| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yo Shinoda, Tetsushi Sadakata, Kaori Yagishita, Emi Kinameri, Ritsuko Katoh-Semba, Yoshitake Sano, Teiichi Furuich. Aspects of excitatory/inhibitory synapses in multiple brain regions are correlated with levels of brain-derived neurotrophic factor/neurotrophin-3. Biochemical and biophysical research communications. vol 509. issue 2. 2019-10-22. PMID:30594389. |
compared with wt, bdnf levels in ko mice were reduced in young/adult hippocampus, but increased in young hypothalamus, while nt-3 levels were reduced in adult cerebellum and young hippocampus, but increased in adult parietal cortex. |
2019-10-22 |
2023-08-13 |
mouse |
| Bruna Ferrary Deniz, Heloísa Deola Confortim, Iohanna Deckmann, Patrícia Maidana Miguel, Loise Bronauth, Bruna Chaves de Oliveira, Sílvia Barbosa, Laura Reck Cechinel, Ionara Rodrigues Siqueira, Lenir Orlandi Pereir. Folic acid supplementation during pregnancy prevents cognitive impairments and BDNF imbalance in the hippocampus of the offspring after neonatal hypoxia-ischemia. The Journal of nutritional biochemistry. vol 60. 2019-10-21. PMID:30064014. |
folic acid supplementation during pregnancy prevents cognitive impairments and bdnf imbalance in the hippocampus of the offspring after neonatal hypoxia-ischemia. |
2019-10-21 |
2023-08-13 |
rat |
| Saray López-Benito, Julia Sánchez-Sánchez, Verónica Brito, Laura Calvo, Silvia Lisa, María Torres-Valle, Mary E Palko, Cristina Vicente-García, Seila Fernández-Fernández, Juan P Bolaños, Silvia Ginés, Lino Tessarollo, Juan C Aréval. Regulation of BDNF Release by ARMS/Kidins220 through Modulation of Synaptotagmin-IV Levels. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 23. 2019-10-16. PMID:29769266. |
interestingly, two mouse models of huntington's disease (hd) showed increased levels of arms/kidins220 in the hippocampus and regulated bdnf secretion deficits. |
2019-10-16 |
2023-08-13 |
mouse |
| Saray López-Benito, Julia Sánchez-Sánchez, Verónica Brito, Laura Calvo, Silvia Lisa, María Torres-Valle, Mary E Palko, Cristina Vicente-García, Seila Fernández-Fernández, Juan P Bolaños, Silvia Ginés, Lino Tessarollo, Juan C Aréval. Regulation of BDNF Release by ARMS/Kidins220 through Modulation of Synaptotagmin-IV Levels. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 23. 2019-10-16. PMID:29769266. |
importantly, reduction of arms/kidins220 in hippocampal slices from hd mice reversed the impaired regulated bdnf release. |
2019-10-16 |
2023-08-13 |
mouse |
| Sara Merlo, Simona Federica Spampinato, Martina Beneventano, Maria Angela Sortin. The contribution of microglia to early synaptic compensatory responses that precede β-amyloid-induced neuronal death. Scientific reports. vol 8. issue 1. 2019-10-14. PMID:29740062. |
a low concentration of aggregated aβ42 induced selective up-regulation of mature brain-derived neurotrophic factor (bdnf) expression and release in rat organotypic hippocampal cultures as well as in cortical pure microglia. |
2019-10-14 |
2023-08-13 |
rat |
| Yu-Fei Ni, Hao Wang, Qiu-Yan Gu, Fei-Ying Wang, Ying-Jie Wang, Jin-Liang Wang, Bo Jian. Gemfibrozil has antidepressant effects in mice: Involvement of the hippocampal brain-derived neurotrophic factor system. Journal of psychopharmacology (Oxford, England). vol 32. issue 4. 2019-10-11. PMID:29534628. |
gemfibrozil treatment also restored cums-induced inhibition of the hippocampal bdnf signaling pathway. |
2019-10-11 |
2023-08-13 |
mouse |
| Yu-Fei Ni, Hao Wang, Qiu-Yan Gu, Fei-Ying Wang, Ying-Jie Wang, Jin-Liang Wang, Bo Jian. Gemfibrozil has antidepressant effects in mice: Involvement of the hippocampal brain-derived neurotrophic factor system. Journal of psychopharmacology (Oxford, England). vol 32. issue 4. 2019-10-11. PMID:29534628. |
gemfibrozil produced antidepressant effects in mice by promoting the hippocampal bdnf system. |
2019-10-11 |
2023-08-13 |
mouse |
| Rinat O Esenaliev, Irene Y Petrov, Yuriy Petrov, Jutatip Guptarak, Debbie R Boone, Emanuele Mocciaro, Harris Weisz, Margaret A Parsley, Stacy L Sell, Helen Hellmich, Jonathan M Ford, Connor Pogue, Douglas DeWitt, Donald S Prough, Maria-Adelaide Micc. Nano-Pulsed Laser Therapy Is Neuroprotective in a Rat Model of Blast-Induced Neurotrauma. Journal of neurotrauma. vol 35. issue 13. 2019-10-07. PMID:29562823. |
nplt also increased expression of bdnf in the hippocampus and the number of proliferating progenitor cells in the dentate gyrus. |
2019-10-07 |
2023-08-13 |
rat |
| Mi-Young Jeong, Hyo-Min Jang, Dong-Hyun Ki. High-fat diet causes psychiatric disorders in mice by increasing Proteobacteria population. Neuroscience letters. vol 698. 2019-10-07. PMID:30615977. |
the intake of a hfd suppressed brain-derived neurotrophic factor (bdnf) expression in the hippocampus and increased blood tnf-α and lps levels. |
2019-10-07 |
2023-08-13 |
mouse |
| Marlena Wosiski-Kuhn, Mihail Bota, Christina A Snider, Steven P Wilson, Kannan U Venkataraju, Pavel Osten, Alexis M Stranaha. Hippocampal brain-derived neurotrophic factor determines recruitment of anatomically connected networks after stress in diabetic mice. Hippocampus. vol 28. issue 12. 2019-10-04. PMID:30098276. |
diabetic rodents exhibit anxiety and reductions in hippocampal brain-derived neurotrophic factor (bdnf) expression, and these studies investigated whether loss of bdnf-driven hippocampal activity promotes anxiety and disinhibits the hpa axis. |
2019-10-04 |
2023-08-13 |
mouse |
| Marlena Wosiski-Kuhn, Mihail Bota, Christina A Snider, Steven P Wilson, Kannan U Venkataraju, Pavel Osten, Alexis M Stranaha. Hippocampal brain-derived neurotrophic factor determines recruitment of anatomically connected networks after stress in diabetic mice. Hippocampus. vol 28. issue 12. 2019-10-04. PMID:30098276. |
these experiments revealed that changes in hippocampal bdnf were necessary and sufficient for behavioral anxiety and hpa axis disinhibition. |
2019-10-04 |
2023-08-13 |
mouse |
| Zhe Li, Xuezhao Cao, Hong Ma, Yong Cui, Xiaoqian Li, Na Wang, Yongjian Zho. Surgical Trauma Exacerbates Cognitive Deficits and Neuroinflammation in Aged Rats: The Role of CX3CL1-CX3CR1 Signaling. Journal of neuropathology and experimental neurology. vol 77. issue 8. 2019-10-03. PMID:29939299. |
hippocampal interleukin-1β, cx3cl1, cx3cr1, brain derived neurotrophic factor (bdnf), ionized calcium-binding adapter molecule 1 (iba-1), and arginase-1 (arg1) levels were measured. |
2019-10-03 |
2023-08-13 |
rat |
| Masami Kojima, Konomi Matsui, Toshiyuki Mizu. BDNF pro-peptide: physiological mechanisms and implications for depression. Cell and tissue research. vol 377. issue 1. 2019-10-01. PMID:31076872. |
interestingly, the pro-domain of bdnf (bdnf pro-peptide) is localized at presynaptic termini, where it facilitates long-term depression (ltd) in hippocampal slices, implicating it as a novel synaptic modulator. |
2019-10-01 |
2023-08-13 |
human |
| Masami Kojima, Konomi Matsui, Toshiyuki Mizu. BDNF pro-peptide: physiological mechanisms and implications for depression. Cell and tissue research. vol 377. issue 1. 2019-10-01. PMID:31076872. |
bdnf binds its pro-peptide with high affinity in a ph-dependent manner and when bound to bdnf, the bdnf pro-peptide cannot facilitate hippocampal ltd, representing a new mechanism of regulation. |
2019-10-01 |
2023-08-13 |
human |
| Yi-Xuan Li, Zi-He Ye, Tong Chen, Xiao-Feng Jia, Ling H. The effects of donepezil on phencyclidine-induced cognitive deficits in a mouse model of schizophrenia. Pharmacology, biochemistry, and behavior. vol 175. 2019-09-30. PMID:30218672. |
furthermore, the content of bdnf and ngf in the hippocampus and cortex of mice was determined using elisa. |
2019-09-30 |
2023-08-13 |
mouse |
| Ting-Ting Zhuang, Chuan Pan, Jing-Jing Chen, Fei Han, Xiu-Ling Zhu, Hui Xu, Ya-Ping L. Chronic asthma-induced behavioral and hippocampal neuronal morphological changes are concurrent with BDNF, cofilin1 and Cdc42/RhoA alterations in immature mice. Brain research bulletin. vol 143. 2019-09-30. PMID:30227235. |
chronic asthma-induced behavioral and hippocampal neuronal morphological changes are concurrent with bdnf, cofilin1 and cdc42/rhoa alterations in immature mice. |
2019-09-30 |
2023-08-13 |
mouse |
| Fu-Sheng Ding, Xiang Cheng, Tong Zhao, Yong-Qi Zhao, Guang-Bo Zhang, Hai-Tao Wu, Ling-Ling Zhu, Kui-Wu W. [Intermittent hypoxic preconditioning relieves fear and anxiety behavior in post-traumatic stress model mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 71. issue 4. 2019-09-26. PMID:31440750. |
the levels of fear and anxiety were valued by the open field, the elevated plus maze (epm) and the fear conditioning tests; the level of spatial memory was valued by y maze test; the number of fos positive neurons in hippocampus, amygdala and medial prefrontal cortex was valued by immunohistochemical staining; and the protein expressions of hypoxia inducible factor-1α (hif-1α), vascular endothelial growth factor (vegf) and brain derived neurotrophic factor (bdnf) in these brain area were valued by western blot. |
2019-09-26 |
2023-08-13 |
mouse |
| Fu-Sheng Ding, Xiang Cheng, Tong Zhao, Yong-Qi Zhao, Guang-Bo Zhang, Hai-Tao Wu, Ling-Ling Zhu, Kui-Wu W. [Intermittent hypoxic preconditioning relieves fear and anxiety behavior in post-traumatic stress model mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 71. issue 4. 2019-09-26. PMID:31440750. |
at the same time, ih reduced the number of fos positive neurons in the hippocampus, amygdala and medial prefrontal cortex of ptsd model mice, and increased the protein expression levels of hif-1α, vegf and bdnf in these brain tissues. |
2019-09-26 |
2023-08-13 |
mouse |
| Magdalena Miranda, Brianne A Kent, Juan Facundo Morici, Francisco Gallo, Lisa M Saksida, Timothy J Bussey, Noelia Weisstaub, Pedro Bekinschtei. NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus. Neurobiology of learning and memory. vol 155. 2019-09-23. PMID:30172952. |
nmda receptors and bdnf are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus. |
2019-09-23 |
2023-08-13 |
Not clear |
| Mauricio P Cunha, Francis L Pazini, Vicente Lieberknecht, Ana Lúcia S Rodrigue. Subchronic administration of creatine produces antidepressant-like effect by modulating hippocampal signaling pathway mediated by FNDC5/BDNF/Akt in mice. Journal of psychiatric research. vol 104. 2019-09-19. PMID:30005372. |
on the hippocampal pgc-1α, fndc5 and bdnf gene expression was investigated. |
2019-09-19 |
2023-08-13 |
mouse |