| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kensuke Nakajima, Shinya Okubo, Shigeru Ois. Identification of traditional Japanese Kampo medicines and crude drugs that upregulate brain‑derived neurotrophic factor in human peripheral cells. Acta neurobiologiae experimentalis. vol 81. issue 4. 2022-01-11. PMID:35014988. |
the neurotrophic hypothesis of depression, which suggests that decreased hippocampal brain‑derived neurotrophic factor (bdnf) levels cause depression, has become increasingly popular. |
2022-01-11 |
2023-08-13 |
human |
| Guo-Liang Dai, Xin-Yi Yang, Shan-Shan Chen, Yi-Qing Wang, Mei-Chen Liu, Yang Cao, Fei-Ran Li, Cheng-Yao Ma, Wen-Zheng J. [Effects of Jiaotai Pills on CUMS-induced depression model in mice based on changes of SIRT1 expression in hippocampus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 24. 2022-01-07. PMID:34994144. |
enzyme-linked immunosorbent assay(elisa) kits were used to detect the levels of interleukin(il)-1β, il-6, tumor necrosis factor-α(tnf-α), and brain-derived neurotrophic factor(bdnf) in the hippocampus and serum of mice. |
2022-01-07 |
2023-08-13 |
mouse |
| Guo-Liang Dai, Xin-Yi Yang, Shan-Shan Chen, Yi-Qing Wang, Mei-Chen Liu, Yang Cao, Fei-Ran Li, Cheng-Yao Ma, Wen-Zheng J. [Effects of Jiaotai Pills on CUMS-induced depression model in mice based on changes of SIRT1 expression in hippocampus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 24. 2022-01-07. PMID:34994144. |
in the hippocampus and serum, the levels of il-1β, il-6, tnf-α, and mda were increased(p<0.01), and the activity of sod and the levels of gsh, da, 5-ht, ne, and bdnf were reduced(p<0.01). |
2022-01-07 |
2023-08-13 |
mouse |
| Guo-Liang Dai, Xin-Yi Yang, Shan-Shan Chen, Yi-Qing Wang, Mei-Chen Liu, Yang Cao, Fei-Ran Li, Cheng-Yao Ma, Wen-Zheng J. [Effects of Jiaotai Pills on CUMS-induced depression model in mice based on changes of SIRT1 expression in hippocampus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 24. 2022-01-07. PMID:34994144. |
the treatment with high-dose jiaotai pills increased the sucrose preference rate, movement distance, and the number of crossing centers(p<0.05), reduced tail suspension time and swimming immobility time(p<0.01), elevated hippocampal sirt1 expression level(p<0.01), decreased hippocampal and serum il-1β, il-6, tnf-α, and mda levels(p<0.01), potentiated sod activity, and up-regulated gsh, da, 5-ht, ne, and bdnf levels in the hippocampus and serum(p<0.05, p<0.01) in model mice. |
2022-01-07 |
2023-08-13 |
mouse |
| Yuan Zhou, Shao-Fu Li, Li-Sha Deng, Yong-Kang Ma, Gang Lei, Yong-Hui Dan. HINT1 deficiency in aged mice reduces anxiety-like and depression-like behaviours and enhances cognitive performances. Experimental gerontology. 2022-01-07. PMID:34995725. |
in addition, hint1 ko mice also showed increased gsh-px and superoxide dismutase, and decreased malondialdehyde, together with enhanced bdnf and trk-b expression in the hippocampus and pfc. |
2022-01-07 |
2023-08-13 |
mouse |
| Rosmara Infantino, Concetta Schiano, Livio Luongo, Salvatore Paino, Gelsomina Mansueto, Serena Boccella, Francesca Guida, Flavia Ricciardi, Monica Iannotta, Carmela Belardo, Ida Marabese, Gorizio Pieretti, Nicola Serra, Claudio Napoli, Sabatino Maion. MED1/BDNF/TrkB pathway is involved in thalamic hemorrhage-induced pain and depression by regulating microglia. Neurobiology of disease. 2022-01-07. PMID:34995755. |
hippocampal med1 and trkb expressions were significantly increased in th compared to sham mice 21 days post-th, whereas bdnf levels were decreased. |
2022-01-07 |
2023-08-13 |
mouse |
| N A Alfaris, G M Alshammari, J Z Altamimi, D H Aljabryn, R I Alagal, H Aldera, M A Alkhateeb, M A Yahy. Ellagic acid prevents streptozotocin-induced hippocampal damage and memory loss in rats by stimulating Nrf2 and nuclear factor-κB, and activating insulin receptor substrate/PI3K/Akt axis. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 72. issue 4. 2022-01-06. PMID:34987124. |
besides, and in the hippocampus of both groups, ea increased the phosphorylation of insulin receptor substrate (irs), pi3k, akt, gs3kβ, and creb, and increased levels of bdnf and bcl-2. |
2022-01-06 |
2023-08-13 |
rat |
| Roya Malekloo, Setayesh Nematollahi, Abbas Ali Vafei, Ali Rashidy-Pou. Effects of different intensities of treadmill exercise on cued fear extinction failure, hippocampal BDNF decline, and Bax/Bcl-2 ratio alteration in chronic - morphine treated male rats. Behavioural brain research. 2022-01-06. PMID:34990697. |
effects of different intensities of treadmill exercise on cued fear extinction failure, hippocampal bdnf decline, and bax/bcl-2 ratio alteration in chronic - morphine treated male rats. |
2022-01-06 |
2023-08-13 |
rat |
| Roya Malekloo, Setayesh Nematollahi, Abbas Ali Vafei, Ali Rashidy-Pou. Effects of different intensities of treadmill exercise on cued fear extinction failure, hippocampal BDNF decline, and Bax/Bcl-2 ratio alteration in chronic - morphine treated male rats. Behavioural brain research. 2022-01-06. PMID:34990697. |
this work investigated the effects of forced exercise with different intensities on cued fear extinction impairment and alternations of hippocampal bdnf and apoptotic proteins induced by chronic morphine. |
2022-01-06 |
2023-08-13 |
rat |
| Roya Malekloo, Setayesh Nematollahi, Abbas Ali Vafei, Ali Rashidy-Pou. Effects of different intensities of treadmill exercise on cued fear extinction failure, hippocampal BDNF decline, and Bax/Bcl-2 ratio alteration in chronic - morphine treated male rats. Behavioural brain research. 2022-01-06. PMID:34990697. |
subsequently, rats received a cued fear conditioning followed by four days of extinction training, and the expression of hippocampal bdnf and apoptotic proteins was determined. |
2022-01-06 |
2023-08-13 |
rat |
| Roya Malekloo, Setayesh Nematollahi, Abbas Ali Vafei, Ali Rashidy-Pou. Effects of different intensities of treadmill exercise on cued fear extinction failure, hippocampal BDNF decline, and Bax/Bcl-2 ratio alteration in chronic - morphine treated male rats. Behavioural brain research. 2022-01-06. PMID:34990697. |
a relatively long time after the last injection of morphine (35 days), rats again showed cued fear extinction failure and reduced hippocampal bdnf, which recovered by light and moderate, but not high exercise. |
2022-01-06 |
2023-08-13 |
rat |
| Serena Camuso, Piergiorgio La Rosa, Maria Teresa Fiorenza, Sonia Canterin. Pleiotropic effects of BDNF on the cerebellum and hippocampus: Implications for neurodevelopmental disorders. Neurobiology of disease. 2022-01-02. PMID:34974125. |
pleiotropic effects of bdnf on the cerebellum and hippocampus: implications for neurodevelopmental disorders. |
2022-01-02 |
2023-08-13 |
Not clear |
| Serena Camuso, Piergiorgio La Rosa, Maria Teresa Fiorenza, Sonia Canterin. Pleiotropic effects of BDNF on the cerebellum and hippocampus: Implications for neurodevelopmental disorders. Neurobiology of disease. 2022-01-02. PMID:34974125. |
bdnf is present in various brain areas, but highest levels of expression are seen in the cerebellum and hippocampus. |
2022-01-02 |
2023-08-13 |
Not clear |
| Serena Camuso, Piergiorgio La Rosa, Maria Teresa Fiorenza, Sonia Canterin. Pleiotropic effects of BDNF on the cerebellum and hippocampus: Implications for neurodevelopmental disorders. Neurobiology of disease. 2022-01-02. PMID:34974125. |
after birth, bdnf acts in the cerebellum as a mitogenic and chemotactic factor, stimulating the cerebellar granule cell precursors to proliferate, migrate and maturate, while in the hippocampus bdnf plays a fundamental role in synaptic transmission and plasticity, representing a key regulator for the long-term potentiation, learning and memory. |
2022-01-02 |
2023-08-13 |
Not clear |
| Serena Camuso, Piergiorgio La Rosa, Maria Teresa Fiorenza, Sonia Canterin. Pleiotropic effects of BDNF on the cerebellum and hippocampus: Implications for neurodevelopmental disorders. Neurobiology of disease. 2022-01-02. PMID:34974125. |
the purpose of this review is to provide an overview of the current state of knowledge on the bdnf biology and its neurotrophic role in the proper development and functioning of neurons and synapses in two important brain areas of postnatal neurogenesis, the cerebellum and hippocampus. |
2022-01-02 |
2023-08-13 |
Not clear |
| Ayse Ozkan, Mutay Aydin Aslan, Osman Sinen, Mustafa Munzuroglu, Narin Derin, Hande Parlak, Mehmet Bulbul, Aysel Aga. Effects of adropin on learning and memory in rats tested in the Morris water maze. Hippocampus. 2021-12-31. PMID:34971006. |
the expression of akt, phospho-akt, creb, phospho-creb, erk1/2, phospho-erk1/2, glycogen synthase kinase 3 β (gsk3β), phospho-gsk3β, brain-derived neurotrophic factor (bdnf), and n-methyl-d-aspartate receptor nr2b subunit were determined in the hippocampal tissues by using western blot. |
2021-12-31 |
2023-08-13 |
rat |
| Tomohiro Umeda, Ayumi Sakai, Keiko Shigemori, Ayumi Yokota, Toru Kumagai, Takami Tomiyam. Oligomer-Targeting Prevention of Neurodegenerative Dementia by Intranasal Rifampicin and Resveratrol Combination - A Preclinical Study in Model Mice. Frontiers in neuroscience. vol 15. 2021-12-30. PMID:34966254. |
notably, resveratrol alone and the combinatorial medicine, but not rifampicin alone, enhanced the levels of brain-derived neurotrophic factor (bdnf) and its precursor, pro-bdnf, in the hippocampus. |
2021-12-30 |
2023-08-13 |
mouse |
| Zhou-Liang Xu, GanLu Chen, XiangFei Liu, DaoFen Xie, Jie Zhang, YongGan Yin. Effects of ginsenosides on memory impairment in propofol-anesthetized rats. Bioengineered. vol 13. issue 1. 2021-12-29. PMID:34964700. |
furthermore, the expression levels of ngf and bdnf on rat hippocampus were significant increased by the treatment of ginsenosides at both two doses compared with the control group (both |
2021-12-29 |
2023-08-13 |
rat |
| Shih-Te Yang, Hsiu-Yi Hung, Long-Sun Ro, Ming-Feng Liao, Tamara G Amstislavskaya, Maria A Tikhonova, Yi-Ling Yang, Kwok-Tung L. Chronic Administration of 7,8-DHF Lessens the Depression-like Behavior of Juvenile Mild Traumatic Brain Injury Treated Rats at Their Adult Age. Pharmaceutics. vol 13. issue 12. 2021-12-28. PMID:34959450. |
after the behavioral experiments, the dorsal hippocampus (dhip) and ventral hippocampus (vhip) were dissected out for western blotting to examine the expression of brain-derived neurotrophic factor (bdnf) and tropomyosin receptor kinase b (trkb). |
2021-12-28 |
2023-08-13 |
rat |
| Shih-Te Yang, Hsiu-Yi Hung, Long-Sun Ro, Ming-Feng Liao, Tamara G Amstislavskaya, Maria A Tikhonova, Yi-Ling Yang, Kwok-Tung L. Chronic Administration of 7,8-DHF Lessens the Depression-like Behavior of Juvenile Mild Traumatic Brain Injury Treated Rats at Their Adult Age. Pharmaceutics. vol 13. issue 12. 2021-12-28. PMID:34959450. |
the hippocampal bdnf expression, but not the trkb, were significantly reduced in mtbi-j, and the mtbi-j treatment-induced depression-like behavior was lessened after four weeks of 7,8-dhf administration. |
2021-12-28 |
2023-08-13 |
rat |