hadi Rashidipour, Behpour Yousefi, Ahmad Reza Bandegi, Ali Rashidy-Pou. Beneficial effects of Spirulina platensis, voluntary exercise and environmental enrichment against adolescent stress induced deficits in cognitive functions, hippocampal BDNF and morphological remolding in adult female rats. Hormones and behavior. vol 112. 2020-01-30. PMID:30917909. |
the present study investigated the combined protective effects of spirulina platensis (sp), a supplement made from blue-green algae with neuroprotective properties, voluntary exercise (ex) and environmental enrichment (ee) against cognitive deficits, alternations in hippocampal bdnf levels, and abnormal neuronal remodeling in adult female rats (pnd 60) induced by exposure to chronic restraint stress during adolescent period (pnd 30-40). |
2020-01-30 |
2023-08-13 |
rat |
| Nasroallah Moradi-Kor, Ali Ghanbari, Hadi Rashidipour, Behpour Yousefi, Ahmad Reza Bandegi, Ali Rashidy-Pou. Beneficial effects of Spirulina platensis, voluntary exercise and environmental enrichment against adolescent stress induced deficits in cognitive functions, hippocampal BDNF and morphological remolding in adult female rats. Hormones and behavior. vol 112. 2020-01-30. PMID:30917909. |
following the interventions, spatial learning and memory, passive avoidance performance, hippocampal dendritic morphology and bdnf levels were assessed. |
2020-01-30 |
2023-08-13 |
rat |
| Nasroallah Moradi-Kor, Ali Ghanbari, Hadi Rashidipour, Behpour Yousefi, Ahmad Reza Bandegi, Ali Rashidy-Pou. Beneficial effects of Spirulina platensis, voluntary exercise and environmental enrichment against adolescent stress induced deficits in cognitive functions, hippocampal BDNF and morphological remolding in adult female rats. Hormones and behavior. vol 112. 2020-01-30. PMID:30917909. |
stressed rats showed deficits in spatial learning and memory and passive avoidance performance, decreased bdnf levels in the hippocampus, and reduced apical dendritic length and branch points of the ca3 pyramidal neurons. |
2020-01-30 |
2023-08-13 |
rat |
| Nasroallah Moradi-Kor, Ali Ghanbari, Hadi Rashidipour, Behpour Yousefi, Ahmad Reza Bandegi, Ali Rashidy-Pou. Beneficial effects of Spirulina platensis, voluntary exercise and environmental enrichment against adolescent stress induced deficits in cognitive functions, hippocampal BDNF and morphological remolding in adult female rats. Hormones and behavior. vol 112. 2020-01-30. PMID:30917909. |
some treatments even enhanced cognitive functions, and bdnf levels and neuroanatomical remodeling in the hippocampus of non-stressed animals. |
2020-01-30 |
2023-08-13 |
rat |
| Pei-Yi Lin, Ege T Kavalali, Lisa M Monteggi. Genetic Dissection of Presynaptic and Postsynaptic BDNF-TrkB Signaling in Synaptic Efficacy of CA3-CA1 Synapses. Cell reports. vol 24. issue 6. 2020-01-27. PMID:30089265. |
brain-derived neurotrophic factor (bdnf) and its high-affinity receptor, tropomyosin receptor kinase b (trkb), regulate long-term potentiation (ltp) in the hippocampus, although the sites of bdnf-trkb receptors in this process are controversial. |
2020-01-27 |
2023-08-13 |
Not clear |
| Pei-Yi Lin, Ege T Kavalali, Lisa M Monteggi. Genetic Dissection of Presynaptic and Postsynaptic BDNF-TrkB Signaling in Synaptic Efficacy of CA3-CA1 Synapses. Cell reports. vol 24. issue 6. 2020-01-27. PMID:30089265. |
taken together, this direct comparison of presynaptic and postsynaptic bdnf-trkb reveals insight into bdnf release and trkb activation sites in hippocampal ltp. |
2020-01-27 |
2023-08-13 |
Not clear |
| Dragos Niculescu, Kristin Michaelsen-Preusse, Ülkü Güner, René van Dorland, Corette J Wierenga, Christian Lohman. A BDNF-Mediated Push-Pull Plasticity Mechanism for Synaptic Clustering. Cell reports. vol 24. issue 8. 2020-01-27. PMID:30134168. |
here, we show that trkb activation and postsynaptic brain-derived neurotrophic factor (bdnf) are required for synaptic clustering in developing hippocampal neurons. |
2020-01-27 |
2023-08-13 |
Not clear |
| Carmen Ferrer-Pérez, Adriana Castro-Zavala, Miguel Ángel Luján, Joanna Filarowska, Raúl Ballestín, José Miñarro, Olga Valverde, Marta Rodríguez-Aria. Oxytocin prevents the increase of cocaine-related responses produced by social defeat. Neuropharmacology. vol 146. 2020-01-23. PMID:30448423. |
the influence of oxt on the levels of bdnf in the prefrontal cortex (pfc), striatum and hippocampus was also measured. |
2020-01-23 |
2023-08-13 |
Not clear |
| Takayo Odaira, Osamu Nakagawasai, Kohei Takahashi, Wataru Nemoto, Wakana Sakuma, Jia-Rong Lin, Koichi Tan-N. Mechanisms underpinning AMP-activated protein kinase-related effects on behavior and hippocampal neurogenesis in an animal model of depression. Neuropharmacology. vol 150. 2020-01-21. PMID:30914305. |
the expression of phosphorylated ampk, protein kinase c ζ (pkcζ), nuclear factor-kappa b (nf-κb), brain-derived neurotrophic factor (bdnf), and camp response element-binding protein (creb) in the hippocampus was assessed by western blotting. |
2020-01-21 |
2023-08-13 |
mouse |
| Xianhui Kang, Wandong Hong, Kangjie Xie, Hongli Tang, Jingjing Tang, Shan Luo, Wujun Geng, Danyun Ji. Ginsenoside Rb1 pretreatment reverses hippocampal changes in BDNF/TrkB mRNA and protein in rats subjected to acute immobilization stress. Drug design, development and therapy. vol 13. 2020-01-21. PMID:31308626. |
the purpose of this study was to investigate the influence of ginsenoside rb1 on plasma corticosterone (cort) and adrenocorticotropic hormone (acth) levels and hippocampal brain-derived neurotrophic factor (bdnf) and tyrosine kinase b (trkb) levels in rats subjected to acute immobilization stress. |
2020-01-21 |
2023-08-13 |
rat |
| Muneeb Iqbal, Xin-Li Xiao, Salman Zafar, Peng-Bo Yang, Kai-Wei Si, Hua Han, Jian-Xin Liu, Yong Li. Forced Physical Training Increases Neuronal Proliferation and Maturation with Their Integration into Normal Circuits in Pilocarpine Induced Status Epilepticus Mice. Neurochemical research. vol 44. issue 11. 2020-01-21. PMID:31560103. |
changes in bdnf gene methylation and its protein level in hippocampus was also measured at latent stage (2-weeks) to explore underlying pathways involved in increasing neurogenesis. |
2020-01-21 |
2023-08-13 |
mouse |