| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bo-Yu Shi, Zhi-Li Rao, Jie Luo, Xiao-Bo Liu, Yang Fang, Hai-Juan Cao, Nan Zen. [Protective effect and mechanism of Xiaoyao San on lipopolysaccharide-induced hippocampal neurons injury]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 44. issue 4. 2019-08-14. PMID:30989892. |
the effect of xiaoyao san serum( final concentration of4%,8%) on the cell proliferation activity was detected by immunofluorescence,the levels of bdnf and β-ngf in the supernatant of hippocampal neurons were detected by elisa,and the expressions of bdnf,ngf,trk b,trk a and creb mrna in cell lysate of hippocampal neuron were detected by pcr. |
2019-08-14 |
2023-08-13 |
Not clear |
| Huancun Feng, Canmao Wang, Wei He, Xinjun Wu, Shujie Li, Zhenkun Zeng, Meidan Wei, Binghong H. Roflumilast ameliorates cognitive impairment in APP/PS1 mice via cAMP/CREB/BDNF signaling and anti-neuroinflammatory effects. Metabolic brain disease. vol 34. issue 2. 2019-08-13. PMID:30610438. |
in addition, roflumilast increased the camp, phosphorylated camp response-element binding protein (p-creb) and brain-derived neurotrophic factor (bdnf) levels, and reduced the nuclear translocation of nuclear factor-kappa b (nf-κb) p65, and proinflammatory cytokine (il-6, tnf-a and il-1β) levels in the hippocampus of app/ps1 transgenic mice. |
2019-08-13 |
2023-08-13 |
mouse |
| Yan Fang, Naiyi Du, Longyan Xing, Yali Duo, Lei Zhen. Evaluation of hippocampal volume and serum brain-derived neurotrophic factor as potential diagnostic markers of conversion from amnestic mild cognitive impairment to Alzheimer disease: A STROBE-compliant article. Medicine. vol 98. issue 30. 2019-08-13. PMID:31348306. |
the aim of this study was to evaluate serum brain-derived neurotrophic factor (bdnf) and hippocampal volume as predictors of amci to ad transition in apoe ε4 genotype patients.a total of 178 subjects were diagnosed with amci. |
2019-08-13 |
2023-08-13 |
human |
| Yan Fang, Naiyi Du, Longyan Xing, Yali Duo, Lei Zhen. Evaluation of hippocampal volume and serum brain-derived neurotrophic factor as potential diagnostic markers of conversion from amnestic mild cognitive impairment to Alzheimer disease: A STROBE-compliant article. Medicine. vol 98. issue 30. 2019-08-13. PMID:31348306. |
meanwhile, we found that amci-ad patients were associated with abnormally low serum bdnf level and greater hippocampal volume loss than mci-mci patients (patients maintaining an amci diagnosis after 2 years). |
2019-08-13 |
2023-08-13 |
human |
| Yan Fang, Naiyi Du, Longyan Xing, Yali Duo, Lei Zhen. Evaluation of hippocampal volume and serum brain-derived neurotrophic factor as potential diagnostic markers of conversion from amnestic mild cognitive impairment to Alzheimer disease: A STROBE-compliant article. Medicine. vol 98. issue 30. 2019-08-13. PMID:31348306. |
moreover, patients with amci who were carriers of apoe ε4 showed a notable decrease in serum bdnf and a significant reduction in hippocampal volume, especially in those who progressed to ad.the present study demonstrates that amci that evolves into ad in patients with the apoe ε4 genotype may be predicted by hippocampal volume and serum bdnf. |
2019-08-13 |
2023-08-13 |
human |
| Wanassanun Pannangrong, Apiwat Sirichoat, Trai Wongsiri, Peter Wigmore, Jariya Umka Welba. Valproic acid withdrawal ameliorates impairments of hippocampal-spatial working memory and neurogenesis. Journal of Zhejiang University. Science. B. vol 20. issue 3. 2019-08-12. PMID:30829012. |
male wistar rats were given intraperitoneal injections of 0.9% normal saline or vpa (300 mg/kg) twice a day for 10 d. at 1, 30, or 45 d after the drug treatment, the novel object location (nol) test was used to examine spatial memory; hippocampal cell division was counted using ki67 immunohistochemistry, and levels of brain-derived neurotrophic factor (bdnf) and notch1 were measured using western immunoblotting. |
2019-08-12 |
2023-08-13 |
rat |
| Wanassanun Pannangrong, Apiwat Sirichoat, Trai Wongsiri, Peter Wigmore, Jariya Umka Welba. Valproic acid withdrawal ameliorates impairments of hippocampal-spatial working memory and neurogenesis. Journal of Zhejiang University. Science. B. vol 20. issue 3. 2019-08-12. PMID:30829012. |
spatial working memory was impaired 1 and 30 d after the final administration, but was restored to control levels by 45 d. cell proliferation had increased to control levels at 30 and 45 d. both markers of neurogenesis (bdnf and notch1 levels) had returned to control levels at 45 d. these results demonstrate that memory recovery occurs over a period of six weeks after discontinuing vpa treatment and is preceded by a return of hippocampal neurogenesis to control levels. |
2019-08-12 |
2023-08-13 |
rat |
| Haiyan Li, Chihiro Ishikawa, Takashi Shig. Effects of postnatal handling on adult behavior and brain mRNA expression of serotonin receptor, brain-derived neurotrophic factor and GABA-A receptor subunit. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 68. 2019-08-06. PMID:29678562. |
in adulthood, mrna expression of bdnf was up-regulated in the amygdala and dorsal hippocampus and down-regulated in the dorsal raphe nucleus, whereas that of gaba-a receptor α2 subunit was down-regulated in the amygdala. |
2019-08-06 |
2023-08-13 |
mouse |
| Haiyan Li, Chihiro Ishikawa, Takashi Shig. Effects of postnatal handling on adult behavior and brain mRNA expression of serotonin receptor, brain-derived neurotrophic factor and GABA-A receptor subunit. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 68. 2019-08-06. PMID:29678562. |
taken together, the present study suggests that postnatal handling reduced anxiety-like behavior and improved learning and memory, which were accompanied by changes in mrna expression of 5-ht1a receptor, bdnf and gaba-a receptor α2 subunit in the amygdala, 5-ht1a receptor in the dorsal raphe nucleus and bdnf in the dorsal hippocampus. |
2019-08-06 |
2023-08-13 |
mouse |
| Sawsan Aboul-Fotouh, Mohamed Habib, Tarek Asaad, Samar K Kassim, Mohamed H Ghane. Behavioral effects of toll-like receptor-4 antagonist 'eritoran' in an experimental model of depression: role of prefrontal and hippocampal neurogenesis and γ-aminobutyric acid/glutamate balance. Behavioural pharmacology. vol 29. issue 5. 2019-07-31. PMID:29561292. |
long-term administration of eri ameliorated crs-induced depressive-like symptoms and hypothalamic-pituitary-adrenal axis hyperactivity alongside reducing levels of hippocampal and pfc inflammatory cytokines, restoring gaba and glutamate balance, and enhancing pfc and hippocampal neurogenesis, by increasing bdnf gene and protein expression in a dose-dependent manner. |
2019-07-31 |
2023-08-13 |
rat |
| Sawsan Aboul-Fotouh, Mohamed Habib, Tarek Asaad, Samar K Kassim, Mohamed H Ghane. Behavioral effects of toll-like receptor-4 antagonist 'eritoran' in an experimental model of depression: role of prefrontal and hippocampal neurogenesis and γ-aminobutyric acid/glutamate balance. Behavioural pharmacology. vol 29. issue 5. 2019-07-31. PMID:29561292. |
the results demonstrate an antidepressant-like activity of eri in wistar rats exposed to crs, which may be largely mediated by its ability to reduce neuroinflammation, increase bdnf, and restore gaba/glutamate balance in prefrontal cortex and hippocampus. |
2019-07-31 |
2023-08-13 |
rat |
| Martins Back Netto, Aloir Neri de Oliveira Junior, Mariana Goldim, Khiany Mathias, Maria Eduarda Fileti, Naiana da Rosa, Ana Olivia Laurentino, Bianca Xavier de Farias, Ana Beatriz Costa, Gislaine Tezza Rezin, Jucelia Jeremias Fortunato, Amanda Della Giustina, Tatiana Barichello, Felipe Dal-Pizzol, Fabricia Petronilh. Oxidative stress and mitochondrial dysfunction contributes to postoperative cognitive dysfunction in elderly rats. Brain, behavior, and immunity. vol 73. 2019-07-31. PMID:30041011. |
control (sham) and fracture (tf) groups were followed to determine nitrite/nitrate concentration; oxidative damage to lipids and proteins; the activity of antioxidant enzymes (superoxide dismutase-sod and catalase-cat), mitochondrial respiratory chain enzymes, and creatine kinase (ck); and bdnf levels in the hippocampus and prefrontal cortex (at 24 h and at seven days) and cognitive function through habituation to the open field task and novel object recognition task (only at seven days). |
2019-07-31 |
2023-08-13 |
rat |
| Joanna I Giza, Jihye Kim, Heidi C Meyer, Agustin Anastasia, Iva Dincheva, Crystal I Zheng, Katherine Lopez, Henrietta Bains, Jianmin Yang, Clay Bracken, Conor Liston, Deqiang Jing, Barbara L Hempstead, Francis S Le. The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior. Neuron. vol 99. issue 1. 2019-07-30. PMID:29909994. |
using super-resolution imaging, we demonstrate that the bdnf met prodomain disassembles dendritic spines and eliminates synapses in hippocampal neurons. |
2019-07-30 |
2023-08-13 |
human |
| Yong-Hyun Ko, Seung-Hwan Kwon, Shi-Xun Ma, Jee-Yeon Seo, Bo-Ram Lee, Kyungin Kim, Sun Yeou Kim, Seok-Yong Lee, Choon-Gon Jan. The memory-enhancing effects of 7,8,4'-trihydroxyisoflavone, a major metabolite of daidzein, are associated with activation of the cholinergic system and BDNF signaling pathway in mice. Brain research bulletin. vol 142. 2019-07-30. PMID:30031818. |
finally, 7,8,4'-thif significantly increased the expression levels of the following molecules in the hippocampus: brain-derived neurotrophic factor (bdnf); phospho extracellular signal-regulated kinase (erk); phospho camp response element binding (creb); and choline acetyltransferase (chat). |
2019-07-30 |
2023-08-13 |
mouse |
| Rosy Wang, R M Damian Holsinge. Exercise-induced brain-derived neurotrophic factor expression: Therapeutic implications for Alzheimer's dementia. Ageing research reviews. vol 48. 2019-07-29. PMID:30326283. |
this perspective draws upon evidence from animal and human studies to highlight such a mechanism whereby exercise drives synthesis and accumulation of neuroactive metabolites such as myokines and ketone bodies in the periphery and in the hippocampus to enhance bdnf expression. |
2019-07-29 |
2023-08-13 |
human |
| Rosy Wang, R M Damian Holsinge. Exercise-induced brain-derived neurotrophic factor expression: Therapeutic implications for Alzheimer's dementia. Ageing research reviews. vol 48. 2019-07-29. PMID:30326283. |
similarly, both bdnf and cardiovascular fitness arising from aerobic exercise have been positively associated with hippocampal volume and function in humans. |
2019-07-29 |
2023-08-13 |
human |
| Xing Wang, Jie Chen, Hailou Zhang, Zhiheng Huang, Zhilu Zou, Yin Chen, Lei Sheng, Wenda Xue, Juanjuan Tang, Haoxin Wu, Hongquan Liu, Gang Che. Immediate and persistent antidepressant-like effects of Chaihu-jia-Longgu-Muli-tang are associated with instantly up-regulated BDNF in the hippocampus of mice. Bioscience reports. vol 39. issue 1. 2019-07-29. PMID:30473537. |
immediate and persistent antidepressant-like effects of chaihu-jia-longgu-muli-tang are associated with instantly up-regulated bdnf in the hippocampus of mice. |
2019-07-29 |
2023-08-13 |
mouse |
| Xing Wang, Jie Chen, Hailou Zhang, Zhiheng Huang, Zhilu Zou, Yin Chen, Lei Sheng, Wenda Xue, Juanjuan Tang, Haoxin Wu, Hongquan Liu, Gang Che. Immediate and persistent antidepressant-like effects of Chaihu-jia-Longgu-Muli-tang are associated with instantly up-regulated BDNF in the hippocampus of mice. Bioscience reports. vol 39. issue 1. 2019-07-29. PMID:30473537. |
here, we aimed to evaluate the immediate and persistent antidepressant-like action of a classic herbal medicine chaihu-jia-longgu-muli decoction (clm) as well as the action of clm on hippocampal brain-derived neurotrophic factor (bdnf) over time. |
2019-07-29 |
2023-08-13 |
mouse |
| Xing Wang, Jie Chen, Hailou Zhang, Zhiheng Huang, Zhilu Zou, Yin Chen, Lei Sheng, Wenda Xue, Juanjuan Tang, Haoxin Wu, Hongquan Liu, Gang Che. Immediate and persistent antidepressant-like effects of Chaihu-jia-Longgu-Muli-tang are associated with instantly up-regulated BDNF in the hippocampus of mice. Bioscience reports. vol 39. issue 1. 2019-07-29. PMID:30473537. |
bdnf expression in the hippocampus was examined at 30 min and 24 hr post a single clm. |
2019-07-29 |
2023-08-13 |
mouse |
| Xing Wang, Jie Chen, Hailou Zhang, Zhiheng Huang, Zhilu Zou, Yin Chen, Lei Sheng, Wenda Xue, Juanjuan Tang, Haoxin Wu, Hongquan Liu, Gang Che. Immediate and persistent antidepressant-like effects of Chaihu-jia-Longgu-Muli-tang are associated with instantly up-regulated BDNF in the hippocampus of mice. Bioscience reports. vol 39. issue 1. 2019-07-29. PMID:30473537. |
the results support that chaihu-jia-longgu-muli decoction was capable to immediately and enduringly elicit antidepressant activity via enhancement of hippocampal bdnf expression, in which the constituent xiaochaihu decoction played the primary role. |
2019-07-29 |
2023-08-13 |
mouse |